Faculty

Institution

Unit

Venue

Bruce A. Freeman

Distinguished Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Bruce A. Freeman is currently serving as an Interdisciplinary Biomedical Graduate Program Distinguished Professor at University of Pittsburgh.

Honors

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Experiences

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Education

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Bruce A. Freeman

University of Pittsburgh

Distinguished Professor

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pharmacology membrane biology redox biology free radical biology biochemistry physiology inflammation liver physiology vascular biology health sciences oxidative stress respiratory medicine cardiology biological chemistry hematology regenerative medicine enzymes medicinal research cardiovascular research cellular physiology chemical biology molecular physiology enzyme inhibition protein science redox signaling nitric oxide animal physiology radical (chemistry) lipid science anti-inflammatory circulatory physiology mammalian biology nitro-oleic acid biochemical sciences lipid chemistry cardiovascular physiology nitrosative stress nitro-fatty acids reactive oxygen species endothelial dysfunction vascular disease xanthine oxidase hypoxia (medicine) human physiology mitochondrial function neurochemistry sickle cell disease functional modification respiration (physiology) superoxide dismutase clinical physiology respiratory neurobiology biological inorganic chemistry hemostasis mammalian physiology redox chemistry renal function lipoprotein metabolism electrophilic nitro-fatty acids clinical medicine disease physiology reperfusion injury liposome-mediated augmentation vascular endothelium cardiovascular function angiogenesis biocatalysis enzyme catalysis functional regulation human serum albumin murine model nitrolinoleic acid hydrogen peroxide unsaturated fatty acids xanthine dehydrogenase fatty acid transduction fatty acids metabolic syndrome cardiovascular pharmacology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Novel Gene Regulatory Networks Identified in Response to Nitro-Conjugated Linoleic Acid in Human Endothelial Cells. Zenodo (CERN European Organization for Nuclear Research) (2025)

Yanbo FanHaocheng Lu

molecular regulationgene functionnitro-conjugated linoleic acidnuclear medicinecell biologygene regulatory networksvascular biologynuclear sciencemolecular cell biologymembrane biologyfunctional genomicsmolecular and cellular biologymolecular physiologygene expressiongeneticshuman endothelial cellsendothelial dysfunctionmolecular biologymolecular geneticsgene regulation

Adipocyte-Specific Nrf2 Deletion Negates Nitro-Oleic Acid Benefits on Glucose Tolerance in Diet-Induced Obesity. Nitric Oxide (2024)

D.V. ChartoumpekisI. ChenS.R. SalvatoreF.J. SchopferB.A. FreemanN.K.H. Khoo

metabolic controlliver physiologyhost responsemetabolic regulationendocrinologyhost factorsobesitybiological functionmembrane biologycell metabolismcellular physiologymolecular physiologyimmunologygene expressionpharmacologygeneticsdiet-induced obesityglucose tolerancesignal transduction

Chemoproteomics Reveals Recql4 Inhibition as a Mediator of Nitroalkene-Dependent Dna Double Strand Break Repair Inhibition in Cancer. Free Radical Biology and Medicine (2024)

Dennis BradenHuiming LuMostafa Abdellatif Abdel AbdelrheemAlp AsanJohn SkokoThomas ConradsBruce FreemanFrancisco SchopferIshu SainiCaroline KiskerAnthony DavisCarola Neumann

cancer researchfree radical biologybiochemistrydna repair

Enhanced Cardiac Mitochondrial Biogenesis by Nitro-Oleic Acid Remedies Diastolic Dysfunction in a Mouse Model of Heart Failure With Preserved Ejection Fraction. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Marion MüllerTorben SchubertCornelius WelkeTina Johanna SchulzThomas PatschkowskiTibor MaskeLuisa Andrea LengenfelderLucia LandwehrjohannElfi DonhauserElisa Theres VogtBernd StratmannJurek HenseSimon LüdtkeMartina DüferElen TolstikJohann DierksFelix-Levin HormannSven HeilesKristina LorenzJan-Christian ReilFrancisco Jose SchopferBruce A. FreemanVolker RudolphUwe SchlomannAnna Klinke

physiologycardiologyheart failurebiophysicspharmacologycardiovascular physiologymouse modelregenerative medicinecardiovascular researchmitochondrial functionpreserved ejection fractionmitochondrial biogenesis

Lipoxin A4 Yields an Electrophilic 15-Oxo Metabolite That Mediates Fpr2 Receptor-Independent Anti-Inflammatory Signaling. Journal of Lipid Research (2024)

Adolf KoudelkaGregory J BuchanVeronika CechovaJames P O'BrienEmily R StevensonCrystal E UvalleHeng LiuSteven R WoodcockSteven J MullettCheng ZhangBruce A FreemanStacy L Gelhaus

lipid peroxidationreceptorspharmacologyredox signalingfree radical biologylipidsredox biologyreactive oxygen speciesbiomolecular engineeringbioactive compoundsmedicinal researchanti-inflammatoryoxidative stressbiochemistryinflammation

Lipoxin a 4 Yields an Electrophilic 15-Oxo Metabolite That Mediates Fpr2 Receptor-Independent Anti-Inflammatory Signaling. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Adolf KoudelkaGregory J. BuchanVeronika CechovaJames P. O’BrienHeng LiuSteven R. WoodcockSteven J. MullettCheng ZhangBruce A. FreemanStacy L. Gelhaus

immunologypharmacologycell signalinganti-inflammatoryinflammation

Nitro-Oleic Acid Mitigates Chlorine-Induced Lung Injury in Mice by Inhibiting Pro-Inflammatory Macrophage Activation. (2024)

