Faculty

Institution

Unit

Venue

Dr. Wayne Guida

Professor

University of South Florida

Affiliations

College of Arts and Sciences

School of Natural Sciences and Mathematics

Department of Chemistry

Dr. Wayne Guida is currently serving as a College Of Arts And Sciences Professor at University of South Florida.

Honors

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Experiences

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Education

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Dr. Wayne Guida

University of South Florida

Professor

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pharmacology drug discovery medicinal chemistry enzyme inhibition molecular biology biochemistry enzymes cancer research protein science medicinal research cancer biology cancer treatment structural biology medicine computational chemistry pharmaceutical chemistry biological chemistry molecular cancer structure-based design protein engineering organic synthesis rational drug design anti-cancer agents cancer genomics purine nucleoside phosphorylase peptide science molecular docking cheminform abstract cellular biochemistry drug development structural molecular biology peptides tumor targeting inhibitory activity molecular cell biology structural chemistry protein chemistry protein synthesis molecular design drug targeting structure determination conformational space structure-based drug design virtual screening conformational searching proteasome inhibitors coordination chemistry biomolecular structure cancer cells transition metal chemistry biological inorganic chemistry peptide engineering protein modeling x-ray crystallography protein bioinformatics antiparasitic agent secretory pathway parasite genomics proteinlipid interaction protein function inorganic synthesis tumor suppressors therapeutic efficacy pyridylthiazole-based ureas phosphate mimics cyclic molecules circular permutation molecular adduct clinical investigation host-guest chemistry chemical probes crystal structure design catalytic process bioorganic molecules software system structure-based virtual screening pharmacological research mechanisms of action

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract A016: A Computational Chemistry and AI-Driven Framework for Structure-Based Drug Design Informed by Underlying Factors of Mutation-Induced Drug Resistance: A Study of Kras. Clinical Cancer Research (2025)

pharmacologyfuture medicinal chemistrymutation-induced drug resistancedrug discoverymolecular propertiesmolecular dockingcomputational biologydrug resistancemolecular informaticsmolecular modellingmolecular designabstract a016systems biologyai-driven frameworkrational drug design

Biophysical Insights Into the Binding Interactions of Inhibitors (Ica-1S/1T) Targeting Protein Kinase C-Ι. Biophysica (2025)

molecular dockingsignal transductiondrug targetsbiophysical insightsenzyme inhibitionbiochemistrybiochemical interactionmolecular biologyprotein kinase c-ιcell signalingbinding interactionsbiomolecular interactionsprotein sciencetherapeutic targets

Bps2025 - Mutations in Drug Binding Sites: Integrating Computational Chemistry and Machine Learning to Understand Mutation-Induced Resistance. Biophysical Journal (2025)

drug discoverybioinformaticsmolecular propertiesdrug targetscomputational biologymachine learningmutation-induced resistancemolecular informaticsdrug binding sitesmolecular biologystructural molecular biologysystems biologyprotein sciencemutagenesis (molecular biology technique)

Detection and Quantification of Changes in Oligomeric States of Sting at Attomolar Concentrations of Analyte. (2025)

allergybioanalysisbiophysicsoligomeric statesvenomicsanalytical chemistryattomolar concentrationsinsect sting allergy

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human Sting Receptor. ACS Central Science (2025)

allergypharmacologypharmacological researchreceptorsdrug discoverymechanisms of actionreceptor (biochemistry)human sting receptorneuropharmacologymolecular pharmacologysub-femtomolar modulatorphysiology

Biophysical Methods for Attomolar Detection of Compounds Acting on Protein Oligomer States. (2024)

William LawlessRobert SparksMark EschenfelderStephanie KrzypkowskiKenyon DanielWayne Guida

attomolar detectionmolecular biophysicsbiophysical methodsbiophysics

Biophysical System for the Detection and Quantification of Changes in Oligomeric States of Sting at Attomolar Concentrations of Clonixeril. (2024)

William LawlessMark EschenfelderRobert SparksSarah LawlessStephanie KrzypkowskiKenyon DanielWayne Guida

cell biologyprotein scienceattomolar concentrationsearly detectioninhibitory activitymembrane biologyoligomeric statescatalyst activationintermediate hostpharmacologygene expressionstructural biologymammalian biologyenzymespeptide scienceenzyme inhibitionfunctional selectivitynucleic acidsmolecular biologybiophysical systemfluorescence spectroscopy

Chemical Synthesis, in Vitro Testing and in Silico Nampt-Based Molecular Docking of Novel Aniline Aromatic Ring-Substituted 2-Aminothiazole Analogues.. Canadian Journal of Physiology and Pharmacology (2024)

Ali A. HusainRavikumar ManickamJonah GordonSandhya SanthanaKatarzyna MizgalskaWayne C GuidaSrinivas M TipparajuKirpal S. Bisht

nanoparticle researchmedicinal chemistrydrug discoverymolecular dockingsynthetic chemistrypeptide sciencepharmaceutical researchtransition metal chemistrypharmaceutical chemistryenzyme inhibitionbiochemistrymolecular biologybiomolecular engineeringmedicinal researchmolecular pharmacologydrug developmenttherapeutic targetschemical synthesis

