Faculty

Institution

Unit

Venue

Bert Vogelstein

Professor

Johns Hopkins University

Affiliations

School of Medicine

Molecular Biology & Genetics

Bert Vogelstein is a Professor of Oncology and Clayton Professor of Oncology at the Johns Hopkins Kimmel Cancer Center, where he also co-directs the Ludwig Center. He earned his M.D. from Johns Hopkins University School of Medicine and an undergraduate degree in mathematics from the University of Pennsylvania. His research focuses on cancer genomics, tumor biology, and the genetic alterations driving colorectal cancer development. Recent work includes pioneering circulating tumor DNA (ctDNA) analysis to guide adjuvant chemotherapy in colorectal and pancreatic cancers, developing TRBC1-targeting antibody-drug conjugates for T cell cancers, and engineering Co-STAR T cells for tumors with low antigen densities. He collaborates extensively with institutions across the US, Australia, Japan, and Europe.

Honors

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Experiences

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Bert Vogelstein

Johns Hopkins University

Professor

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genetics oncology cancer research cancer biology cancer genetics molecular biology tumor biology cancer genomics genomics medicine colorectal cancer molecular cancer cell biology oncogenes medicinal research gene expression genome biology human genetics cancer care cancer treatment molecular genetics cancer immunotherapy medical genetics cytogenetics molecular diagnostics cancer cells brain tumor research surgical oncology pancreatic cancer tumor targeting mutagenesis cancer imaging cellular therapy leukemia cancer detection tumor dna mammalian biology gastrointestinal oncology tumor suppressors genitourinary cancers cancer risk protein science cancer management dna analysis somatic mutations cell death gene function cancer screening molecular cell biology apoptosis chromosome biology rna biology cell regulation sequence analysis anti-cancer agents genome instability genome analysis drug targeting gene regulation disease gene identification genetic disorders cellular biology human cancers nuclear matrix genetic instability human cancer cells gene amplification colorectal cancer cells microsatellite instability tumor dna analysis colorectal tumors colorectal tumorigenesis colorectal carcinomas adjuvant therapy tert promoter mutations recurrence risk

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 6844: Discovery of a Novel Sialic Acid O-Acetyltransferase in Colon Tissue. Cancer Research (2024)

Bum Seok LeeAshley CookMaged ZeineldinSurojit SurLaura DobbynMaria PopoliSana KhaliliBert VogelsteinNickolas PapadopoulosShibin ZhouChetan BettegowdaPhillip BuckhaultsTatianna LarmanKathy GabrielsonKenneth W. KinzlerNicolas Wyhs

gastrointestinal oncologypharmacologycancer biologymolecular cancercancer treatmenthealth sciencestumor targetingcancer researchoncologycolon tissuecancer genomicscancer discoverymolecular biologytumor biologybiotechnologymedicinal researchcancer careenzymes

Abstract A049: Peritoneal Tumor Dna as a Prognostic Biomarker in Locally Advanced Gastroesophageal Cancer: A Pilot Prospective Cohort Study. Clinical Cancer Research (2024)

Zexi AllanYuxuan WangJeanne TieNiall TebbuttNicholas ClemonsNickolas PapadopoulosKenneth KinzlerBert VogelsteinDavid SH Liu

prognostic biomarkerhealth sciencescancer researchperitoneal tumor dnaclinical researchprognostic biomarkers

Author Response: Identification of Nonsense-Mediated Decay Inhibitors That Alter the Tumor Immune Landscape. (2024)

Ashley L CookSurojit SurLaura DobbynEvangeline WatsonJoshua D CohenBlair PtakBum Seok LeeSuman PaulEmily HsiueMaria PopoliBert VogelsteinNickolas PapadopoulosChetan BettegowdaKathy GabrielsonShibin ZhouKenneth W KinzlerNicolas Wyhs

cancer immunotherapytumor suppressorscancer cellstumor microenvironmenttumor heterogeneitycancer discoverytumor immune landscapemolecular biologysystems biologytumor biologyimmunologymedicinal researchcancer immunosurveillanceimmune responsesnonsense-mediated decay inhibitorstherapeutic targets

Author Response: Me3bp-7 is a Targeted Cytotoxic Agent That Rapidly Kills Pancreatic Cancer Cells Expressing High Levels of Monocarboxylate Transporter Mct1. (2024)

