Faculty

Institution

Unit

Venue

Ziwei HUANG

Adjunct Professor

University of California, San Diego

Affiliations

School Of Medicine

Medicine

Ziwei Huang is currently serving as a Medicine Adjunct Professor at University of California, San Diego.

Honors

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Experiences

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Education

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Ziwei HUANG

University of California, San Diego

Adjunct Professor

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molecular biology biochemistry pharmacology medicinal research drug discovery medicinal chemistry therapeutic targets enzyme inhibition biomolecular engineering protein science peptides peptide science pharmaceutical chemistry chemical biology antiviral research hiv protein structure tumor biology apoptosis virus research cell signaling anti-cancer agents oncogenes antiviral drug development peptide therapeutics biological chemistry cancer discovery cell death drug targeting tumor targeting structural molecular biology protein chemistry cellular therapy antiviral drugs antiviral therapy peptide synthesis protein function experimental biology rational drug design protein modeling cancer treatment molecular science molecular cell biology experimental medicine peptide engineering drug targets molecular virology non-peptide ligand biomolecular interactions signaling pathways inhibitory activity pharmaceutical research virus-host interactions viral structural protein antiviral compounds receptor (biochemistry) pharmacokinetics structure-based discovery drug discovery research biological evaluation feedback loop key site cytokines tumor cells molecular modeling anti-hiv activity chemical strategy biological characterization organic compound death receptor pathway caspase-promoting activity xiap mediates anticancer drug design differential regulation acute myelogenous leukemia simultaneous disruption future medicinal chemistry pharmaceutical sciences translational research medicine pharmacological research chemokine receptors

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Small Molecule Cxcr4 Antagonist Improves Anticancer Therapy by Blocking the Interaction of Malignant Cells With Their Associated Niches. Authorea (Authorea) (2024)

Yazi HuangZiwei HuangJing AnXiong FangGe ZhangYan XuLinlin Nie

anti-cancer agentscancer discoverypharmacologytherapeutic targetstumor biologycancer immunotherapynovel therapiescancer researchtumor suppressorsmalignant cellsmolecular biologycancer cellscancer treatmentoncogenesmedicinal researchcellular therapysystems biologytumor targetingoncology

Discovery of Novel Nonpeptidic Proteasome Inhibitors Using Covalent Virtual Screening and Biological Evaluation. ACS Medicinal Chemistry Letters (2024)

Jiao ZhouXiaohong SangMeixian WuTingli QianAaron CiechanoverJing AnYan XuZiwei Huang

high-throughput screeningnon-peptide ligandbiological evaluationpharmaceutical chemistryproteomicsprotein sciencemedicinal researchpeptide sciencemedicinal chemistryrational drug designcovalent virtual screeningpharmacologymolecular biologytherapeutic targetsdrug discoveryenzyme inhibitionbiomolecular engineeringproteome research

A Chemical Strategy for the Degradation of the Main Protease of Sars-Cov-2 in Cells. Journal of the American Chemical Society (2023)

Xiaohong SangJuan WangJiao ZhouYan XuJing AnArieh WarshelZiwei Huang

protein expressionprotein engineeringchemical sciencesmain proteaseenzymescell signalingcell biologychemical biologymolecular biologyviral structural proteinprotein functionbiochemistrychemical strategyvirus researchprotein chemistryprotein scienceenzyme catalysissars-cov-2antiviral researchenzyme inhibition

Biological and Mutational Analyses of Cxcr4–Antagonist Interactions and Design of New Antagonistic Analogs. Bioscience Reports (2023)

Qian MengRuohan ZhuYujia MaoSiyu ZhuYi WuLina S.M. HuangAaron CiechanoverJing AnYan XuZiwei Huang

mutational analysesimmunologybiochemistryrational drug designdrug resistancemolecular biologydrug discoveryenzyme inhibition

Cxcr4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of Hiv-1 Gp120. Viruses (2023)

Ruohan ZhuXiaohong SangJiao ZhouQian MengLina S. M. HuangYan XuJing AnZiwei Huang

medical virologygeneral virologymolecular immunologyviral pathogenesisinfectious diseasesvirologyvirus-host interactionshivvirus structuremicrobiologyantiviral researchpeptidesmolecular virologyprotein structuresystems biologyvirus researchdrug discoverymicrobial pathogenesis

Discovery of Potential Inhibitors of Sars-Cov-2 Main Protease by a Transfer Learning Method. Viruses (2023)

Huijun ZhangBoqiang LiangXiaohong SangJing AnZiwei Huang

transfer learningtransfer learning methodvirologysars-cov-2antiviral researchsystems biologydrug discoveryvirus research

Elucidation of the α-Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome. ACS Catalysis (2023)

Jiao ZhouXiaohong SangJuan WangYan XuJing AnZhen Tao ChuArjun SahaArieh WarshelZiwei Huang

electrostatic reorganization effectprotein chemistryprotein scienceenzyme catalysismolecular catalysisbiocatalysiscell biologyprotein functionneurosciencea-ketoamide inhibition mechanismactive sitecatalysispharmacologyenzyme inhibition

