Faculty

Institution

Unit

Venue

Ralf Langen

PhD

University of Southern California

Affiliations

Keck School of Medicine

Physiology and Neuroscience

School of Gerontology

Ralf Langen is currently serving as a Keck School Of Medicine PhD at University of Southern California.

Honors

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Experiences

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Education

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Ralf Langen

University of Southern California

PhD

You can click a keyword to filter the displayed items

structural biology molecular biology biophysics protein science biochemistry protein structure neuroscience membrane biology biological chemistry structural molecular biology biomolecular structure site-directed spin labeling molecular neurodegeneration neurodegenerative diseases cellular biochemistry protein misfolding alzheimer's disease protein folding protein function protein assembly molecular neurobiology molecular neuroscience gene expression protein transport biomolecular interactions redox biology molecular physiology cell death medicinal research molecular structure molecular science amyloid fibrils islet amyloid polypeptide biochemical sciences conformational studies protein chemistry biochemical genetics membrane structure membrane curvature structural features helical hairpin structural characterization virus research apoptosis mutant huntingtin liver physiology general virology molecular aggregate neurochemistry viral genetics mutagenesis antibody engineering molecular regulation protein phosphorylation integrative biology protein bioinformatics immunochemistry hemostasis membrane interaction amphipathic helices lipid vesicles huntingtin fibrils membrane binding hydration dynamics membrane curvature generation structural bioinformatics cellular neurobiology structure elucidation structural morphology fragmentation effect cellular structure geriatric endocrinology comparative endocrinology steroid metabolism endocrine research computational refinement protein refolding protein modeling

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pleiotropic Effects of Mutant Huntingtin on Retinopathy in Two Mouse Models of Huntington's Disease. Neurobiology of Disease (2024)

Hui XuAnakha AjayanRalf LangenJeannie Chen

ophthalmologyneuro-ophthalmologyneuropathologyneuroradiologymutant huntingtinexperimental neuropathologyophthalmology retinaocular diseaseneurologyneuroinflammationvascular biologyocular pathologycentral nervous systemexperimental ophthalmologyneurodegenerative diseasesmouse modelsmammalian biologymolecular neurodegenerationhuntington's diseasepleiotropic effectsneuroscience

Retraction Note: Pericyte Degeneration Causes White Matter Dysfunction in the Mouse Central Nervous System. Nature Medicine (2024)

Axel MontagneAngeliki M. NikolakopoulouZhen ZhaoAbhay P. SagareGabriel SiDivna LazicSamuel R. BarnesMadelaine DaianuAnita RamanathanAriel GoErica J. LawsonYaoming WangWilliam J. MackPaul M. ThompsonJulie A. SchneiderJobin VarkeyRalf LangenEric MullinsRussell E. JacobsBerislav V. Zlokovic

physiologyneurologyretraction notepericyte degenerationwhite mattermammalian biologycentral nervous systemwhite matter dysfunctionneuroscience

Tdp43 and Huntingtin Exon-1 Undergo a Conformationally Specific Interaction That Strongly Alters the Fibril Formation of Both Proteins. Journal of Biological Chemistry (2024)

Gincy GeorgeAnakha AjayanJobin VarkeyNitin K PandeyJeannie ChenRalf Langen

specific interactionbiological macromoleculesprotein functionprotein structurebiological chemistrybiochemistrybiomolecular interactionsmolecular cell biologystructural biologyfibril formationprotein scienceprotein foldingprotein assemblyprotein misfoldingmolecular and cellular biologyprotein phosphorylationbiophysicsmolecular biologystructural molecular biology

Fluorescent Protein Tagging Promotes Phase Separation and Alters the Aggregation Pathway of Huntingtin Exon-1. Journal of Biological Chemistry (2023)

Nitin K. PandeyJobin VarkeyAnakha AjayanGincy GeorgeJeannie ChenRalf Langen

aggregation pathwaymolecular biologycell biologyneurosciencebioinformatics

Molecular Basis of Q-Length Selectivity for the Mw1 Antibody–Huntingtin Interaction. Journal of Biological Chemistry (2023)

Jose M. Bravo-ArredondoRajashree VenkataramanJobin VarkeyJose Mario IsasAlan J. SituHui XuJeannie ChenTobias S. UlmerRalf Langen

immunologybiomolecular interactionsprotein sciencemolecular scienceimmunochemistrymolecular immunologymolecular biologybiological chemistryantibody engineeringstructural biologymolecular medicineq-length selectivitybiochemistry

The Dynamic Interactions of a Multitargeting Domain in Ameloblastin Protein With Amelogenin and Membrane. International Journal of Molecular Sciences (2023)

Natalie C. KegulianRalf LangenJanet Moradian-Oldak

protein structurepath dependencebiomolecular interactionsenzymesstructural biologyprotein scienceameloblastin proteinmolecular biophysicsdynamic interactionsmammalian biologymultitargeting domaincellular biochemistryimmunologygene expressionredox biologyprotein bioinformaticssoft modemolecular biologystructural molecular biologyfeedback loopneuroscience

