Faculty

Institution

Unit

Venue

Marcus A. Tius

Professor

University of Hawaii at Manoa

Affiliations

College of Natural Sciences

Department of Chemistry

Marcus A. Tius is currently serving as a College Of Natural Sciences Professor at University of Hawaii At Manoa.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Marcus A. Tius

University of Hawaii at Manoa

Professor

You can click a keyword to filter the displayed items

chemistry organic synthesis chemical synthesis organic chemistry pharmacology medicinal chemistry drug discovery medicinal research synthetic chemistry enzyme inhibition transition metal chemistry catalysis cancer treatment cancer care anti-cancer agents cancer biology total synthesis tumor biology chemical sciences asymmetric catalysis stereoselective synthesis molecular cancer natural product synthesis medicine tumor targeting materials science pharmacotherapy drug targeting aromatic annelation cancer immunotherapy polyhedron organometallic catalysis catalytic synthesis nazarov cyclization pharmaceutical chemistry heterocycle chemistry natural product research coordination chemistry oncogenes enantioselective synthesis heterocyclic combinatorial chemistry tumor suppressors cationic cyclopentannelation xenon difluoride nazarov-type cyclization convenient synthesis human glioma cancer management macrocyclic core asymmetric cyclopentannelation marine chemistry material chemistry cancer risk viral replication human retrovirus synthesis methods breast oncology protein isoprenylation crassin acetate asymmetric nazarov cyclizations absolute stereochemistry c-glycosylanthraquinone synthesis formal total synthesis experimental medicine gynecologic oncology scientific data phytochemistry molecular catalysis cannabis use organic material chemistry skin pharmacology clinical medicine cytokines methanol halogenation organic process research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 663: Irreversible Covalent Azetidine-Based Small Molecule Inhibitors of Stat3 Activity Block Growth of Human Pancreatic Tumors. Cancer Research (2024)

Yue ChenNing ZhaiPeibin YueChristine Brotherton-PleissWenzhen FuKayo NakamuraWeiliang ChenMarcus TiusFrancisco Lopez-TapiaJames Turkson

medicinal chemistrycancer carecancer managementmolecular cancercancer genomicsanti-cancer agentscancer biologyhealth sciencescancer researchcancer treatmenttumor biologyhuman pancreatic tumorsenzyme inhibitionpharmacologyradiation oncologypharmacotherapydrug discoveryclinical researchmedicinal research

Abstract 2782: Small Molecule H182 Suppresses Stat3 Activation in Tumor Cells and Combines With Radiation Therapy to Block Breast Tumor Growth in Mouse Syngeneic Models. Cancer Research (2023)

Yue ChenPeibin YueWenzhen FuWeiliang ChenKathleen M. KershawStephen L. ShiaoMarcus A. TiusFrancisco Lopez-TapiaJames Turkson

cell signalingbreast tumor growththerapeutic efficacycell biologycancer caremolecular cancerbreast cancercancer biologytumor cellscancer researchtumor suppressorsradiation therapycancer treatmenttumor biologypharmacologyradiation oncologymouse syngeneic modelsoncologymedicinal researchcellular therapy

Abstract 514: Novel Potent Azetidine-Based Inhibitors Bind Irreversibly to Stat3 Dna-Binding Domain (Dbd) and Are Efficacious Against Tumor Growth in Mice. Cancer Research (2023)

Yue ChenNing ZhaiYinsong ZhuPeibin YueNagendra VermaChristine Brotherton-PleissWenzhen FuKayo NakamuraWeiliang ChenMarcus TiusFrancisco J. Lopez-TapiaJames Turkson

tumor targetingcancer caremolecular canceranti-cancer agentscancer biologyhealth sciencescancer researchdrug targetingcancer treatmenttumor biologytumor growthdna-binding domainenzyme inhibitionpharmacologypharmacotherapydrug discoverymolecular biologyoncologyclinical researchmedicinal research

Anion-Accelerated Asymmetric Nazarov Cyclization: Access to Vicinal All-Carbon Quaternary Stereocenters. Organic & Biomolecular Chemistry (2023)

Cody F. DickinsonGlenn P. A. YapMarcus A. Tius

organic chemistrybiochemistry

Azetidine Ring, Salicylic Acid, and Salicylic Acid Bioisosteres as Determinants of the Binding Characteristics of Novel Potent Compounds to Stat3. Bioorganic & Medicinal Chemistry Letters (2023)

