Faculty

Institution

Unit

Venue

Guan Chen, MD, PhD

Professor

Medical College of Wisconsin

Affiliations

Department of Medicine

Departments of Pharmacology and Toxicology

Graduate School

Pancreatic Cancer Program

Guan Chen, Md, Phd is currently serving as a Medicine Professor at Medical College of Wisconsin.

Honors

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Experiences

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Education

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Guan Chen, MD, PhD

Medical College of Wisconsin

Professor

You can click a keyword to filter the displayed items

molecular biology biochemistry cell signaling tumor biology cancer biology cancer research biological chemistry cell biology signal transduction oncogenes pharmacology breast cancer signaling pathways medicinal research cancer cells gene expression therapeutic targets molecular cell biology protein phosphorylation molecular and cellular biology enzyme inhibition protein science cell regulation breast oncology cancer treatment estrogen receptor apoptosis anti-cancer agents clinical biochemistry cell death cancer discovery pharmacotherapy inhibitory activity tumor targeting molecular physiology biochemical sciences pharmacological research redox biology free radical biology transcription regulation protein function clinical pharmacology cancer genetics pathway analysis novel therapies colorectal cancer cancer genomics glutathione s-transferase stress response biochemical genetics functional selectivity metalloproteins oligonucleotides host factors cytokines reductive stress oncogenic agent remedial action redox signaling enzyme specificity biological inorganic chemistry cell control cancer immunosurveillance negative feedback opposite effects jnk pathways cellular glutathione c-ki-ras proteins diploid human fibroblasts antisense oligonucleotides k-ras transformation ras transformation c-jun-dependent ubiquitin-proteasome pathways oncogenic transformation potentiates s-phase arrest stress-kinase activation molecular cancer

Notable Scholarly Works

Notable Federal Grants

Collaborators

CORRECTION: P38γ Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. Cancer Research (2025)

Fang WangXiao-Mei QiRyan WertzMatthew MortensenCatherine HagenJohn EvansYuri SheininMichael JamesPengyuan LiuSusan TsaiJames ThomasAlexander MackinnonMichael DwinellCharles R. MyersRamon Bartrons BachLiwu FuGuan Chen

oncologytumor biologycancer researchmolecular biologypancreatic tumorigenesisaerobic glycolysisbiomolecular engineeringcancer biology

Protein Tyrosine Phosphatase Ptph1 Potentiates Receptor Tyrosine Kinase Her2 Oncogenesis via a Pdz-Coupled and Phosphorylation-Driven Scaffold. American Journal of Cancer Research (2024)

Xiaomei QiFang WangLinda ThomasShao MaKatie PalenYan LuYuri SheininJill GershanLiwu FuGuan Chen

oncogenesreceptor tyrosine kinasestumor biologyprotein phosphorylationbiochemistrycancer researchphosphorylation-driven scaffoldmolecular biologyreceptorsoncologycancer biology

Figure S6 From P38γ Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (2023)

pancreatic tumorigenesistumor biologyaerobic glycolysisbiochemistry

P38γ Mapk Inflammatory and Metabolic Signaling in Physiology and Disease. Cells (2023)

Xiao-Mei QiGuan Chen

inflammatory diseasesinflammationphysiologycell signalingmetabolic regulationcell biologymetabolic pathwayscellular physiologysignaling pathwaysmetabolic signalingmolecular physiologyimmune responsesmetabolic networksinsulin signalingsystems biologysignal transduction

Supplementary Data From P38γ Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (2023)

aerobic glycolysispancreatic tumorigenesisbiochemistry

Isoform-Specific and Cell/Tissue-Dependent Effects of P38 Mapks in Regulating Inflammation and Inflammation-Associated Oncogenesis. Frontiers in Bioscience-Landmark (2022)

Jian-Zhong QinHong XinXiao-Mei QiGuan Chen

inflammationcell signalingcell biologymolecular biologysystems biologycancer biologyinflammation-associated oncogenesis

Kidney-Targeted Epoxyeicosatrienoic Acid Analog, Eet-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity. International Journal of Molecular Sciences (2021)

