Faculty

Institution

Unit

Venue

Isaac Krauss

Professor of Chemistry

Brandeis University

Affiliations

Division of Science

Department of Chemistry

School of Arts and Sciences

Division of Science

Isaac Krauss is currently serving as a Chemistry Professor of Chemistry at Brandeis University.

Honors

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Experiences

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Education

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Isaac Krauss

Brandeis University

Professor of Chemistry

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biochemistry biomolecular engineering molecular biology organic chemistry organic synthesis hiv immunology chemical biology glycobiology transition metal chemistry peptide science enzymes glycosylation enantioselective synthesis chemical sciences coordination chemistry carbohydrate chemistry virus research antiviral research peptides medicinal research therapeutic targets protein science antibody engineering directed evolution aldehyde dehydrogenase catalytic synthesis total synthesis carbohydrate polymer carbohydrate-protein interactions biological inorganic chemistry heterocyclic molecular science enzyme inhibition biological macromolecules biomolecular structure structural molecular biology free radical biology synthetic immunology immunochemistry vaccine design virus structure biocatalysis enzymatic modification enzyme catalysis protein synthesis peptide synthesis glycan core supramolecular assemblies molecular self-assembly antiviral responses g protein-coupled receptor bioassay-guided isolation chemoprevention strategies rational drug design cell migration drug targeting cancer treatment dna nanotechnology nucleic acid chemistry cluster chemistry molecular recognition supramolecular hydrogel taxol derivative carbohydrate-specific antibodies mimotope vaccine hiv glycans multivalent glycopeptides multivalent glycocluster design cell-migration inhibitors mechanistic studies tumor metastasis high temperature selma dna-supported oligomannose clusters structural characterization fluorinated substrate analogues chemical biotechnology molecular diversity molecular informatics bioenergetics synthetic biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2195 Directed Evolution of Multivalent 2'-Fluoro Rna Aptamers Against Protein Targets. Journal of Biological Chemistry (2024)

Emily ZipermanRichard RedmanIsaac Krauss

directed evolutionprotein targetsbiochemistrymolecular biologybiological chemistrymolecular evolution

Crystal Structure of Caryolan-1-Ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction. Biochemistry (2024)

Ramasamy P. KumarJason O. MatosBrandon Y. BlackWilliam H. EllenburgJiahua ChenMacKenzie PattersonJacob A. GehtmanDouglas L. TheobaldIsaac J. KraussDaniel D. Oprian

sesquiterpene synthaseenzymesbiochemistry

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

A Mechanistic Switch From Homoallylation to Cyclopropylcarbinylation of Aldehydes. Organic Letters (2022)

Woojin LeeDaniel PolyakBokai XuK. N. HoukIsaac J. Krauss

aldehyde dehydrogenasenatural productsmechanistic switchglycosylationchemical synthesischemistryorganic chemistryfree radical biologyorganometallic chemistrybiomolecular engineeringorganic synthesis

An Optimized Synthesis of Fmoc- L -Homopropargylglycine-Oh. The Journal of Organic Chemistry (2022)

Daniel PolyakIsaac J. Krauss

synthesis methodschemical synthesischemistryorganic chemistryoptimized synthesisorganic synthesis

Homoallylboration of Aldehydes: Stereoselective Synthesis of Allylic-Substituted Alkenes and E-Alkenes. Organic Letters (2022)

Daniel PolyakBokai XuIsaac J. Krauss

natural productsallylic-substituted alkeneschemistryorganic chemistryorganometallic chemistrysustainable chemistryorganic synthesisaldehyde dehydrogenasechemical engineeringbiochemistrychemical synthesiscross-coupling reactionstereoselective synthesisasymmetric catalysisstructural chemistrycoordination chemistrynatural product communicationorganometallic catalysistransition metal chemistry

Large-Scale Synthesis of Man 9 Glcnac 2 High-Mannose Glycan and the Effect of the Glycan Core on Multivalent Recognition by Hiv Antibody 2g12. ACS Infectious Diseases (2022)

Mahesh NeralkarBokai XuSatoru HoriyaIsaac J. Krauss

antiviral drug developmenthivtherapeutic targetsinfectious diseasescarbohydrate-protein interactionsimmunotherapymultivalent recognitioncarbohydrate chemistryimmunochemistryglycan coreglycosylationmedicinal researchbiochemistryglycobiologyvirus researchpeptide sciencelarge-scale synthesisantibody engineeringantiviral researchcarbohydrate polymerbiomolecular engineering

