Faculty

Institution

Unit

Venue

Michael Dunn

Professor Of Biochemistry & Biochemist Emeritus

University of California, Riverside

Affiliations

College of Natural & Agricultural Sciences (CNAS)

Chemistry

Michael Dunn is currently serving as a Chemistry Professor Of Biochemistry & Biochemist Emeritus at University of California, Riverside.

Honors

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Experiences

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Education

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Michael Dunn

University of California, Riverside

Professor Of Biochemistry & Biochemist Emeritus

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biochemistry enzymes protein science molecular biology structural biology protein structure pharmacology enzyme catalysis tryptophan synthase protein chemistry structural molecular biology biophysics biological chemistry enzyme inhibition biological inorganic chemistry coordination chemistry catalysis biocatalysis protein synthesis redox biology biochemical sciences protein engineering membrane biology enzyme specificity salmonella typhimurium biomolecular structure transition metal chemistry structure-function enzyme kinetics protein biosynthesis chemical biology nuclear magnetic resonance structural chemistry insulin signaling molecular catalysis conformational studies allosteric regulation insulin hexamer x-ray crystallography substrate channeling liver alcohol dehydrogenase protein nmr surface reactivity molecular microbiology escherichia coli molecular physiology alcohol dehydrogenases protein expression zinc ion nmr crystallography insulin hexamers substrate specificity liver physiology crystal growth molecular regulation catalytic synthesis catalyst activation functional modification molecular substrates protein assembly proton transfer biomolecular interactions catalytic activity protonation states half-site reactivity catalytic mechanism mammalian biology clinical biochemistry biochemical genetics protein evolution molecular spectroscopy microbial physiology solid-state nmr spectroscopy catalyst preparation active-site cobalt fish biology catalytic process molecular endocrinology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Integrative Structural Biology of Enzyme Active Sites. Royal Society of Chemistry eBooks (2023)

Rittik K. GhoshJacob B. HolmesMichael F. DunnLeonard J. Mueller

molecular biologyintegrative structural biologystructural biologyenzyme active sites

Nmr-Assisted Crystallography of the Tryptophan Synthase α-Aminoacrylate Intermediate: Proton Positions and Role in Inhibition. Biophysical Journal (2023)

Jacob HolmesRittik GhoshMichael F. DunnLeonard J. Mueller

biophysicsenzymescrystallographynuclear magnetic resonanceprotein sciencestructural biologybiochemistrypharmacologynmr-assisted crystallographyenzyme inhibitionbiophysical chemistry

Allosteric Regulation of Substrate Channeling: Salmonella Typhimurium Tryptophan Synthase. Frontiers in Molecular Biosciences (2022)

Rittik K. GhoshEduardo HilarioChia-en A. ChangLeonard J. MuellerMichael F. Dunn

geneticsenzymesmicrobial geneticsmolecular microbiologymicrobial pathogenesisprotein scienceallosteric regulationmolecular regulationimmunologymembrane biologybiotechnologymolecular biologymicrobial physiologyfood microbiologysubstrate channeling

Imaging Active Site Chemistry and Protonation States: Nmr Crystallography of the Tryptophan Synthase α-Aminoacrylate Intermediate. Proceedings of the National Academy of Sciences (2022)

Jacob B. HolmesViktoriia LiuBethany G. CaulkinsEduardo HilarioRittik K. GhoshVictoria N. DragoRobert P. YoungJennifer A. RomeroAdam D. GillPaul M. BogieJoana PaulinoXiaoling WangGwladys RiviereYuliana K. BoskenJochem StruppeAlia HassanJevgeni GuidoulianovBarbara PerroneFrederic Mentink-VigierChia-en A. ChangJoanna R. LongRichard J. HooleyTimothy C. MueserMichael F. DunnLeonard J. Mueller

biophysicsenzymesprotonation statescrystallographyprotein scienceactive site chemistryprotein structureprotein chemistrybiochemistrynmr crystallographymolecular biologystructural biology

Discovery of Antimicrobial Agent Targeting Tryptophan Synthase. Protein Science (2021)

Yuliana K. BoskenRizi AiEduardo HilarioRittik K. GhoshMichael F. DunnShih‐Hsin KanDimitri NiksHuanbin ZhouWenbo MaLeonard J. MuellerLi FanChia‐En A. Chang

medicinetryptophan synthaseprotein scienceimmunologypharmacologyantimicrobial agentsdrug discovery

Mutation of βGln114 to Ala Alters the Stabilities of Allosteric States in Tryptophan Synthase Catalysis. Biochemistry (2021)

Rittik K. GhoshEduardo HilarioViktoriia LiuYangyang WangDimitri NiksJacob B. HolmesVarun V. SakhraniLeonard J. MuellerMichael F. Dunn

enzymestryptophan synthase catalysisenzyme catalysisbiochemistrypharmacologymolecular biologyallosteric statesstructural biology

The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex With N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6F) Inhibitor at the Beta-Site, Sodium Ion at the Metal Coordination Site and Dual Beta-Q114 Rotamer Conformation at 1.60 Angstrom Resolution. (2021)

E. HilarioM.F. DunnL.J. Mueller

pathogenic bacteriaenzymesfragmentation effectinfectious diseasesmicrobial pathogenesismedicinal chemistryprotein scienceprotein structureprotein chemistrybiochemistrypharmacologycoordination chemistryprotein synthesisinternal aldimine formcoordination complex

