Faculty

Institution

Unit

Venue

Michael A Mancini

Professor and Core Director Professor

Baylor College of Medicine

Affiliations

Baylor College of Medicine Research

Michael A Mancini is currently serving as a Baylor College Of Medicine Research Professor and Core Director Professor at Baylor College of Medicine.

Honors

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Experiences

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Education

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Michael A Mancini

Baylor College of Medicine

Professor and Core Director Professor

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molecular biology cell biology endocrinology biochemistry gene expression molecular cell biology systems biology cancer biology cell signaling tumor biology hormonal receptor receptors molecular and cellular biology oncogenes cellular biochemistry transcription (biology) medicinal research cellular biology transcription regulation membrane biology cancer cells liver physiology protein science cancer treatment molecular cancer nuclear organization rat liver vascular biology mammalian biology enzyme inhibition cellular physiology molecular physiology molecular regulation endocrine research single-cell analysis receptor (biochemistry) gene regulation chromatin remodeling nucleic acids biomedical imaging rna biology cell regulation endocrine mechanisms bioimage analysis redox biology retina cancer genetics steroid metabolism cell cycle novel imaging methods signaling pathways tumor targeting high-throughput screening glucocorticoids prostatic disease breast oncology high content analysis protein function gene regulatory networks estrogen receptor-a estrogen receptor chromosomal rearrangements chromosome biology protein misfolding retinoblastoma gene product androgen receptor estrogen receptor α alternative splicing intranuclear dynamics high throughput microscopy retinovitreal neovascularization subnuclear dynamics androgen receptor function confers cross-resistance ordered fashion coincident mitosis-specific phosphorylation single cell analysis cell and molecular biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Phenotypic Screen Identifies Xanthohumol and Other Flavonoids as Killers of Bladder Cancer. Pharmacological Research - Natural Products (2025)

chemoprevention strategiesanti-cancer agentscancer researchoncologynatural productsbioactive compoundsmolecular cancerphytochemical analysispharmacologybladder cancerother flavonoidsnatural product researchcancer discoverypathology

Inhibition of the Gsk3β/Nav1.6 Complex Suppresses Early‐Stage Alzheimer's Hyperexcitability. Alzheimer s & Dementia (2025)

neuroscience of agingneurodegenerative diseasesmolecular neurosciencealzheimer's diseaseneuroprotectionneurosciencemolecular neurobiologymolecular neurodegenerationgsk3β/nav1.6 complex suppressesneurologyneuropsychopharmacology

Cancer Cell-Selective Induction of Mitochondrial Stress and Immunogenic Cell Death by Pt-112 in Human Prostate Cell Lines. Journal of Translational Medicine (2024)

tumor biologyprostatic diseaseapoptosiscancer biologycell biologycancer cellsimmunologymitochondrial stresscancer cell-selective inductionprostate cancertumor microenvironmentcell deathimmunogenic cell death

Characterization of Flavonoids With Potent and Subtype-Selective Actions on Estrogen Receptors Alpha and Beta. iScience (2024)

Michael J BoltJessica OcegueraPankaj K SinghKazem SafariDerek H AbbottKaley A NeugebauerMaureen G ManciniDaniel A GorelickFabio StossiMichael A Mancini

receptorschemistrysubtype-selective actionsendocrinologyphytochemistrypharmacologyestrogen receptors

Eef1A2 Promotes Pten-Gsk3β-Scf Complex-Dependent Degradation of Aurora Kinase a and is Inactivated in Breast Cancer. Science Signaling (2024)

Warapen TreekitkarnmongkolLuisa M. SolisDeivendran SankaranMihai GageaPankaj K. SinghRagini MistryTristian NguyenKazuharu KaiJiajun LiuKaori SasaiYoshimi JitsumoriJianwen LiuNorio NagaoFabio StossiMichael A. ManciniIgnacio I. WistubaAlastair M. ThompsonJonathan M. LeeJuan CadiñanosKwong-Kwok WongCatherine M. AbbottAysegul A. SahinSuyu LiuHiroshi KatayamaSubrata Sen

aurora kinasecancer biologycell biologycell signalingneurosciencepharmacologygene expressiontumor biologymolecular cancerredox biologytumor targetingprotein functionbreast cancercell deathsignaling pathwaysinsulin signalingoncogenessignal transductionenzyme inhibition

SPACE: An Open-Source, Single-Cell Analysis of Cell Painting Data. Nature Communications (2024)

Fabio StossiPankaj K. SinghMichela MariniKazem SafariAdam T. SzafranAlejandra Rivera TostadoChristopher D. CandlerMaureen G. ManciniElina A. MosaMichael J. BoltDemetrio LabateMichael A. Mancini

single-cell analysiscell biologyscientific communicationcell painting datacell research

Space (Swift Phenotypic Analysis of Cells): An Open-Source, Single Cell Analysis of Cell Painting Data. bioRxiv (Cold Spring Harbor Laboratory) (2024)

developmental biologysingle-cell analysiscell biologybiological imagingdevelopmental cellcell painting datacomputational biologycell researchspatial omicssingle cell analysisswift phenotypic analysisbioimage analysis

