Faculty

Institution

Unit

Venue

Daniel Sem

Vice Provost - Research and Innovation; Professor

Concordia University Wisconsin

Affiliations

Concordia University Wisconsin

School of Pharmacy

Daniel Sem is currently serving as a Concordia University Wisconsin Vice Provost - Research and Innovation; Professor at Concordia University Wisconsin.

Honors

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Experiences

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Education

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Daniel Sem

Concordia University Wisconsin

Vice Provost - Research and Innovation; Professor

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biochemistry molecular biology protein science pharmacology enzymes drug discovery structural biology protein structure medicinal chemistry enzyme inhibition chemical biology structural molecular biology protein nmr medicinal research proteomics biomolecular structure neuroscience nuclear magnetic resonance spectroscopy enzyme specificity pharmaceutical chemistry therapeutic targets peptide science molecular docking redox biology proteome research molecular structure rational drug design protein modeling protein phosphorylation protein bioinformatics human phosphomevalonate kinase biochemical sciences biological chemistry biochemical interaction biomolecular interactions pharmaceutical sciences protein function drug targets molecular substrates inhibitory activity molecular regulation protein chemistry free radical biology clinical biochemistry clinical chemistry molecular informatics biomolecules lead identification key site enzymatic modification heterocyclic biomolecular analysis dynamic nuclear polarization kinetic mechanism drug design structural characterization solid-state nmr spectroscopy nuclear quadrupole resonance functional selectivity translational proteomics cardiovascular toxicity molecular neurobiology structure-function enzyme kinetics enzyme catalysis fluorescence-based detection dithiol probes large protein-ligand interactions nmr-based structural characterization reductive half-reaction mechanistic studies uniform binding energy primary source systems-based design bi-ligand inhibitors chemical proteomics-based analysis off-target binding profiles entrepreneurship intellectual property

Notable Scholarly Works

Notable Federal Grants

Collaborators

Analogues of the Potent and Selective Erβ Agonist Trans-4-(4-Hydroxyphenyl)Cyclohexanemethanol: Synthesis and Evaluation. Synlett (2025)

William A. DonaldsonSubhabrata ChaudhuryEdward A. WetzelMohamed F. ElmansyAlicia M. HansonSandra Brown-FordAlexandra GleasonK. L. Iresha Sampathi PereraDaniel S. Sem

drug developmentenantioselective synthesisselective erbpeptide sciencemedicinal researchpharmacological agentsmedicinal chemistrypeptidespharmacologytherapeutic targetsmolecular pharmacologydrug discoveryenzyme inhibitionfunctional modificationorganic synthesis

Structural and Kinetic Characterization of Dusp5 With a DI-Phosphorylated Tripeptide Substrate From the Erk Activation Loop. Frontiers in Chemical Biology (2024)

Andrea ImhoffNoreena L. SweeneyRobert D. BongardRaulia SyrlybaevaAnkan GuptaEdgar Del CarpioMarat R. TalipovCostanza Garcia-KellerDebbie C. CransRamani RamchandranDaniel S. Sem

kinetic characterizationerk activation loopbiochemistrychemical biologydi-phosphorylated tripeptide substrateprotein structure

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

Effects of Long‐Term Oral Treatment With a Novel Estrogen Receptor Beta Agonist on Memory, Vasomotor, and Anxiety Outcomes in an Efad Mouse Model of Alzheimer’s Disease. Alzheimer s & Dementia (2023)

Aaron W FleischerMiranda R SchwabeRachel K KuehnSubhabrata ChauduryJason YorkMary Jo LaduDaniel S SemWilliam A DonaldsonKaryn M Frick

neuropharmacologybiological psychiatryneurosciencebehavioral neuroendocrinologypharmacologypsychopharmacologyhormonal receptoralzheimer's diseaseefad mouse modellong-term oral treatmentmedicinal researchneuropsychopharmacologypsychoneuroendocrinologyendocrinologymemorytreatment and preventioncognitive neuroscienceanxiety outcomesgeriatric medicinemedicineexperimental medicine