Jordina Rincon-TorroellaMarco Dal MolinBrian MogGyuri HanEvangeline WatsonNicolas WyhsShun IshiyamaTaha AhmednaIl MinnNilofer S AzadChetan BettegowdaNickolas PapadopoulosKenneth W KinzlerShibin ZhouBert VogelsteinKathleen GabrielsonSurojit Sur

tumor targetingbiochemistrycancer cellstumor biologycarcinogenesispharmacologyhigh levelspancreatic cancer cellskey siteauthor responsecellular therapytargeted cytotoxic agentgastrointestinal oncologycancer immunotherapyoncogenestumor microenvironmentcancer discoverymolecular biologytherapeutic efficacymedicinal researchtherapeutic targetspancreatic cancer

Circulating Tumor Dna Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer: Overall Survival and Updated 5-Year Results From the Randomized Dynamic Trial.. Journal of Clinical Oncology (2024)

Jeanne TieYuxuan WangSerigne N LoKamel LahouelJoshua D. CohenRachel WongJeremy David ShapiroSamuel John HarrisAdnan KhattakMatthew E. BurgeMargaret LeeMarion HarrisSue-Anne McLachlanSumitra AnandaCRAIG R UNDERHILLNickolas PapadopoulosCristian TomasettiKenneth W. KinzlerBert VogelsteinPeter Gibbs

overall survivalcolorectal cancerrandomized dynamic trialclinical researchcancer researchcancer genomicstumor biologyclinical evidencepharmacologyoncologyadjuvant therapyimmunologycancer carecancer riskgastrointestinal oncologyclinical trialscancer imagingradiation oncologythoracic oncologymedicinal researchexperimental medicinetumor dna analysis

Circulating Tumor Dna Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: The Randomized Agitg Dynamic-Rectal Study.. Journal of Clinical Oncology (2024)

Jeanne TieJoshua D. CohenYuxuan WangPablo Gonzalez GinestetRachel WongJeremy David ShapiroRob CampbellFiona DayTheresa M. HayesMorteza AghmeshehChristos Stelios KarapetisMaria PopoliLisa DobbynJanine PtakNatalie SillimanChristopher B. DouvilleNickolas PapadopoulosKenneth W. KinzlerBert VogelsteinPeter Gibbs

surgical oncologyclinical researchadvanced rectal cancercancer biologycancer researchcancer genomicstumor biologysurgeryoncologyclinical radiation oncologycancer caregastrointestinal oncologyurologyclinical trialscancer imagingadjuvant chemotherapyradiation oncologyoncologic imagingmedicinal researchtumor dna analysis

Detection of Human Brain Cancers Using Genomic and Immune Cell Characterization of Cerebrospinal Fluid Through Csf-Bam. medRxiv (2024)

Alexander H. PearlmanYuxuan WangAnita KalluriMegan ParkerJoshua D CohenJonathan DudleyJordina Rincon-TorroellaYuanxuan XiaRyan GenslerMelanie Alfonzo HorwitzJohn TheodoreLisa DobbynMaria PopoliJanine PtakNatalie SillimanKathy JudgeMari GrovesChristopher M. JacksonEric M. JacksonGeorge I. JalloMichael LimMark LucianoDebraj MukherjeeJarushka NaidooSima RozatiCole H. SterlingJon WeingartCarl KoschmannAlireza MansooriMichael GlantzDavid KamsonKarisa C. SchreckCarlos A. PardoMatthias HoldhoffSuman PaulKenneth W. KinzlerNickolas PapadopoulosBert VogelsteinChristopher DouvilleChetan Bettegowda

cerebrospinal fluidcerebral blood flowmedical imagingimmune cell characterizationbrain-immune interactionhuman brain cancersbrain pathologycancer biologyneuroscienceneuro-oncologytumor biologyimaging genomicsbrain tumor researchbiomedical imagingneuroimmunologyurologycancer imagingneuroimagingcancer discoverysystems biology

Figure S7 From the Origin of Highly Elevated Cell-Free Dna in Healthy Individuals and Patients With Pancreatic, Colorectal, Lung, or Ovarian Cancer. (2024)