Directed Evolution of 2′-Fluoro-Modified, Rna-Supported Carbohydrate Clusters That Bind Tightly to Hiv Antibody 2g12. Journal of the American Chemical Society (2021)

Richard L. RedmanIsaac J. Krauss

biological macromoleculeshivstructural molecular biologycarbohydrate-protein interactionschemical biologymolecular biologygene expressioncarbohydrate chemistryglycosylationbiomolecular structurebiochemistrymicrobiologyglycobiologyvirus researchenzymatic modificationrna-supported carbohydrate clustersantiviral researchmolecular virologyvirus structure

Synthesis of Mannosidase-Stable Man 3 and Man 4 Glycans Containing S-Linked Manα1→2Man Termini. Organic Letters (2021)

Mahesh NeralkarLeiming TianRichard L. RedmanIsaac J. Krauss

heterocyclicpeptide engineeringchemical engineeringglycosylationpeptide sciencepeptide synthesispeptideschemical synthesistransition metal chemistrychemistryorganic chemistrycarbohydrate chemistrycarbohydrate polymerpolysaccharidesorganometallic chemistrybiomolecular engineeringorganic synthesis

Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase. Biochemistry (2020)

Jason O. MatosRamasamy P. KumarAlison C. MaMacKenzie PattersonIsaac J. KraussDaniel D. Oprian

bioelectrochemistrycatalysisstructural molecular biologybiophysical chemistrybiological inorganic chemistryenzymeschemical biologyprotein synthesismolecular biologybiochemistrypentalenene synthaseenzymatic modificationanti-markovnikov additionprotein scienceenzyme catalysistransition metal chemistryfree radical biologysignal transductionredox biologybiomolecular engineering

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Isaac Krauss

Professor of Chemistry

Brandeis University

Affiliations

Division of Science

Department of Chemistry

School of Arts and Sciences

Division of Science

Isaac Krauss is currently serving as a Chemistry Professor of Chemistry at Brandeis University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Isaac Krauss

Brandeis University

Professor of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2195 Directed Evolution of Multivalent 2'-Fluoro Rna Aptamers Against Protein Targets. Journal of Biological Chemistry (2024)

Emily ZipermanRichard RedmanIsaac Krauss

directed evolutionprotein targetsbiochemistrymolecular biologybiological chemistrymolecular evolution

Crystal Structure of Caryolan-1-Ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction. Biochemistry (2024)

Ramasamy P. KumarJason O. MatosBrandon Y. BlackWilliam H. EllenburgJiahua ChenMacKenzie PattersonJacob A. GehtmanDouglas L. TheobaldIsaac J. KraussDaniel D. Oprian

sesquiterpene synthaseenzymesbiochemistry

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

A Mechanistic Switch From Homoallylation to Cyclopropylcarbinylation of Aldehydes. Organic Letters (2022)

Woojin LeeDaniel PolyakBokai XuK. N. HoukIsaac J. Krauss

aldehyde dehydrogenasenatural productsmechanistic switchglycosylationchemical synthesischemistryorganic chemistryfree radical biologyorganometallic chemistrybiomolecular engineeringorganic synthesis

An Optimized Synthesis of Fmoc- L -Homopropargylglycine-Oh. The Journal of Organic Chemistry (2022)

Daniel PolyakIsaac J. Krauss

synthesis methodschemical synthesischemistryorganic chemistryoptimized synthesisorganic synthesis

Homoallylboration of Aldehydes: Stereoselective Synthesis of Allylic-Substituted Alkenes and E-Alkenes. Organic Letters (2022)

Daniel PolyakBokai XuIsaac J. Krauss

Large-Scale Synthesis of Man 9 Glcnac 2 High-Mannose Glycan and the Effect of the Glycan Core on Multivalent Recognition by Hiv Antibody 2g12. ACS Infectious Diseases (2022)

Mahesh NeralkarBokai XuSatoru HoriyaIsaac J. Krauss

Directed Evolution of 2′-Fluoro-Modified, Rna-Supported Carbohydrate Clusters That Bind Tightly to Hiv Antibody 2g12. Journal of the American Chemical Society (2021)

Richard L. RedmanIsaac J. Krauss

Synthesis of Mannosidase-Stable Man 3 and Man 4 Glycans Containing S-Linked Manα1→2Man Termini. Organic Letters (2021)

Mahesh NeralkarLeiming TianRichard L. RedmanIsaac J. Krauss

Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase. Biochemistry (2020)

Jason O. MatosRamasamy P. KumarAlison C. MaMacKenzie PattersonIsaac J. KraussDaniel D. Oprian

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microelectrode arrays

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synthetic photoswitches