Faculty

Institution

Unit

Venue

Li Lan

Instructor

Duke University

Affiliations

Duke University School of Medicine

Cell & Molecular Biology

Molecular Cancer Biology

Molecular Genetics & Microbiology

University Program in Genetics & Genomics*

Li Lan is currently serving as a Cell & Molecular Biology Instructor at Duke University.

Honors

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Experiences

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Education

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Li Lan

Duke University

Instructor

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molecular biology genetics dna repair cell biology gene expression genome biology protein science biochemistry epigenetics cancer research tumor biology enzymes membrane biology oncology molecular cancer cancer genetics molecular cell biology cancer genomics redox biology rna biology genome instability cancer biology cancer treatment medicinal research free radical biology molecular regulation enzyme inhibition transcription regulation cancer care mammalian biology nucleic acids oncogenes gene function oxidative dna damage biological chemistry epigenetic changes dna damage homologous recombination cellular biology epigenomics gene regulation dna damage response biochemical sciences structural molecular biology molecular research radiation biology nucleic acid amplification molecular biotechnology chromosome biology cytogenetics enzyme specificity cell regulation oxidative damage leukemia cell-matrix interactions gene editing molecular substrates biomolecular interactions cancer management nucleic acid chemistry molecular biological method mammalian cells alternative lengthening rna-dna hybrids physiological relevance dna double-strand breaks transcription-coupled homologous recombination tumor suppressors cancer immunosurveillance cancer growth cell cycle dna damage checkpoint single-strand breaks temporal cellular responses repair processes differential phosphorylation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5581: The Dach1 Gene, Frequently Co-Deleted With Brca2 in Prostate Cancer, Governs Parp Inhibitor Resistance. Cancer Research (2024)

Zhiping LiXuanmao JiaoTaimoor KhanDanni LiShan ZhaLai Yee PhoonLi LanA. Gordon RobertsonAnthony W. AshtonKenneth A. IczkowskiAlexander D. BorowskyAlan AshworthRichard G. Pestell

neurologygene expressionpharmacologyenzyme inhibitioncancer geneticscancer researchmolecular cancerurologycancer genomicstherapy resistancedrug resistanceoncologyoncogenesmedicinal researchcancer treatmentcancer biologyprostate cancerparp inhibitor resistance

Abstract Pr001: Targeting Mrna Methyltransferase in Rna-Dependent Dna Repair in Cancer Therapy. Molecular Cancer Therapeutics (2024)

Li Lan

rna-dependent dna repaircancer therapymolecular cancermrna methyltransferasedna repairmolecular biologycancer treatment

Author Correction: Meiotic Protein Sycp2 Confers Resistance to Dna-Damaging Agents Through R-Loop-Mediated Dna Repair. Nature Communications (2024)

Yumin WangBoya GaoLuyuan ZhangXudong WangXiaolan ZhuHaibo YangFengqi ZhangXueping ZhuBadi ZhouSean YaoAiko NagayamaSanghoon LeeJian OuyangSiang-Boon KohEric L. EisenhauerDominique ZarrellaKate LuBo R. RuedaLee ZouXiaofeng A. SuOladapo YekuLeif W. EllisenXiao-Song WangLi Lan

immunologydna-damaging agentspharmacologyr-loop-mediated dna repairgeneticsdna repairprotein scienceauthor correction

Meiotic Protein Sycp2 Confers Resistance to Dna-Damaging Agents Through R-Loop-Mediated Dna Repair. Nature communications (2024)

immunologydna-damaging agentsr-loop-mediated dna repairgeneticsdna repairmolecular biologyepigeneticsprotein science

Transcription‐Coupled Dna Repair Protects Genome Stability Upon Oxidative Stress‐Derived Dna Strand Breaks. FEBS Letters (2024)

Haibo YangLi Lan

genome biologygene expressiontranscription regulationgenome stabilitygenome editinggenomic mechanismstranscription (biology)redox biologygeneticsgene functionmolecular biologygene structuredna repairoxidative stressgenome instabilitybiochemistry

Abstract 6100: The Fanconi Anemia Pathway Protein Complex Fanci/Fancd2 Couples the Dna Damage Response to R-Loop Regulation Through Srsf1-Mediated Mrna Export. Cancer Research (2023)

Anne Olazabal-HerreroFengshan LiangArijit DuttaYuxin HuangZhuobin LiangAbhishek GuptaYaqun TengLi LanXiaoyong ChenHuadong PeiManoj PillaiPatrick SungGary Kupfer

r-loop regulationcancer geneticsdna damage responsecancer researchgeneticscancer genomicsmolecular biologyoncologymedicinal researchdna repaircancer biologytumor biologycell biology

Atr Inhibition Induces Synthetic Lethality in Mismatch Repair-Deficient Cells and Augments Immunotherapy. Genes & Development (2023)

Mingchao WangXiaojuan RanWendy LeungAjinkya KawaleSneha SaxenaJian OuyangParasvi S. PatelYuting DongTao YinJian ShuRobert T. MangusoLi LanXiao-Fan WangMichael S. LawrenceLee Zou

immunologygene therapygene expressiongeneticsmismatch repair-deficient cellsgene functionimmunotherapycell biology

