Faculty

Institution

Unit

Venue

Gary Gerfen

Professor

Albert Einstein College of Medicine

Affiliations

Department of Biochemistry

Gary Gerfen is currently serving as a Biochemistry Professor at Albert Einstein College of Medicine.

Honors

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Experiences

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Education

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Gary Gerfen

Albert Einstein College of Medicine

Professor

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biochemistry molecular biology enzymes biophysics protein science redox biology structural biology biological chemistry spectroscopy structural molecular biology protein structure chemistry physical chemistry free radical biology chemical biology enzyme inhibition enzyme catalysis biophysical chemistry membrane biology transition metal chemistry structure-function enzyme kinetics radical (chemistry) quantum chemistry magnetic resonance coordination chemistry biomolecular structure nuclear magnetic resonance spectroscopy atomic spectroscopy vibrational spectroscopy structural chemistry protein chemistry biochemical sciences biological macromolecules dynamic nuclear polarization molecular basis biological inorganic chemistry biocatalysis electron paramagnetic resonance electron spectroscopy frozen solution prion protein high frequency electron spin electronic structure spin phenomenon protein phosphorylation magnetic resonance spectroscopy enzymatic modification enzyme specificity solid-state nmr spectroscopy reactivity (chemistry) microbial genetics coordination complex octarepeat domain tyrosyl radical altmetric attention score tyrosyl radicals envelope modulation study adenosylcobalamin destruction hyperfine interactions heme signaling aldo-keto reductase molecular regulation molecular evidence biomolecular interactions residual stress selective separation protein nmr protein modeling nucleic acid chemistry bacteriology polarization-enhanced nmr spectroscopy copper binding sites molecular features cd spectroscopy n-terminal domain biosynthesis

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Active Site of the Mycobacterium Tuberculosis Branched-Chain Amino Acid Biosynthesis Enzyme Dihydroxyacid Dehydratase Contains a 2Fe–2S Cluster. Journal of Biological Chemistry (2019)

Ghader BashiriTyler L. GroveSubray S. HegdeThomas LagautriereGary J. GerfenSteven C. AlmoChristopher J. SquireJohn S. BlanchardEdward N. Baker

enzymesbiochemistrymolecular biologybiological chemistrybiosynthesis

Catalytic Intermediates of Inducible Nitric-Oxide Synthase Stabilized by the W188H Mutation*. Journal of Biological Chemistry (2012)

Joseph SabatTsuyoshi EgawaChangyuan LuDennis J. StuehrGary J. GerfenDenis L. RousseauSyun-Ru Yeh

catalysiscatalytic intermediatesbiosynthesisenzymesenzyme inhibitionchemical biologymolecular biologynitrosative stressbiocatalysisbiochemistrybiological chemistryinducible nitric-oxide synthasestructural biologyenzymatic modificationenzyme catalysistransition metal chemistrybiochemical sciencesstructure-function enzyme kineticsredox biologybiomolecular engineering

Two Tyrosyl Radicals Stabilize High Oxidation States in Cytochrome C Oxidase for Efficient Energy Conservation and Proton Translocation. Journal of the American Chemical Society (2012)

Michelle A. YuTsuyoshi EgawaKyoko Shinzawa-ItohShinya YoshikawaVictor GuallarSyun-Ru YehDenis L. RousseauGary J. Gerfen

biophysicsenzymesprotein sciencebiocatalysisbiochemistryhigh oxidation statesmembrane biologymolecular biologybiological chemistryfree radical biologytyrosyl radicalsproton translocationredox biology

Investigating the Intermediates in the Reaction of Ribonucleoside Triphosphate Reductase From Lactobacillus Leichmannii: An Application of Hf Epr–Rfq Technology. Journal of Magnetic Resonance (2011)

Julia ManzerovaVladimir KrymovGary J. Gerfen

lipidsbiological macromoleculespharmacologystructural molecular biologygeneticscell biologymolecular biophysicshf epr-rfq technologygene expressionmolecular basisnovel interfacestructural biologyenzymatic modificationprotein sciencenucleic acid amplificationribonucleoside triphosphate reductasemembrane biologybiochemical scienceslactobacillus leichmanniienzyme inhibitionreporter gene assay

Radical Formation in Cytochrome C Oxidase. Biochimica et Biophysica Acta (BBA) - Bioenergetics (2011)

Michelle A. YuTsuyoshi EgawaKyoko Shinzawa-ItohShinya YoshikawaSyun-Ru YehDenis L. RousseauGary J. Gerfen

biophysicsredox biologybiochemistrybioenergeticsmolecular biologyradical formationfree radical biologybiophysical chemistry

Inactivation of Lactobacillus Leichmannii Ribonucleotide Reductase by 2′,2′-Difluoro-2′-Deoxycytidine 5′-Triphosphate: Adenosylcobalamin Destruction and Formation of a Nucleotide-Based Radical. Biochemistry (2010)

Gregory J. S. LohmanGary J. GerfenJoAnne Stubbe

clinical microbiologyadenosylcobalamin destructionenzymesmolecular microbiologyredox biologybiochemistrymicrobiologymicrobial geneticsmolecular biologybiological chemistryenzyme inhibitionapplied microbiology

Inactivation of Lactobacillus Leichmannii Ribonucleotide Reductase by F2Ctp: Adenosylcobalamin Destruction and Formation of a Nucleotide Based Radical. DSpace@MIT (Massachusetts Institute of Technology) (2010)

