Faculty

Institution

Unit

Venue

Fred Gage

Adjunct Professor

University of California, San Diego

Affiliations

School Of Medicine

Neurosciences

Fred Gage is an Adjunct Professor of Neurobiology at the University of California, San Diego. His research integrates neuroscience, genetics, and molecular psychiatry to investigate brain aging, neurodegeneration, and cellular maturation. Recent work published in *Science* and *Nature Biotechnology* explores neuronal senescence, hippocampal glucose metabolism in Alzheimer’s disease, and astrocyte maturation in cortical organoids. He also studies synaptic dysfunction in Parkinson’s disease and long-read telomere sequencing in aging. His collaborative network spans leading institutions across the US, Europe, and Asia, and he has secured major funding for research on genetic variants and gender bias in Alzheimer’s disease.

Honors

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Fred Gage

University of California, San Diego

Adjunct Professor

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neuroscience neurology central nervous system developmental neurobiology neuroanatomy genetics developmental biology neurophysiology nervous system stem cell research brain science cognitive neuroscience neuroscience of aging neurogenetics brain function neuroregeneration stem cells cellular neurobiology neural science neurorehabilitation molecular neurobiology developmental cognitive neuroscience mammalian biology molecular neurodegeneration neural stem cells neuropsychopharmacology neurodevelopmental disorders vascular biology molecular psychiatry neurochemistry medicinal research biological psychiatry cell transplantation clinical neuroscience adult neurogenesis neurological function neural tissue engineering affective neuroscience neuroradiology adult stem cells cellular therapy neurotransmission induced pluripotent stem cells neuroprotection brain organization gene transfer neuroinflammation brain structure fibroblast growth factors stem-cell therapy embryonic stem cells dopamine adult hippocampus neurodynamics gene delivery dentate gyrus adult hippocampal neurogenesis neurotology neuronal networks brain circuitry brain modeling adult brain geriatric neurology intracerebral grafting rna biology brain mechanisms adult dentate gyrus human neurons neural progenitor cells hippocampal formation hippocampal neurogenesis nerve growth factor cholinergic neurons fimbria-fornix transection septal lesions spatial learning degenerative pathology gene therapy alzheimer's disease aging cell parkinson's disease experimental neuropathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Adult Neurogenesis in the Human Dentate Gyrus. Hippocampus (2024)

Fred H. Gage

cognitive neuroscienceneuroregenerationhuman dentate gyrusneuroscience of agingdevelopmental cognitive neuroscienceoral biologydevelopmental neurobiologyneural sciencecentral nervous systemneuroanatomybiological psychiatryadult neurogenesisneurorehabilitationbiologybrain organizationdevelopmental biologycellular neurobiologycortical remodelinghuman brainneuroscience

A Framework for Neural Organoids, Assembloids and Transplantation Studies. Nature (2024)

Sergiu P. PașcaPaola ArlottaHelen S. BateupJ. Gray CampSilvia CappelloFred H. GageJürgen A. KnoblichArnold R. KriegsteinMadeline A. LancasterGuo-Li MingGaia NovarinoHideyuki OkanoMalin ParmarIn-Hyun ParkOrly ReinerHongjun SongLorenz StuderJun TakahashiSally TempleGiuseppe TestaBarbara TreutleinFlora M. VaccarinoPierre VanderhaeghenTracy Young-Pearse

transplant surgerytransplantation studiesnervous systemorgan allocationstem cell researchcartilagevascular biologycerebral organoidsneuroanatomyorgan developmentneural circuitsregenerative medicinebiologymammalian biologyneural organoidstransplantation medicineorgan transplantationbiomedical engineeringclinical transplantationneuroscience

High Resolution Long-Read Telomere Sequencing Reveals Dynamic Mechanisms in Aging and Cancer. Nature Communications (2024)

Tobias T. SchmidtCarly TyerPreeyesh RughaniCandy HaggblomJeffrey R. JonesXiaoguang DaiKelly A. FrazerFred H. GageSissel JuulScott HickeyJan Karlseder

genomicslong-read sequencinggene expressionnext-generation sequencinghigh throughput sequencingcancer researchaging cellcancer genomicshigh resolution long-readhigh resolutionmolecular biology

Human in Neuronal Model of Schizophrenia Displays Dysregulation of Chromogranin B and Related Neuropeptide Transmitter Signatures. Molecular Psychiatry (2024)

