Faculty

Institution

Unit

Venue

Gary A. Sulikowski

Stevenson Professor of Chemistry & Professor of Pharmacology

Vanderbilt University

Affiliations

Graduate School

Chemical and Physical Biology

Gary A. Sulikowski is currently serving as a Chemical And Physical Biology Stevenson Professor of Chemistry & Professor of Pharmacology at Vanderbilt University.

Honors

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Experiences

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Education

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Gary A. Sulikowski

Vanderbilt University

Stevenson Professor of Chemistry & Professor of Pharmacology

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chemistry pharmacology organic synthesis organic chemistry medicinal chemistry molecular biology chemical synthesis drug discovery total synthesis redox biology neuroscience membrane biology enzyme inhibition protein science stereoselective synthesis enzymes chemical biology apoptosis clinical microbiology applied microbiology biological chemistry medicinal research transition metal chemistry pharmaceutical chemistry drug targeting angucycline antibiotics functional modification biocatalysis enzyme catalysis synthetic studies mammalian biology coordination chemistry vascular biology clinical chemistry catalyst activation organometallic catalysis molecular microbiology asymmetric catalysis bacteriology natural product synthesis heme biosynthesis biological evaluation plant science pharmacotherapy medical mycology membrane science rational drug design neurochemistry cellular neurobiology anti-cancer agents antiparasitic agent cellular biology heme signaling lipid chemistry lipid science enzyme specificity remedial action biological inorganic chemistry tumor targeting lactate dehydrogenase selective activator metal carbenes molecular neurobiology brain science clinical neuroscience parasite genomics biomimetic chemistry biological targets small-molecule inhibition ch insertion reaction cell-active pyrazole-based inhibitors girk potassium channel antiepileptic properties allosteric antagonism antiparasitic activity trypanosoma cruzi synthetic chemistry natural product research natural product biosynthesis biochemistry marine drug biosynthesis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Photoaffinity Ligand of Cystic Fibrosis Corrector Vx-445 Identifies Sccpdh as an Off-Target. ACS Chemical Biology (2025)

fibrosiscystic fibrosisphotoaffinity ligandcell signalingcell biologyprotein functionmolecular biologybiological chemistrysignal transductionreceptorscellular biochemistry

Time-Resolved Analysis of Protein–Protein Ensembles Using a Destabilizing Domain to Map Dynamic Interactions of Sars-Cov-2 Nsp15. ACS Chemical Biology (2025)

biophysicsprotein structureprotein–protein ensemblesprotein sciencebiomolecular structuredestabilizing domainprotein modelingsars-cov-2molecular biologyprotein foldingtime-resolved analysisstructural molecular biologystructural biologyviral structural protein

Dry Heating of Curcumin in the Presence of Basic Salts Yields Anti-Inflammatory Dimerization Products. ACS Omega (2024)

Paula B. LuisFumie NakashimaSai Han PresleyGary A. SulikowskiClaus Schneider

dry heatinganti-inflammatory

Properties of Configurationally Stable Atropoenantiomers in Macrocyclic Natural Products and the Chrysophaentin Family. Accounts of Chemical Research (2023)

Carole A. BewleyGary A. SulikowskiZhongyue J. YangGiuseppe BifulcoHyo-Moon ChoChristopher R. Fullenkamp

chemical sciencesmacrocyclic natural productschrysophaentin familybiochemistrychemical synthesismaterials sciencechemical biologychemistryorganic synthesis

Small Molecule Activation of Nape-Pld Enhances Efferocytosis by Macrophages. ACS Chemical Biology (2023)

Jonah E. ZarrowAbdul-Musawwir Alli-OluwafuyiCristina M. YouwakimKwangho KimAndrew N. JenkinsIsabelle C. SueroMargaret R. JonesZahra MashhadiKen MackieAlex G. WatersonAmanda C. DoranGary A. SulikowskiSean S. Davies

inflammationinhibitory activityimmunologycell biologyredox biologyhematologyenzyme inhibitionremedial actionmembrane biologychemical biologysmall molecule activationpharmacologymammalian biologyreceptorshost specificity

The 5-Lipoxygenase/Cyclooxygenase-2 Cross-Over Metabolite, Hemiketal E2, Enhances Vegfr2 Activation and Promotes Angiogenesis. Journal of Biological Chemistry (2023)

Fumie NakashimaJuan A. Giménez-BastidaPaula B. LuisSai H. PresleyRobert E. BoerManuel ChiusaTakahiro ShibataGary A. SulikowskiAmbra PozziClaus Schneider

lipidsvascular biologyangiogenesisangiologyenzymesliver physiologycell biologyredox signalingtissue developmentbiochemistryenzyme inhibitionmembrane biologytissue oxygenationmolecular biologybiological chemistrysignal transductiongene expressionredox biology

Discovery of Small Molecule Kcc2 Potentiators Which Attenuate in Vitro Seizure-Like Activity in Cultured Neurons. Frontiers in Cell and Developmental Biology (2022)

Francis J. Prael IIIKwangho KimYu DuBrittany D. SpitznagelGary A. SulikowskiEric DelpireC. David Weaver

neural sciencecellular neurobiologycell biologyelectrophysiologyneurosciencedevelopmental biologycultured neuronsneurophysiologydevelopmental sciencemolecular neurosciencedevelopmental neurobiology

Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as a Redox-State Modifying Clockwork Tuner. ACS Chemical Biology (2022)