Transcriptional Coactivation of Nrf2 Signaling in Cardiac Fibroblasts Promotes Resistance to Oxidative Stress. Journal of Molecular and Cellular Cardiology (2024)

Lisa K. McClendonRainer B. LanzAnil PanigrahiKristan GomezMichael J. BoltMin LiuFabio StossiMichael A. ManciniClifford C. DacsoDavid M. LonardBert W. O'Malley

mitochondrial functionoxidative stresscardiologycardiovascular physiologycardiac fibroblastsredox biologyregenerative medicineimmunologymembrane biologyfree radical biologyphysiologysignal transductioncardiovascular researchmolecular biologytranscription regulationtranscriptional coactivationcellular physiologymolecular physiology

Abstract C128: Pt-112, a Novel Immunogenic Cell Death Inducer, Causes Ribosomal Biogenesis Inhibition and Organelle Stress in Cancer Cells. Molecular Cancer Therapeutics (2023)

Christina Y. YimMaria T. CongenieHannah L. JohnsonMaureen G. ManciniFabio StossiMichael A. ManciniJoey AzofeifaMatthew R. PriceJohan BaeckTyler D. Ames

molecular biologyribosomal biogenesis inhibitionmolecular cancerorganelle stress

Analysis and Modeling of Early Estradiol-Induced Greb1 Single Allele Gene Transcription at the Population Level. bioRxiv (Cold Spring Harbor Laboratory) (2023)

S. Mahmood GhasemiPankaj K. SinghHannah L. JohnsonAyse KoksoyMichael A. ManciniFabio StossiRobert Azencott

geneticsgene expressionbioinformaticspopulation geneticssingle-cell analysismathematical biosciencepopulation levelinformaticsbiological evolutionsystems biologygenomicstranscription regulationgenome biologymolecular biologyepigenetic changestranslational bioinformatics

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Michael A Mancini

Professor and Core Director Professor

Baylor College of Medicine

Affiliations

Baylor College of Medicine Research

Michael A Mancini is currently serving as a Baylor College Of Medicine Research Professor and Core Director Professor at Baylor College of Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael A Mancini

Baylor College of Medicine

Professor and Core Director Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Phenotypic Screen Identifies Xanthohumol and Other Flavonoids as Killers of Bladder Cancer. Pharmacological Research - Natural Products (2025)

Inhibition of the Gsk3β/Nav1.6 Complex Suppresses Early‐Stage Alzheimer's Hyperexcitability. Alzheimer s & Dementia (2025)

Cancer Cell-Selective Induction of Mitochondrial Stress and Immunogenic Cell Death by Pt-112 in Human Prostate Cell Lines. Journal of Translational Medicine (2024)

Characterization of Flavonoids With Potent and Subtype-Selective Actions on Estrogen Receptors Alpha and Beta. iScience (2024)

Michael J BoltJessica OcegueraPankaj K SinghKazem SafariDerek H AbbottKaley A NeugebauerMaureen G ManciniDaniel A GorelickFabio StossiMichael A Mancini

receptorschemistrysubtype-selective actionsendocrinologyphytochemistrypharmacologyestrogen receptors

Eef1A2 Promotes Pten-Gsk3β-Scf Complex-Dependent Degradation of Aurora Kinase a and is Inactivated in Breast Cancer. Science Signaling (2024)

SPACE: An Open-Source, Single-Cell Analysis of Cell Painting Data. Nature Communications (2024)

Fabio StossiPankaj K. SinghMichela MariniKazem SafariAdam T. SzafranAlejandra Rivera TostadoChristopher D. CandlerMaureen G. ManciniElina A. MosaMichael J. BoltDemetrio LabateMichael A. Mancini

single-cell analysiscell biologyscientific communicationcell painting datacell research

Space (Swift Phenotypic Analysis of Cells): An Open-Source, Single Cell Analysis of Cell Painting Data. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Transcriptional Coactivation of Nrf2 Signaling in Cardiac Fibroblasts Promotes Resistance to Oxidative Stress. Journal of Molecular and Cellular Cardiology (2024)

Lisa K. McClendonRainer B. LanzAnil PanigrahiKristan GomezMichael J. BoltMin LiuFabio StossiMichael A. ManciniClifford C. DacsoDavid M. LonardBert W. O'Malley

Abstract C128: Pt-112, a Novel Immunogenic Cell Death Inducer, Causes Ribosomal Biogenesis Inhibition and Organelle Stress in Cancer Cells. Molecular Cancer Therapeutics (2023)

Christina Y. YimMaria T. CongenieHannah L. JohnsonMaureen G. ManciniFabio StossiMichael A. ManciniJoey AzofeifaMatthew R. PriceJohan BaeckTyler D. Ames

molecular biologyribosomal biogenesis inhibitionmolecular cancerorganelle stress

Analysis and Modeling of Early Estradiol-Induced Greb1 Single Allele Gene Transcription at the Population Level. bioRxiv (Cold Spring Harbor Laboratory) (2023)

S. Mahmood GhasemiPankaj K. SinghHannah L. JohnsonAyse KoksoyMichael A. ManciniFabio StossiRobert Azencott

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gynecology

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