1.45 Angstrom Resolution Internal Aldimine Crystal Structure of the Beta-Q114A Mutant of Tryptophansynthase in Complex With N-(4'-Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site and Cesium Ion at the Metal Coordination Site. (2020)

E. HilarioM.F. DunnL.J. Mueller

biophysicsgeneticsenzymescrystallographymolecular structureprotein sciencemolecular sciencebiological inorganic chemistrybiomolecular structureprotein structureprotein engineeringstructural molecular biologycrystal structuresprotein chemistryprotein x-ray crystallographymolecular biologystructural biologyprotein assembly

1.60 Angstrom Resolution Crystal Structure of the Beta-Q114A Mutant of Tryptophan Synthase in Complex With N-(4'-Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site, and 2-Aminophenol Quinonoid at the Enzyme Beta Site. (2020)

E. HilarioM.F. DunnL.J. Mueller

geneticsenzymescrystallographytryptophan synthaseprotein sciencebiomolecular structureprotein structurestructural molecular biologybiochemistrypharmacologyprotein chemistryprotein x-ray crystallographyprotein modelingprotein synthesisprotein engineeringenzyme inhibitionenzyme specificitystructural biology

1.60 Angstrom Resolution Crystal Structure of the Beta-Q114A Mutant Tryptophan Synthase in Complex With Inhibitor N-(4'-Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Alpha-Site, Aminoacrylate at the Beta Site, and Cesium Ion at the Metal Coordination Site. (2020)

E. HilarioM.F. DunnL.J. Mueller

enzymesx-ray crystallographycrystallographymedicinal chemistryprotein sciencemolecular structurestructural molecular biologyprotein structurebiomolecular structurebiochemistrypharmacologyprotein x-ray crystallographyprotein chemistrymolecular biologyenzyme inhibitionstructural biology

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Michael Dunn

Professor Of Biochemistry & Biochemist Emeritus

University of California, Riverside

Affiliations

College of Natural & Agricultural Sciences (CNAS)

Chemistry

Michael Dunn is currently serving as a Chemistry Professor Of Biochemistry & Biochemist Emeritus at University of California, Riverside.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Dunn

University of California, Riverside

Professor Of Biochemistry & Biochemist Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Integrative Structural Biology of Enzyme Active Sites. Royal Society of Chemistry eBooks (2023)

Rittik K. GhoshJacob B. HolmesMichael F. DunnLeonard J. Mueller

molecular biologyintegrative structural biologystructural biologyenzyme active sites

Nmr-Assisted Crystallography of the Tryptophan Synthase α-Aminoacrylate Intermediate: Proton Positions and Role in Inhibition. Biophysical Journal (2023)

Jacob HolmesRittik GhoshMichael F. DunnLeonard J. Mueller

biophysicsenzymescrystallographynuclear magnetic resonanceprotein sciencestructural biologybiochemistrypharmacologynmr-assisted crystallographyenzyme inhibitionbiophysical chemistry

Allosteric Regulation of Substrate Channeling: Salmonella Typhimurium Tryptophan Synthase. Frontiers in Molecular Biosciences (2022)

Rittik K. GhoshEduardo HilarioChia-en A. ChangLeonard J. MuellerMichael F. Dunn

Imaging Active Site Chemistry and Protonation States: Nmr Crystallography of the Tryptophan Synthase α-Aminoacrylate Intermediate. Proceedings of the National Academy of Sciences (2022)

biophysicsenzymesprotonation statescrystallographyprotein scienceactive site chemistryprotein structureprotein chemistrybiochemistrynmr crystallographymolecular biologystructural biology

Discovery of Antimicrobial Agent Targeting Tryptophan Synthase. Protein Science (2021)

Yuliana K. BoskenRizi AiEduardo HilarioRittik K. GhoshMichael F. DunnShih‐Hsin KanDimitri NiksHuanbin ZhouWenbo MaLeonard J. MuellerLi FanChia‐En A. Chang

medicinetryptophan synthaseprotein scienceimmunologypharmacologyantimicrobial agentsdrug discovery

Mutation of βGln114 to Ala Alters the Stabilities of Allosteric States in Tryptophan Synthase Catalysis. Biochemistry (2021)

Rittik K. GhoshEduardo HilarioViktoriia LiuYangyang WangDimitri NiksJacob B. HolmesVarun V. SakhraniLeonard J. MuellerMichael F. Dunn

enzymestryptophan synthase catalysisenzyme catalysisbiochemistrypharmacologymolecular biologyallosteric statesstructural biology

E. HilarioM.F. DunnL.J. Mueller

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Similar Faculty Members

Leonard Mueller

Institution

University of California, Riverside

physical chemistry

protein structure

Mary F. Roberts

Institution

Boston College

biochemistry

enzymes

Peter J. Tonge

Institution

Stony Brook University

biological data

biomedical informatics

Charles E. McKenna

Institution

University of Southern California

future medicinal chemistry

medicinal chemistry

Catherine Drennan

Institution

Massachusetts Institute of Technology

biochemistry

molecular biology

R. David Britt

Institution

University of California, Davis

transition metal chemistry

photosynthesis

Richard B. Silverman

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pharmacology

medicinal chemistry

Carsten Krebs

Institution

Pennsylvania State University

enzyme catalysis

energy research

E. Neil G. Marsh

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University of Michigan

biological engineering

biomolecular engineering

Robert Phillips

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University of Georgia

organic chemistry

biological chemistry