Faculty

Institution

Unit

Venue

Joseph Falke

Professor

University of Colorado Boulder

Affiliations

Natural Sciences

Biochemistry Department

College of Arts and Sciences

Natural Sciences

Joseph Falke is currently serving as a Biochemistry Professor at University of Colorado Boulder.

Honors

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Experiences

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Education

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Joseph Falke

University of Colorado Boulder

Professor

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biochemistry molecular biology biophysics protein science membrane biology protein structure structural biology signal transduction cell signaling structural molecular biology receptors membrane proteins biomolecular structure membranes receptor (biochemistry) systems biology signaling pathways protein phosphorylation aspartate receptor molecular docking proteinlipid interaction biophysical review protein assembly biological chemistry molecular physiology molecular cell biology single molecule biophysics medicinal research molecular structure enzyme inhibition membrane transport biological macromolecules g protein-coupled receptor transition metal chemistry membrane science vascular biology protein transport nmr study coordination chemistry receptor tyrosine kinases molecular regulation inhibitory activity peptides microbial physiology conformational studies key site biological inorganic chemistry membrane systems biomolecular interactions intracellular trafficking bacterial chemotaxis chea kinase host response biochemical interaction molecular microbiology protein chemistry charge transport lipid movement molecular mechanism d-galactose chemosensory receptor cytoplasmic domain bacterial chemosensory array single molecule diffusion macromolecular architecture protein x-ray crystallography feedback loop ion exchange ion structure cellular regulatory mechanism bacterial chemoreceptors molecular tuning transmembrane signaling kinase activation protein kinase activation parameters ph domain

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cosmic-Linked Ras Mutations at the Interface Between H-Ras and Pi3Kγ Rbd Frequently Generate Affinity Increases. bioRxiv (Cold Spring Harbor Laboratory) (2026)

mutagenesis (molecular biology technique)geneticsmolecular geneticssignal recognitioncosmic-linked ras mutationsmolecular cell biologyinterface between h-rashigh energy physicsmolecular biology

Learning Diffusion Coefficients, Kinetic Parameters, and the Number of Underlying States From a Multistate Diffusion Process: Robustness Results and Application to Pdk1/Pkcα Dynamics. (2024)

Lewis R. BakerMoshe T. GordonBrian P. ZiembaVictoria GershunyJoseph J. FalkeDavid M. Bortz

biophysicsdiffusion coefficientsmultistate diffusion processprotein sciencediffusion processneurosciencesystems biologydiffusionkinetic parameters

Ras Signaling Mechanisms: New Insights From Single-Molecule Biophysics. Biophysical Journal (2024)

Anne Marie McCombsJoy R ArmendarizJoseph J Falke

biophysicssingle molecule biophysicsbiophysical chemistry

PDK1: Pkcα Heterodimer Association-Dissociation Dynamics in Single-Molecule Diffusion Tracks on a Target Membrane. Biophysical Journal (2023)

Moshe T. GordonBrian P. ZiembaJoseph J. Falke

biophysicssingle-molecule diffusion trackssingle molecule biophysicstarget membranebiophysical chemistry

Binding of Active Ras and Its Mutants to the Ras Binding Domain of Pi-3-Kinase: A Quantitative Approach to Kd Measurements. Analytical Biochemistry (2022)

Ian R FlemingJonathan P HannanGeorge Hayden SwisherCorey D TesdahlJustin G MartyrNicholas J CordaroAnnette H ErbseJoseph J Falke

biophysicsprotein phosphorylationenzymesprotein sciencemolecular biophysicsprotein structurestructural molecular biologybiochemistryactive rasmolecular biologyanalytical chemistrystructural biology

Hplc Method to Resolve, Identify and Quantify Guanine Nucleotides Bound to Recombinant Ras Gtpase. Analytical Biochemistry (2021)

Jonathan P. HannanG. Hayden SwisherJustin G. MartyrNicholas J. CordaroAnnette H. ErbseJoseph J. Falke

hplc methodbiochemistrybioanalysisguanine nucleotides

Hplc Method to Resolve, Identify and Quantify Guanine Nucleotides Bound to the Gtpase Ras. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Jonathan P. HannanG. Hayden SwisherJustin G. MartyrNicholas J. CordaroAnnette H. ErbseJoseph J. Falke

hplc methodbiochemistrygtpase rasmolecular biologyguanine nucleotides

Pdk1 Forms Homodimers on Supported Lipid Bilayers in a Pip3 Dependent Manner. Biophysical Journal (2021)

Moshe T. GordonJoseph J. Falke

biophysicsbiomolecular engineeringbiophysical modelingsupported lipid bilayersproteinlipid interactionbiomolecular structuremembrane proteinsmembrane formationmembranesmembrane biologylipidsmembrane sciencevascular biologymolecular biologylipid movementexperimental biophysicsbiophysical chemistrybiophysical review

