Faculty

Institution

Unit

Venue

James M. Downey

University of South Alabama

Affiliations

Frederick P. Whiddon College of Medicine

Physiology & Cell Biology

NoneJames M. Downey is currently serving as a Frederick P. Whiddon College Of Medicine faculty at University of South Alabama.

Honors

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Experiences

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Education

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James M. Downey

University of South Alabama

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cardiology pharmacology cardiovascular research physiology cardiovascular physiology respiratory medicine neuroscience medicine circulatory physiology cardiovascular disease electrophysiology animal physiology membrane biology cellular physiology cardiovascular pharmacology vascular biology molecular physiology reperfusion injury inflammation veterinary medicine mammalian biology ischemic preconditioning myocardial infarction hematology redox biology human physiology neurophysiology free radical biology cardiac muscle hemostasis mitochondrial function cardiovascular function applied physiology veterinary physiology rabbit hearts cardiovascular interventions liver physiology rabbit heart medicinal research protein science pharmacotherapy receptor tyrosine kinases clinical pharmacology angiology redox signaling cerebrovascular disease pulmonary circulation myocardial infarct size ischemic syndrome protein function cardiac pathologies infarct size myocardial protection xanthine oxidase isolated rabbit hearts coronary artery disease cardiovascular translational research signaling pathways in vivo systems cardiomyopathy clinical medicine coronary blood flow rabbit cardiomyocytes free radicals acute ethanol exposure medical biophysics respiration (physiology) blood flow treatment effects pharmacokinetics ischemic rabbit myocardium mild hypothermia ischemic myocardium arterial disease protein transport preconditioned state

Notable Scholarly Works

Notable Federal Grants

Collaborators

Initial Despair and Current Hope of Identifying a Clinically Useful Treatment of Myocardial Reperfusion Injury: Insights Derived From Studies of Platelet P2Y12 Antagonists and Interference With Inflammation and Nlrp3 Assembly. International Journal of Molecular Sciences (2024)

Michael V. CohenJames M. Downey

resuscitationmedicinepharmacologycritical carecardiovascular researchinitial despaircardiovascular diseaseuseful treatmentanticoagulantsplatelet antagonistmyocardial reperfusion injuryanti-inflammatorythrombosishematologycardiovascular interventionshemostasisinflammationcardiologymolecular sciencereperfusion injuryclinical researchcurrent hope

Gamma Secretase Activating Protein Promotes End-Organ Dysfunction After Bacterial Pneumonia. American Journal of Physiology-Lung Cellular and Molecular Physiology (2023)

Meredith S. GwinMikhail F. AlexeyevAron M. GeurtsJi Young LeeChun ZhouXi-Ming YangMichael V. CohenJames M. DowneyRobert A. BarringtonDomenico SpadaforaJonathon P. AudiaDara W. FrankSarah VothViktoriya V. PastukhJessica BellLinn AyersDhananjay T. TambeAmy R. NelsonRon BalczonMike T. LinTroy Stevens

host responsemicrobial pathogenesisprotein scienceneurosciencerespiratory medicinemolecular physiologyliver physiologymolecular and cellular biologymembrane biologyinfectious respiratory diseaseveterinary medicinehost factorsgamma secretaseimmunologyphysiologyprotein functioninflammationbacterial pneumoniacellular physiologyrespiration (physiology)

Health Position Paper and Redox Perspectives on Reactive Oxygen Species as Signals and Targets of Cardioprotection. Redox Biology (2023)

Gerd HeuschIoanna AndreadouRobert BellEdoardo BerteroHans-Erik BotkerSean M. DavidsonJames DowneyPhilip EatonPeter FerdinandyBernard J. GershMauro GiaccaDerek J. HausenloyBorja IbanezThomas KriegChristoph MaackRainer SchulzFrank SellkeAjay M. ShahHolger ThieleDerek M. YellonFabio Di Lisa

redox biologyhealth sciencesredox perspectiveshealth position paper

Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity. International Journal of Molecular Sciences (2023)

Xi-Ming YangMichael V. CohenSarah SaynerJonathon P. AudiaJames M. Downey

molecular biologycoronary reperfusionmolecular medicinefirst minutes

The Infarct-Limiting Effect of Remote Ischemic Conditioning in Rats is Not Affected by Aspirin. Cardiovascular Drugs and Therapy (2023)

M. V. BasalayJames M. DowneyS. M. DavidsonD. M. Yellon

medicinecardiologyinfarct-limiting effectremote ischemic conditioningpharmacologyrespiratory medicine

Abstract 9506: Calpain Activation in Early Reperfusion Triggers Pyroptosis Resulting in Myocardial Ischemia/Reperfusion Injury. Circulation (2022)

