Faculty

Institution

Unit

Venue

Jialing Lin

Professor

University of Oklahoma

Affiliations

College of Medicine

Biochemistry and Molecular Biology

HEALTH SCIENCES CENTER CAMPUS COLLEGES

College of Medicine

Health Sciences Center Graduate College

Jialing Lin is currently serving as a Biochemistry And Molecular Biology Professor at University of Oklahoma.

Honors

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Experiences

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Education

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Jialing Lin

University of Oklahoma

Professor

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molecular biology membrane biology cell biology structural biology biochemistry membrane proteins protein science cell death molecular and cellular biology apoptosis membranes signal transduction biological chemistry cell signaling molecular cell biology biomolecular interactions pharmacology cellular physiology mitochondrial function cell and molecular biology structural molecular biology peptides peptide science protein function membrane systems molecular physiology protein transport molecular regulation conformational studies protein secretion enzyme inhibition molecular cancer cancer cells oncogenes medicinal research biochemical sciences biopolymers cellular biology cancer biology rna biology signal recognition secretory pathway ribosome-bound signal sequences cell interactions cancer growth protein bioinformatics molecular recognition cell regulation neuroprotection surface chemistry fragmentation effect functional modification biological inorganic chemistry novel interface therapeutic efficacy tumor targeting anti-cancer agents cancer treatment biological oceanography cell migration quantitative microbiology death consequences bax oligomerization membrane protein integration cytosolic gating multistep process cotranslational integration phospholipid bilayer mitochondrial membrane permeability apoptosis protein bax fluorescence-detected subnanomolar affinity signal recognition particle nascent chain lengthens cellular fate nascent chains er membrane medicine internal medicine cancer care pediatric surgery translational research pediatric hematology palliative care behavioral pediatrics oncology pediatric urology cancer letter pediatrics

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Protein Bridge to Death Between the Er and Mitochondria. Journal of Biological Chemistry (2023)

Jialing Lin

cell deathprotein functionprotein bridgemolecular biologybiological chemistrybiochemistry

Structure-Destabilizing Mutations Unleash an Intrinsic Perforation Activity of Antiapoptotic Bcl-2 in the Mitochondrial Membrane Enabling Apoptotic Cell Death. Mitochondrial Communications (2023)

Ping GaoZhi ZhangRui WangLi HuangHao WuZhenzhen QiaoXiaohui WangHaijing JinJun PengLei LiuQuan ChenJialing Lin

immunologymitochondrial membranecell deathcancer geneticsapoptotic cell deathapoptosismolecular biologystructure-destabilizing mutationsintrinsic perforation activitymembrane biology

An Amphipathic Bax Core Dimer Forms Part of the Apoptotic Pore Wall in the Mitochondrial␣Membrane. The EMBO Journal (2021)

Fujiao LvFei QiZhi ZhangMaorong WenJustin KaleAlessandro PiaiLingyu DuShuqing WangLiujuan ZhouYaqing YangBin WuZhijun LiuJuan del RosarioJustin PogmoreJames J ChouDavid W AndrewsJialing LinBo OuYang

mitochondrial functionapoptotic pore wallmolecular biologymembrane biologystructural biologyneurosciencecell biology

Cysteine-Based Crosslinking Approach for Characterization of Oligomeric Pore-Forming Proteins in the Mitochondrial Membranes. Methods in enzymology on CD-ROM/Methods in enzymology (2021)

Zhi ZhangBo HuangXuejun C. ZhangJialing Lin

biophysicsproteomicsmitochondrial membranesmembrane characterizationoligomeric pore-forming proteinsbiomolecular engineeringstructural molecular biologybiopolymersmembrane biologystructural biologyprotein scienceprotein engineeringbiological engineering

Pd-L1 Degradation is Regulated by Electrostatic Membrane Association of Its Cytoplasmic Domain. Nature Communications (2021)

Maorong WenYunlei CaoBin WuTaoran XiaoRuiyu CaoQian WangXiwei LiuHongjuan XueYang YuJialing LinChenqi XuJie XuBo OuYang

structural biologycytoplasmic domaincell biology

The Carboxyl-Terminal Sequence of Bim Enables Bax Activation and Killing of Unprimed Cells. eLife (2020)

Xiaoke ChiDang NguyenJames M PembertonElizabeth J OsterlundQian LiuHetal BrahmbhattZhi ZhangJialing LinBrian LeberDavid W Andrews

immunologycarboxyl-terminal sequencecell deathapoptosisunprimed cells

Dynamic Pgam5 Multimers Dephosphorylate Bcl-XL or Fundc1 to Regulate Mitochondrial and Cellular Fate. Cell Death and Differentiation (2019)

Kaili MaZhi ZhangRui ChangHongcheng ChengChenglong MuTian ZhaoLinbo ChenChuanmei ZhangQian LuoJialing LinYushan ZhuQuan Chen

cellular fategene expressionprotein functionmitochondrial functiongeneticsmolecular regulationmolecular biologysignal transductionprotein sciencecell regulationmembrane biologycell biology

