Faculty

Institution

Unit

Venue

Rudolf Jaenisch

Professor of Biology; Core Member Whitehead Institute; Member Institute of Medicine

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Rudolf Jaenisch is a Professor of Biology at the Massachusetts Institute of Technology and a Founding Member of the Whitehead Institute, where he also serves as a Core Member and is a Member of the Institute of Medicine. He earned his MD from the University of Munich in 1967. His research investigates the genetic and epigenetic basis of human diseases, including Parkinson’s, Alzheimer’s, autism, and cancer, using pluripotent stem cells and neural models. Recent work explores microglial function, MECP2 transcription mechanisms, blood-brain barrier dynamics, and viral neuroinvasion, with publications in *Neuron*, *Immunity*, and *PNAS*. He has received substantial funding for heritable immunization strategies against Lyme disease and collaborates extensively with institutions across the US, Europe, and Asia.

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Rudolf Jaenisch

Massachusetts Institute of Technology

Professor of Biology; Core Member Whitehead Institute; Member Institute of Medicine

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genetics cell biology developmental biology molecular biology mammalian biology gene expression virology stem cell research epigenetics stem cells genomics genome biology human genetics developmental genetics molecular genetics viral genetics developmental neurobiology cytogenetics animal biotechnology cancer genetics embryonic development gene function molecular cell biology chromosome biology developmental science cancer biology medicinal research virus research molecular neurobiology dna methylation protein science cellular biology avian biology rna biology neural science matrix biology epigenetic changes gene regulation oncogenes leukemia transcription regulation cloning epigenomics cancer genomics embryonic stem cells viral oncology vascular biology knockout mice cell regulation cell transplantation medical genetics adaptive immune system mutagenesis cellular neurobiology brain function viral evolution cellular therapy histocompatibility direct reprogramming transgenic mice animal genetics collagen gene dna hypomethylation nuclear cloning molecular regulation brain science mouse embryos nuclear transplantation nuclear reprogramming brain-derived neurotrophic factor es cells retroviral genomes germ line integration embryonal carcinoma cells mammalian development chromosomal position aging cell transcription (biology) stem-cell therapy regeneration (biology) nervous system development cell specialization

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Human Blood-Brain Barrier Model Reveals Pericytes as Critical Regulators of Viral Neuroinvasion. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Alexsia RichardsAndrew KhalilPunam BishtTroy W. WhitfieldXinlei GaoRoger KammDavid MooneyLee GehrkeRudolf Jaenisch

viral pathogenesisvirologyneurovirologyneuroscienceviral neuroinvasionvirus researchsystems biologybrain-immune interactionvascular biologyneuroimmunology

Abortive Infection of Bat Fibroblasts With Sars-Cov-2. Proceedings of the National Academy of Sciences (2024)

Punam BishtMichael D. GallagherM. Inmaculada BarrasaJulie BoucauAlfred HardingMarion DéjosezCarlos Godoy-ParejoMargaret E. BisherGiovanni de NolaAbigail K. R. Lytton-JeanLee GehrkeThomas P. ZwakaRudolf Jaenisch

bat fibroblastssars-cov-2virologyinfectious diseasesvirus researchabortive infection

Astrocytic Modulation of Population Encoding in Mouse Visual Cortex via Gaba Transporter 3 Revealed by Multiplexed Crispr/Cas9 Gene Editing. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jiho ParkGrayson O. SipeXin TangPrachi OjhaGiselle FernandesYi Ning LeowCaroline ZhangYuma OsakoArundhati NatesanGabrielle T. DrummondRudolf JaenischMriganka Sur

crisprsynthetic biologymouse visual cortexneurogeneticsastrocytic modulationvisual pathwaysneurosciencemolecular neurobiologyvisual sciencemolecular biologysystems biologymolecular neurosciencegenome editingneurophysiology