Michael V CohenXiming YangSarah SaynerJonathon AudiaJames Downey

cerebral blood flowcalpain activationpharmacologycritical carecardiovascular researchcardiovascular diseasecirculatory physiologyoxidative stresscardiovascular physiologypulmonary circulationemergency medicinevascular biologycell deathhematologyinflammationcardiologyischemic syndromereperfusion injuryfunctional regulation

Contributors. Elsevier eBooks (2022)

Ron AltermanJeffrey E. ArleKerry BradleySergio CanaveroSteven M. FalowskiChad W. FarleyYakov GologorskyJianwen Wendy GuH. Louis JournéeJohn KastOlga KhazenJoachim K. KraussVignessh KumarMark LentRobert M. LevyAndres M. LozanoCharles MackelGeorge T. MandyburBryan L. McLaughlinDaniel R. MerrillAlon Y. MogilnerGabi MolnarGuillermo A. MonsalveRichard B. NorthYunseo Linda ParkJohn ParkerShrey PatelJulie G. PilitsisFrancisco A. PonceJason E. PopeAdolfo Ramirez-ZamoraLouis J. RasoJoshua M. RosenowJay L. ShilsPeter SingleKonstantin V. SlavinMichael D. StaudtMark M. SteckerHuy Q. Truong

Remote Ischemic Conditioning: More Explanations and More Expectations. Basic Research in Cardiology (2022)

Efstathios K. IliodromitisMichael V. CohenJames M. Downey

cardiologyhealth sciencesremote ischemic conditioning

Abstract 13089: Reperfusion Injury is Reduced by Antagonism of Nlrp3'S Caspase-1. Circulation (2021)

Michael V CohenXi-Ming YangAmanda N TuckeyJonathon AudiaJames M Downey

neurologycardiologyreperfusion injury

The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart. Journal of Cardiovascular Pharmacology and Therapeutics (2021)

Sergey V. PopovLeonid N. MaslovNatalia V. NaryzhnayaAlexandr V. MukhomezyanovAndrey V. KrylatovSergey Y. TsibulnikovVyacheslav V. RyabovMichael V. CohenJames M. Downey

medicinecardiologypharmacologyreperfusion injurycardiovascular pharmacology

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James M. Downey

University of South Alabama

Affiliations

Frederick P. Whiddon College of Medicine

Physiology & Cell Biology

NoneJames M. Downey is currently serving as a Frederick P. Whiddon College Of Medicine faculty at University of South Alabama.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

James M. Downey

University of South Alabama

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Michael V. CohenJames M. Downey

Gamma Secretase Activating Protein Promotes End-Organ Dysfunction After Bacterial Pneumonia. American Journal of Physiology-Lung Cellular and Molecular Physiology (2023)

Health Position Paper and Redox Perspectives on Reactive Oxygen Species as Signals and Targets of Cardioprotection. Redox Biology (2023)

redox biologyhealth sciencesredox perspectiveshealth position paper

Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity. International Journal of Molecular Sciences (2023)

Xi-Ming YangMichael V. CohenSarah SaynerJonathon P. AudiaJames M. Downey

molecular biologycoronary reperfusionmolecular medicinefirst minutes

The Infarct-Limiting Effect of Remote Ischemic Conditioning in Rats is Not Affected by Aspirin. Cardiovascular Drugs and Therapy (2023)

M. V. BasalayJames M. DowneyS. M. DavidsonD. M. Yellon

medicinecardiologyinfarct-limiting effectremote ischemic conditioningpharmacologyrespiratory medicine

Abstract 9506: Calpain Activation in Early Reperfusion Triggers Pyroptosis Resulting in Myocardial Ischemia/Reperfusion Injury. Circulation (2022)

Michael V CohenXiming YangSarah SaynerJonathon AudiaJames Downey

Contributors. Elsevier eBooks (2022)

Remote Ischemic Conditioning: More Explanations and More Expectations. Basic Research in Cardiology (2022)

Efstathios K. IliodromitisMichael V. CohenJames M. Downey

cardiologyhealth sciencesremote ischemic conditioning

Abstract 13089: Reperfusion Injury is Reduced by Antagonism of Nlrp3'S Caspase-1. Circulation (2021)

Michael V CohenXi-Ming YangAmanda N TuckeyJonathon AudiaJames M Downey

neurologycardiologyreperfusion injury

The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart. Journal of Cardiovascular Pharmacology and Therapeutics (2021)

Sergey V. PopovLeonid N. MaslovNatalia V. NaryzhnayaAlexandr V. MukhomezyanovAndrey V. KrylatovSergey Y. TsibulnikovVyacheslav V. RyabovMichael V. CohenJames M. Downey

medicinecardiologypharmacologyreperfusion injurycardiovascular pharmacology

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5
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10 / page

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cardiology

pharmacology

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University of Illinois Chicago

electrophysiology

cellular physiology

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Johns Hopkins University

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Brian D. Hoit

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cardiovascular translational research

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