Faculty

Institution

Unit

Venue

William Dewey

Professor and Chair

Virginia Commonwealth University

Affiliations

School of Medicine

Pharmacology and Toxicology

William Dewey is currently serving as a Pharmacology And Toxicology Professor and Chair at Virginia Commonwealth University.

Honors

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Experiences

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Education

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William Dewey

Virginia Commonwealth University

Professor and Chair

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pharmacology neuroscience neuropharmacology neurology medicine pharmacotherapy mammalian biology medicinal chemistry addiction medicinal research pain management receptors drug discovery pharmacokinetics neurochemistry neurophysiology clinical pharmacology veterinary medicine experimental pharmacology pharmacological research pain research pain medicine morphine tolerance animal physiology neurotransmission drug treatment brain science pharmaceutical sciences cannabis use experimental medicine protein science liver physiology psychopharmacology peptides pharmaceutical chemistry neuroinflammation pharmaceutics applied pharmacology clinical chemistry drug intolerance treatment effects enteric neurons spinal cord addiction medicine pain mechanism therapeutic efficacy gastrointestinal pharmacology drug targeting mouse brain rational drug design clinical neuroscience pain therapy mechanisms of action remedial action neuromodulation (medicine) cerebrospinal fluid mammalian physiology brain function morphine dependence biological evaluation ethanol reversal nicotine tolerance induction cellular neurobiology antinociceptive activity narcotic antagonists subcellular distribution morphine antinociceptive tolerance antinociceptive effects morphine antinociception intrathecal morphine neural science neuropathic pain naltrexamine derivatives endogenous opioids antinociceptive action chronic pain optogenetics physiology anesthesiology molecular pain opioid use disorder physical dependence neuropsychopharmacology opioid overdose anesthetic pharmacology blood flow drug analysis addiction biology molecular pharmacology clinical research anesthesia

Notable Scholarly Works

Notable Federal Grants

Collaborators

Acute Biodistribution Comparison of Fentanyl and Morphine. Psychoactives (2024)

Rosamond GoodsonJustin PoklisHarrison J. ElderD. Matthew WalentinyWilliam DeweyMatthew Halquist

opioid epidemictoxicologyanesthesiologyopioid overdosepsychoactive substance useforensic toxicologypain medicinepsychoanalysisaddictionsubstance use disordersaddiction medicinepsychiatrysubstance usepsychoactive drugssubstance abusepharmacologypsychopharmacologypharmacotherapyacute biodistribution comparison

Blocking Potential Metabolic Sites on Nat to Improve Its Safety Profile While Retaining the Pharmacological Profile. Bioorganic Chemistry (2024)

Rachael FlammiaBoshi HuangPiyusha P. PagareCelsey M. St. OngeAbeje AbebayehuJames C. GillespieRolando E. MendezDana E. SelleyWilliam L. DeweyYan Zhang

enzyme inhibitionpharmacologybioorganic chemistrymetabolismpharmacological profilesafety profile

Discovery of 6α-Thiazolylcarboxamidonaltrexamine Derivative (Ntz) as a Potent and Central Nervous System Penetrant Opioid Receptor Modulator With Drug-Like Properties for Potential Treatment of Opioid Use Disorder. ACS Pharmacology & Translational Science (2024)

Boshi HuangHongguang MaPiyusha P. PagareMengchu LiRolando E. MendezJames C. GillespieJustin L. PoklisMatthew S. HalquistDavid L. StevensWilliam L. DeweyDana E. SelleyYan Zhang

opioid use disorderpharmacologytranslational researchtranslational pharmacologytreatment effectsdrug-like propertiesneuropharmacologytherapeutic targetsdrug discoverysubstance use disordersmedicinal researchexperimental pharmacologypotential treatmentneurosciencedrug targetspharmacological research

SYMPOSIUM: In Memoriam Martin Adler. Drug and Alcohol Dependence (2024)

Scott LukasToby EisensteinWilliam DeweyToby EisensteinScott LukasEllen Unterwald

pharmacologysociologysocial sciencesphilosophy of social scienceaddictionmemoriam martin adleralcohol dependence

