Faculty

Institution

Unit

Venue

Francis Ali-Osman

Professor Emeritus in Neurosurgery

Duke University

Affiliations

School of Medicine

Clinical Science Departments

Department of Neurosurgery

Francis Ali-osman is currently serving as a Clinical Science S Professor Emeritus in Neurosurgery at Duke University.

Honors

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Experiences

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Education

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Francis Ali-Osman

Duke University

Professor Emeritus in Neurosurgery

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tumor biology cancer research molecular biology oncology brain tumor research cancer biology gliomas medicinal research cell biology biochemistry oncogenes cancer cells neuro-oncology cancer genetics cancer treatment gene expression tumor microenvironment molecular cancer genetics tumor targeting vascular biology enzyme inhibition cancer genomics cancer discovery carcinogenesis tumor suppressors cellular therapy cancer care anti-cancer agents pharmacotherapy tumor heterogeneity protein phosphorylation molecular neurodegeneration surgical oncology molecular cell biology leukemia melanoma human glioma cells cancer risk cancer growth epidemiology of cancer cancer prevention cancer management biological chemistry inhibitory activity cell regulation human glioblastoma cells oncogenic agent cell culture secondary metabolism allelic variant g protein-coupled receptor protein expression medical genetics biomedical research reporter gene assay gene transfer radiation biology therapeutic efficacy cellular biology cellular immune responses tumor necrosis factor antiproliferative effects dna damage functional characterization genome-wide association studies escherichia coli genetic polymorphism brain tumor cells mismatch repair deficiency malignant glioma case-control study tissue factor dna interstrand cross-linking glioblastoma cells breast cancer risk radiation oncology stem cell research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Brain Tumors. Elsevier eBooks (2021)

Harald Sontheimer

neurologypathologybrain lesionmalignant diseasebrain cellsbrain tumor researchsurgical pathologytumoral pathologyneuropathologycancer researchprimary brain tumorsbrain tumorsoncologyneuro-oncology

A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-Kit–Positive Acute Myeloid Leukemia. Clinical Lymphoma Myeloma & Leukemia (2020)

Anjali S. AdvaniWilliam TseHong LiXuefei JiaPaul ElsonBrenda CooperFrancis Ali-OsmanJino ParkArati V. RaoDavid A. RizzieriEunice S. WangClaudiu V. CottaMatt KalaycioRonald M. SobecksBasel RouphailJaroslaw P. MaciejewskiJaime FensterlJennifer S. CarewBethany FosterMary Lynn RushBarbara TrippDonna AdamsDonna CorriganElizabeth A. GriffithsMikkael A. Sekeres

phase ii trialneurologycohort studiesclinical mycologymaintenance therapyimatinib mesylatelymphoid neoplasiamedicinal researchpharmacologymedicinetherapeutic efficacypharmacotherapycancer treatmentclinical trialsoncology

European Genetic Ancestry Associated With Risk of Childhood Ependymoma. Neuro-Oncology (2020)

Chenan ZhangQuinn T OstromHelen M HansenJulio Gonzalez-MayaDonglei HuElad ZivLibby MorimotoAdam J de SmithIvo S MuskensCassie N KlineZalman VaksmanHakon HakonarsonSharon J DiskinCarol KruchkoJill S Barnholtz-SloanVijay RamaswamyFrancis Ali-OsmanMelissa L BondyMichael D TaylorCatherine MetayerJoseph L WiemelsKyle M Walsh

neurologychildhood ependymomaneurosciencecancer riskgeneticseuropean genetic ancestryoncologyneuro-oncology

Aspirin, Nsaids, and Glioma Risk: Original Data From the Glioma International Case–Control Study and a Meta-Analysis. Cancer Epidemiology Biomarkers & Prevention (2018)

E. Susan AmirianQuinn T. OstromGeorgina N. ArmstrongRose K. LaiXiangjun GuDaniel I. JacobsAli JalaliElizabeth B. ClausJill S. Barnholtz-SloanDora Il'yasovaJoellen M. SchildkrautFrancis Ali-OsmanSiegal SadetzkiRobert B. JenkinsDaniel H. LachanceSara H. OlsonJonine L. BernsteinRyan T. MerrellMargaret R. WrenschChristoffer JohansenRichard S. HoulstonMichael E. ScheurerSanjay SheteChristopher I. AmosBeatrice MelinMelissa L. Bondy

gliomasmeta-analysismedicinal researchcancer preventionbrain tumor researchglioma riskcancer researchepidemiology of cancercancer riskpharmacologymedicinehealth sciencesoncologyneuro-oncologyoriginal data

