Faculty

Institution

Unit

Venue

Frederick J. Ehlert

Professor Pharmacology

University of California, Irvine

Affiliations

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Frederick J. Ehlert is currently serving as a Pharmaceutical Sciences Professor Pharmacology at University of California, Irvine.

Honors

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Experiences

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Education

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Frederick J. Ehlert

University of California, Irvine

Professor Pharmacology

You can click a keyword to filter the displayed items

pharmacology receptors neuroscience neuropharmacology physiology medicinal chemistry neurology molecular pharmacology mammalian biology medicinal research protein science experimental pharmacology pharmacokinetics pharmacological research membrane biology neurochemistry cell signaling clinical pharmacology receptor (biochemistry) veterinary medicine signal transduction animal physiology pharmacotherapy muscarinic receptors experimental medicine g protein-coupled receptor mammalian physiology vascular biology guinea pig ileum liver physiology muscarinic receptor avian biology molecular physiology signaling pathways rat brain smooth muscle functional studies translational pharmacology phosphoinositide hydrolysis muscarinic receptor binding avian medicine pharmaceutics experimental biology pathway analysis inhibitory activity functional regulation longitudinal muscle agonist activity applied pharmacology biological chemistry gastrointestinal pharmacology pharmaceutical sciences rat ileum differential coupling contractile role functional role biochemical sciences muscle function mechanisms of action molecular regulation brain science fragmentation effect in vivo systems cerebrovascular disease functional selectivity therapeutic efficacy surface reactivity mutagenesis angiology allosteric ligands cerebral cortex brain function biochemical interaction human physiology vascular adaptation arterial disease neuropsychopharmacology receptor subtypes

Notable Scholarly Works

Notable Federal Grants

Collaborators

Acetylcholine Receptors (Muscarinic) in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

Nigel J. M. BirdsallSophie BradleyDavid A. BrownNoel J. BuckleyR.A. John ChallissArthur ChristopoulosRichard M. EglenFrederick EhlertChristian C. FelderRudolf HammerHeinz J. KilbingerGünter LambrechtChris LangmeadFred MitchelsonErnst MutschlerNeil M. NathansonRoy D. SchwarzDavid ThalAndrew B. TobinCeline ValantJurgen Wess

acetylcholine receptorspharmacologymolecular pharmacology

International Union of Basic and Clinical Pharmacology. Guidelines for Gpcr Ligand Bias. Authorea (Authorea) (2021)

Peter KolbTerry KenakinStephen AlexanderMarcel BermudezLaura BohnChristian BreinholtMichel BouvierFrederick EhlertStephen HillKirill A. MartemyanovRichard D NeubigOngun OnaranSudar RajagopalBryan RothJana SelentArun ShuklaMartha SommerDavid Gloriam

international unionpharmacologygpcr ligand biasclinical pharmacology

Comparison of Pharmacological Properties Between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect Between in Vitro Agonist Bias and in Vivo Pharmacological Effects. ACS Chemical Neuroscience (2020)

Danni CaoPeng HuangYi-Ting ChiuChongguang ChenHuiqun WangMengchu LiYi ZhengFrederick J. EhlertYan ZhangLee-Yuan Liu-Chen

pharmacological propertiespharmacology

Acetylcholine Receptors (Muscarinic) (Version 2019.4) in the Iuphar/Bps Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE (2019)

receptorspharmacologyacetylcholine receptors

Quantifying Gpcr Allostery and Biased Signaling. Elsevier eBooks (2019)

Frederick J. Ehlert

signaling pathwayscell signalingsystems biologygpcr allosterymolecular biology

Quantitating Ligand Bias Using the Competitive Model of Ligand Activity. Methods in molecular biology (2019)

Edward L. StahlFrederick J. EhlertLaura M. Bohn

competitive modelprotein scienceligand biasquantum chemistryligand activitypharmacologymolecular biologycomputational chemistry

Analysis of Biased Agonism. Progress in molecular biology and translational science (2018)

Frederick J. Ehlert

behavioral sciencespharmacologymolecular biologytranslational researchbiased agonism

