Faculty

Institution

Unit

Venue

Navnath Gavande

Assistant Professor

Wayne State University

Affiliations

Eugene Applebaum College of Pharmacy and Health Sciences

Pharmaceutical Sciences

Navnath Gavande is currently serving as a Eugene Applebaum College Of Pharmacy And Health Sciences Assistant Professor at Wayne State University.

Honors

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Experiences

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Education

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Navnath Gavande

Wayne State University

Assistant Professor

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pharmacology drug discovery oncology medicinal chemistry enzyme inhibition cancer treatment radiation oncology cancer research medicinal research dna repair molecular cancer pharmacotherapy molecular biology medicine cancer biology tumor targeting anti-cancer agents tumor biology pharmaceutical chemistry cancer care oncogenes drug targeting cancer genomics dna damage response rational drug design nanomedicine cancer therapy cancer discovery nucleic acids pharmaceutical sciences novel therapies future medicinal chemistry cellular therapy replication protein enzymes biological chemistry cancer genetics pharmaceutical nanotechnology biomolecular interactions biological evaluation interaction inhibitors thoracic oncology infection control nucleic acid amplification therapeutic efficacy oncogenic agent nucleic acid chemistry rna biology anticancer mechanism pro-inflammatory cytokines cellular proliferation clinical chemistry vascular biology respiratory medicine dna nanotechnology molecular research functional modification cancer disparities cell proliferation tumor heterogeneity cell regulation cell migration lymphocyte development lymphoid neoplasia hypoxia (medicine) innovative treatment treatment development precision medicine precision genome engineering dna repair pathways protein degradation xanthine oxidase inhibition structure-guided optimization molecular degraders future opportunities diverse population organic chemistry chemical biology drug development in vitro toxicology drug analysis high-throughput screening systems biology preclinical drug evaluation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure-Guided Design of Potent and Selective Covalent Inhibitors of Sars-Cov-1 and Sars-Cov-2 Papain-Like Proteases With Antiviral Activity. European Journal of Medicinal Chemistry (2026)

antiviral drug developmentsars-cov-2 papain-like proteasesantiviral researchmedical virologysars-cov-2structure-guided designbiochemistrypharmacologyantiviral drugstherapeutic targetsantiviral therapyselective covalent inhibitorsenzyme inhibitiondrug discoveryvirus research

Design, Synthesis, and Structure–Activity Relationship Studies of 4-Substituted Phenylpyrazolidinone Derivatives as Potent Ku70/80 Targeted Dna-Pk Inhibitors. RSC Medicinal Chemistry (2025)

pharmacological researchchemical synthesisdrug developmentmedicinal chemistrycombinatorial chemistry4-substituted phenylpyrazolidinone derivativesstructure–activity relationship studiesbiochemistrypharmacologyorganic synthesistherapeutic targetsrational drug designenzyme inhibitiondrug discoverypharmacotherapy

Evolution of Structure-Guided Drug Design Strategies Targeting Mutations in Codon 12 of Kras. RSC Medicinal Chemistry (2025)

mutagenesis (molecular biology technique)biomolecular engineeringnucleic acidsrational drug designstructural molecular biologyprotein structuredirected evolutionfuture medicinal chemistrycodon 12molecular biologydrug discoverystructural biology

Integrated Computational Approach for Designing Potent Egfr‐Tk Inhibitors: Qsar, Docking, Admet and Molecular Dynamics Studies. Chemistry & Biodiversity (2025)

molecular dynamics studiesbiomolecular engineeringmolecular dockingmolecular designdrug targetspharmacologymolecular informaticstherapeutic targetscancer discoveryreceptor tyrosine kinasesrational drug designcomputational approachdrug discoverymolecular modelling

Structure-Based Design and Development of 2-Oxindole Derivatives as Next Generation Ku-Dna Binding Inhibitors (Ku-Dbi’s) for Cancer Therapy.. (2025)

anti-cancer agentschemical biologystructure-based designmedicinal chemistrymolecular dockingku-dbi ’ sbiochemistrypharmacologyfuture medicinal chemistrytherapeutic targets2-oxindole derivativesrational drug designenzyme inhibitiondrug discovery

Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects. Biomolecules (2025)

Mohamad BakkarSara KhalilKomal BhayekarNarva Deshwar KushwahaAmirreza SamarbakhshSadaf DorandishHolly EdwardsQ. Ping DouYubin GeNavnath S. Gavande

ubiquitin-specific protease inhibitorsprotein sciencecancer therapypharmacologytherapeutic targetspeptide sciencetumor biologychemoprevention strategiesenzymescancer researchmolecular biologycancer discoverytherapeutic efficacyanti-cancer agentstumor targetingmedicinal researchbiomolecular engineeringfuture prospectsmolecular dockingprotein engineeringenzyme inhibition

Abstract 1713 Shaping Antiviral Strategies With Potent and Selective Non-Covalent Sars-Cov-2 Papain-Like Protease Inhibitors. Journal of Biological Chemistry (2024)

Abdullah Al-HomoudiAmirreza SamarbakhshHariprasad AruriDineshsinha ChauhanJoseph EngelNavnath S. GavandeLadislau C. Kovari

antiviral drug developmentvirologyenzymesantiviral researchmedicinal chemistrysars-cov-2biological chemistryimmunologypharmacologyantiviral therapymolecular biologyenzyme inhibitiondrug discoveryantiviral strategies