Amplification of Neurotoxic Httex1 Assemblies in Human Neurons. Neurobiology of Disease (2021)

Anjalika ChongthamJ. Mario IsasNitin K. PandeyAnoop RawatJung Hyun YooTara MastroMary B. KennedyRalf LangenAli Khoshnan

human neuronsneurologyneuroscienceneurons

A New Biochemical Method for Ultra-Purification of Amyloids From Alzheimer's Disease Brain Tissues.. PubMed (2021)

Arun UpadhyayAnsgar SiemerRalf LangenRobert J VassarJeffrey N Savas

purification methodbiological engineeringprotein purificationalzheimer's diseaseneurosciencebiochemistry

Huntingtin Fibrils With Different Toxicity, Structure, and Seeding Potential Can Be Interconverted. Nature Communications (2021)

J Mario IsasNK PandeyH XuK TeranishiAK OkadaEK FultzA Rawat...

biophysicsprotein structuredifferent toxicityhuntingtin fibrilsstructural biologyneuroscience

Lysine Acetylation Regulates the Interaction Between Proteins and Membranes. Nature Communications (2021)

Alan K. OkadaKazuki TeranishiMark R. AmbrosoJose Mario IsasElena Vazquez-SarandesesJoo-Yeun LeeArthur Alves MeloPriyatama PandeyDaniel MerkenLeona BerndtMichael LammersOliver DaumkeKaren ChangIan S. HaworthRalf Langen

biomolecular interactionsbiophysicsmolecular biologystructural biologylysine acetylationprotein sciencemembrane biologybiochemistry

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Ralf Langen

PhD

University of Southern California

Affiliations

Keck School of Medicine

Physiology and Neuroscience

School of Gerontology

Ralf Langen is currently serving as a Keck School Of Medicine PhD at University of Southern California.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ralf Langen

University of Southern California

PhD

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pleiotropic Effects of Mutant Huntingtin on Retinopathy in Two Mouse Models of Huntington's Disease. Neurobiology of Disease (2024)

Hui XuAnakha AjayanRalf LangenJeannie Chen

Retraction Note: Pericyte Degeneration Causes White Matter Dysfunction in the Mouse Central Nervous System. Nature Medicine (2024)

physiologyneurologyretraction notepericyte degenerationwhite mattermammalian biologycentral nervous systemwhite matter dysfunctionneuroscience

Tdp43 and Huntingtin Exon-1 Undergo a Conformationally Specific Interaction That Strongly Alters the Fibril Formation of Both Proteins. Journal of Biological Chemistry (2024)

Gincy GeorgeAnakha AjayanJobin VarkeyNitin K PandeyJeannie ChenRalf Langen

Fluorescent Protein Tagging Promotes Phase Separation and Alters the Aggregation Pathway of Huntingtin Exon-1. Journal of Biological Chemistry (2023)

Nitin K. PandeyJobin VarkeyAnakha AjayanGincy GeorgeJeannie ChenRalf Langen

aggregation pathwaymolecular biologycell biologyneurosciencebioinformatics

Molecular Basis of Q-Length Selectivity for the Mw1 Antibody–Huntingtin Interaction. Journal of Biological Chemistry (2023)

Jose M. Bravo-ArredondoRajashree VenkataramanJobin VarkeyJose Mario IsasAlan J. SituHui XuJeannie ChenTobias S. UlmerRalf Langen

The Dynamic Interactions of a Multitargeting Domain in Ameloblastin Protein With Amelogenin and Membrane. International Journal of Molecular Sciences (2023)

Natalie C. KegulianRalf LangenJanet Moradian-Oldak

Amplification of Neurotoxic Httex1 Assemblies in Human Neurons. Neurobiology of Disease (2021)

Anjalika ChongthamJ. Mario IsasNitin K. PandeyAnoop RawatJung Hyun YooTara MastroMary B. KennedyRalf LangenAli Khoshnan

human neuronsneurologyneuroscienceneurons

A New Biochemical Method for Ultra-Purification of Amyloids From Alzheimer's Disease Brain Tissues.. PubMed (2021)

Arun UpadhyayAnsgar SiemerRalf LangenRobert J VassarJeffrey N Savas

purification methodbiological engineeringprotein purificationalzheimer's diseaseneurosciencebiochemistry

Huntingtin Fibrils With Different Toxicity, Structure, and Seeding Potential Can Be Interconverted. Nature Communications (2021)

J Mario IsasNK PandeyH XuK TeranishiAK OkadaEK FultzA Rawat...

biophysicsprotein structuredifferent toxicityhuntingtin fibrilsstructural biologyneuroscience

Lysine Acetylation Regulates the Interaction Between Proteins and Membranes. Nature Communications (2021)

biomolecular interactionsbiophysicsmolecular biologystructural biologylysine acetylationprotein sciencemembrane biologybiochemistry

1
2
3
4
5
16
10 / page

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