Gregory J. S. LohmanGary J. GerfenJoAnne Stubbe

redox biologyredox signalingdisease progressionpharmacologyenzymesmicrobial geneticsmolecular biologyoxidative stressmedicinal researchbiochemistrymedicinal chemistrybiological chemistryenzyme specificityadenosylcobalamin destructionenzyme catalysisbiotechnologymembrane biologyfree radical biologyenzyme inhibition

Structural Comparisons of Arachidonic Acid-Induced Radicals Formed by Prostaglandin H Synthase-1 and -2. Journal of Inorganic Biochemistry (2010)

Ah-lim TsaiGang WuCorina E. RoggeJian-Ming LüSheng PengWilfred A. van der DonkGraham PalmerGary J. GerfenRichard J. Kulmacz

enzymesmolecular metabolismstructural comparisonsreactive oxygen speciesprostaglandin h synthase-1arachidonic acid-induced radicalsbiochemistrybioorganic chemistrychemical biologyoxidative stressbiological chemistryfree radical biologyradical (chemistry)redox biologybiomolecular engineeringbiosynthesis

The Structure of P85Ni in Class Ia Phosphoinositide 3-Kinase Exhibits Interdomain Disorder. Biochemistry (2010)

K. Ilker SenHaiyan WuJonathan M. BackerGary J. Gerfen

biophysicsprotein structure predictionbiological macromoleculesreceptor tyrosine kinasesenzymesprotein phosphorylationprotein sciencebiomolecular structureprotein foldingbiochemistryprotein assemblychemical biologymolecular biologyprotein structuremolecular structurestructural molecular biologystructural biology

An Oxyferrous Heme/Protein-Based Radical Intermediate is Catalytically Competent in the Catalase Reaction of Mycobacterium Tuberculosis Catalase-Peroxidase (Katg). Journal of Biological Chemistry (2009)

Javier SuarezKalina RanguelovaAndrzej A. JarzeckiJulia ManzerovaVladimir KrymovXiangbo ZhaoShengwei YuLeonid MetlitskyGary J. GerfenRichard S. Magliozzo

biological engineeringenzymesprotein chemistryprotein scienceenzyme catalysisbiocatalysiscatalase reactionbiochemistrycatalysischemical biologymolecular biologybiological chemistryfree radical biologyheme signalingredox biologymycobacterium tuberculosis catalase-peroxidasebiological inorganic chemistry

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Gary Gerfen

Professor

Albert Einstein College of Medicine

Affiliations

Department of Biochemistry

Gary Gerfen is currently serving as a Biochemistry Professor at Albert Einstein College of Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gary Gerfen

Albert Einstein College of Medicine

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Active Site of the Mycobacterium Tuberculosis Branched-Chain Amino Acid Biosynthesis Enzyme Dihydroxyacid Dehydratase Contains a 2Fe–2S Cluster. Journal of Biological Chemistry (2019)

Ghader BashiriTyler L. GroveSubray S. HegdeThomas LagautriereGary J. GerfenSteven C. AlmoChristopher J. SquireJohn S. BlanchardEdward N. Baker

enzymesbiochemistrymolecular biologybiological chemistrybiosynthesis

Catalytic Intermediates of Inducible Nitric-Oxide Synthase Stabilized by the W188H Mutation*. Journal of Biological Chemistry (2012)

Joseph SabatTsuyoshi EgawaChangyuan LuDennis J. StuehrGary J. GerfenDenis L. RousseauSyun-Ru Yeh

Two Tyrosyl Radicals Stabilize High Oxidation States in Cytochrome C Oxidase for Efficient Energy Conservation and Proton Translocation. Journal of the American Chemical Society (2012)

Michelle A. YuTsuyoshi EgawaKyoko Shinzawa-ItohShinya YoshikawaVictor GuallarSyun-Ru YehDenis L. RousseauGary J. Gerfen

biophysicsenzymesprotein sciencebiocatalysisbiochemistryhigh oxidation statesmembrane biologymolecular biologybiological chemistryfree radical biologytyrosyl radicalsproton translocationredox biology

Julia ManzerovaVladimir KrymovGary J. Gerfen

Radical Formation in Cytochrome C Oxidase. Biochimica et Biophysica Acta (BBA) - Bioenergetics (2011)

Michelle A. YuTsuyoshi EgawaKyoko Shinzawa-ItohShinya YoshikawaSyun-Ru YehDenis L. RousseauGary J. Gerfen

biophysicsredox biologybiochemistrybioenergeticsmolecular biologyradical formationfree radical biologybiophysical chemistry

Gregory J. S. LohmanGary J. GerfenJoAnne Stubbe

Structural Comparisons of Arachidonic Acid-Induced Radicals Formed by Prostaglandin H Synthase-1 and -2. Journal of Inorganic Biochemistry (2010)

Ah-lim TsaiGang WuCorina E. RoggeJian-Ming LüSheng PengWilfred A. van der DonkGraham PalmerGary J. GerfenRichard J. Kulmacz

The Structure of P85Ni in Class Ia Phosphoinositide 3-Kinase Exhibits Interdomain Disorder. Biochemistry (2010)

K. Ilker SenHaiyan WuJonathan M. BackerGary J. Gerfen

Javier SuarezKalina RanguelovaAndrzej A. JarzeckiJulia ManzerovaVladimir KrymovXiangbo ZhaoShengwei YuLeonid MetlitskyGary J. GerfenRichard S. Magliozzo

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6
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catalytic intermediates

biomolecular structure

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biological engineering

biomolecular engineering

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University of Michigan

inorganic chemistry

transition metal chemistry

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chemical biology

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transition metal chemistry

resonance raman

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chemical structure

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