Faculty

Institution

Unit

Venue

Eric S. Lander

Professor of Biology; Professor of Systems Biology Harvard Medical School; Founding Director Emeritus Broad Institute of MIT and Harvard

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Eric S. Lander is a Professor of Biology at MIT and of Systems Biology at Harvard Medical School, and Founding Director Emeritus of the Broad Institute of MIT and Harvard. He earned his AB from Princeton and PhD from Oxford. A geneticist, molecular biologist, and mathematician, his research spans human genetics, cancer genomics, and genome biology. His recent work includes elucidating coronary artery disease genetics, reconstructing 3D genome architecture from ancient DNA, and dissecting causal variants underlying complex traits. He served as President Biden’s Science Advisor and co-chaired the President’s Council of Advisors on Science and Technology.

Honors

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Experiences

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Education

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Eric S. Lander

Massachusetts Institute of Technology

Professor of Biology; Professor of Systems Biology Harvard Medical School; Founding Director Emeritus Broad Institute of MIT and Harvard

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genetics genomics molecular biology genome biology human genetics cancer research oncology cancer biology cancer genomics cancer genetics bioinformatics gene expression population genetics cell biology tumor biology mammalian biology evolutionary biology cytogenetics medicinal research medical genetics genome analysis animal genetics molecular cancer genome sequencing sequence analysis rna biology chromosome biology cancer care human genome epigenomics cancer cells computational genomics animal science oncogenes gene regulation avian biology genome-wide association studies brain tumor research molecular diagnostics crispr respiratory medicine dna sequencing protein science comparative genomics mutagenesis genomic medicine transcription regulation yeast gene function linkage analysis virus research heredity genome studies developmental genetics population genomics linkage disequilibrium complex traits chronic lymphocytic leukemia stem cell research molecular regulation evolutionary genetics genome structure mouse genome transcriptomics technology chromosome substitution strains genetic dissection genetic linkage map lung adenocarcinoma dna sequence quantitative traits mendelian factors genome sequence single-nucleotide polymorphisms mouse genes genetic mapping genetic map forensic genetics functional genomics systems biology genetic information gene characterization

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Rewriting Regulatory Dna to Dissect and Reprogram Gene Expression. Cell (2025)

Gabriella E MartynMichael T MontgomeryHank JonesKatherine GuoBenjamin R DoughtyJohannes LinderDeepa BishtFan XiaXiangmeng S CaiZiwei ChenKelly CochranKathryn A LawrenceGlen MunsonAnusri PampariCharles P FulcoNidhi SahniDavid R KelleyEric S LanderAnshul KundajeJesse M Engreitz

genomicsgene expressiongeneticsregulatory dnamolecular biologyrna biologybiological engineeringgene regulationbioinformatics

Abstract 6940: The Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Plasticity in Patient-Derived Pancreatic Cancer Cell Lines. Cancer Research (2024)

Deepika YeramosuLynn BiAbigail CollinsMike BogaevMartin JankowiakAziz Al’KhafajiMilan ParikhMehrtash BabadiAlex BloemendalSurya NagarajaRay JonesJay ShendureDavid T. TingAndrew AguirreNir HacohenDana Pe’erEric S. LanderArnav Mehta

cancer geneticscell researchcell biologycancer careepigenetic regulationtranscription factorscancer genomicsmolecular cell biologycancer biologyepithelial-mesenchymal plasticitycancer researchcell regulationtumor biologytranscription regulationgeneticsmolecular biologyclinical researchoncologycancer cellsmedicinal research

Abstract Ng08: Dissecting and Quantifying Pancreatic Cancer Plasticity Using Single-Cell Multiomics, Lineage Tracing and Functional Genomics Reveals Novel Mediators of Therapy Resistance. Cancer Research (2024)

Arnav MehtaLynn BiDeepika YeramosuMichael BogaevMartin JankowiakAbigail CollinsAziz Al'KhafajiMilan ParikhMehrtash BabadiKyle EvansAlex BloemendalRussell KunnesMarc SchwartzGlen MunsonElisa DonnardThouis R. JonesBen Z. StangerJay ShendureJonathan WeissmanDavid T. TingAndrew AguirreNir HacohenDana Pe'erEric S. Lander

lineage tracingpancreatic cancercell biologygenome biologycancer carecancer genomicscancer biologyhealth sciencespancreatic cancer plasticityfunctional genomicscancer researchsingle-cell analysiscancer treatmenttumor biologybiomedical informaticssystems biologysingle-cell multiomicsoncologyclinical researchmedicinal researchcellular therapy