Epigenomics and Single Cell Crispr Screening to Investigate the Risk‐Modifying Role of Microglia in Alzheimer’s Disease and Multiple Sclerosis. Alzheimer s & Dementia (2024)

Michael D GallagherWenjuan DuKatheryn EA HazelZeynep AydinYiran ChengBingbing YuanGeorge W BellRichard A YoungRudolf JaenischOlivia Corradin

alzheimer's diseasecrisprmultiple sclerosisneurosciencerisk-modifying roledementiaepigenomicsneurodegenerative diseasessingle cell crispr

Heritable Immunization Establishes a New Model for Pathogen Control. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Joanna BuchthalEmma J. ChoryZachary HillYu ZhouDevanand BondageSummer DeAmelioJulien FreemanRudolf JaenischStyliani MarkoulakiWayne A. MarascoSam R. TelfordKevin M. Esvelt

pathogen controlpathogensimmunologyheritable immunization

Human-Specific Paralogs of Srgap2 Induce Neotenic Features of Microglia Structural and Functional Maturation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Carlos Diaz-SalazarMarine KrzischJuyoun YooPatricia R. NanoAparna BhaduriRudolf JaenischFranck Polleux

biophysicshuman-specific paralogsneurosciencemolecular neurobiologyneurochemistryfunctional maturationmolecular biologymolecular neurosciencesystems neuroscienceneuroinflammation

Mecp2 Directly Interacts With Rna Polymerase II to Modulate Transcription in Human Neurons. Neuron (2024)

Yi LiuAnthony FlamierGeorge W BellAnnette Jun DiaoTroy W WhitfieldHao-Che WangYizhe WuFabian SchulteMax FriesenRuisi GuoMaisam MitalipovaX Shawn LiuSeychelle M VosRichard A YoungRudolf Jaenisch

geneticsneurologygene expressionneurogeneticshuman neuronsneurosciencemolecular neurobiologymolecular neurosciencerna polymerase iitranscription regulation

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Production in Mecp2 Mutant Astrocytes and Their Impact on Neurons. Scientific Reports (2024)

Danielle L TomaselloM Inmaculada BarrasaDavid MankusKatia I AlarconAbigail K R Lytton-JeanX Shawn LiuRudolf Jaenisch

neurologyreactive oxygen speciesmitochondrial dysfunctionneuroscienceredox biologyoxidative stressrenal functioncell biologyneurodegenerative diseasesneuroinflammation

Multi-Species Genome-Wide Crispr Screens Identify Conserved Suppressors of Cold-Induced Cell Death. (2024)

Breanna LamKathrin M KajderowiczHeather R KeysJulian M RoesslerEvgeni M FrenkelAdina KirklandPunam BishtMohamed A El-BrolosyRudolf JaenischGeorge W BellJonathan S WeissmanEric C GriffithSinisa Hrvatin

geneticscrisprgenomicscold-induced cell deathmolecular biologycell death

Rapid Phagosome Isolation Enables Unbiased Multiomic Analysis of Human Microglial Phagosomes. Immunity (2024)

Emile WogramFelix SümpelmannWentao DongEshaan RawatInés Fernández MaestreDongdong FuBrandyn BraswellAndrew KhalilJoerg M BuescherGerhard MittlerGeorg H H BornerAndreas VlachosStefan TholenOliver SchillingGeorge W BellAngelika S RamboldAsifa AkhtarOliver SchnellJürgen BeckMonther Abu-RemailehMarco PrinzRudolf Jaenisch

neurologyimmunity (medicine)human microglial phagosomesneuroscienceimmunologybrain-immune interactionimmune responsesneuroimmunology

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Rudolf Jaenisch

Professor of Biology; Core Member Whitehead Institute; Member Institute of Medicine

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Rudolf Jaenisch

Massachusetts Institute of Technology

Professor of Biology; Core Member Whitehead Institute; Member Institute of Medicine