Sonia PodvinJeffrey JonesAustin KangRyan GoodmanPatrick ReedChristopher B. LietzJoshua ThenKelly C. LeeLisa T. EylerDilip V. JesteFred H. GageVivian Hook

neurologyschizophreniatransmitter signaturesneurotransmissionneuronal modelpsychiatrymolecular psychiatryneuroscience

Long Interspersed Nuclear Elements Safeguard Neural Progenitors From Precocious Differentiation. Cell Reports (2024)

Tomohisa TodaTracy A. BedrosianSimon T. SchaferMichael S. CuocoSara B. LinkerSaeed GhassemzadehLisa MitchellJack T. WhiteleyNicole NovaresiAidan H. McDonaldIryna S. GallinaHyojung YoonMark E. HesterMonique PenaChristina LimEmelia SuljicAbed AlFatah MansourMatthieu BoulardSarah L. ParylakFred H. Gage

cell biologycellular differentiationprecocious differentiationdevelopmental biology

Mapping Recurrent Mosaic Copy Number Variation in Human Neurons. Nature Communications (2024)

Chen SunKunal KathuriaSarah B. EmeryByungJun KimIan E. BurbulisJoo Heon ShinJoseph G. GleesonMartin W. BreussXiaoxu YangDanny AntakiChanguk ChungDan AverbujLaurel L. BallSubhojit RoyDaniel WeinbergerAndrew JaffeApua PaquolaJennifer ErwinRichard StraubRujuta NarurkarGary MathernChristopher A. WalshAlice LeeAugust Yue HuangAlissa D’GamaCaroline DiasEduardo MauryJavier GanzMichael LodatoMichael MillerPengpeng LiRachel RodinRebeca Borges-MonroyRobert HillSara BizzottoSattar KhoshkhooSonia KimZinan ZhouPeter J. ParkAlison BartonAlon GalorChong ChuCraig BohrsonDoga GulhanElaine LimEuncheon LimGiorgio MelloniIsidro CortesJake LeeJoe LuquetteLixing YangMaxwell ShermanMichael CoulterMinseok KwonSemin LeeSoo LeeVinary ViswanadhamYanmei DouAndrew J. ChessAttila JonesChaggai RosenbluhSchahram AkbarianBen LangmeadJeremy ThorpeSean ChoAlexej AbyzovTaejeong BaeYeongjun JangYifan WangCindy MolitorMette PetersFred H. GageMeiyan WangPatrick ReedSara LinkerAlexander UrbanBo ZhouReenal PattniXiaowei ZhuAitor Serres AmeroDavid JuanInna PovolotskayaIrene LobonManuel Solis MorunoRaquel Garcia PerezTomas Marques-BonetEduardo SorianoJohn V. MoranDiane A. FlaschTrenton J. FrisbieHuira C. KoperaJohn B. MoldovanKenneth Y. KwanRyan E. MillsWeichen ZhouXuefang ZhaoAakrosh RatanFlora M. VaccarinoAdriana CherskovAlexandre Jourdon

neurogeneticsgeneticshuman neuronshuman variationbrain mappingneuroscience

Mir-124 Coordinates Metabolic Regulators Acting at Early Stages of Human Neurogenesis. Communications Biology (2024)

Geurim SonYongwoo NaYongsung KimJi-Hoon SonGregory D. ClemensonSimon T. SchaferJong-Yeon YooSarah L. ParylakApua PaquolaHyunsu DoDayeon KimInsook AhnMingyu JuChanhee S. KangYounghee JuEunji JungAidan H. McDonaldYoungjin ParkGilhyun KimSe-Bum PaikJunho HurJoon KimYong-Mahn HanSeung-Hee LeeFred H. GageJong-Seo KimJinju Han

early stageshuman neurogenesismetabolic regulationsystems biologybiologydevelopmental neurobiologydevelopmental biologymetabolismmetabolic pathways

Modeling Alzheimer’s Disease Using Human Cell Derived Brain Organoids and 3D Models. Frontiers in Neuroscience (2024)

Sarah FernandesJasmin RevannaJoshua PrattNicholas HayesMaria C. MarchettoFred H. Gage

brain organoidsneuroimaginghuman cellscerebral organoidsbrain modelingalzheimer's diseaseneuroscienceneurodegenerative diseases

Monozygotic Twins Discordant for Schizophrenia Differ in Maturation and Synaptic Transmission. Molecular Psychiatry (2024)

