Faculty

Institution

Unit

Venue

Thomas Pochapsky

Professor of Chemistry and Biochemistry

Brandeis University

Affiliations

Division of Science

Biological Physics Program

Department of Chemistry

School of Arts and Sciences

Division of Science

Thomas Pochapsky is currently serving as a Biological Physics Program Professor of Chemistry and Biochemistry at Brandeis University.

Honors

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Experiences

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Education

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Thomas Pochapsky

Brandeis University

Professor of Chemistry and Biochemistry

You can click a keyword to filter the displayed items

biochemistry molecular biology protein science biophysics structural biology structural molecular biology protein structure chemical biology chemistry biophysical chemistry enzymes biomolecular structure nuclear magnetic resonance redox biology transition metal chemistry molecular structure nuclear magnetic resonance spectroscopy protein nmr oxidative stress molecular biophysics biological macromolecules acireductone dioxygenase structural chemistry enzyme inhibition peptide science biochemical interaction biological inorganic chemistry molecular science biological chemistry magnetic resonance free radical biology chromatographic analysis protein chemistry biomolecular analysis structure-function enzyme kinetics toxins single molecule biophysics conformational studies magnetic resonance spectroscopy solution structure chemical sciences liquid chromatography biomolecular interactions redox chemistry reactive oxygen species redox signaling inhibitory activity structural integrity functional selectivity ion structure solid-state nmr spectroscopy klebsiella pneumoniae enzyme specificity nuclear overhauser effects chiral stationary phases protein assembly biophysical modeling bioelectrochemistry surface reactivity pharmaceutical chemistry molecular substrates catalyst activation intermediate host bioactive metal complex formation redox-dependent dynamics oxidized putidaredoxin resonance assignments chiral recognition relevant methionine salvage pathway altmetric attention score proton nmr study refined model vertebrate-type ferredoxins substrate recognition human acireductone dioxygenase protein folding

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structural and Biochemical Characterization of Cyp2D6-Mediated Dextromethorphan Metabolism Using Isonitrile-Based Analogs. Journal of Pharmacology and Experimental Therapeutics (2024)

Kurt HarrisThomas C. PochapskyEmily Scott

pharmacologybiochemical characterizationdrug metabolismbiochemistry

Tracking Protein-Protein Interactions by Nmr: Conformational Selection in Human Steroidogenic Cytochrome P450 Cyp17A1 Induced by Cytochrome B5.. Physical Chemistry Chemical Physics (2024)

Alaina M. RichardD. Fernando EstradaLiam FlynnSusan Sondej PochapskyEmily E. ScottThomas C. Pochapsky

pharmacologyphysicsbiophysicsconformational selectionphysical chemistryprotein-protein interactionsnuclear magnetic resonance

Conformational Heterogeneity Suggests Multiple Substrate Binding Modes in Cyp106a2. Journal of Inorganic Biochemistry (2023)

Nathan R. WongReethy SundarSophia KazanisJeetayu BiswasThomas C. Pochapsky

molecular substratesbiomolecular structurebiological inorganic chemistryprotein scienceprotein structurebiochemistrymolecular structuremolecular biologybiomolecular engineeringstructural molecular biologyconformational heterogeneityconformational studiesinorganic chemistrychemical biology

Selective Steroidogenic Cytochrome P450 Haem Iron Ligation by Steroid-Derived Isonitriles. Communications Chemistry (2023)

Alaina M. RichardNathan R. WongKurt HarrisReethy SundarEmily E. ScottThomas C. Pochapsky

medicinal chemistrypharmacologycommunicationendocrinologysteroid-derived isonitriles

Hydroxylation Regiochemistry is Robust to Active Site Mutations in Cytochrome P450 Cam (Cyp101A1). Biochemistry (2022)

Guadalupe AlvarezThu LeNathan WongJulian EchaveThomas C. PochapskyEliana K. Asciutto

hydroxylation regiochemistrybiochemistrymolecular biologyactive site mutationschemical biology

Steroid‐Derived Isonitriles Are Potent Cytochrome P450 Ligands That Should Enable Solution Nmr as a Structural Technique to Probe P450 Dynamics. The FASEB Journal (2022)

Alaina M. RichardThomas C. PochapskyEmily E. Scott

structural techniquepharmacologybiophysicsstructural biologymolecular biologysteroid-derived isonitriles

A Dynamic Understanding of Cytochrome P450 Structure and Function Through Solution Nmr. Current Opinion in Biotechnology (2020)

Thomas C Pochapsky

chemical structurestructural chemistrybiochemistryprotein sciencenuclear magnetic resonancebiomolecular structuremolecular structurebiomolecular engineeringcatalyst activationdynamic understandingstructural biologynuclear magnetic resonance spectroscopyprotein structurestructural molecular biologybiotechnologyprotein nmrbiophysicssolution nmrstructure determination

A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions With the Regulatory Domain of Matrix Metalloproteinase I (Mmp-I). Biochemistry (2020)