Ras–Guanine Nucleotide Complexes: A Uv Spectral Deconvolution Method to Analyze Protein Concentration, Nucleotide Stoichiometry, and Purity. Analytical Biochemistry (2021)

G. Hayden SwisherJonathan P. HannanNicholas J. CordaroAnnette H. ErbseJoseph J. Falke

bioanalysisbiomolecular engineeringras-guanine nucleotide complexesprotein sciencebiochemistrynucleotide stoichiometrymolecular biologyanalytical chemistryprotein concentrationspectrochemical analysis

Single Molecule Studies and Kinase Activity Measurements Reveal Regulatory Interactions Between the Master Kinases Phosphoinositide-Dependent-Kinase-1 (Pdk1), Protein Kinase B (Akt1/Pkb) and Protein Kinase C (Pkcα). bioRxiv (Cold Spring Harbor Laboratory) (2021)

Moshe T. GordonBrian P. ZiembaJoseph J. Falke

regulatory interactionskinase activity measurementsmolecular biologyintermediate hostsingle molecule studies

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Joseph Falke

Professor

University of Colorado Boulder

Affiliations

Natural Sciences

Biochemistry Department

College of Arts and Sciences

Natural Sciences

Joseph Falke is currently serving as a Biochemistry Professor at University of Colorado Boulder.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Joseph Falke

University of Colorado Boulder

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cosmic-Linked Ras Mutations at the Interface Between H-Ras and Pi3Kγ Rbd Frequently Generate Affinity Increases. bioRxiv (Cold Spring Harbor Laboratory) (2026)

mutagenesis (molecular biology technique)geneticsmolecular geneticssignal recognitioncosmic-linked ras mutationsmolecular cell biologyinterface between h-rashigh energy physicsmolecular biology

Learning Diffusion Coefficients, Kinetic Parameters, and the Number of Underlying States From a Multistate Diffusion Process: Robustness Results and Application to Pdk1/Pkcα Dynamics. (2024)

Lewis R. BakerMoshe T. GordonBrian P. ZiembaVictoria GershunyJoseph J. FalkeDavid M. Bortz

biophysicsdiffusion coefficientsmultistate diffusion processprotein sciencediffusion processneurosciencesystems biologydiffusionkinetic parameters

Ras Signaling Mechanisms: New Insights From Single-Molecule Biophysics. Biophysical Journal (2024)

Anne Marie McCombsJoy R ArmendarizJoseph J Falke

biophysicssingle molecule biophysicsbiophysical chemistry

PDK1: Pkcα Heterodimer Association-Dissociation Dynamics in Single-Molecule Diffusion Tracks on a Target Membrane. Biophysical Journal (2023)

Moshe T. GordonBrian P. ZiembaJoseph J. Falke

biophysicssingle-molecule diffusion trackssingle molecule biophysicstarget membranebiophysical chemistry

Binding of Active Ras and Its Mutants to the Ras Binding Domain of Pi-3-Kinase: A Quantitative Approach to Kd Measurements. Analytical Biochemistry (2022)

Ian R FlemingJonathan P HannanGeorge Hayden SwisherCorey D TesdahlJustin G MartyrNicholas J CordaroAnnette H ErbseJoseph J Falke

biophysicsprotein phosphorylationenzymesprotein sciencemolecular biophysicsprotein structurestructural molecular biologybiochemistryactive rasmolecular biologyanalytical chemistrystructural biology

Hplc Method to Resolve, Identify and Quantify Guanine Nucleotides Bound to Recombinant Ras Gtpase. Analytical Biochemistry (2021)

Jonathan P. HannanG. Hayden SwisherJustin G. MartyrNicholas J. CordaroAnnette H. ErbseJoseph J. Falke

hplc methodbiochemistrybioanalysisguanine nucleotides

Hplc Method to Resolve, Identify and Quantify Guanine Nucleotides Bound to the Gtpase Ras. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Jonathan P. HannanG. Hayden SwisherJustin G. MartyrNicholas J. CordaroAnnette H. ErbseJoseph J. Falke

hplc methodbiochemistrygtpase rasmolecular biologyguanine nucleotides

Pdk1 Forms Homodimers on Supported Lipid Bilayers in a Pip3 Dependent Manner. Biophysical Journal (2021)

Moshe T. GordonJoseph J. Falke

Ras–Guanine Nucleotide Complexes: A Uv Spectral Deconvolution Method to Analyze Protein Concentration, Nucleotide Stoichiometry, and Purity. Analytical Biochemistry (2021)

G. Hayden SwisherJonathan P. HannanNicholas J. CordaroAnnette H. ErbseJoseph J. Falke

Moshe T. GordonBrian P. ZiembaJoseph J. Falke

regulatory interactionskinase activity measurementsmolecular biologyintermediate hostsingle molecule studies

1
2
3
4
5
16
10 / page

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