Faculty

Institution

Unit

Venue

Kendall Blumer

Professor of Cell Biology & Physiology

Washington University in St. Louis

Affiliations

School of Medicine

Cell Biology & Physiology

Kendall Blumer is currently serving as a Cell Biology & Physiology Professor of Cell Biology & Physiology at Washington University In St. Louis.

Honors

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Experiences

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Education

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Kendall Blumer

Washington University in St. Louis

Professor of Cell Biology & Physiology

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molecular biology cell signaling signal transduction cell biology protein science genetics biochemistry gene expression membrane biology biological chemistry molecular physiology g protein-coupled receptor structural biology yeast molecular and cellular biology molecular cell biology receptors vascular biology cardiology molecular regulation melanoma cellular biochemistry mammalian biology cellular physiology protein function cardiovascular research medicinal research cardiovascular physiology receptor (biochemistry) skin cancer structural molecular biology signaling pathways protein transport uveal melanoma circulatory physiology animal physiology biochemical sciences biological function liver physiology cell regulation blood pressure cellular biology clinical investigation physiological regulation gene regulation molecular adaptation mammalian physiology human physiology transcription regulation endothelial dysfunction functional selectivity g-protein-coupled receptors plasma membrane rgs proteins clinical medicine clinical physiology protein chemistry biochemical genetics host specificity gene function intracellular trafficking redox signaling clinical pharmacology cardiovascular pharmacology g protein yeast a-factor receptor saccharomyces cerevisiae receptor-g protein mek kinase rgs family members map kinase pathways giα family members rgs protein carboxy-terminal segment regulatory domain developmental adaptation molecular cancer photocarcinogenesis signal transduction mechanisms oncogenic agent

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1362 Gnaq/11-Driven Melanoma is Safeguarded Against Calcium Overload by a Phosphatase That Degrades Inositol (1,4,5)-Trisphosphate. Journal of Biological Chemistry (2025)

cell physiologycalcium overloadcancer cellstumor biologygnaq/11-driven melanomaprotein phosphorylationcell signalingcell biologycellular physiologymolecular cancerbiochemistrymelanomaabstract 1362signal transductioncellular biochemistrycancer biology

Inositol (1,4,5)-Trisphosphate 5-Phosphatase Promotes Survival of Uveal Melanoma by Regulating Oncogenic G Protein-Driven Calcium Oscillations. Journal of Biological Chemistry (2025)

cell physiologyoncogenesreceptor tyrosine kinasestumor biologyprotein phosphorylationcell signalingcell biologycellular physiologymelanomaphotocarcinogenesiscarcinogenesis5-phosphatase promotes survivalmolecular cell biologyuveal melanomasignal transductionophthalmology

The G Protein Inhibitor Ym-254890 is an Allosteric Glue. Journal of Molecular Biology (2025)

Tony TrentJustin J MillerKendall J BlumerGregory R Bowman

biophysicsprotein sciencebiochemistrymolecular biologyg protein-coupled receptorprotein structureallosteric glue

The Guanine Nucleotide Exchange Factor Ric-8A Regulates the Sensitivity of Constitutively Active GαQ to the Inhibitor Ym-254890. Journal of Biological Chemistry (2025)

inhibitory activitymolecular pharmacologycell signalingtranscription factorsfunctional selectivityexchange factor ric-8amolecular cell biologyactive gαqinhibitor ym-254890pharmacologymolecular biologytherapeutic targetsbiological chemistrysignal transductionpharmacological researchenzyme inhibitiong protein-coupled receptormechanisms of action

Abstract 1998: Abcb1 Promotes Uveal Melanoma Cell Resistance to Fr900359 and Identifies a Tumor Cell Subpopulation With a Distinct Gene Expression Signature. Cancer Research (2024)

Sarina Dion MurrayJesse D. RiordanEric R. AndersonMichael D. OnkenKendall J. BlumerAdam J. DupuyChristopher S. Stipp

tumor biologycancer biologycancer immunotherapycell biologymedicinal researchdermatologymelanomaskin cancertumor cell subpopulationcancer researchcancer geneticscancer cellsgene expressionleukemiacancer genomicsoncologygenetics

Examination of Inpp5A in Uveal Melanoma Uncovers Novel Calcium Transients. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Michael D OnkenKevin M KaltenbronnCarol M MakepeaceKisha D PiggottKendall J Blumer

calcium transientsmelanomamolecular biology

G Protein Activation Occurs via a Largely Universal Mechanism. The Journal of Physical Chemistry B (2024)

Neha VithaniTyson D. ToddSukrit SinghTony TrentKendall J. BlumerGregory R. Bowman

biophysicsphysiologyphysicsprotein sciencephysical chemistrystructural biologyuniversal mechanism

Stabilization of Interdomain Closure by a G Protein Inhibitor. Proceedings of the National Academy of Sciences (2024)

Tyson D. ToddNeha VithaniSukrit SinghGregory R. BowmanKendall J. BlumerAndrea Soranno

protein sciencebiochemistrymolecular biologyg protein-coupled receptorprotein structureinterdomain closure