Austin K. MattoxChristopher DouvilleYuxuan WangMaria PopoliJanine PtakNatalie SillimanLisa DobbynJoy SchaeferSteve LuAlexander H. PearlmanJoshua D. CohenJeanne TiePeter GibbsKamel LahouelChetan BettegowdaRalph H. HrubanCristian TomasettiPeiyong JiangK.C. Allen ChanYuk Ming Dennis LoNickolas PapadopoulosKenneth W. KinzlerBert Vogelstein

cell-free dnaovarian cancermolecular biologyhealthy individualspancreatic cancerlung cancer

Genetic Alterations During Colorectal-Tumor Development. CRC Press eBooks (2024)

Fadwa AliEmina Huang

geneticscancer biologygenetic alterationshealth sciencesmedicinecancer researchcolorectal cancermedical geneticscancer geneticscolorectal-tumor development

Machine Learning to Detect the Sines of Cancer. Science Translational Medicine (2024)

Christopher DouvilleKamel LahouelAlbert KuoHaley GrantBracha Erlanger AvigdorSamuel D. CurtisMahmoud SummersJoshua D. CohenYuxuan WangAustin MattoxJonathan DudleyLisa DobbynMaria PopoliJanine PtakNadine NehmeNatalie SillimanCherie BlairKatharine RomansChristopher ThoburnJennifer GizziRobert E. SchoenJeanne TiePeter GibbsLan T. Ho-PhamBich N. H. TranThach S. TranTuan V. NguyenMichael GogginsChristopher L. WolfgangTian-Li WangIe-Ming ShihAnne Marie LennonRalph H. HrubanChetan BettegowdaKenneth W. KinzlerNickolas PapadopoulosBert VogelsteinCristian Tomasetti

cancer biologycancer imaginghealth sciencesmedicinemachine learningcancer researchcancer detectiononcologytranslational medicinediagnosiscancer screeningdisease detectiondisease classification

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Bert Vogelstein

Professor

Johns Hopkins University

Affiliations

School of Medicine

Molecular Biology & Genetics

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Bert Vogelstein

Johns Hopkins University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 6844: Discovery of a Novel Sialic Acid O-Acetyltransferase in Colon Tissue. Cancer Research (2024)

Abstract A049: Peritoneal Tumor Dna as a Prognostic Biomarker in Locally Advanced Gastroesophageal Cancer: A Pilot Prospective Cohort Study. Clinical Cancer Research (2024)

Zexi AllanYuxuan WangJeanne TieNiall TebbuttNicholas ClemonsNickolas PapadopoulosKenneth KinzlerBert VogelsteinDavid SH Liu

prognostic biomarkerhealth sciencescancer researchperitoneal tumor dnaclinical researchprognostic biomarkers

Author Response: Identification of Nonsense-Mediated Decay Inhibitors That Alter the Tumor Immune Landscape. (2024)

Author Response: Me3bp-7 is a Targeted Cytotoxic Agent That Rapidly Kills Pancreatic Cancer Cells Expressing High Levels of Monocarboxylate Transporter Mct1. (2024)

Circulating Tumor Dna Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer: Overall Survival and Updated 5-Year Results From the Randomized Dynamic Trial.. Journal of Clinical Oncology (2024)

Circulating Tumor Dna Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: The Randomized Agitg Dynamic-Rectal Study.. Journal of Clinical Oncology (2024)

Detection of Human Brain Cancers Using Genomic and Immune Cell Characterization of Cerebrospinal Fluid Through Csf-Bam. medRxiv (2024)

Figure S7 From the Origin of Highly Elevated Cell-Free Dna in Healthy Individuals and Patients With Pancreatic, Colorectal, Lung, or Ovarian Cancer. (2024)

cell-free dnaovarian cancermolecular biologyhealthy individualspancreatic cancerlung cancer

Genetic Alterations During Colorectal-Tumor Development. CRC Press eBooks (2024)

Fadwa AliEmina Huang

geneticscancer biologygenetic alterationshealth sciencesmedicinecancer researchcolorectal cancermedical geneticscancer geneticscolorectal-tumor development

Machine Learning to Detect the Sines of Cancer. Science Translational Medicine (2024)

cancer biologycancer imaginghealth sciencesmedicinemachine learningcancer researchcancer detectiononcologytranslational medicinediagnosiscancer screeningdisease detectiondisease classification

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10 / page