R. MalaviyaA. GowB. FreemanR. RancourtE. AbramovaK. VayasJ. LaskinD.L. Laskin

immunologyhematologynitro-oleic acidmammalian biologypro-inflammatory macrophage activationrespiratory medicinechlorine-induced lung injuryneurosciencehealth sciencesinflammation

Cardioprotective Efficacy of Ultrasound-Targeted Nitrofatty Acid Microbubbles in Rat Myocardial Ischemia-Reperfusion Injury Model. The Journal of the Acoustical Society of America (2023)

Muhammad Wahab AmjadSoheb Anwar MohammedMarco FazzariXucai ChenBruce FreemanTerry MatsunagaJohn J. Pacella

cardiologyneurologyultrasoundaudiology

Chemoproteomics Reveals Recql4 Inhibition as a Mediator of Nitroalkene-Dependent Dna Double Strand Break Repair Inhibition in Cancer.. Free radical biology & medicine (2023)

Dennis BradenAlp AsanJohn SkokoBruce FreemanFrancisco SchopferThomas ConradsIshu SainiCaroline KiskerCarola Neumann

medicinepharmacologyproteomicscancer researchfree radical biologyredox biologymolecular biologyoncologycancer treatmentdna repairtumor biology

Failure to Apply Standard Limit-Of-Detection or Limit-Of-Quantitation Criteria to Specialized Pro-Resolving Mediator Analysis Incorrectly Characterizes Their Presence in Biological Samples. Nature Communications (2023)

Valerie B. O’DonnellNils H. SchebbGinger L. MilneMichael P. MurphyChristopher P. ThomasDieter SteinhilberStacy L. GelhausHartmut KühnMichael H. GelbPer-Johan JakobssonIan A. BlairRobert C. MurphyBruce A. FreemanAlan R. BrashGarret A. FitzGerald

bioanalysisbiological samplesbiostatisticslimit-of-quantitation criteriastandard limit-of-detection

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Bruce A. Freeman

Distinguished Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Bruce A. Freeman is currently serving as an Interdisciplinary Biomedical Graduate Program Distinguished Professor at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Bruce A. Freeman

University of Pittsburgh

Distinguished Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Novel Gene Regulatory Networks Identified in Response to Nitro-Conjugated Linoleic Acid in Human Endothelial Cells. Zenodo (CERN European Organization for Nuclear Research) (2025)

Yanbo FanHaocheng Lu

Adipocyte-Specific Nrf2 Deletion Negates Nitro-Oleic Acid Benefits on Glucose Tolerance in Diet-Induced Obesity. Nitric Oxide (2024)

D.V. ChartoumpekisI. ChenS.R. SalvatoreF.J. SchopferB.A. FreemanN.K.H. Khoo

Chemoproteomics Reveals Recql4 Inhibition as a Mediator of Nitroalkene-Dependent Dna Double Strand Break Repair Inhibition in Cancer. Free Radical Biology and Medicine (2024)

Dennis BradenHuiming LuMostafa Abdellatif Abdel AbdelrheemAlp AsanJohn SkokoThomas ConradsBruce FreemanFrancisco SchopferIshu SainiCaroline KiskerAnthony DavisCarola Neumann

cancer researchfree radical biologybiochemistrydna repair

Lipoxin A4 Yields an Electrophilic 15-Oxo Metabolite That Mediates Fpr2 Receptor-Independent Anti-Inflammatory Signaling. Journal of Lipid Research (2024)

Adolf KoudelkaGregory J BuchanVeronika CechovaJames P O'BrienEmily R StevensonCrystal E UvalleHeng LiuSteven R WoodcockSteven J MullettCheng ZhangBruce A FreemanStacy L Gelhaus

Lipoxin a 4 Yields an Electrophilic 15-Oxo Metabolite That Mediates Fpr2 Receptor-Independent Anti-Inflammatory Signaling. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Adolf KoudelkaGregory J. BuchanVeronika CechovaJames P. O’BrienHeng LiuSteven R. WoodcockSteven J. MullettCheng ZhangBruce A. FreemanStacy L. Gelhaus

immunologypharmacologycell signalinganti-inflammatoryinflammation

Nitro-Oleic Acid Mitigates Chlorine-Induced Lung Injury in Mice by Inhibiting Pro-Inflammatory Macrophage Activation. (2024)

R. MalaviyaA. GowB. FreemanR. RancourtE. AbramovaK. VayasJ. LaskinD.L. Laskin

immunologyhematologynitro-oleic acidmammalian biologypro-inflammatory macrophage activationrespiratory medicinechlorine-induced lung injuryneurosciencehealth sciencesinflammation

Cardioprotective Efficacy of Ultrasound-Targeted Nitrofatty Acid Microbubbles in Rat Myocardial Ischemia-Reperfusion Injury Model. The Journal of the Acoustical Society of America (2023)

Muhammad Wahab AmjadSoheb Anwar MohammedMarco FazzariXucai ChenBruce FreemanTerry MatsunagaJohn J. Pacella

cardiologyneurologyultrasoundaudiology

Chemoproteomics Reveals Recql4 Inhibition as a Mediator of Nitroalkene-Dependent Dna Double Strand Break Repair Inhibition in Cancer.. Free radical biology & medicine (2023)

Dennis BradenAlp AsanJohn SkokoBruce FreemanFrancisco SchopferThomas ConradsIshu SainiCaroline KiskerCarola Neumann

medicinepharmacologyproteomicscancer researchfree radical biologyredox biologymolecular biologyoncologycancer treatmentdna repairtumor biology

bioanalysisbiological samplesbiostatisticslimit-of-quantitation criteriastandard limit-of-detection

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free radical biology

toxicological mechanism

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tissue (biology)

developmental biology

Sruti Shiva

Institution

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nitrogen species

free radical biology

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elevated cholesterol

clinical lipidology

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nanomedicine

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