Discovery of Two Novel (4-Hydroxyphenyl) Substituted Polycyclic Carbocycles as Potent and Selective Estrogen Receptor Beta Agonists. Bioorganic & Medicinal Chemistry Letters (2022)

Edward A. WetzelKylee J. MarksAlexandra A. GleasonSandra Brown-FordTerry-Elinor ReidSubhabrata ChaudhurySergey LindemanDaniel S. SemWilliam A. Donaldson

medicinal chemistrychemical synthesispharmacologydrug discoveryendocrinologyorganic synthesispolycyclic carbocycles

Synthesis and Evaluation of (1,4-Disubstituted)-1,2,3-Triazoles as Estrogen Receptor Beta Agonists. Scientia Pharmaceutica (2022)

Edward A. WetzelGrace C. CorrieroSandra Brown-FordDaniel S. SemWilliam A. Donaldson

pharmaceutical chemistrypharmaceutical sciencespharmaceuticsmedicinal chemistrypharmacologydrug discoveryendocrinologypharmaceutical research

Long-Term Oral Administration of a Novel Estrogen Receptor Beta Agonist Enhances Memory and Alleviates Drug-Induced Vasodilation in Young Ovariectomized Mice. Hormones and Behavior (2021)

Aaron W. FleischerJayson C. SchalkEdward A. WetzelAlicia M. HansonDaniel S. SemWilliam A. DonaldsonKaryn M. Frick

memoryphysiologyneuroscienceyoung ovariectomized micepharmacologylong-term oral administrationdrug-induced vasodilationendocrinologymammalian biology

Chronic Oral Administration of a Novel Estrogen Receptor Beta Agonist Enhances Memory Consolidation and Alleviates Vasomotor Symptoms in a Mouse Model of Menopause. Alzheimer s & Dementia (2020)

Aaron W FleischerJayson C SchalkEdward A WetzelAlicia M HansonDaniel S SemWilliam A DonaldsonKaryn M Frick

neurologychronic oral administrationalzheimer's diseasemouse modelneurosciencepharmacologyendocrinology

Synthesis and Evaluation of 17α-Triazolyl and 9α-Cyano Derivatives of Estradiol. Bioorganic & Medicinal Chemistry (2020)

Edward A. WetzelAlicia M. HansonCallie L. TroutfetterDaniel J. BurkettDaniel S. SemWilliam A. Donaldson

heterocyclicmedicinal chemistrybioorganic chemistrychemical synthesischemistryorganic synthesis

Discovery and Characterization of Halogenated Xanthene Inhibitors of Dusp5 as Potential Photodynamic Therapeutics. Journal of Photochemistry and Photobiology A Chemistry (2019)

Robert D. BongardMichael LepleyAdam GastonguayRaulia R. SyrlybaevaMarat R. TalipovRachel A. Jones LipinskiNoah R. LeighJaladhi BrahmbhattRaman KuttyRajendra RathoreRamani RamchandranDaniel S. Sem

halogenated xanthene inhibitorsdrug deliveryphotomedicinenanomedicinemedicinal researchphotodynamic therapymedicinal chemistrymicrobiologyphotochemistrycancer imagingphotobiologychemistrypharmacologytherapeutic targetscombined modality treatmentenzyme inhibition

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Daniel Sem

Vice Provost - Research and Innovation; Professor

Concordia University Wisconsin

Affiliations

Concordia University Wisconsin

School of Pharmacy

Daniel Sem is currently serving as a Concordia University Wisconsin Vice Provost - Research and Innovation; Professor at Concordia University Wisconsin.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Daniel Sem

Concordia University Wisconsin

Vice Provost - Research and Innovation; Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Analogues of the Potent and Selective Erβ Agonist Trans-4-(4-Hydroxyphenyl)Cyclohexanemethanol: Synthesis and Evaluation. Synlett (2025)