Xinyue LiuAbigail GarberJulia RyanAditi DeshpandeDagmar RingeThomas C. Pochapsky

human febiophysical chemistrybiological inorganic chemistrybiochemistryoxidative stressprotein scienceacireductone dioxygenasebiomolecular analysissolution structurestructure-function enzyme kineticsbiomolecular engineeringmetalloproteinsmolecular biophysicsstructural biologystructural molecular biologyenzymespeptide scienceregulatory domainbioelectrochemistrymolecular biologybiological macromoleculesbiomolecules

Analysis of α-Synuclein Species Enriched From Cerebral Cortex of Humans With Sporadic Dementia With Lewy Bodies. Brain Communications (2020)

John B SandersonSuman DeHaiyang JiangMatteo RovereMing JinLudovica ZaccagniniAurelia Hays WatsonLaura De BoniValentina N LagomarsinoTracy L Young-PearseXinyue LiuThomas C PochapskyBradley T HymanDennis W DicksonDavid KlenermanDennis J SelkoeTim Bartels

geneticsneurologya-synuclein speciesneuroscienceneuroanatomycerebral cortexdementiacognitive neurosciencesporadic dementia

Human Acireductone Dioxygenase (Hsard), Cancer and Human Health: Black Hat, White Hat or Gray?. Inorganics (2019)

Xinyue LiuThomas C. Pochapsky

health sciencesoncologyhuman acireductone dioxygenasepublic health

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Thomas Pochapsky

Professor of Chemistry and Biochemistry

Brandeis University

Affiliations

Division of Science

Biological Physics Program

Department of Chemistry

School of Arts and Sciences

Division of Science

Thomas Pochapsky is currently serving as a Biological Physics Program Professor of Chemistry and Biochemistry at Brandeis University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thomas Pochapsky

Brandeis University

Professor of Chemistry and Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structural and Biochemical Characterization of Cyp2D6-Mediated Dextromethorphan Metabolism Using Isonitrile-Based Analogs. Journal of Pharmacology and Experimental Therapeutics (2024)

Kurt HarrisThomas C. PochapskyEmily Scott

pharmacologybiochemical characterizationdrug metabolismbiochemistry

Tracking Protein-Protein Interactions by Nmr: Conformational Selection in Human Steroidogenic Cytochrome P450 Cyp17A1 Induced by Cytochrome B5.. Physical Chemistry Chemical Physics (2024)

Alaina M. RichardD. Fernando EstradaLiam FlynnSusan Sondej PochapskyEmily E. ScottThomas C. Pochapsky

pharmacologyphysicsbiophysicsconformational selectionphysical chemistryprotein-protein interactionsnuclear magnetic resonance

Conformational Heterogeneity Suggests Multiple Substrate Binding Modes in Cyp106a2. Journal of Inorganic Biochemistry (2023)

Nathan R. WongReethy SundarSophia KazanisJeetayu BiswasThomas C. Pochapsky

Selective Steroidogenic Cytochrome P450 Haem Iron Ligation by Steroid-Derived Isonitriles. Communications Chemistry (2023)

Alaina M. RichardNathan R. WongKurt HarrisReethy SundarEmily E. ScottThomas C. Pochapsky

medicinal chemistrypharmacologycommunicationendocrinologysteroid-derived isonitriles

Hydroxylation Regiochemistry is Robust to Active Site Mutations in Cytochrome P450 Cam (Cyp101A1). Biochemistry (2022)

Guadalupe AlvarezThu LeNathan WongJulian EchaveThomas C. PochapskyEliana K. Asciutto

hydroxylation regiochemistrybiochemistrymolecular biologyactive site mutationschemical biology

Steroid‐Derived Isonitriles Are Potent Cytochrome P450 Ligands That Should Enable Solution Nmr as a Structural Technique to Probe P450 Dynamics. The FASEB Journal (2022)

Alaina M. RichardThomas C. PochapskyEmily E. Scott

structural techniquepharmacologybiophysicsstructural biologymolecular biologysteroid-derived isonitriles

A Dynamic Understanding of Cytochrome P450 Structure and Function Through Solution Nmr. Current Opinion in Biotechnology (2020)

Thomas C Pochapsky

A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions With the Regulatory Domain of Matrix Metalloproteinase I (Mmp-I). Biochemistry (2020)

Xinyue LiuAbigail GarberJulia RyanAditi DeshpandeDagmar RingeThomas C. Pochapsky

Analysis of α-Synuclein Species Enriched From Cerebral Cortex of Humans With Sporadic Dementia With Lewy Bodies. Brain Communications (2020)

geneticsneurologya-synuclein speciesneuroscienceneuroanatomycerebral cortexdementiacognitive neurosciencesporadic dementia

Human Acireductone Dioxygenase (Hsard), Cancer and Human Health: Black Hat, White Hat or Gray?. Inorganics (2019)

Xinyue LiuThomas C. Pochapsky

health sciencesoncologyhuman acireductone dioxygenasepublic health

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2
3
4
5
12
10 / page

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biochemistry

biophysics

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biochemistry

molecular biology

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biomolecular structure

protein structure

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metallodrug discovery

transition metal chemistry

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enzyme catalysis

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protein bioinformatics

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biomolecular engineering