Faculty

Institution

Unit

Venue

Patrick J. Pagano

Primary Faculty Professor; Assistant Dean for Graduate Studies

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Pharmacology and Chemical Biology

Patrick J. Pagano is currently serving as an Interdisciplinary Biomedical Graduate Program Primary Faculty Professor; Assistant Dean for Graduate Studies at University of Pittsburgh.

Honors

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Experiences

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Education

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Patrick J. Pagano

University of Pittsburgh

Primary Faculty Professor; Assistant Dean for Graduate Studies

You can click a keyword to filter the displayed items

pharmacology vascular biology physiology cardiology immunology hematology health sciences redox biology membrane biology cardiovascular research circulatory physiology inflammation cardiovascular physiology oxidative stress liver physiology free radical biology respiratory medicine angiogenesis cardiovascular disease redox signaling angiology regenerative medicine thrombosis medicinal research electrophysiology applied physiology molecular physiology animal physiology cardiovascular function human physiology hemostasis vascular disease cellular physiology mammalian biology arterial disease reactive oxygen species enzyme inhibition blood pressure vascular pharmacology cerebrovascular disease vascular adaptation endothelial dysfunction clinical physiology cardiovascular pharmacology clinical medicine heme homeostasis cell migration tissue physiology signaling pathways protein function cell regulation mammalian physiology cardiac muscle renal function molecular regulation antihypertensive therapy nadph oxidases rat carotid artery nitric oxide pulmonary hypertension matrix biology cell physiology cell biomechanics in vivo systems cardiac myocytes rabbit aorta angiotensin ii-induced hypertension neointimal hyperplasia vascular adventitia rational design arachidonic acid calcium-dependent potassium channels vascular smooth muscle collagen synthesis matrix metalloproteinase activity cardiac fibroblasts system pharmacology drug discovery pharmacotherapy pharmacological research medicine hypertension

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2109: Nox1-Mediated Endothelial Ros Propagates Hypoxia-Induced Pulmonary Hypertension via the Unfolded Protein Response.. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Christian J GoossenDamir KracunPatrick J PaganoAdam C StraubDelphine A GomezImad Al GhoulehChristopher DustinEugenia Cifuentes-PaganoShuai Yuan

liver physiologyimmunologyneurosciencetissue physiologypharmacologyvascular biologynephrologyhematologyhypoxia (medicine)protein foldingcardiologyangiologyrespiratory medicinemedicinal researchthrombosisfunctional regulationinflammationhypoxia-induced pulmonary hypertensionbiological functionunfolded protein response

Development of New Peptidomimetic Nadph Oxidase Inhibitors With Antithrombotic Properties. ChemMedChem (2024)

Elisabetta ScaliaAntony ChircoLorenzo CalugiElena LenciPatrick J. PaganoGiordano PulaAndrea Trabocchi

immunologymedicinal chemistrytreatment developmentpharmacologyantithrombotic properties

Lrrk2 Regulates Production of Reactive Oxygen Species in Cell and Animal Models of Parkinson’s Disease. Science Translational Medicine (2024)

Matthew T. KeeneyEmily M. RochaEric K. HoffmanKyle FarmerRoberto Di MaioJulie WeirWeston G. WagnerXiaoping HuCourtney L. ClarkSandra L. CastroAbigail ScheirerMarco FazzariBriana R. De MirandaSean A. PintchovskiWilliam D. ShraderPatrick J. PaganoTeresa G. HastingsJ. Timothy Greenamyre

animal modelsredox signalingreactive nitrogen speciespathogenesiscell biologyparkinson's diseaseoxysterolmolecular biologyoxidative stressreceptor tyrosine kinasesmolecular neurodegenerationtranslational medicinereactive oxygen speciescell metabolismneurologyinflammationmolecular physiologyfree radical biologyredox biology

Nox2 in Alzheimer’s and Parkinson’s Disease. Redox Biology (2024)

Christopher M DustinSruti S ShivaAlberto VazquezAnum SaeedTharick PascoalEugenia Cifuentes-PaganoPatrick J Pagano

neurologyalzheimer's diseasemolecular neurodegenerationreactive oxygen speciesparkinson's diseaseneuroscienceneurodegenerative diseasesoxidative stressredox biology

Pannexin-3 Stabilizes the Transcription Factor Bcl6 in a Channel-Independent Manner to Protect Against Vascular Oxidative Stress. Science Signaling (2024)

Abigail G. WolpeMelissa A. LuseChristopher BaryiamesWyatt J. SchugJacob B. WolpeScott R. JohnstoneLuke S. DunawayZuzanna J. JuśkiewiczSkylar A. LoebHenry R. Askew PageYen-Lin ChenVikram SabapathyCaitlin M. PavelecBrent WakefieldEugenia Cifuentes-PaganoMykhaylo V. ArtamonovAvril V. SomlyoAdam C. StraubRahul SharmaFrank BeierEugene J. BarrettNorbert LeitingerPatrick J. PaganoSwapnil K. SonkusareStefanie RedemannLinda ColumbusSilvia PenuelaBrant E. Isakson

vascular oxidative stressliver physiologyredox signalinghemostasispharmacologybiomolecular interactionsvascular biologycell signalingcell biologytranscription factorsmolecular biologyoxidative stresschannel-independent mannercell regulationmolecular physiologymembrane biologyfree radical biologysignal transductionredox biologymolecular regulation

Role of the Ccl5 and Its Receptor, Ccr5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage. Hypertension (2024)

