Faculty

Institution

Unit

Venue

Hazel M. Holden

Professor

University of Wisconsin–Madison

Affiliations

College of Agricultural and Life Sciences

Biochemistry

Hazel M. Holden is currently serving as a Biochemistry Professor at University of Wisconsin–Madison.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Hazel M. Holden

University of Wisconsin–Madison

Professor

You can click a keyword to filter the displayed items

biochemistry enzymes molecular biology structural biology protein structure protein science structural molecular biology microbiology biomolecular structure biological chemistry protein chemistry pharmacology crystallography biosynthesis biological inorganic chemistry enzyme catalysis membrane biology molecular structure biocatalysis protein biosynthesis bacteria redox biology biochemical sciences three-dimensional structure molecular microbiology carbamoyl phosphate synthetase crystal structures protein x-ray crystallography enzyme inhibition medicinal chemistry structure-function enzyme kinetics clinical microbiology molecular architecture structure determination molecular substrates biological macromolecules structural chemistry nutritional biochemistry microbial physiology biochemical genetics cellular enzymology protein genetics enzyme specificity microbial genetics carbohydrate-protein interactions molecular biotechnology capsular polysaccharides insect molecular biology molecular physiology enzymatic modification bacteriology protein synthesis x-ray crystallography isoaspartyl dipeptidase clinical biochemistry molecular science structure elucidation chemical biotechnology kanamycin nucleotidyltransferase active site catalytic mechanism functional studies preliminary analysis structural studies x-ray structure molecular catalysis trace elements metalloproteins glycosylation polysaccharides protein function salmonella typhi biochemical investigation structural composition muscle contraction x-ray structures

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Method for Facile Production of Variable Lymphocyte Receptors Using Shuffle Escherichia Coli. Biotechnology Progress (2025)

protein expressionmolecular immunologysystem immunologymolecular biological methodpathogenesisimmunologysynthetic biologyfacile productionbiotechnology advanceimmune responsesimmunity (medicine)molecular biologyprotein engineeringantigen processingcell researchreceptorsvariable lymphocyte receptors

Biosynthesis of Cytidine Diphosphate-6- D -Glucitol for the Capsular Polysaccharides of Campylobacter Jejuni. Biochemistry (2024)

Manas K. GhoshTamari NarindoshviliJames B. ThodenMitchell E. SchumannHazel M. HoldenFrank M. Raushel

biological engineeringnatural product biosynthesiscarbohydrate-protein interactionsnutritional biochemistrybiochemistrymicrobiologyglycobiologybiotechnologycapsular polysaccharidescarbonyl metabolismbiological chemistrycarbohydrate chemistrypolysaccharidesbiosynthesisprotein biosynthesis

The High‐Resolution Structure of a Variable Lymphocyte Receptor From Petromyzon Marinus Capable of Binding to the Brain Extracellular Matrix. Proteins Structure Function and Bioinformatics (2024)

Elizabeth A. AppeltJames B. ThodenSeth A. GehrkeHannah D. BachmeierIvan RaymentEric V. ShustaHazel M. Holden

high-resolution structurehigh resolutionneurosciencebrain extracellular matrixvariable lymphocyte receptorprotein structureextracellular matrixbioinformatics

Characterization of a Novel Inhibitor for the New Delhi Metallo-β-Lactamase-4: Implications for Drug Design and Combating Bacterial Drug Resistance. Journal of Biological Chemistry (2023)

James B. ThodenBogdan M. BeninAdam PriebeWoo Shik ShinRamaiah MuthyalaYuk Yin ShamHazel M. Holden

drug designmedicinal chemistrydrug resistancebacterial drug resistancepharmacologydrug discoveryenzyme inhibitionnovel inhibitor

Structural Analysis of a Bacterial Udp-Sugar 2-Epimerase Reveals the Active Site Architecture Before and After Catalysis. Journal of Biological Chemistry (2023)

James B. ThodenJames O. McKnightCharles W. KroftJoshua D.T. JastHazel M. Holden

enzymesprotein scienceenzyme catalysisbiochemistrymicrobiologycatalysisactive site architecturemolecular biologyprotein structurestructural biology

Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter Jejuni. Biochemistry (2022)

Dao Feng XiangManas K. GhoshAlexander S. RiegertJames B. ThodenHazel M. HoldenFrank M. Raushel

enzymesinfectious diseasesbiochemistrymicrobiologycapsular polysaccharides

C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides From Campylobacter Jejuni. Biochemistry (2022)

Manas K. GhoshDao Feng XiangJames B. ThodenHazel M. HoldenFrank M. Raushel

enzymesbiochemistrymicrobiologybacteriacapsular polysaccharidesmolecular biologygene expressionbiosynthesisprotein biosynthesis

Investigation of the Enzymes Required for the Biosynthesis of 2, 3‐ Diacetamido‐2,3‐Dideoxy‐ D ‐Glucuronic Acid in Psychrobacter Cryohalolentis K5 T. Protein Science (2022)

Daniel L. HofmeisterChase A. SeltznerNicholas J. BockhausJames B. ThodenHazel M. Holden

enzymatic modificationlipidsnatural product biosynthesisenzymesenzyme catalysisnutritional biochemistrybiocatalysiscell biologybiochemistrybioenergeticsmembrane biologymolecular biologybiological chemistryfree radical biologygene expressionredox biologybiosynthesisprotein biosynthesis

Reaction Mechanism and Three-Dimensional Structure of Gdp- D -Glycero-α- D -Manno-Heptose 4,6-Dehydratase From Campylobacter Jejuni. Biochemistry (2022)

Dao Feng XiangJames B. ThodenManas K. GhoshHazel M. HoldenFrank M. Raushel

three-dimensional structureenzymesreaction mechanismprotein sciencebiocatalysiscell biologybiochemistryglycobiologycatalysisbiochemical sciencesbiological chemistryprotein structurecarbohydrate chemistrygeneticsbiological inorganic chemistry

Structure and Function of an N ‐Acetyltransferase From the Human Pathogen Acinetobacter Baumannii Isolate Bal_212. Proteins Structure Function and Bioinformatics (2022)

Noah R. HerkertJames B. ThodenHazel M. Holden

clinical microbiologyenzymesinfectious diseasesprotein chemistryprotein sciencemolecular microbiologyprotein functionmicrobiologybacteriapathogensmolecular biologyprotein structurebacteriologystructural molecular biologystructural biologypathogen characterization

1
2
3
4
5
41
10 / page

Hazel M. Holden

Professor

University of Wisconsin–Madison

Affiliations

College of Agricultural and Life Sciences

Biochemistry

Hazel M. Holden is currently serving as a Biochemistry Professor at University of Wisconsin–Madison.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Hazel M. Holden

University of Wisconsin–Madison

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Method for Facile Production of Variable Lymphocyte Receptors Using Shuffle Escherichia Coli. Biotechnology Progress (2025)

Biosynthesis of Cytidine Diphosphate-6- D -Glucitol for the Capsular Polysaccharides of Campylobacter Jejuni. Biochemistry (2024)

Manas K. GhoshTamari NarindoshviliJames B. ThodenMitchell E. SchumannHazel M. HoldenFrank M. Raushel

The High‐Resolution Structure of a Variable Lymphocyte Receptor From Petromyzon Marinus Capable of Binding to the Brain Extracellular Matrix. Proteins Structure Function and Bioinformatics (2024)

Elizabeth A. AppeltJames B. ThodenSeth A. GehrkeHannah D. BachmeierIvan RaymentEric V. ShustaHazel M. Holden

high-resolution structurehigh resolutionneurosciencebrain extracellular matrixvariable lymphocyte receptorprotein structureextracellular matrixbioinformatics

Characterization of a Novel Inhibitor for the New Delhi Metallo-β-Lactamase-4: Implications for Drug Design and Combating Bacterial Drug Resistance. Journal of Biological Chemistry (2023)