Comparison of Agonist Occupancy of M 2 Muscarinic Receptor‐G Protein Complexes in Myocardial Homogenates With Functional Estimates of Active Receptor‐State Affinity in Isolated Atria. The FASEB Journal (2018)

Frederick J. Ehlert

receptorsreceptor (biochemistry)protein scienceactive receptor-state affinitypharmacologymolecular pharmacologycardiovascular researchinhibitory activitymolecular physiologyg protein-coupled receptormembrane biologyisolated atriabiochemistryvascular biologyagonist occupancymedicinal researchfunctional estimatesmyocardial infarctionmyocardial homogenatesinflammationmolecular dockingmolecular biology

Pde8 Activity Regulates Camp Signaling by β 2 Ar but Not Prostanoid Ep 2 nor Ep 4 Receptors in Human Airway Smooth Muscle. The FASEB Journal (2018)

Timothy JohnstoneMaia CorpuzAustin KazarianFrederick EhlertRennolds Ostrom

receptorssignaling pathwaysgene expressioncell signalingneuroscienceredox biologypharmacologymembrane biologysignal transductionmolecular biology

Pde8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates Camp Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6. American Journal of Respiratory Cell and Molecular Biology (2017)

Timothy B. JohnstoneKaitlyn H. SmithCynthia J. Koziol-WhiteFengying LiAustin G. KazarianMaia L. CorpuzMaya ShumyatcherFrederick J. EhlertBlanca E. HimesReynold A. PanettieriRennolds S. Ostrom

signaling pathwaysgene expressioncell biologycell signalingrespiratory neurobiologyrespiration (physiology)membrane biologyrespiratory medicinephysiologysignal transductioncell and molecular biologymolecular biologycellular physiologymolecular physiology

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Frederick J. Ehlert

Professor Pharmacology

University of California, Irvine

Affiliations

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Frederick J. Ehlert is currently serving as a Pharmaceutical Sciences Professor Pharmacology at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Frederick J. Ehlert

University of California, Irvine

Professor Pharmacology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Acetylcholine Receptors (Muscarinic) in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

acetylcholine receptorspharmacologymolecular pharmacology

International Union of Basic and Clinical Pharmacology. Guidelines for Gpcr Ligand Bias. Authorea (Authorea) (2021)

international unionpharmacologygpcr ligand biasclinical pharmacology

Danni CaoPeng HuangYi-Ting ChiuChongguang ChenHuiqun WangMengchu LiYi ZhengFrederick J. EhlertYan ZhangLee-Yuan Liu-Chen

pharmacological propertiespharmacology

Acetylcholine Receptors (Muscarinic) (Version 2019.4) in the Iuphar/Bps Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE (2019)

receptorspharmacologyacetylcholine receptors

Quantifying Gpcr Allostery and Biased Signaling. Elsevier eBooks (2019)

Frederick J. Ehlert

signaling pathwayscell signalingsystems biologygpcr allosterymolecular biology

Quantitating Ligand Bias Using the Competitive Model of Ligand Activity. Methods in molecular biology (2019)

Edward L. StahlFrederick J. EhlertLaura M. Bohn

competitive modelprotein scienceligand biasquantum chemistryligand activitypharmacologymolecular biologycomputational chemistry

Analysis of Biased Agonism. Progress in molecular biology and translational science (2018)

Frederick J. Ehlert

behavioral sciencespharmacologymolecular biologytranslational researchbiased agonism

Frederick J. Ehlert

Pde8 Activity Regulates Camp Signaling by β 2 Ar but Not Prostanoid Ep 2 nor Ep 4 Receptors in Human Airway Smooth Muscle. The FASEB Journal (2018)

Timothy JohnstoneMaia CorpuzAustin KazarianFrederick EhlertRennolds Ostrom

receptorssignaling pathwaysgene expressioncell signalingneuroscienceredox biologypharmacologymembrane biologysignal transductionmolecular biology

Timothy B. JohnstoneKaitlyn H. SmithCynthia J. Koziol-WhiteFengying LiAustin G. KazarianMaia L. CorpuzMaya ShumyatcherFrederick J. EhlertBlanca E. HimesReynold A. PanettieriRennolds S. Ostrom

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