Abstract 416: Development of Substituted Oxindole Derivatives as a Ku-Targeted Dna-Pk Inhibitors for Cancer Therapy. Cancer Research (2024)

Dineshsinha ChauhanPamela L. Mendoza-MunozNarva Deshwar KushwahaHariprasad AruriJohn J. TurchiNavnath S. Gavande

medicinecancer biologycancer therapyleukemiapharmacologycancer researchoncologymedicinal chemistrycancer treatmentdrug discoveryanti-cancer agentsradiation oncologymolecular cancerku-targeted dna-pk inhibitorstumor targetingmedicinal researchsubstituted oxindole derivativesdrug targetingenzyme inhibitionclinical researchpharmacotherapy

Abstract 7128: Novel Ku-Dna Binding Inhibitors Impact on the Cellular and in Vivo Dna Damage Response to Radio- and Radiomimetic-Therapy. Cancer Research (2024)

Pamela L. Mendoza-MunozDineshsinha ChauhanNavnath S. GavandeJoseph R. DynlachtJoy E. GarrettJohn J. Turchi

cancer genomicstumor biologycellular therapyanti-cancer agentscancer researchradiation oncologyoncologymolecular cancercancer biologycell biologycancer cellscancer carepharmacologycancer treatmenttumor targetingdna repairclinical researchmedicinal research

Abstract A027: Development of Small Molecule Inhibitors of the Ku-Dna Interaction: Impacts on Nhej, Ddr Signaling, Optimizing Genome Editing Technologies, and Therapeutic Intervention for the Treatment of Cancer. Cancer Research (2024)

John J. TurchiPamela L. Mendoza-MunozPamela S. VanderVere-CarozzaNavnath S. GavandeJoseph R. DynlachtJoy E. GarrettDineshsinha ChauhanKatherine S. Pawelczak

cancer biologygenome editing technologiespharmacologygenome editingtumor biologycancer researchoncologycancer carebiomedical engineeringcancer treatmentsmall molecule inhibitorscancer genomicsanti-cancer agentsddr signalingradiation oncologymolecular cancermedicinal researchcancer managementoncogenesku-dna interactiontherapeutic interventionenzyme inhibitionclinical research

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Navnath Gavande

Assistant Professor

Wayne State University

Affiliations

Eugene Applebaum College of Pharmacy and Health Sciences

Pharmaceutical Sciences

Navnath Gavande is currently serving as a Eugene Applebaum College Of Pharmacy And Health Sciences Assistant Professor at Wayne State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Navnath Gavande

Wayne State University

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure-Guided Design of Potent and Selective Covalent Inhibitors of Sars-Cov-1 and Sars-Cov-2 Papain-Like Proteases With Antiviral Activity. European Journal of Medicinal Chemistry (2026)

Design, Synthesis, and Structure–Activity Relationship Studies of 4-Substituted Phenylpyrazolidinone Derivatives as Potent Ku70/80 Targeted Dna-Pk Inhibitors. RSC Medicinal Chemistry (2025)

Evolution of Structure-Guided Drug Design Strategies Targeting Mutations in Codon 12 of Kras. RSC Medicinal Chemistry (2025)

Integrated Computational Approach for Designing Potent Egfr‐Tk Inhibitors: Qsar, Docking, Admet and Molecular Dynamics Studies. Chemistry & Biodiversity (2025)

Structure-Based Design and Development of 2-Oxindole Derivatives as Next Generation Ku-Dna Binding Inhibitors (Ku-Dbi’s) for Cancer Therapy.. (2025)

Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects. Biomolecules (2025)

Mohamad BakkarSara KhalilKomal BhayekarNarva Deshwar KushwahaAmirreza SamarbakhshSadaf DorandishHolly EdwardsQ. Ping DouYubin GeNavnath S. Gavande

Abstract 1713 Shaping Antiviral Strategies With Potent and Selective Non-Covalent Sars-Cov-2 Papain-Like Protease Inhibitors. Journal of Biological Chemistry (2024)

Abdullah Al-HomoudiAmirreza SamarbakhshHariprasad AruriDineshsinha ChauhanJoseph EngelNavnath S. GavandeLadislau C. Kovari

Abstract 416: Development of Substituted Oxindole Derivatives as a Ku-Targeted Dna-Pk Inhibitors for Cancer Therapy. Cancer Research (2024)

Dineshsinha ChauhanPamela L. Mendoza-MunozNarva Deshwar KushwahaHariprasad AruriJohn J. TurchiNavnath S. Gavande

Abstract 7128: Novel Ku-Dna Binding Inhibitors Impact on the Cellular and in Vivo Dna Damage Response to Radio- and Radiomimetic-Therapy. Cancer Research (2024)

Pamela L. Mendoza-MunozDineshsinha ChauhanNavnath S. GavandeJoseph R. DynlachtJoy E. GarrettJohn J. Turchi

John J. TurchiPamela L. Mendoza-MunozPamela S. VanderVere-CarozzaNavnath S. GavandeJoseph R. DynlachtJoy E. GarrettDineshsinha ChauhanKatherine S. Pawelczak

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future medicinal chemistry

mechanisms of action

Gregory Thatcher

Institution

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biochemistry

drug development

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Institution

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future medicinal chemistry

medicinal chemistry

Stan Gee Louie

Institution

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neural degeneration

Charles E. McKenna

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University of California, San Diego

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future medicinal chemistry

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