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Human Blood-Brain Barrier Model Reveals Pericytes as Critical Regulators of Viral Neuroinvasion. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Alexsia RichardsAndrew KhalilPunam BishtTroy W. WhitfieldXinlei GaoRoger KammDavid MooneyLee GehrkeRudolf Jaenisch

viral pathogenesisvirologyneurovirologyneuroscienceviral neuroinvasionvirus researchsystems biologybrain-immune interactionvascular biologyneuroimmunology

Abortive Infection of Bat Fibroblasts With Sars-Cov-2. Proceedings of the National Academy of Sciences (2024)

bat fibroblastssars-cov-2virologyinfectious diseasesvirus researchabortive infection

Astrocytic Modulation of Population Encoding in Mouse Visual Cortex via Gaba Transporter 3 Revealed by Multiplexed Crispr/Cas9 Gene Editing. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jiho ParkGrayson O. SipeXin TangPrachi OjhaGiselle FernandesYi Ning LeowCaroline ZhangYuma OsakoArundhati NatesanGabrielle T. DrummondRudolf JaenischMriganka Sur

Epigenomics and Single Cell Crispr Screening to Investigate the Risk‐Modifying Role of Microglia in Alzheimer’s Disease and Multiple Sclerosis. Alzheimer s & Dementia (2024)

Michael D GallagherWenjuan DuKatheryn EA HazelZeynep AydinYiran ChengBingbing YuanGeorge W BellRichard A YoungRudolf JaenischOlivia Corradin

alzheimer's diseasecrisprmultiple sclerosisneurosciencerisk-modifying roledementiaepigenomicsneurodegenerative diseasessingle cell crispr

Heritable Immunization Establishes a New Model for Pathogen Control. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Joanna BuchthalEmma J. ChoryZachary HillYu ZhouDevanand BondageSummer DeAmelioJulien FreemanRudolf JaenischStyliani MarkoulakiWayne A. MarascoSam R. TelfordKevin M. Esvelt

pathogen controlpathogensimmunologyheritable immunization

Human-Specific Paralogs of Srgap2 Induce Neotenic Features of Microglia Structural and Functional Maturation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Carlos Diaz-SalazarMarine KrzischJuyoun YooPatricia R. NanoAparna BhaduriRudolf JaenischFranck Polleux

biophysicshuman-specific paralogsneurosciencemolecular neurobiologyneurochemistryfunctional maturationmolecular biologymolecular neurosciencesystems neuroscienceneuroinflammation

Mecp2 Directly Interacts With Rna Polymerase II to Modulate Transcription in Human Neurons. Neuron (2024)

Yi LiuAnthony FlamierGeorge W BellAnnette Jun DiaoTroy W WhitfieldHao-Che WangYizhe WuFabian SchulteMax FriesenRuisi GuoMaisam MitalipovaX Shawn LiuSeychelle M VosRichard A YoungRudolf Jaenisch

geneticsneurologygene expressionneurogeneticshuman neuronsneurosciencemolecular neurobiologymolecular neurosciencerna polymerase iitranscription regulation

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Production in Mecp2 Mutant Astrocytes and Their Impact on Neurons. Scientific Reports (2024)

Danielle L TomaselloM Inmaculada BarrasaDavid MankusKatia I AlarconAbigail K R Lytton-JeanX Shawn LiuRudolf Jaenisch

neurologyreactive oxygen speciesmitochondrial dysfunctionneuroscienceredox biologyoxidative stressrenal functioncell biologyneurodegenerative diseasesneuroinflammation

Multi-Species Genome-Wide Crispr Screens Identify Conserved Suppressors of Cold-Induced Cell Death. (2024)

geneticscrisprgenomicscold-induced cell deathmolecular biologycell death

Rapid Phagosome Isolation Enables Unbiased Multiomic Analysis of Human Microglial Phagosomes. Immunity (2024)

neurologyimmunity (medicine)human microglial phagosomesneuroscienceimmunologybrain-immune interactionimmune responsesneuroimmunology

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