A Standing Platform for Cancer Drug Development Using Ctdna-Based Evidence of Recurrence. Nature reviews. Cancer (2024)

Arielle J MedfordAriel B CarmeliAlexandra RitchieNikhil WagleLevi GarrawayEric S LanderAparna Parikh

baseline correctionkidney cancerprostate cancercell biologybiological significancevascular biologygenetic basismolecular diagnosticscancer drug developmentctdna-based evidencedermatologyleukemiaurologytherapeutic targetsearly detectioncancer lettercarcinogenesisvariant interpretationgliomasstanding platformmedicinal research

Cohesin-Mediated 3D Contacts Tune Enhancer-Promoter Regulation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Philine GuckelbergerBenjamin R. DoughtyGlen MunsonSuhas S. P. RaoYingxuan TanXiangmeng Shawn CaiCharles P. FulcoJoseph NasserKristy S. MualimDrew T. BergmanJudhajeet RayEvelyn JagodaChad J. MungerAndreas R. GschwindMaya U. ShethAnthony S. TanSaul Godinez PulidoNamita MitraDavid WeiszMuhammad Saad ShamimNeva C. DurandRagini MahajanRuqayya KhanLars M. SteinmetzMasato T. KanemakiEric S. LanderAlexander MeissnerErez Lieberman AidenJesse M. Engreitz

molecular biologytranscription regulationgene regulation

Convergence of Coronary Artery Disease Genes Onto Endothelial Cell Programs. Nature (2024)

Gavin R. SchnitzlerHelen KangShi FangRamcharan S. AngomVivian S. Lee-KimX. Rosa MaRonghao ZhouTony ZengKatherine GuoMartin S. TaylorShamsudheen K. VellarikkalAurelie E. BarryOscar Sias-GarciaAlex BloemendalGlen MunsonPhiline GuckelbergerTung H. NguyenDrew T. BergmanStephen HinshawNathan ChengBrian ClearyKrishna AragamEric S. LanderHilary K. FinucaneDebabrata MukhopadhyayRajat M. GuptaJesse M. Engreitz

cardiologyneurologygene expressionendothelial cell programshematologyvascular biologygeneticsangiologycoronary artery diseaseneurosciencecardiovascular disease

Functional Dissection of Complex and Molecular Trait Variants at Single Nucleotide Resolution. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Layla SirajRodrigo I CastroHannah DeweySusan KalesThanh Thanh L NguyenMasahiro KanaiDaniel BerenzyKousuke MouriQingbo WangZachary R McCawSager J GosaiFrançois AguetRan CuiChristopher M VockleyCaleb A LareauYukinori OkadaAlexander GusevThouis R JonesEric S LanderPardis C SabetiHilary K FinucaneSteven K ReillyJacob C UlirschRyan Tewhey

genomicssingle nucleotide resolutiongeneticsmolecular trait variantsmolecular biologyfunctional dissection

Genetic Association Data Are Broadly Consistent With Stabilizing Selection Shaping Human Common Diseases and Traits. bioRxiv (Cold Spring Harbor Laboratory) (2024)

E. KochN. J. ConnallyN. BayaM. P. ReeveM. DalyB. NealeE. S. LanderA. BloemendalS. Sunyaev

genomicsgeneticsevolutionary biologyhuman common diseasesmedical geneticshuman geneticsgenome-wide association studiespopulation genetics

Genome-Wide Association Study Identifies Human Genetic Variants Associated With Fatal Outcome From Lassa Fever. Nature Microbiology (2024)