Systematic Structure–Activity Relationship Study of Nalfurafine Analogues Toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of Medicinal Chemistry (2024)

Celsey M. St. OngePiyusha P. PagareYi ZhengMichelle ArriagaDavid L. StevensRolando E. MendezJustin L. PoklisMatthew S. HalquistDana E. SelleyWilliam L. DeweyMatthew L. BanksYan Zhang

medicinal chemistrymedicinepain managementpharmacologynalfurafine analogues

The Role of Morphine‐ and Fentanyl‐Induced Impairment of Intestinal Epithelial Antibacterial Activity in Dysbiosis and Its Impact on the Microbiota‐Gut‐Brain Axis. The FASEB Journal (2024)

Karan H. MuchhalaPrajkta S. KallurkarMinho KangEda KoseliJustin L. PoklisQingguo XuWilliam L. DeweyJennifer M. FettweisNicole R. JimenezHamid I. Akbarali

microbiomegut microbespharmacologyanesthesiologydysbiosismicrobiota-gut-brain axisfentanyl-induced impairmentmicrobiologyinflammation

Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression. Journal of Medicinal Chemistry (2023)

Mengchu LiPiyusha P. PagareHongguang MaCelsey M. St. OngeRolando E. MendezJames C. GillespieDavid L. StevensWilliam L. DeweyDana E. SelleyYan Zhang

medicinal chemistryadrenergic mechanismpharmacologymolecular pharmacology profilingmolecular pharmacologyfentanyl-induced respiratory depression

Characterization of a Potential Kor/Dor Dual Agonist With No Apparent Abuse Liability via a Complementary Structure–Activity Relationship Study on Nalfurafine Analogues. ACS Chemical Neuroscience (2022)

Mengchu LiDavid L. StevensMichelle ArriagaE. Andrew TownsendRolando E. MendezNadejda A. BlajkevchDana E. SelleyMatthew L. BanksS. Stevens NegusWilliam L. DeweyYan Zhang

medicinal chemistryneurologypharmacologyclinical chemistrynalfurafine analoguesneurochemistryclinical neuroscienceneuropharmacologyneuroscience

Chronic Morphine Induces Il-18 in Ileum Myenteric Plexus Neurons Through Mu-Opioid Receptor Activation in Cholinergic and Vipergic Neurons. Journal of Neuroimmune Pharmacology (2022)

Karan H. MuchhalaEda KoseliAravind R. GadeKareem WoodsSuha MinaiMinho KangA Rory McQuistonWilliam L. DeweyHamid I. Akbarali

neurologyneuroinflammationpharmacologymu-opioid receptor activationcell signalingneuroimmunologyneuropharmacologyinhibitory activityvipergic neuronsneurotransmittersbrain-immune interactionremedial actionneuroscienceneurophysiologyinflammation

Design, Synthesis, and Biological Evaluation of Nap Isosteres: A Switch From Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. Journal of Medicinal Chemistry (2022)

Piyusha P. PagareMengchu LiYi ZhengAbhishek S. KulkarniSamuel ObengBoshi HuangChristian RuizJames C. GillespieRolando E. MendezDavid L. StevensJustin L. PoklisMatthew S. HalquistWilliam L. DeweyDana E. SelleyYan Zhang

medicinal chemistrymedicinereceptorspharmacologypharmaceutical chemistrychemical engineeringpharmacokineticsneurochemistrybiological evaluationdrug discoverysynthetic biologymu-opioid receptor antagonistsnap isosterespharmaceutical scienceschemical synthesis

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William Dewey

Professor and Chair

Virginia Commonwealth University

Affiliations

School of Medicine

Pharmacology and Toxicology

William Dewey is currently serving as a Pharmacology And Toxicology Professor and Chair at Virginia Commonwealth University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

William Dewey

Virginia Commonwealth University

Professor and Chair

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Acute Biodistribution Comparison of Fentanyl and Morphine. Psychoactives (2024)

