Faculty

Institution

Unit

Venue

Graham Moran

Loyola University Chicago

Affiliations

College of Arts and Sciences

Chemistry & Biochemistry

NoneGraham Moran is currently serving as a Chemistry & Biochemistry faculty at Loyola University Chicago.

Honors

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Experiences

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Education

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Graham Moran

Loyola University Chicago

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biochemistry enzymes protein science molecular biology redox biology biophysics pharmacology structural biology membrane biology enzyme catalysis enzyme inhibition biological chemistry biocatalysis biological inorganic chemistry protein chemistry catalysis biophysical chemistry structural molecular biology medicinal chemistry protein structure biochemical sciences pyruvate dioxygenase protein engineering catalyst activation protein biosynthesis hydroxymandelate synthase structural chemistry biomolecular structure tryptophan hydroxylase molecular science protein expression structure-function enzyme kinetics enzyme specificity transient-state analysis applied microbiology clinical microbiology avian biology mammalian biology enzymatic modification molecular catalysis pseudomonas fluorescens porcine dihydropyrimidine dehydrogenase mammalian dihydropyrimidine dehydrogenase free radical biology biological macromolecules coordination chemistry electron spectroscopy plant biochemistry protein function structural bioinformatics molecular microbiology protein purification surface reactivity structural composition microbial physiology electronic structure studies a-keto acid-dependent dioxygenases metabolic function human renalase kinetic analysis substrate specificity electronic structure spectroelectrochemistry pharmaceutical chemistry surface modification bio-orthogonal chemistry bacteriology pigments medical microbiology benchmark studies molecular substrates molecular base metabolic regulation non-heme iron enzymes hydrogen-atom abstraction aromatic electrophilic attack enzyme mechanisms aldehyde dehydrogenase alcohol dehydrogenases molecular metabolism biosynthesis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Using Transient State Kinetics to Contextualize the Catalytic Strategy of Human Ferroptosis Suppressor Protein 1. ACS Catalysis (2025)

Tyler B. AltGraham R. Moran

transient state kineticscatalytic strategyprotein chemistryprotein scienceenzyme catalysisbiocatalysisbiochemistrycatalysismolecular biologycatalyst activationstructural molecular biologybiomolecular engineeringprotein biosynthesis

Building on a Theme: The Redox Hierarchy of Pyridine Nucleotide-Disulfide Oxidoreductases. Archives of Biochemistry and Biophysics (2024)

Madison M. SmithGraham R. Moran

biophysicsenzymespyridine nucleotide-disulfide oxidoreductasesprotein scienceredox biologybiochemistrymolecular biologyredox chemistrybiophysical chemistryredox hierarchy

Correction to “Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-Difluorocyclohex-1-Ene-1-Carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase”. ACS Chemical Biology (2024)

Allison N. DevittAbigail L. VargasWei ZhuBenjamin James Des SoyeFatma Ayaloglu ButunTyler AltNicholas KaleyGlaucio M. FerreiraGraham R. MoranNeil L. KelleherDali LiuRichard B. Silverman

chemical sciencesinduced resistancebiochemistrymedicinal chemistryrational drug designchemical biologychemistrypharmacologyorganic chemistrybiosynthesisorganic synthesismechanistic studies

CORRIGENDUM: Assigning Function to Active Site Residues of Schistosoma Mansoni Thioredoxin/Glutathione Reductase From Analysis of Transient State Reductive Half-Reactions With Variant Forms of the Enzyme. Frontiers in Molecular Biosciences (2024)

Madison M. SmithGraham R. Moran

trace metalsstructural molecular biologyselective separationenzymesenzyme inhibitionchemical biologyvariant formsbiocatalysisbiochemistryactive site residuesstructural biologybiophysicsmetabolismsurface reactivityprotein sciencefunctional selectivitymolecular cell biologysignal transductionredox biologybiomolecular engineering

Corrigendum to “Building on a Theme: The Redox Hierarchy of Pyridine Nucleotide-Disulfide Oxidoreductases” [Arch. Biochem. Biophys. 755 (2024) 109966]. Archives of Biochemistry and Biophysics (2024)

Madison M SmithGraham R Moran

biophysicspyridine nucleotide-disulfide oxidoreductasesprotein scienceredox biologybiochemistrybiophysical chemistryredox hierarchy

Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-Difluorocyclohex-1-Ene-1-Carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology (2024)

Allison N. DevittAbigail L. VargasWei ZhuBenjamin James Des SoyeFatma Ayaloglu ButunTyler AltNicholas KaleyGlaucio M. FerreiraGraham R. MoranNeil L. KelleherDali LiuRichard B. Silverman

biochemistrychemistryorganic chemistrypharmacologyorganic synthesismechanistic studies

Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B From Lactoccocus Lactis: Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis. Biochemistry (2024)

Corine O. SmithGraham R. Moran

enzymesprotein scienceenzyme catalysismolecular catalysisbiocatalysisbiochemistrycatalysismolecular biologyflavin bisemiquinone statecatalytic sequence