Yue ChenNing ZhaiYinsong ZhuPeibin YueNagendra VermaChristine Brotherton-PleissWenzhen FuKayo NakamuraWeiliang ChenJoel KawakamiRamachandran MuraliMarcus A. TiusFrancisco Lopez-TapiaJames Turkson

immunologymedicinal chemistrynovel potent compoundspharmacologybioorganic chemistrysalicylic aciddrug discoveryazetidine ring

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicsstructure elucidationcrystal researchcrystal diffraction studystructure determinationstructural chemistryccdc 2157502chemistrydeposited datasetcrystal engineeringchemical structurecrystal structurescrystallography

Data From Hydroxamic Acid and Benzoic Acid–Based Stat3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes I in Vitro /I and I in Vivo /I. (2023)

Peibin YueFrancisco Lopez-TapiaDavid PaladinoYifei LiChih-Hong ChenTyvette HilliardYuan ChenMarcus A. TiusJames Turkson

novel therapieschemoprevention strategiesbreast cancercancer biologycancer researchtumor suppressorshydroxamic acidbiostatisticscancer treatmenttumor biologyhuman gliomaphytotherapy researchenzyme inhibitionpharmacologygliomasbrain tumor researchpharmacotherapybiomolecular engineeringoncologymedicinal research

Supplementary Materials From Hydroxamic Acid and Benzoic Acid–Based Stat3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes I in Vitro /I and I in Vivo /I. (2023)

Peibin YueFrancisco Lopez-TapiaDavid PaladinoYifei LiChih-Hong ChenTyvette HilliardYuan ChenMarcus A. TiusJames Turkson

prostate cancerneurologymedicinetumor targetingcancer careanti-cancer agentsbreast cancertumor suppressorscancer immunotherapyhydroxamic acidcancer treatmentcancer preventionimmunologyhuman gliomaenzyme inhibitiongliomassupplementary materialsbrain tumor researchoncologymedicinal researchcellular therapy

Abstract 5476: Novel Azetidine-Based Stat3 Inhibitors Induce Misfolded Protein Response, Endoplasmic Reticulum Stress and Mitophagy, and Inhibit Breast Tumor Growth in Vivo. Cancer Research (2022)

Peibin YueFrancisco Lopez-TapiaYinsong ZhuNagendra VermaFelix Alonso-ValenteenSimoun MikhaelLali Medina-KauweMarcus TiusJames Turkson

metastasiscancer geneticsbreast tumor growthprotein responsebreast oncologycancer caremolecular cancercancer genomicsbreast cancerendoplasmic reticulum stresscancer biologydermatologytherapeutic targetscancer treatmentenzyme inhibitionpharmacologyradiation oncologycancer discoverydrug discoveryoncologymedicinal research

Abstract 5482: Natural Product Inhibitor of Stat3, G6Pd, and Trxr1 Functions Induces an Early Oxidative Stress and Pyroptosis, and a Late-Stage Dna Damage and Cell Cycle Arrest to Block Tumor Growth in Human Breast Cancer Models. Cancer Research (2022)

Yinsong ZhuCody F. DickinsonJustin YangKyrstin DatanaganNing ZhaiPeibin YueFrancisco Lopez-TapiaMarcus A. TiusJames Turkson

medicinal chemistrydna repaircancer carecancer managementmolecular canceranti-cancer agentsearly oxidative stresshealth sciencesendocrine disruptorscancer preventiontumor growthcell cycle arrestpharmacologylate-stage dna damageradiation oncologyfree radical biologygrowth hormonenatural product inhibitoroncologyclinical researchoncogenesmedicinal researchoxidative stress

1
2
3
4
5
24
10 / page

Marcus A. Tius

Professor

University of Hawaii at Manoa

Affiliations

College of Natural Sciences

Department of Chemistry

Marcus A. Tius is currently serving as a College Of Natural Sciences Professor at University of Hawaii At Manoa.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Marcus A. Tius

University of Hawaii at Manoa

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 663: Irreversible Covalent Azetidine-Based Small Molecule Inhibitors of Stat3 Activity Block Growth of Human Pancreatic Tumors. Cancer Research (2024)

Yue ChenNing ZhaiPeibin YueChristine Brotherton-PleissWenzhen FuKayo NakamuraWeiliang ChenMarcus TiusFrancisco Lopez-TapiaJames Turkson

Abstract 2782: Small Molecule H182 Suppresses Stat3 Activation in Tumor Cells and Combines With Radiation Therapy to Block Breast Tumor Growth in Mouse Syngeneic Models. Cancer Research (2023)

Yue ChenPeibin YueWenzhen FuWeiliang ChenKathleen M. KershawStephen L. ShiaoMarcus A. TiusFrancisco Lopez-TapiaJames Turkson