Abstract 4053: Disulfiram-Copper Combination Induces Cell Death Time- and Schedule-Dependently in Glioblastoma (Gbm) and Medulloblastoma Cell Lines, and Enhances Temozolomide Sensitivity of Methylator+Ve Gbm Cellsin Vitroandin Vivo. Cancer Research (2017)

Mostafa GabrStephen MarcusHanumantha R. MadalaKalkunte S. SrivenugopalFrancis Ali-Osman

anti-cancer agentsgliomascell deathdisulfiram-copper combination inducescell linesvascular biologytumor biologycell biologycancer researchmolecular biologycancer cellscancer treatmentoncogenesinduced resistancemedicinal researchbiochemistrytumor microenvironmentcancer biologyearly detectiononcology

Brain- and Brain Tumor-Penetrating Disulfiram Nanoparticles: Sequence of Cytotoxic Events and Efficacy in Human Glioma Cell Lines and Intracranial Xenografts. Oncotarget (2017)

Hanumantha Rao MadalaSurendra R. PunganuruFrancis Ali-OsmanRuiwen ZhangKalkunte S. Srivenugopal

anti-cancer agentsdrug targetinggliomasneuroscienceintracranial xenograftspharmacologynanotoxicologydrug deliverynanoparticle researchcytotoxic eventsnanomedicinemedicinal researchcellular therapynanobiotechnologyneurologybrain tumor researchcancer imagingbrain scienceoncologyneuro-oncology

Exth-36. Development of Stable and Brain-Penetrating Disulfiram Nanoparticles, Characterization and Efficacy in Glioma Cell Culture and Xenograft Models. Neuro-Oncology (2017)

Hanumantha Rao MadalaSurendra Reddy PunganuruKalkunte SrivenugopalFrancis Ali-Osman

tumor targetingtumor biologynanoparticlesgliomasbrain-penetrating disulfiram nanoparticlesglioma cell culturecell biologyneurosciencebrain tumor researchcellular therapynanoparticle researchxenograft modelsbiomolecular engineeringneuro-oncology

Genome-Wide Association Study of Glioma Subtypes Identifies Specific Differences in Genetic Susceptibility to Glioblastoma and Non-Glioblastoma Tumors. Nature Genetics (2017)

Beatrice S MelinJill S Barnholtz-SloanMargaret R WrenschChristoffer JohansenDora Il'yasovaBen KinnersleyQuinn T OstromKarim LabrecheYanwen ChenGeorgina ArmstrongYanhong LiuJeanette E Eckel-PassowPaul A DeckerMarianne LabussièreAhmed IdbaihKhe Hoang-XuanAnna-Luisa Di StefanoKarima MokhtariJean-Yves DelattrePeter BroderickPilar GalanKonstantinos GousiasJohannes SchrammMinouk J SchoemakerSarah J FlemingStefan HermsStefanie HeilmannMarkus M NöthenHeinz-Erich WichmannStefan SchreiberAnthony SwerdlowMark LathropMatthias SimonMarc SansonUlrika AnderssonPreetha RajaramanStephen ChanockMartha LinetZhaoming WangMeredith YeagerJohn K WienckeHelen HansenLucie McCoyTerri RiceMatthew L KoselHugues SicotteChristopher I AmosJonine L BernsteinFaith DavisDan LachanceChing LauRyan T MerrellJoellen ShildkrautFrancis Ali-OsmanSiegal SadetzkiMichael ScheurerSanjay SheteRose K LaiElizabeth B ClausSara H OlsonRobert B JenkinsRichard S HoulstonMelissa L Bondy

neurologyneurogeneticsneuro-oncologygenetic susceptibilitymedicinal researchgenomicsneurosciencebrain tumor researchgenome biologycancer researchmedical geneticsgenome-wide association studiesgenomic medicinenon-glioblastoma tumorscancer geneticscancer genomicsoncologygenetics

Abstract 3446: Aspirin, Non-Steroidal Anti-Inflammatory Drugs (Nsaids) and the Risk of Glioma: Results From the Glioma International Case Control Study. Cancer Research (2016)