Dylan KotliarSiddharth RajuShervin TabriziIkponmwosa OdiaAugustine GobaMambu MomohJohn Demby SandiParvathy NairEric PhelanRidhi TariyalPhilomena E. EromonSamar MehtaRefugio Robles-SikisakaKatherine J. SiddleMatt StremlauSimbirie JallohStephen K. GireSarah WinnickiBridget ChakStephen F. SchaffnerMatthias PauthnerElinor K. KarlssonSarah R. ChapinSharon G. KennedyLuis M. BrancoLansana KannehJoseph J. VittiNisha BroodieAdrianne Gladden-YoungOmowunmi OmoniwaPan-Pan JiangNathan YozwiakShannon HeuklomLina M. MosesGeorge O. AkpedeDanny A. AsogunKathleen RubinsSusan KalesAnise N. HappiChristopher O. IruolagbeMercy Dic-IjiewereKelly IraoyahOmoregie O. OsazuwaAlexander K. OkonkwoStefan KunzJoseph B. McCormickS. Humarr KhanAnna N. HonkoEric S. LanderMichael B. A. OldstoneLisa HensleyOnikepe A. FolarinSylvanus A. OkogbeninStephan GüntherHanna M. OllilaRyan TewheyPeter O. OkokhereJohn S. SchieffelinKristian G. AndersenSteven K. ReillyDonald S. GrantRobert F. GarryKayla G. BarnesChristian T. HappiPardis C. Sabeti

public healthgenomicsvirus researchlassa fevergenome-wide association studiestropical medicineveterinary medicinemicrobial geneticsfatal outcomeinfectious diseasesgenetic epidemiologyhuman geneticshealth sciences

Pervasive Findings of Directional Selection Realize the Promise of Ancient Dna to Elucidate Human Adaptation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Ali AkbariAlison R. BartonSteven GazalZheng LiMohammadreza KariminejadAnnabel PerryYating ZengAlissa MittnikNick PattersonMatthew MahXiang ZhouAlkes L. PriceEric S. LanderRon PinhasiNadin RohlandSwapan MallickDavid Reich

human adaptationadaptationdirectional selectiongeneticsgenetic variationhuman evolutionbiologyevolutionary geneticsbiological evolutionnatural selectionancient dnapervasive findingsevolutionary biology

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Eric S. Lander

Professor of Biology; Professor of Systems Biology Harvard Medical School; Founding Director Emeritus Broad Institute of MIT and Harvard

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Eric S. Lander

Massachusetts Institute of Technology

Professor of Biology; Professor of Systems Biology Harvard Medical School; Founding Director Emeritus Broad Institute of MIT and Harvard

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Rewriting Regulatory Dna to Dissect and Reprogram Gene Expression. Cell (2025)

genomicsgene expressiongeneticsregulatory dnamolecular biologyrna biologybiological engineeringgene regulationbioinformatics

Abstract 6940: The Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Plasticity in Patient-Derived Pancreatic Cancer Cell Lines. Cancer Research (2024)

A Standing Platform for Cancer Drug Development Using Ctdna-Based Evidence of Recurrence. Nature reviews. Cancer (2024)

Arielle J MedfordAriel B CarmeliAlexandra RitchieNikhil WagleLevi GarrawayEric S LanderAparna Parikh

Cohesin-Mediated 3D Contacts Tune Enhancer-Promoter Regulation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

molecular biologytranscription regulationgene regulation

Convergence of Coronary Artery Disease Genes Onto Endothelial Cell Programs. Nature (2024)

cardiologyneurologygene expressionendothelial cell programshematologyvascular biologygeneticsangiologycoronary artery diseaseneurosciencecardiovascular disease

Functional Dissection of Complex and Molecular Trait Variants at Single Nucleotide Resolution. bioRxiv (Cold Spring Harbor Laboratory) (2024)

genomicssingle nucleotide resolutiongeneticsmolecular trait variantsmolecular biologyfunctional dissection

Genetic Association Data Are Broadly Consistent With Stabilizing Selection Shaping Human Common Diseases and Traits. bioRxiv (Cold Spring Harbor Laboratory) (2024)

E. KochN. J. ConnallyN. BayaM. P. ReeveM. DalyB. NealeE. S. LanderA. BloemendalS. Sunyaev

genomicsgeneticsevolutionary biologyhuman common diseasesmedical geneticshuman geneticsgenome-wide association studiespopulation genetics

Genome-Wide Association Study Identifies Human Genetic Variants Associated With Fatal Outcome From Lassa Fever. Nature Microbiology (2024)

Pervasive Findings of Directional Selection Realize the Promise of Ancient Dna to Elucidate Human Adaptation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

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