Abstract 514: Novel Potent Azetidine-Based Inhibitors Bind Irreversibly to Stat3 Dna-Binding Domain (Dbd) and Are Efficacious Against Tumor Growth in Mice. Cancer Research (2023)

Yue ChenNing ZhaiYinsong ZhuPeibin YueNagendra VermaChristine Brotherton-PleissWenzhen FuKayo NakamuraWeiliang ChenMarcus TiusFrancisco J. Lopez-TapiaJames Turkson

Anion-Accelerated Asymmetric Nazarov Cyclization: Access to Vicinal All-Carbon Quaternary Stereocenters. Organic & Biomolecular Chemistry (2023)

Cody F. DickinsonGlenn P. A. YapMarcus A. Tius

organic chemistrybiochemistry

Azetidine Ring, Salicylic Acid, and Salicylic Acid Bioisosteres as Determinants of the Binding Characteristics of Novel Potent Compounds to Stat3. Bioorganic & Medicinal Chemistry Letters (2023)

Yue ChenNing ZhaiYinsong ZhuPeibin YueNagendra VermaChristine Brotherton-PleissWenzhen FuKayo NakamuraWeiliang ChenJoel KawakamiRamachandran MuraliMarcus A. TiusFrancisco Lopez-TapiaJames Turkson

immunologymedicinal chemistrynovel potent compoundspharmacologybioorganic chemistrysalicylic aciddrug discoveryazetidine ring

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Data From Hydroxamic Acid and Benzoic Acid–Based Stat3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes I in Vitro /I and I in Vivo /I. (2023)

Peibin YueFrancisco Lopez-TapiaDavid PaladinoYifei LiChih-Hong ChenTyvette HilliardYuan ChenMarcus A. TiusJames Turkson

Supplementary Materials From Hydroxamic Acid and Benzoic Acid–Based Stat3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes I in Vitro /I and I in Vivo /I. (2023)

Peibin YueFrancisco Lopez-TapiaDavid PaladinoYifei LiChih-Hong ChenTyvette HilliardYuan ChenMarcus A. TiusJames Turkson

Abstract 5476: Novel Azetidine-Based Stat3 Inhibitors Induce Misfolded Protein Response, Endoplasmic Reticulum Stress and Mitophagy, and Inhibit Breast Tumor Growth in Vivo. Cancer Research (2022)

Peibin YueFrancisco Lopez-TapiaYinsong ZhuNagendra VermaFelix Alonso-ValenteenSimoun MikhaelLali Medina-KauweMarcus TiusJames Turkson

Yinsong ZhuCody F. DickinsonJustin YangKyrstin DatanaganNing ZhaiPeibin YueFrancisco Lopez-TapiaMarcus A. TiusJames Turkson

1
2
3
4
5
24
10 / page

Similar Faculty Members

John Porco

Institution

Boston University

complex synthesis

complex chemical libraries

Daniel Romo

Institution

Baylor University

organic synthesis

chemistry

Jetze Tepe

Institution

University of Virginia

pharmacology

organic synthesis

Jon T. Njardarson

Institution

University of Arizona

synthetic chemistry

biomolecular engineering

Karl A. Scheidt

Institution

Northwestern University

chemistry

organic synthesis

Charles E. McKenna

Institution

University of Southern California

future medicinal chemistry

medicinal chemistry

Branko Jursic

Institution

University of New Orleans

chemistry

molecular structure

Gordon Wayne Gribble

Institution

Dartmouth College

synthetic chemistry

natural product

Michael Jung

Institution

University of California, Los Angeles

organic chemistry

synthetic organic chemistry

Paul Hergenrother

Institution

University of Illinois Urbana-Champaign

enzyme inhibitors

antibacterial compounds

Similar Faculty Members

John Porco

Institution

Boston University

complex synthesis

complex chemical libraries

Daniel Romo

Institution

Baylor University

organic synthesis

chemistry

Jetze Tepe

Institution

University of Virginia

pharmacology

organic synthesis

Jon T. Njardarson

Institution

University of Arizona

synthetic chemistry

biomolecular engineering

Karl A. Scheidt

Institution

Northwestern University

chemistry

organic synthesis

Charles E. McKenna

Institution

University of Southern California

future medicinal chemistry

medicinal chemistry

Branko Jursic

Institution

University of New Orleans

chemistry

molecular structure

Gordon Wayne Gribble

Institution

Dartmouth College

synthetic chemistry

natural product

Michael Jung

Institution

University of California, Los Angeles

organic chemistry

synthetic organic chemistry

Paul Hergenrother

Institution

University of Illinois Urbana-Champaign

enzyme inhibitors

antibacterial compounds