James B. ThodenBogdan M. BeninAdam PriebeWoo Shik ShinRamaiah MuthyalaYuk Yin ShamHazel M. Holden

drug designmedicinal chemistrydrug resistancebacterial drug resistancepharmacologydrug discoveryenzyme inhibitionnovel inhibitor

Structural Analysis of a Bacterial Udp-Sugar 2-Epimerase Reveals the Active Site Architecture Before and After Catalysis. Journal of Biological Chemistry (2023)

James B. ThodenJames O. McKnightCharles W. KroftJoshua D.T. JastHazel M. Holden

enzymesprotein scienceenzyme catalysisbiochemistrymicrobiologycatalysisactive site architecturemolecular biologyprotein structurestructural biology

Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter Jejuni. Biochemistry (2022)

Dao Feng XiangManas K. GhoshAlexander S. RiegertJames B. ThodenHazel M. HoldenFrank M. Raushel

enzymesinfectious diseasesbiochemistrymicrobiologycapsular polysaccharides

C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides From Campylobacter Jejuni. Biochemistry (2022)

Manas K. GhoshDao Feng XiangJames B. ThodenHazel M. HoldenFrank M. Raushel

enzymesbiochemistrymicrobiologybacteriacapsular polysaccharidesmolecular biologygene expressionbiosynthesisprotein biosynthesis

Investigation of the Enzymes Required for the Biosynthesis of 2, 3‐ Diacetamido‐2,3‐Dideoxy‐ D ‐Glucuronic Acid in Psychrobacter Cryohalolentis K5 T. Protein Science (2022)

Daniel L. HofmeisterChase A. SeltznerNicholas J. BockhausJames B. ThodenHazel M. Holden

Reaction Mechanism and Three-Dimensional Structure of Gdp- D -Glycero-α- D -Manno-Heptose 4,6-Dehydratase From Campylobacter Jejuni. Biochemistry (2022)

Dao Feng XiangJames B. ThodenManas K. GhoshHazel M. HoldenFrank M. Raushel

Structure and Function of an N ‐Acetyltransferase From the Human Pathogen Acinetobacter Baumannii Isolate Bal_212. Proteins Structure Function and Bioinformatics (2022)

Noah R. HerkertJames B. ThodenHazel M. Holden

1
2
3
4
5
41
10 / page

Similar Faculty Members

Ivan Rayment

Institution

University of Wisconsin–Madison

protein bioinformatics

biomolecular structure

Frank Raushel

Institution

Texas A&M University

biochemistry

enzymes

Kelley Moremen

Institution

University of Georgia

glycan trimming enzymes

glycosylation

James Sacchettini

Institution

Texas A&M University

molecular biology

structural biology

Robert Phillips

Institution

University of Georgia

organic chemistry

biological chemistry

Vern Schramm

Institution

Albert Einstein College of Medicine

protein modeling

protein structure

David Sherman

Institution

University of Michigan

biochemistry

molecular biology

Xi Chen

Institution

University of California, Davis

glycosylation

bio-orthogonal chemistry

Liang Tong

Institution

Columbia University

molecular biology

structural biology

Shahriar Mobashery

Institution

University of Notre Dame

pharmacology

biochemistry

Similar Faculty Members

Ivan Rayment

Institution

University of Wisconsin–Madison

protein bioinformatics

biomolecular structure

Frank Raushel

Institution

Texas A&M University

biochemistry

enzymes

Kelley Moremen

Institution

University of Georgia

glycan trimming enzymes

glycosylation

James Sacchettini

Institution

Texas A&M University

molecular biology

structural biology

Robert Phillips

Institution

University of Georgia

organic chemistry

biological chemistry

Vern Schramm

Institution

Albert Einstein College of Medicine

protein modeling

protein structure

David Sherman

Institution

University of Michigan

biochemistry

molecular biology

Xi Chen

Institution

University of California, Davis

glycosylation

bio-orthogonal chemistry

Liang Tong

Institution

Columbia University

molecular biology

structural biology

Shahriar Mobashery

Institution

University of Notre Dame

pharmacology

biochemistry