Rose K. LaiRenke ZhouE. Susan AmirianChristoffer JohansenMichael E. ScheurerGeorgina N. ArmstrongChing C. LauElizabeth B. ClausJill S. Barnholtz-SloanDora Il’yasovaJoellen SchildkrautFrancis Ali-OsmanSiegal SadetzkiRichard HoulstonRobert B. JenkinsDaniel LachanceSara H. OlsonJonine L. BernsteinRyan T. MerrellMargaret R. WrenschFaith G. DavisSanjay SheteChristopher I. AmosBeatrice S. MelinMelissa Bondy

neurologycancer caretumor targetingcancer biologyanti-inflammatorygliomasdrug treatmentmedicinal researchbrain tumor researchcancer researchmedicinenon-steroidal anti-inflammatory drugsclinical researchpharmacotherapycancer treatmenthealth sciencesoncologyneuro-oncology

Epid-12. Demographics and Lifestyle Factors in Glioma Risk: A Report From the Glioma International Case-Control Study. Neuro-Oncology (2016)

E. Susan AmirianGeorgina ArmstrongRenke ZhouMargaret WrenschSara OlsonMichael ScheurerDora Il’yasovaDaniel LachanceChing LauElizabeth ClausJill Barnholtz-SloanJoellen SchildkrautFrancis Ali-OsmanSiegal SadetzkiChristoffer JohansenRichard HoulstonRobert JenkinsJonine BernsteinRyan MerrellFaith DavisRose LaiSanjay SheteChristopher AmosBeatrice MelinMelissa Bondy

neurologyepidemiologybrain healthlifestyle factorsgliomascross-sectional studiesmedicinal researchcancer preventionbrain tumor researchglioma riskcancer researchunderserved populationspopulation exposurepopulation healthhealth sciencesoncologyneuro-oncology

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Francis Ali-Osman

Professor Emeritus in Neurosurgery

Duke University

Affiliations

School of Medicine

Clinical Science Departments

Department of Neurosurgery

Francis Ali-osman is currently serving as a Clinical Science S Professor Emeritus in Neurosurgery at Duke University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Francis Ali-Osman

Duke University

Professor Emeritus in Neurosurgery

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Brain Tumors. Elsevier eBooks (2021)

Harald Sontheimer

neurologypathologybrain lesionmalignant diseasebrain cellsbrain tumor researchsurgical pathologytumoral pathologyneuropathologycancer researchprimary brain tumorsbrain tumorsoncologyneuro-oncology

A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-Kit–Positive Acute Myeloid Leukemia. Clinical Lymphoma Myeloma & Leukemia (2020)

European Genetic Ancestry Associated With Risk of Childhood Ependymoma. Neuro-Oncology (2020)

neurologychildhood ependymomaneurosciencecancer riskgeneticseuropean genetic ancestryoncologyneuro-oncology

Aspirin, Nsaids, and Glioma Risk: Original Data From the Glioma International Case–Control Study and a Meta-Analysis. Cancer Epidemiology Biomarkers & Prevention (2018)

Mostafa GabrStephen MarcusHanumantha R. MadalaKalkunte S. SrivenugopalFrancis Ali-Osman

Brain- and Brain Tumor-Penetrating Disulfiram Nanoparticles: Sequence of Cytotoxic Events and Efficacy in Human Glioma Cell Lines and Intracranial Xenografts. Oncotarget (2017)

Hanumantha Rao MadalaSurendra R. PunganuruFrancis Ali-OsmanRuiwen ZhangKalkunte S. Srivenugopal

Exth-36. Development of Stable and Brain-Penetrating Disulfiram Nanoparticles, Characterization and Efficacy in Glioma Cell Culture and Xenograft Models. Neuro-Oncology (2017)

Hanumantha Rao MadalaSurendra Reddy PunganuruKalkunte SrivenugopalFrancis Ali-Osman

Genome-Wide Association Study of Glioma Subtypes Identifies Specific Differences in Genetic Susceptibility to Glioblastoma and Non-Glioblastoma Tumors. Nature Genetics (2017)

Abstract 3446: Aspirin, Non-Steroidal Anti-Inflammatory Drugs (Nsaids) and the Risk of Glioma: Results From the Glioma International Case Control Study. Cancer Research (2016)

Epid-12. Demographics and Lifestyle Factors in Glioma Risk: A Report From the Glioma International Case-Control Study. Neuro-Oncology (2016)

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