John D. ImigMd Abdul Hye KhanAnna BurkhanGuan ChenAdeniyi Michael AdebesinJohn R. Falck

anti-inflammatorykidney researchtherapeutic targetsvascular biologynephrologynovel therapiesmolecular sciencepeptidesmolecular biologyoxidative stressrenal functionmedicinal researchbiochemistrycisplatin-induced nephrotoxicityrenal pathophysiologyinflammationreduces inflammationantioxidantsbiomolecular engineeringchronic kidney disease

P38Gamma Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. Cancer Research (2020)

oncogenesp38gamma mapkpathologytumor biologycell biologymetabolic pathwaysmolecular cancercell metabolismcarcinogenesiscancer researchmetabolic remodelingpancreatic cancercancer cellsoncologycancer biology

P38Gamma Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis.. Cancer Res. (2020)

Editorial Preface for Targeted Cancer Therapy. Acta Pharmaceutica Sinica B (2018)

Guan ChenWei Li

drug targetingcancer discoverypharmacologytherapeutic targetstumor biologynovel therapiescancer researchmolecular biologydrug discoverycancer treatmentpharmacotherapybiomolecular engineeringtargeted cancer therapymedicinal researchtranslational pharmacologytumor targetingapplied pharmacologyeditorial prefaceenzyme inhibitiononcology

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Guan Chen, MD, PhD

Professor

Medical College of Wisconsin

Affiliations

Department of Medicine

Departments of Pharmacology and Toxicology

Graduate School

Pancreatic Cancer Program

Guan Chen, Md, Phd is currently serving as a Medicine Professor at Medical College of Wisconsin.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Guan Chen, MD, PhD

Medical College of Wisconsin

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

CORRECTION: P38γ Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. Cancer Research (2025)

oncologytumor biologycancer researchmolecular biologypancreatic tumorigenesisaerobic glycolysisbiomolecular engineeringcancer biology

Protein Tyrosine Phosphatase Ptph1 Potentiates Receptor Tyrosine Kinase Her2 Oncogenesis via a Pdz-Coupled and Phosphorylation-Driven Scaffold. American Journal of Cancer Research (2024)

Xiaomei QiFang WangLinda ThomasShao MaKatie PalenYan LuYuri SheininJill GershanLiwu FuGuan Chen

oncogenesreceptor tyrosine kinasestumor biologyprotein phosphorylationbiochemistrycancer researchphosphorylation-driven scaffoldmolecular biologyreceptorsoncologycancer biology

Figure S6 From P38γ Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (2023)

pancreatic tumorigenesistumor biologyaerobic glycolysisbiochemistry

P38γ Mapk Inflammatory and Metabolic Signaling in Physiology and Disease. Cells (2023)

Xiao-Mei QiGuan Chen

Supplementary Data From P38γ Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (2023)

aerobic glycolysispancreatic tumorigenesisbiochemistry

Isoform-Specific and Cell/Tissue-Dependent Effects of P38 Mapks in Regulating Inflammation and Inflammation-Associated Oncogenesis. Frontiers in Bioscience-Landmark (2022)

Jian-Zhong QinHong XinXiao-Mei QiGuan Chen

inflammationcell signalingcell biologymolecular biologysystems biologycancer biologyinflammation-associated oncogenesis

Kidney-Targeted Epoxyeicosatrienoic Acid Analog, Eet-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity. International Journal of Molecular Sciences (2021)

John D. ImigMd Abdul Hye KhanAnna BurkhanGuan ChenAdeniyi Michael AdebesinJohn R. Falck

P38Gamma Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. Cancer Research (2020)

P38Gamma Mapk is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis.. Cancer Res. (2020)

Editorial Preface for Targeted Cancer Therapy. Acta Pharmaceutica Sinica B (2018)

Guan ChenWei Li

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University of Pittsburgh

cancer letter

pathology

Lee Graves

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University of North Carolina at Chapel Hill

molecular biology

pharmacology

Ratna K Vadlamudi

Institution

University of Texas Health Science Center at San Antonio

molecular cancer

estrogen signaling

Francis Ali-Osman

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molecular cancer

carcinogenesis

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cell biology

oncogenes

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Thomas Jefferson University

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therapeutic response

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breast cancer

oncogene

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cancer biology