William A. DonaldsonSubhabrata ChaudhuryEdward A. WetzelMohamed F. ElmansyAlicia M. HansonSandra Brown-FordAlexandra GleasonK. L. Iresha Sampathi PereraDaniel S. Sem

Structural and Kinetic Characterization of Dusp5 With a DI-Phosphorylated Tripeptide Substrate From the Erk Activation Loop. Frontiers in Chemical Biology (2024)

Andrea ImhoffNoreena L. SweeneyRobert D. BongardRaulia SyrlybaevaAnkan GuptaEdgar Del CarpioMarat R. TalipovCostanza Garcia-KellerDebbie C. CransRamani RamchandranDaniel S. Sem

kinetic characterizationerk activation loopbiochemistrychemical biologydi-phosphorylated tripeptide substrateprotein structure

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Aaron W FleischerMiranda R SchwabeRachel K KuehnSubhabrata ChauduryJason YorkMary Jo LaduDaniel S SemWilliam A DonaldsonKaryn M Frick

Discovery of Two Novel (4-Hydroxyphenyl) Substituted Polycyclic Carbocycles as Potent and Selective Estrogen Receptor Beta Agonists. Bioorganic & Medicinal Chemistry Letters (2022)

Edward A. WetzelKylee J. MarksAlexandra A. GleasonSandra Brown-FordTerry-Elinor ReidSubhabrata ChaudhurySergey LindemanDaniel S. SemWilliam A. Donaldson

medicinal chemistrychemical synthesispharmacologydrug discoveryendocrinologyorganic synthesispolycyclic carbocycles

Synthesis and Evaluation of (1,4-Disubstituted)-1,2,3-Triazoles as Estrogen Receptor Beta Agonists. Scientia Pharmaceutica (2022)

Edward A. WetzelGrace C. CorrieroSandra Brown-FordDaniel S. SemWilliam A. Donaldson

pharmaceutical chemistrypharmaceutical sciencespharmaceuticsmedicinal chemistrypharmacologydrug discoveryendocrinologypharmaceutical research

Long-Term Oral Administration of a Novel Estrogen Receptor Beta Agonist Enhances Memory and Alleviates Drug-Induced Vasodilation in Young Ovariectomized Mice. Hormones and Behavior (2021)

Aaron W. FleischerJayson C. SchalkEdward A. WetzelAlicia M. HansonDaniel S. SemWilliam A. DonaldsonKaryn M. Frick

memoryphysiologyneuroscienceyoung ovariectomized micepharmacologylong-term oral administrationdrug-induced vasodilationendocrinologymammalian biology

Chronic Oral Administration of a Novel Estrogen Receptor Beta Agonist Enhances Memory Consolidation and Alleviates Vasomotor Symptoms in a Mouse Model of Menopause. Alzheimer s & Dementia (2020)

Aaron W FleischerJayson C SchalkEdward A WetzelAlicia M HansonDaniel S SemWilliam A DonaldsonKaryn M Frick

neurologychronic oral administrationalzheimer's diseasemouse modelneurosciencepharmacologyendocrinology

Synthesis and Evaluation of 17α-Triazolyl and 9α-Cyano Derivatives of Estradiol. Bioorganic & Medicinal Chemistry (2020)

Edward A. WetzelAlicia M. HansonCallie L. TroutfetterDaniel J. BurkettDaniel S. SemWilliam A. Donaldson

heterocyclicmedicinal chemistrybioorganic chemistrychemical synthesischemistryorganic synthesis

Discovery and Characterization of Halogenated Xanthene Inhibitors of Dusp5 as Potential Photodynamic Therapeutics. Journal of Photochemistry and Photobiology A Chemistry (2019)

Robert D. BongardMichael LepleyAdam GastonguayRaulia R. SyrlybaevaMarat R. TalipovRachel A. Jones LipinskiNoah R. LeighJaladhi BrahmbhattRaman KuttyRajendra RathoreRamani RamchandranDaniel S. Sem

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molecular biology

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Carl Frieden

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