Tightening a Deadly Pore Former. Nature Chemical Biology (2019)

Jialing Lin

pore structurebiochemistrychemical biology

Photocrosslinking Approach to Investigate Protein Interactions in the Bcl-2 Family. Methods in molecular biology (2018)

Jialing LinArthur E. JohnsonZhi Zhang

structural biologymolecular biologyprotein interactionsbiophysics

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell chemical biology (2017)

Xin NiuHetal BrahmbhattPhilipp MergenthalerZhi ZhangJing SangMichael DaudeFabian G.R. EhlertWibke E. DiederichEve WongWeijia ZhuJustin PogmoreJyoti P. NandyMaragani SatyanarayanaRavi K. JimmidiPrabhat AryaBrian LeberJialing LinCarsten CulmseeJing YiDavid W. Andrews

medicinal chemistrycell deathpharmacologyneuroprotectionsmall-molecule inhibitorneurosciencecell biology

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Jialing Lin

Professor

University of Oklahoma

Affiliations

College of Medicine

Biochemistry and Molecular Biology

HEALTH SCIENCES CENTER CAMPUS COLLEGES

College of Medicine

Health Sciences Center Graduate College

Jialing Lin is currently serving as a Biochemistry And Molecular Biology Professor at University of Oklahoma.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jialing Lin

University of Oklahoma

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Protein Bridge to Death Between the Er and Mitochondria. Journal of Biological Chemistry (2023)

Jialing Lin

cell deathprotein functionprotein bridgemolecular biologybiological chemistrybiochemistry

Structure-Destabilizing Mutations Unleash an Intrinsic Perforation Activity of Antiapoptotic Bcl-2 in the Mitochondrial Membrane Enabling Apoptotic Cell Death. Mitochondrial Communications (2023)

Ping GaoZhi ZhangRui WangLi HuangHao WuZhenzhen QiaoXiaohui WangHaijing JinJun PengLei LiuQuan ChenJialing Lin

immunologymitochondrial membranecell deathcancer geneticsapoptotic cell deathapoptosismolecular biologystructure-destabilizing mutationsintrinsic perforation activitymembrane biology

An Amphipathic Bax Core Dimer Forms Part of the Apoptotic Pore Wall in the Mitochondrial␣Membrane. The EMBO Journal (2021)

Fujiao LvFei QiZhi ZhangMaorong WenJustin KaleAlessandro PiaiLingyu DuShuqing WangLiujuan ZhouYaqing YangBin WuZhijun LiuJuan del RosarioJustin PogmoreJames J ChouDavid W AndrewsJialing LinBo OuYang

mitochondrial functionapoptotic pore wallmolecular biologymembrane biologystructural biologyneurosciencecell biology

Cysteine-Based Crosslinking Approach for Characterization of Oligomeric Pore-Forming Proteins in the Mitochondrial Membranes. Methods in enzymology on CD-ROM/Methods in enzymology (2021)

Zhi ZhangBo HuangXuejun C. ZhangJialing Lin

Pd-L1 Degradation is Regulated by Electrostatic Membrane Association of Its Cytoplasmic Domain. Nature Communications (2021)

Maorong WenYunlei CaoBin WuTaoran XiaoRuiyu CaoQian WangXiwei LiuHongjuan XueYang YuJialing LinChenqi XuJie XuBo OuYang

structural biologycytoplasmic domaincell biology

The Carboxyl-Terminal Sequence of Bim Enables Bax Activation and Killing of Unprimed Cells. eLife (2020)

Xiaoke ChiDang NguyenJames M PembertonElizabeth J OsterlundQian LiuHetal BrahmbhattZhi ZhangJialing LinBrian LeberDavid W Andrews

immunologycarboxyl-terminal sequencecell deathapoptosisunprimed cells

Dynamic Pgam5 Multimers Dephosphorylate Bcl-XL or Fundc1 to Regulate Mitochondrial and Cellular Fate. Cell Death and Differentiation (2019)

Kaili MaZhi ZhangRui ChangHongcheng ChengChenglong MuTian ZhaoLinbo ChenChuanmei ZhangQian LuoJialing LinYushan ZhuQuan Chen

cellular fategene expressionprotein functionmitochondrial functiongeneticsmolecular regulationmolecular biologysignal transductionprotein sciencecell regulationmembrane biologycell biology

Tightening a Deadly Pore Former. Nature Chemical Biology (2019)

Jialing Lin

pore structurebiochemistrychemical biology

Photocrosslinking Approach to Investigate Protein Interactions in the Bcl-2 Family. Methods in molecular biology (2018)

Jialing LinArthur E. JohnsonZhi Zhang

structural biologymolecular biologyprotein interactionsbiophysics

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell chemical biology (2017)

medicinal chemistrycell deathpharmacologyneuroprotectionsmall-molecule inhibitorneurosciencecell biology

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pharmacology

autophagy

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Medical College of Wisconsin

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University of Illinois Chicago

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