A Building Block Approach for the Total Synthesis of Ym‐385781. European Journal of Organic Chemistry (2023)

Yu ZhuSiyue LiuJohnny ZigmondKevin M. KaltenbronnKendall J. BlumerKevin D. Moeller

total synthesisorganic chemistryorganic synthesis

Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Molecular & Cellular Proteomics (2023)

Michael D OnkenPetra Erdmann-GilmoreQiang ZhangKisan ThapaEmily KingKevin M KaltenbronnSarah E NodaCarol M MakepeaceDennis GoldfarbÖzgün BaburR Reid TownsendKendall J Blumer

molecular and cellular biologyproteomicspharmacologytumor biologycell signalingprotein kinasemelanomamolecular biologyoncogenesmedicinal researchmolecular cancerbiochemistrysignaling pathwaysuveal melanomapathway analysisprotein sciencebioinformatic analysesskin cancersignal transductionleukemiacancer genomics

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Kendall Blumer

Professor of Cell Biology & Physiology

Washington University in St. Louis

Affiliations

School of Medicine

Cell Biology & Physiology

Kendall Blumer is currently serving as a Cell Biology & Physiology Professor of Cell Biology & Physiology at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Kendall Blumer

Washington University in St. Louis

Professor of Cell Biology & Physiology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1362 Gnaq/11-Driven Melanoma is Safeguarded Against Calcium Overload by a Phosphatase That Degrades Inositol (1,4,5)-Trisphosphate. Journal of Biological Chemistry (2025)

Inositol (1,4,5)-Trisphosphate 5-Phosphatase Promotes Survival of Uveal Melanoma by Regulating Oncogenic G Protein-Driven Calcium Oscillations. Journal of Biological Chemistry (2025)

The G Protein Inhibitor Ym-254890 is an Allosteric Glue. Journal of Molecular Biology (2025)

Tony TrentJustin J MillerKendall J BlumerGregory R Bowman

biophysicsprotein sciencebiochemistrymolecular biologyg protein-coupled receptorprotein structureallosteric glue

The Guanine Nucleotide Exchange Factor Ric-8A Regulates the Sensitivity of Constitutively Active GαQ to the Inhibitor Ym-254890. Journal of Biological Chemistry (2025)

Abstract 1998: Abcb1 Promotes Uveal Melanoma Cell Resistance to Fr900359 and Identifies a Tumor Cell Subpopulation With a Distinct Gene Expression Signature. Cancer Research (2024)

Sarina Dion MurrayJesse D. RiordanEric R. AndersonMichael D. OnkenKendall J. BlumerAdam J. DupuyChristopher S. Stipp

Examination of Inpp5A in Uveal Melanoma Uncovers Novel Calcium Transients. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Michael D OnkenKevin M KaltenbronnCarol M MakepeaceKisha D PiggottKendall J Blumer

calcium transientsmelanomamolecular biology

G Protein Activation Occurs via a Largely Universal Mechanism. The Journal of Physical Chemistry B (2024)

Neha VithaniTyson D. ToddSukrit SinghTony TrentKendall J. BlumerGregory R. Bowman

biophysicsphysiologyphysicsprotein sciencephysical chemistrystructural biologyuniversal mechanism

Stabilization of Interdomain Closure by a G Protein Inhibitor. Proceedings of the National Academy of Sciences (2024)

Tyson D. ToddNeha VithaniSukrit SinghGregory R. BowmanKendall J. BlumerAndrea Soranno

protein sciencebiochemistrymolecular biologyg protein-coupled receptorprotein structureinterdomain closure

A Building Block Approach for the Total Synthesis of Ym‐385781. European Journal of Organic Chemistry (2023)

Yu ZhuSiyue LiuJohnny ZigmondKevin M. KaltenbronnKendall J. BlumerKevin D. Moeller

total synthesisorganic chemistryorganic synthesis

Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Molecular & Cellular Proteomics (2023)

Michael D OnkenPetra Erdmann-GilmoreQiang ZhangKisan ThapaEmily KingKevin M KaltenbronnSarah E NodaCarol M MakepeaceDennis GoldfarbÖzgün BaburR Reid TownsendKendall J Blumer

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Similar Faculty Members

Harvey R. Herschman

Institution

University of California, Los Angeles

imaging genomics

cell biology

Joan Heller Brown

Institution

University of California, San Diego

cam kinase

brain tumor research

Andrius Kazlauskas

Institution

University of Illinois Chicago

endothelial dysfunction

endothelial cell biology

Richard Neubig

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Michigan State University

signaling pathway

molecular regulation

Kermit Carraway

Institution

University of California, Davis

pharmacological research

toxicological mechanism

James R. Goldenring

Institution

Vanderbilt University

gastrointestinal oncology

gastroenterology

Salvatore Vincent Pizzo

Institution

Duke University

pharmacology

biochemistry

Bruce Spiegelman

Institution

Harvard University

physiology

molecular biology

Daria Mochly-Rosen

Institution

Stanford University

pharmacology

cardiology

Gary Johnson

Institution

University of North Carolina at Chapel Hill

mapk kinase

apoptosis