More Pieces of the Puzzle: Transient State Analysis of Dihydroorotate Dehydrogenase B From Lactoccocus Lactis. Biochemistry (2024)

Corine O. SmithGraham R. Moran

metabolic modelsexperimental analysisstructural molecular biologybiosynthesisenzymesbioanalysismolecular biologybiomolecular analysisbiochemistrycell metabolismbioenergeticsstructural biologyenzymatic modificationmetabolismmolecular metabolismprotein scienceenzyme catalysistransient state analysisbiomolecular engineering

Probing the Site of Glutathione Reduction by Thioredoxin/Glutathione Reductase From Schistosoma Mansoni Under Anaerobic Conditions. Archives of Biochemistry and Biophysics (2024)

Tyler B AltMadison M SmithGraham R Moran

schistosoma mansonibioelectrochemistryprocess biochemistrytrace metalsredox signalingbiosynthesisenzymesresidual stressenzyme inhibitionoxidative stressbiochemical engineeringglutathione reductionbiochemistrymicrobiologycell metabolismschistosomiasismetabolismprotein scienceanaerobic conditionsredox biologybiomolecular engineering

Carborane-Containing Hydroxamate Mmp Ligands for the Treatment of Tumors Using Boron Neutron Capture Therapy (Bnct): Efficacy Without Tumor Cell Entry. International Journal of Molecular Sciences (2023)

Sebastian FliegerMao TakagakiNatsuko KondoMarlon R. LutzYash GuptaHiroki UedaYoshinori SakuraiGraham MoranPrakasha KempaiahNarayan HosmaneMinoru SuzukiDaniel P. Becker

anti-cancer agentssurgical oncologypharmacologytherapeutic targetstumor biologymolecular scienceradiologycancer researchcarborane-containing hydroxamate mmppharmacotherapycancer treatmentradiation oncologytumor cell entrynanomedicinemedicinal researchmolecular cancercancer managementradiation therapytumor targetingoncology

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Graham Moran

Loyola University Chicago

Affiliations

College of Arts and Sciences

Chemistry & Biochemistry

NoneGraham Moran is currently serving as a Chemistry & Biochemistry faculty at Loyola University Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Graham Moran

Loyola University Chicago

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Using Transient State Kinetics to Contextualize the Catalytic Strategy of Human Ferroptosis Suppressor Protein 1. ACS Catalysis (2025)

Tyler B. AltGraham R. Moran

Building on a Theme: The Redox Hierarchy of Pyridine Nucleotide-Disulfide Oxidoreductases. Archives of Biochemistry and Biophysics (2024)

Madison M. SmithGraham R. Moran

biophysicsenzymespyridine nucleotide-disulfide oxidoreductasesprotein scienceredox biologybiochemistrymolecular biologyredox chemistrybiophysical chemistryredox hierarchy

Allison N. DevittAbigail L. VargasWei ZhuBenjamin James Des SoyeFatma Ayaloglu ButunTyler AltNicholas KaleyGlaucio M. FerreiraGraham R. MoranNeil L. KelleherDali LiuRichard B. Silverman

chemical sciencesinduced resistancebiochemistrymedicinal chemistryrational drug designchemical biologychemistrypharmacologyorganic chemistrybiosynthesisorganic synthesismechanistic studies

Madison M. SmithGraham R. Moran

Madison M SmithGraham R Moran

biophysicspyridine nucleotide-disulfide oxidoreductasesprotein scienceredox biologybiochemistrybiophysical chemistryredox hierarchy

Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-Difluorocyclohex-1-Ene-1-Carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology (2024)

Allison N. DevittAbigail L. VargasWei ZhuBenjamin James Des SoyeFatma Ayaloglu ButunTyler AltNicholas KaleyGlaucio M. FerreiraGraham R. MoranNeil L. KelleherDali LiuRichard B. Silverman

biochemistrychemistryorganic chemistrypharmacologyorganic synthesismechanistic studies

Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B From Lactoccocus Lactis: Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis. Biochemistry (2024)

Corine O. SmithGraham R. Moran

enzymesprotein scienceenzyme catalysismolecular catalysisbiocatalysisbiochemistrycatalysismolecular biologyflavin bisemiquinone statecatalytic sequence

More Pieces of the Puzzle: Transient State Analysis of Dihydroorotate Dehydrogenase B From Lactoccocus Lactis. Biochemistry (2024)

Corine O. SmithGraham R. Moran

Probing the Site of Glutathione Reduction by Thioredoxin/Glutathione Reductase From Schistosoma Mansoni Under Anaerobic Conditions. Archives of Biochemistry and Biophysics (2024)

Tyler B AltMadison M SmithGraham R Moran

Sebastian FliegerMao TakagakiNatsuko KondoMarlon R. LutzYash GuptaHiroki UedaYoshinori SakuraiGraham MoranPrakasha KempaiahNarayan HosmaneMinoru SuzukiDaniel P. Becker

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