Kevin P. KellyHugo BorsettiMarta E. WenzlerAlessandro UstioneKwangho KimPlamen P. ChristovBianca RamirezJoshua A. BauerDavid W. PistonCarl Hirschie JohnsonGary A. Sulikowski

small-molecule modulatorsmolecular biology

The 5-Lox/Cox-2 Cross-Over Metabolite, Hemiketal E 2, Enhances Vegfr2 Activation and Promotes Angiogenesis. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Fumie NakashimaJuan A. Giménez-BastidaPaula B. LuisSai H. PresleyRobert E. BoerManuel ChiusaTakahiro ShibataGary A. SulikowskiAmbra PozziClaus Schneider

vascular biologyangiogenesiscell signalingcell biologyredox signalingdevelopmental biologymembrane biologymolecular biologygene expressionredox biologytissue engineering

VU6036720: The First Potent and Selective in Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels. Molecular Pharmacology (2022)

Samantha J. McClenahanCaitlin N. KentSujay V. KharadeElena IsaevaJade C. WilliamsChangho HanAndrew TerkerRobert GreshamRoman M. LazarenkoEmily L. DaysIan M. RomaineJoshua A. BauerOlivier BoutaudGary A. SulikowskiRaymond HarrisC. David WeaverAlexander StaruschenkoCraig W. LindsleyJerod S. Denton

neuropharmacologyprotein scienceneurosciencemedicinepharmacologymolecular pharmacologydrug discoverysignal transductiontranslational pharmacologyreceptorsfirst potentfunctional modification

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Gary A. Sulikowski

Stevenson Professor of Chemistry & Professor of Pharmacology

Vanderbilt University

Affiliations

Graduate School

Chemical and Physical Biology

Gary A. Sulikowski is currently serving as a Chemical And Physical Biology Stevenson Professor of Chemistry & Professor of Pharmacology at Vanderbilt University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gary A. Sulikowski

Vanderbilt University

Stevenson Professor of Chemistry & Professor of Pharmacology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Photoaffinity Ligand of Cystic Fibrosis Corrector Vx-445 Identifies Sccpdh as an Off-Target. ACS Chemical Biology (2025)

fibrosiscystic fibrosisphotoaffinity ligandcell signalingcell biologyprotein functionmolecular biologybiological chemistrysignal transductionreceptorscellular biochemistry

Time-Resolved Analysis of Protein–Protein Ensembles Using a Destabilizing Domain to Map Dynamic Interactions of Sars-Cov-2 Nsp15. ACS Chemical Biology (2025)

Dry Heating of Curcumin in the Presence of Basic Salts Yields Anti-Inflammatory Dimerization Products. ACS Omega (2024)

Paula B. LuisFumie NakashimaSai Han PresleyGary A. SulikowskiClaus Schneider

dry heatinganti-inflammatory

Properties of Configurationally Stable Atropoenantiomers in Macrocyclic Natural Products and the Chrysophaentin Family. Accounts of Chemical Research (2023)

Carole A. BewleyGary A. SulikowskiZhongyue J. YangGiuseppe BifulcoHyo-Moon ChoChristopher R. Fullenkamp

chemical sciencesmacrocyclic natural productschrysophaentin familybiochemistrychemical synthesismaterials sciencechemical biologychemistryorganic synthesis

Small Molecule Activation of Nape-Pld Enhances Efferocytosis by Macrophages. ACS Chemical Biology (2023)

The 5-Lipoxygenase/Cyclooxygenase-2 Cross-Over Metabolite, Hemiketal E2, Enhances Vegfr2 Activation and Promotes Angiogenesis. Journal of Biological Chemistry (2023)

Fumie NakashimaJuan A. Giménez-BastidaPaula B. LuisSai H. PresleyRobert E. BoerManuel ChiusaTakahiro ShibataGary A. SulikowskiAmbra PozziClaus Schneider

Discovery of Small Molecule Kcc2 Potentiators Which Attenuate in Vitro Seizure-Like Activity in Cultured Neurons. Frontiers in Cell and Developmental Biology (2022)

Francis J. Prael IIIKwangho KimYu DuBrittany D. SpitznagelGary A. SulikowskiEric DelpireC. David Weaver

neural sciencecellular neurobiologycell biologyelectrophysiologyneurosciencedevelopmental biologycultured neuronsneurophysiologydevelopmental sciencemolecular neurosciencedevelopmental neurobiology

Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as a Redox-State Modifying Clockwork Tuner. ACS Chemical Biology (2022)

Kevin P. KellyHugo BorsettiMarta E. WenzlerAlessandro UstioneKwangho KimPlamen P. ChristovBianca RamirezJoshua A. BauerDavid W. PistonCarl Hirschie JohnsonGary A. Sulikowski

small-molecule modulatorsmolecular biology

The 5-Lox/Cox-2 Cross-Over Metabolite, Hemiketal E 2, Enhances Vegfr2 Activation and Promotes Angiogenesis. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Fumie NakashimaJuan A. Giménez-BastidaPaula B. LuisSai H. PresleyRobert E. BoerManuel ChiusaTakahiro ShibataGary A. SulikowskiAmbra PozziClaus Schneider

vascular biologyangiogenesiscell signalingcell biologyredox signalingdevelopmental biologymembrane biologymolecular biologygene expressionredox biologytissue engineering

VU6036720: The First Potent and Selective in Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels. Molecular Pharmacology (2022)

neuropharmacologyprotein scienceneurosciencemedicinepharmacologymolecular pharmacologydrug discoverysignal transductiontranslational pharmacologyreceptorsfirst potentfunctional modification

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10 / page

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