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human Sting Receptor. (2024)

Robert SparksWilliam LawlessAnna KharitonovaRainer MetcalfJamie NunziataGrace BinderSauradip ChaudhuryChristine GambinoMichelle WildeLinette HardingJaret CrewsMansi GopuEmilia DalamangusSarah LawlessMark EschenfelderRobert GreenElizabeth NompleggiTimothy TranKathy YangDonna TraskPaul ThompsonNiketa PatelRekha PatelWesley BrooksGuy BradleyMildred Acevedo-DuncanAlan MullenJames LeahyKenyon DanielWayne Guida

human sting receptorbiochemistryplatelet antagonistvascular biologypharmacologyreceptorsimmunologypain medicinesub-femtomolar modulatorpeptide scienceinsect sting allergypheromone biochemistrydrug discoverysignal transductionendocrinologyreceptor (biochemistry)peptidesmedicinal researchvenomicstherapeutic targets

Helical Sulfonyl-γ-Aapeptides Modulating Aβ Oligomerization and Cytotoxicity by Recognizing Aβ Helix. Proceedings of the National Academy of Sciences (2024)

Heng LiuYunpeng CuiXue ZhaoLulu WeiXudong WangNing ShenTimothy OdomXuming LiWilliam LawlessKanchana KarunarathneMartin MuscholWayne GuidaChuanhai CaoLibin YeJianfeng Cai

pharmacologyab helixprotein engineeringneurosciencehelical sulfonyl-g-aapeptidesmolecular biologyprotein functionprotein modelingab oligomerizationmedicinal researchprotein science

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Dr. Wayne Guida

Professor

University of South Florida

Affiliations

College of Arts and Sciences

School of Natural Sciences and Mathematics

Department of Chemistry

Dr. Wayne Guida is currently serving as a College Of Arts And Sciences Professor at University of South Florida.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dr. Wayne Guida

University of South Florida

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Biophysical Insights Into the Binding Interactions of Inhibitors (Ica-1S/1T) Targeting Protein Kinase C-Ι. Biophysica (2025)

Bps2025 - Mutations in Drug Binding Sites: Integrating Computational Chemistry and Machine Learning to Understand Mutation-Induced Resistance. Biophysical Journal (2025)

Detection and Quantification of Changes in Oligomeric States of Sting at Attomolar Concentrations of Analyte. (2025)

allergybioanalysisbiophysicsoligomeric statesvenomicsanalytical chemistryattomolar concentrationsinsect sting allergy

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human Sting Receptor. ACS Central Science (2025)

Biophysical Methods for Attomolar Detection of Compounds Acting on Protein Oligomer States. (2024)

William LawlessRobert SparksMark EschenfelderStephanie KrzypkowskiKenyon DanielWayne Guida

attomolar detectionmolecular biophysicsbiophysical methodsbiophysics

Biophysical System for the Detection and Quantification of Changes in Oligomeric States of Sting at Attomolar Concentrations of Clonixeril. (2024)

William LawlessMark EschenfelderRobert SparksSarah LawlessStephanie KrzypkowskiKenyon DanielWayne Guida

Ali A. HusainRavikumar ManickamJonah GordonSandhya SanthanaKatarzyna MizgalskaWayne C GuidaSrinivas M TipparajuKirpal S. Bisht

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human Sting Receptor. (2024)

Helical Sulfonyl-γ-Aapeptides Modulating Aβ Oligomerization and Cytotoxicity by Recognizing Aβ Helix. Proceedings of the National Academy of Sciences (2024)

Heng LiuYunpeng CuiXue ZhaoLulu WeiXudong WangNing ShenTimothy OdomXuming LiWilliam LawlessKanchana KarunarathneMartin MuscholWayne GuidaChuanhai CaoLibin YeJianfeng Cai

pharmacologyab helixprotein engineeringneurosciencehelical sulfonyl-g-aapeptidesmolecular biologyprotein functionprotein modelingab oligomerizationmedicinal researchprotein science

1
2
3
4
5
12
10 / page

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Richard B. Silverman

Institution

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pharmacology

medicinal chemistry

Jianfeng Cai

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protein-protein interactions

biomolecular engineering

Kevin Dalby

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University of Texas at Austin

anti-cancer agent

molecular pathway

Brian Blagg

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future medicinal chemistry

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general chemistry

fine chemical

Charles E. McKenna

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future medicinal chemistry

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Gregory Thatcher

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Barbara Imperiali

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Massachusetts Institute of Technology

biochemistry

molecular biology

Ziwei HUANG

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University of California, San Diego

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future medicinal chemistry

Paul Hergenrother

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enzyme inhibitors

antibacterial compounds