Rosamond GoodsonJustin PoklisHarrison J. ElderD. Matthew WalentinyWilliam DeweyMatthew Halquist

Blocking Potential Metabolic Sites on Nat to Improve Its Safety Profile While Retaining the Pharmacological Profile. Bioorganic Chemistry (2024)

Rachael FlammiaBoshi HuangPiyusha P. PagareCelsey M. St. OngeAbeje AbebayehuJames C. GillespieRolando E. MendezDana E. SelleyWilliam L. DeweyYan Zhang

enzyme inhibitionpharmacologybioorganic chemistrymetabolismpharmacological profilesafety profile

Boshi HuangHongguang MaPiyusha P. PagareMengchu LiRolando E. MendezJames C. GillespieJustin L. PoklisMatthew S. HalquistDavid L. StevensWilliam L. DeweyDana E. SelleyYan Zhang

SYMPOSIUM: In Memoriam Martin Adler. Drug and Alcohol Dependence (2024)

Scott LukasToby EisensteinWilliam DeweyToby EisensteinScott LukasEllen Unterwald

pharmacologysociologysocial sciencesphilosophy of social scienceaddictionmemoriam martin adleralcohol dependence

Systematic Structure–Activity Relationship Study of Nalfurafine Analogues Toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of Medicinal Chemistry (2024)

Celsey M. St. OngePiyusha P. PagareYi ZhengMichelle ArriagaDavid L. StevensRolando E. MendezJustin L. PoklisMatthew S. HalquistDana E. SelleyWilliam L. DeweyMatthew L. BanksYan Zhang

medicinal chemistrymedicinepain managementpharmacologynalfurafine analogues

The Role of Morphine‐ and Fentanyl‐Induced Impairment of Intestinal Epithelial Antibacterial Activity in Dysbiosis and Its Impact on the Microbiota‐Gut‐Brain Axis. The FASEB Journal (2024)

Karan H. MuchhalaPrajkta S. KallurkarMinho KangEda KoseliJustin L. PoklisQingguo XuWilliam L. DeweyJennifer M. FettweisNicole R. JimenezHamid I. Akbarali

microbiomegut microbespharmacologyanesthesiologydysbiosismicrobiota-gut-brain axisfentanyl-induced impairmentmicrobiologyinflammation

Mengchu LiPiyusha P. PagareHongguang MaCelsey M. St. OngeRolando E. MendezJames C. GillespieDavid L. StevensWilliam L. DeweyDana E. SelleyYan Zhang

medicinal chemistryadrenergic mechanismpharmacologymolecular pharmacology profilingmolecular pharmacologyfentanyl-induced respiratory depression

Mengchu LiDavid L. StevensMichelle ArriagaE. Andrew TownsendRolando E. MendezNadejda A. BlajkevchDana E. SelleyMatthew L. BanksS. Stevens NegusWilliam L. DeweyYan Zhang

medicinal chemistryneurologypharmacologyclinical chemistrynalfurafine analoguesneurochemistryclinical neuroscienceneuropharmacologyneuroscience

Chronic Morphine Induces Il-18 in Ileum Myenteric Plexus Neurons Through Mu-Opioid Receptor Activation in Cholinergic and Vipergic Neurons. Journal of Neuroimmune Pharmacology (2022)

Karan H. MuchhalaEda KoseliAravind R. GadeKareem WoodsSuha MinaiMinho KangA Rory McQuistonWilliam L. DeweyHamid I. Akbarali

Design, Synthesis, and Biological Evaluation of Nap Isosteres: A Switch From Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. Journal of Medicinal Chemistry (2022)

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gastrointestinal microbiome

opioid addiction

Dana E. Selley

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pharmacological research

neuropsychopharmacology

Aron H. Lichtman

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pain research

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chronic pain

Barbara Slusher

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Johns Hopkins University

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neuroscience

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pharmacological research

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pharmacological research

neuropsychopharmacology

Theodore Price

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University of Texas at Dallas

pharmacological research

pain research

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Institution

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cancer letter

polycyclic aromatic hydrocarbon

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