Helz is a Rna-Dna Helicase That Resolves R Loops to Facilitate Homologous Recombination Repair. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Ramona Haji-Seyed-JavadiAllyson E. KoyenSandip K. RathMatthew Z. MaddenYingzi HouBoying S. SongAnna M. KenneyLi LanBing YaoDavid S. Yu

biophysicsmolecular biologyhomologous recombinationdna repairbiological engineering

Revisiting Aurora Kinase B: A Promising Therapeutic Target for Cancer Therapy. Medicinal Research Reviews (2023)

Naga Rajiv LakkanigaZhengyu WangYao XiaoAnupreet KharbandaLi LanHong‐yu Li

tumor targetingmedicinepharmacologycancer therapycell therapyclinical therapeuticspharmacotherapytherapeutic targetspharmaceutical researchoncologymedicinal researchcancer treatmenttumor biologycell biology

The Rna M5C Modification in R-Loops as an Off Switch of Alt-Nhej. Nature Communications (2023)

Haibo YangEmily M. LachtaraXiaojuan RanJessica HopkinsParasvi S. PatelXueping ZhuYao XiaoLaiyee PhoonBoya GaoLee ZouMichael S. LawrenceLi Lan

gene expressiongeneticsmolecular geneticsmolecular biologyrna biology

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Li Lan

Instructor

Duke University

Affiliations

Duke University School of Medicine

Cell & Molecular Biology

Molecular Cancer Biology

Molecular Genetics & Microbiology

University Program in Genetics & Genomics*

Li Lan is currently serving as a Cell & Molecular Biology Instructor at Duke University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Li Lan

Duke University

Instructor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5581: The Dach1 Gene, Frequently Co-Deleted With Brca2 in Prostate Cancer, Governs Parp Inhibitor Resistance. Cancer Research (2024)

Zhiping LiXuanmao JiaoTaimoor KhanDanni LiShan ZhaLai Yee PhoonLi LanA. Gordon RobertsonAnthony W. AshtonKenneth A. IczkowskiAlexander D. BorowskyAlan AshworthRichard G. Pestell

Abstract Pr001: Targeting Mrna Methyltransferase in Rna-Dependent Dna Repair in Cancer Therapy. Molecular Cancer Therapeutics (2024)

Li Lan

rna-dependent dna repaircancer therapymolecular cancermrna methyltransferasedna repairmolecular biologycancer treatment

Author Correction: Meiotic Protein Sycp2 Confers Resistance to Dna-Damaging Agents Through R-Loop-Mediated Dna Repair. Nature Communications (2024)

immunologydna-damaging agentspharmacologyr-loop-mediated dna repairgeneticsdna repairprotein scienceauthor correction

Meiotic Protein Sycp2 Confers Resistance to Dna-Damaging Agents Through R-Loop-Mediated Dna Repair. Nature communications (2024)

immunologydna-damaging agentsr-loop-mediated dna repairgeneticsdna repairmolecular biologyepigeneticsprotein science

Transcription‐Coupled Dna Repair Protects Genome Stability Upon Oxidative Stress‐Derived Dna Strand Breaks. FEBS Letters (2024)

Haibo YangLi Lan

Abstract 6100: The Fanconi Anemia Pathway Protein Complex Fanci/Fancd2 Couples the Dna Damage Response to R-Loop Regulation Through Srsf1-Mediated Mrna Export. Cancer Research (2023)

Anne Olazabal-HerreroFengshan LiangArijit DuttaYuxin HuangZhuobin LiangAbhishek GuptaYaqun TengLi LanXiaoyong ChenHuadong PeiManoj PillaiPatrick SungGary Kupfer

r-loop regulationcancer geneticsdna damage responsecancer researchgeneticscancer genomicsmolecular biologyoncologymedicinal researchdna repaircancer biologytumor biologycell biology

Atr Inhibition Induces Synthetic Lethality in Mismatch Repair-Deficient Cells and Augments Immunotherapy. Genes & Development (2023)

Mingchao WangXiaojuan RanWendy LeungAjinkya KawaleSneha SaxenaJian OuyangParasvi S. PatelYuting DongTao YinJian ShuRobert T. MangusoLi LanXiao-Fan WangMichael S. LawrenceLee Zou

immunologygene therapygene expressiongeneticsmismatch repair-deficient cellsgene functionimmunotherapycell biology

Helz is a Rna-Dna Helicase That Resolves R Loops to Facilitate Homologous Recombination Repair. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Ramona Haji-Seyed-JavadiAllyson E. KoyenSandip K. RathMatthew Z. MaddenYingzi HouBoying S. SongAnna M. KenneyLi LanBing YaoDavid S. Yu

biophysicsmolecular biologyhomologous recombinationdna repairbiological engineering

Revisiting Aurora Kinase B: A Promising Therapeutic Target for Cancer Therapy. Medicinal Research Reviews (2023)

Naga Rajiv LakkanigaZhengyu WangYao XiaoAnupreet KharbandaLi LanHong‐yu Li

The Rna M5C Modification in R-Loops as an Off Switch of Alt-Nhej. Nature Communications (2023)

Haibo YangEmily M. LachtaraXiaojuan RanJessica HopkinsParasvi S. PatelXueping ZhuYao XiaoLaiyee PhoonBoya GaoLee ZouMichael S. LawrenceLi Lan

gene expressiongeneticsmolecular geneticsmolecular biologyrna biology

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