Rafael M. CostaDébora M. CerqueiraAriane Bruder-NascimentoJuliano V. AlvesWanessa M.C. AwataShubhnita SinghAlexander KufnerDouglas S. PradoEbin JohnyEugenia Cifuentes-PaganoWilliam F. HawsePartha DuttaPatrick J. PaganoJacqueline HoThiago Bruder-Nascimento

vascular dysfunctionmedicinepharmacologyaldosterone-induced hypertensionendocrinologyhypertensionend-organ damage

Isoform-Selective Nox Inhibitors: Advances and Future Perspectives. Springer eBooks (2023)

Christopher M. DustinEugenia Cifuentes-PaganoPatrick J. Pagano

isoform-selective nox inhibitorspharmacologyfuture perspectives

Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology (2023)

Emilie CoppinXinyi ZhangLee OhayonEbin JohnyAnkush DasariKang H. ZhengLotte StiekemaEugenia Cifuentes-PaganoPatrick J. PaganoSrilakshmi ChaparalaErik S. StroesPartha Dutta

inflammationcardiologyvascular biologyangiologyhematopoietic stem cellscell biologythrombosisatherosclerosishematologygenetics

Role of the C-C Motif Chemokine Ligand 5 (Ccl5) and Its Receptor, C-C Motif Chemokine Receptor 5 (Ccr5) in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Rafael M. CostaDébora M. CerqueiraAriane Bruder-NascimentoJuliano V. AlvesWanessa A.C. AwataShubhnita SinghAlexander KufnerEugenia Cifuentes-PaganoPatrick J. PaganoJacqueline HoThiago Bruder-Nascimento

liver physiologyimmunologypharmacologyaldosterone-induced hypertensionvascular biologycardiovascular pharmacologyphysiologyvascular dysfunctiongene expressionreceptorscardiovascular physiologyend-organ damagemedicinal researchendothelial dysfunctionendocrinologycardiovascular researchreceptor (biochemistry)molecular physiologymembrane biologyblood pressurehypertension

Targeting Nox2 With Bivalent Small-Molecule P47Phox–P22Phox Inhibitors. Journal of Medicinal Chemistry (2023)

Jie ZangFelix PetersYves CambetEugenia Cifuentes-PaganoMunira Mohamed Shishay HissabuChristopher M. DustinLars Henrik SvenssonMartin Mariboe OlesenMathias Feldt Lomholt PoulsenStig JacobsenPernille Sønderby TuelungDilip NarayananAnnette Eva LangkildeMichael GajhedePatrick J. PaganoVincent JaquetFrederik VilhardtAnders Bach

drug targetingdrug targetsmedicinal chemistrysmall moleculesrational drug designpharmacologytherapeutic targetsdrug discoveryenzyme inhibition

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Patrick J. Pagano

Primary Faculty Professor; Assistant Dean for Graduate Studies

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Pharmacology and Chemical Biology

Patrick J. Pagano is currently serving as an Interdisciplinary Biomedical Graduate Program Primary Faculty Professor; Assistant Dean for Graduate Studies at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Patrick J. Pagano

University of Pittsburgh

Primary Faculty Professor; Assistant Dean for Graduate Studies

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2109: Nox1-Mediated Endothelial Ros Propagates Hypoxia-Induced Pulmonary Hypertension via the Unfolded Protein Response.. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Christian J GoossenDamir KracunPatrick J PaganoAdam C StraubDelphine A GomezImad Al GhoulehChristopher DustinEugenia Cifuentes-PaganoShuai Yuan

Development of New Peptidomimetic Nadph Oxidase Inhibitors With Antithrombotic Properties. ChemMedChem (2024)

Elisabetta ScaliaAntony ChircoLorenzo CalugiElena LenciPatrick J. PaganoGiordano PulaAndrea Trabocchi

immunologymedicinal chemistrytreatment developmentpharmacologyantithrombotic properties

Lrrk2 Regulates Production of Reactive Oxygen Species in Cell and Animal Models of Parkinson’s Disease. Science Translational Medicine (2024)

Nox2 in Alzheimer’s and Parkinson’s Disease. Redox Biology (2024)

Christopher M DustinSruti S ShivaAlberto VazquezAnum SaeedTharick PascoalEugenia Cifuentes-PaganoPatrick J Pagano

neurologyalzheimer's diseasemolecular neurodegenerationreactive oxygen speciesparkinson's diseaseneuroscienceneurodegenerative diseasesoxidative stressredox biology

Pannexin-3 Stabilizes the Transcription Factor Bcl6 in a Channel-Independent Manner to Protect Against Vascular Oxidative Stress. Science Signaling (2024)

Role of the Ccl5 and Its Receptor, Ccr5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage. Hypertension (2024)

vascular dysfunctionmedicinepharmacologyaldosterone-induced hypertensionendocrinologyhypertensionend-organ damage

Isoform-Selective Nox Inhibitors: Advances and Future Perspectives. Springer eBooks (2023)

Christopher M. DustinEugenia Cifuentes-PaganoPatrick J. Pagano

isoform-selective nox inhibitorspharmacologyfuture perspectives

Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology (2023)

Emilie CoppinXinyi ZhangLee OhayonEbin JohnyAnkush DasariKang H. ZhengLotte StiekemaEugenia Cifuentes-PaganoPatrick J. PaganoSrilakshmi ChaparalaErik S. StroesPartha Dutta

inflammationcardiologyvascular biologyangiologyhematopoietic stem cellscell biologythrombosisatherosclerosishematologygenetics

Targeting Nox2 With Bivalent Small-Molecule P47Phox–P22Phox Inhibitors. Journal of Medicinal Chemistry (2023)

drug targetingdrug targetsmedicinal chemistrysmall moleculesrational drug designpharmacologytherapeutic targetsdrug discoveryenzyme inhibition

1
2
3
4
5
17
10 / page

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