A Fragment Integrational Approach to Gpcr Inhibition: Identification of a High Affinity Small Molecule Cxcr4 Antagonist. European Journal of Medicinal Chemistry (2022)

Xiong FangQian MengHuijun ZhangXiao FangLina S. HuangXingquan ZhangRobert T. SchooleyAaron CiechanoverJing AnYan XuZiwei Huang

future medicinal chemistrypharmaceutical chemistrymolecular pharmacologydrug targetingdrug targetsmedicinal researchpeptide sciencemolecular dockingmedicinal chemistrysmall moleculespeptidespharmacologymolecular biologytherapeutic targetsdrug discoveryg protein-coupled receptorenzyme inhibitionbiomolecular engineering

A Synthetic Bivalent Peptide Ligand of Ephb4 With Potent Agonistic Activity. European Journal of Medicinal Chemistry (2022)

Tingting FanBoqiang LiangLingling NieJuan WangHuijun ZhangAaron CiechanoverYan XuJing AnZiwei Huang

peptide engineeringpharmacologytherapeutic targetspharmaceutical chemistrypeptide therapeuticspeptideschemical biologymolecular biologydrug discoverynon-peptide ligandmedicinal researchpeptide synthesismedicinal chemistryprotein structureprotein sciencepeptide sciencepotent agonistic activityenzyme inhibitionbiomolecular engineering

Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of Sars-Cov-2 Main Protease and 20S Proteasome. Journal of the American Chemical Society (2022)

Jiao ZhouArjun SahaZiwei HuangArieh Warshel

molecular chemistrypharmacologychemical sciencesenzymesmolecular sciencechemical biologymolecular biologydrug discoveryprotein structure predictionprotein modelingbiochemistrymedicinal chemistryeffective predictionprotein chemistryprotein sciencebiomolecular structure predictionsars-cov-2antiviral researchenzyme inhibitioncovalent inhibitors

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Ziwei HUANG

Adjunct Professor

University of California, San Diego

Affiliations

School Of Medicine

Medicine

Ziwei Huang is currently serving as a Medicine Adjunct Professor at University of California, San Diego.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ziwei HUANG

University of California, San Diego

Adjunct Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Small Molecule Cxcr4 Antagonist Improves Anticancer Therapy by Blocking the Interaction of Malignant Cells With Their Associated Niches. Authorea (Authorea) (2024)

Yazi HuangZiwei HuangJing AnXiong FangGe ZhangYan XuLinlin Nie

Discovery of Novel Nonpeptidic Proteasome Inhibitors Using Covalent Virtual Screening and Biological Evaluation. ACS Medicinal Chemistry Letters (2024)

Jiao ZhouXiaohong SangMeixian WuTingli QianAaron CiechanoverJing AnYan XuZiwei Huang

A Chemical Strategy for the Degradation of the Main Protease of Sars-Cov-2 in Cells. Journal of the American Chemical Society (2023)

Xiaohong SangJuan WangJiao ZhouYan XuJing AnArieh WarshelZiwei Huang

Biological and Mutational Analyses of Cxcr4–Antagonist Interactions and Design of New Antagonistic Analogs. Bioscience Reports (2023)

Qian MengRuohan ZhuYujia MaoSiyu ZhuYi WuLina S.M. HuangAaron CiechanoverJing AnYan XuZiwei Huang

mutational analysesimmunologybiochemistryrational drug designdrug resistancemolecular biologydrug discoveryenzyme inhibition

Cxcr4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of Hiv-1 Gp120. Viruses (2023)

Ruohan ZhuXiaohong SangJiao ZhouQian MengLina S. M. HuangYan XuJing AnZiwei Huang

Discovery of Potential Inhibitors of Sars-Cov-2 Main Protease by a Transfer Learning Method. Viruses (2023)

Huijun ZhangBoqiang LiangXiaohong SangJing AnZiwei Huang

transfer learningtransfer learning methodvirologysars-cov-2antiviral researchsystems biologydrug discoveryvirus research

Elucidation of the α-Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome. ACS Catalysis (2023)

Jiao ZhouXiaohong SangJuan WangYan XuJing AnZhen Tao ChuArjun SahaArieh WarshelZiwei Huang

A Fragment Integrational Approach to Gpcr Inhibition: Identification of a High Affinity Small Molecule Cxcr4 Antagonist. European Journal of Medicinal Chemistry (2022)

Xiong FangQian MengHuijun ZhangXiao FangLina S. HuangXingquan ZhangRobert T. SchooleyAaron CiechanoverJing AnYan XuZiwei Huang

A Synthetic Bivalent Peptide Ligand of Ephb4 With Potent Agonistic Activity. European Journal of Medicinal Chemistry (2022)

Tingting FanBoqiang LiangLingling NieJuan WangHuijun ZhangAaron CiechanoverYan XuJing AnZiwei Huang

Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of Sars-Cov-2 Main Protease and 20S Proteasome. Journal of the American Chemical Society (2022)

Jiao ZhouArjun SahaZiwei HuangArieh Warshel

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future medicinal chemistry

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biochemistry

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Johns Hopkins University

pharmacology

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protein-protein interactions

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