Shani SternLei ZhangMeiyan WangRebecca WrightIdan RoshYara HusseinTchelet SternAshwani ChoudharyUtkarsh TripathiPatrick ReedHagit SadisRitu NayakAviram ShemenKarishma AgarwalDiogo CordeiroDavid PelesYuqing HangAna P. D. MendesTithi D. BaulJulien G. RothShashank CoorapatiMarco P. BoksW. Richard McCombieHilleke Hulshoff PolKristen J. BrennandJános M. RéthelyiRené S. KahnMaria C. MarchettoFred H. Gage

schizophreniamonozygotic twinsgeneticssynaptic transmissionpsychiatric geneticsmolecular psychiatry

Morphological Diversification and Functional Maturation of Human Astrocytes in Glia-Enriched Cortical Organoid Transplanted in Mouse Brain. Nature Biotechnology (2024)

Meiyan WangLei ZhangSammy Weiser NovakJingting YuIryna S. GallinaLynne L. XuChristina K. LimSarah FernandesMaxim N. ShokhirevApril E. WilliamsMonisha D. SaxenaShashank CoorapatiSarah L. ParylakCristian QuinteroElsa MolinaLeonardo R. AndradeUri ManorFred H. Gage

brain scienceneurologyfunctional maturationglia-enriched cortical organoidmouse brainmorphological diversificationhuman astrocytesbiotechnologymammalian biologyanimal biotechnologycell transplantationneuroscienceneuroanatomycell biology

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Fred Gage

Adjunct Professor

University of California, San Diego

Affiliations

School Of Medicine

Neurosciences

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Fred Gage

University of California, San Diego

Adjunct Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Adult Neurogenesis in the Human Dentate Gyrus. Hippocampus (2024)

Fred H. Gage

A Framework for Neural Organoids, Assembloids and Transplantation Studies. Nature (2024)

High Resolution Long-Read Telomere Sequencing Reveals Dynamic Mechanisms in Aging and Cancer. Nature Communications (2024)

Tobias T. SchmidtCarly TyerPreeyesh RughaniCandy HaggblomJeffrey R. JonesXiaoguang DaiKelly A. FrazerFred H. GageSissel JuulScott HickeyJan Karlseder

genomicslong-read sequencinggene expressionnext-generation sequencinghigh throughput sequencingcancer researchaging cellcancer genomicshigh resolution long-readhigh resolutionmolecular biology

Human in Neuronal Model of Schizophrenia Displays Dysregulation of Chromogranin B and Related Neuropeptide Transmitter Signatures. Molecular Psychiatry (2024)

Sonia PodvinJeffrey JonesAustin KangRyan GoodmanPatrick ReedChristopher B. LietzJoshua ThenKelly C. LeeLisa T. EylerDilip V. JesteFred H. GageVivian Hook

neurologyschizophreniatransmitter signaturesneurotransmissionneuronal modelpsychiatrymolecular psychiatryneuroscience

Long Interspersed Nuclear Elements Safeguard Neural Progenitors From Precocious Differentiation. Cell Reports (2024)

cell biologycellular differentiationprecocious differentiationdevelopmental biology

Mapping Recurrent Mosaic Copy Number Variation in Human Neurons. Nature Communications (2024)

neurogeneticsgeneticshuman neuronshuman variationbrain mappingneuroscience

Mir-124 Coordinates Metabolic Regulators Acting at Early Stages of Human Neurogenesis. Communications Biology (2024)

early stageshuman neurogenesismetabolic regulationsystems biologybiologydevelopmental neurobiologydevelopmental biologymetabolismmetabolic pathways

Modeling Alzheimer’s Disease Using Human Cell Derived Brain Organoids and 3D Models. Frontiers in Neuroscience (2024)

Sarah FernandesJasmin RevannaJoshua PrattNicholas HayesMaria C. MarchettoFred H. Gage

brain organoidsneuroimaginghuman cellscerebral organoidsbrain modelingalzheimer's diseaseneuroscienceneurodegenerative diseases

Monozygotic Twins Discordant for Schizophrenia Differ in Maturation and Synaptic Transmission. Molecular Psychiatry (2024)

schizophreniamonozygotic twinsgeneticssynaptic transmissionpsychiatric geneticsmolecular psychiatry

Morphological Diversification and Functional Maturation of Human Astrocytes in Glia-Enriched Cortical Organoid Transplanted in Mouse Brain. Nature Biotechnology (2024)

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