Faculty

Institution

Unit

Venue

Andrew S. Murkin

Associate Professor

University at Buffalo

Affiliations

College of Arts and Sciences

Department of Chemistry

Andrew S. Murkin is currently serving as a College Of Arts And Sciences Associate Professor at University At Buffalo.

Honors

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Experiences

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Education

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Andrew S. Murkin

University at Buffalo

Associate Professor

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biochemistry enzymes molecular biology pharmacology medicinal chemistry enzyme inhibition protein science enzyme catalysis drug discovery biological chemistry redox biology biophysics structural biology chemical biology membrane biology catalysis protein structure structure-function enzyme kinetics human purine protein chemistry biocatalysis molecular substrates purine nucleoside phosphorylase peptide science medicinal research chemical sciences molecular science biochemical sciences pharmaceutical chemistry enzyme specificity drug targeting enzymatic modification protein synthesis functional modification tropical medicine neglected tropical diseases material chemistry organic process research structural molecular biology clinical chemistry clinical biochemistry lead identification host-parasite relationships bacteriology nuclear magnetic resonance spectroscopy molecular microbiology organic material chemistry molecular catalysis rational drug design drug targets feedback loop deoxygenation microbial physiology biological inorganic chemistry femtosecond dynamics born-oppenheimer enzyme chemical library screening heteroaromatic compounds intracellular trypanosoma cruzi plasmodium falciparum parasites primate animal model transition state analogue third-generation immucillins acyclic immucillin inhibitors transition state mechanism-based inactivator b-fluoroamine inhibitor neuc protein process biochemistry bioorganic chemistry enzyme mechanisms transition state structures biomolecular engineering

Notable Scholarly Works

Notable Federal Grants

Collaborators

Demystifying Functional Parameters for Irreversible Enzyme Inhibitors. Journal of Medicinal Chemistry (2024)

David E. HeppnerBlessing C. OgbooDaniel A. UrulEarl W. MayErik M. SchaeferAndrew S. MurkinMatthias Gehringer

enzymatic modificationfunctional parametersprotein scienceenzyme catalysisfunctional modificationstructure-function enzyme kineticsbiomolecular engineeringmedicinal chemistryirreversible enzyme inhibitorsenzymeschemical biologypeptide sciencedrug discoveryenzyme inhibitionmolecular biologysystems biologypeptidesmedicinal researchtherapeutic targetsenzyme specificity

Methylthio-D-Ribose-1-Phosphate Isomerase Uses a Novel Mechanism for Aldose–Ketose Isomerization. (2024)

Andrew MurkinSubashi Ubayawardhana

pharmacologymolecular substratesbiochemical sciencesprotein engineeringbiochemical engineeringbiocatalysisfunctional modificationenzyme catalysisbiochemistryredox biologycatalysisnovel mechanismaldose-ketose isomerizationprotein synthesisenzymesprotein sciencechemical synthesisbiological engineering

Kinetic Characterization of Methylthio-D-Ribose-1-Phosphate Isomerase. Methods in enzymology on CD-ROM/Methods in enzymology (2023)

Vamsee M VeeramachineniSubashi T UbayawardhanaAndrew S Murkin

kinetic characterizationenzymesbiological engineeringbiochemistry

Covalent Adduct Formation in Methylthio- D -Ribose-1-Phosphate Isomerase: Reaction Intermediate or Artifact?. Biochemistry (2022)

Vamsee M. VeeramachineniSubashi T. UbayawardhanaAndrew S. Murkin

covalent adduct formationenzymescrystallographybiochemistry

Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions. Molecules (2020)

Patrick L. FernandezAndrew S. Murkin

enzyme catalysisbiocatalysisbiochemistrycatalysisenzyme-catalyzed reactions

New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design. Biochemistry (2019)

Sneha RayAndrew S. Murkin

medicinal chemistrypharmacologydrug discoveryenzyme inhibitionbiochemistry

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition. ACS Chemical Biology (2018)

Sneha RayDale F. KreitlerAndrew M. GulickAndrew S. Murkin

medicinal chemistrypharmacologydrug discoverybiological chemistrybiochemistrycovalent enzyme inhibitionnitro groupchemical biology

Mechanism-Based Inactivator of Isocitrate Lyases 1 and 2 From Mycobacterium Tuberculosis. Proceedings of the National Academy of Sciences (2017)

Truc V. PhamAndrew S. MurkinMargaret M. MoynihanLawrence HarrisPeter C. TylerNishant ShettyJames C. SacchettiniHsiao-ling HuangThomas D. Meek

tuberculosismicrobiologyinfectious diseasesbiochemistrymechanism-based inactivator

COMMENTARY: Ohm's Law as an Analogy for Enzyme Kinetics. Biochemistry and Molecular Biology Education (2015)

Andrew S. Murkin

biophysicsenzyme catalysisenzyme kineticsbiochemistrymolecular biologyenzymes

The Role of Phosphate in a Multistep Enzymatic Reaction: Reactions of the Substrate and Intermediate in Pieces. Journal of the American Chemical Society (2015)

Svetlana A. KholodarC. Leigh AllenAndrew M. GulickAndrew S. Murkin

chemical kineticsmolecular substratesstructural biologybiological chemistrymultistep enzymatic reactionbiochemistrymolecular biologychemical sciencesenzymeschemical biologychemistry

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Andrew S. Murkin

Associate Professor

University at Buffalo

Affiliations

College of Arts and Sciences

Department of Chemistry

Andrew S. Murkin is currently serving as a College Of Arts And Sciences Associate Professor at University At Buffalo.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Andrew S. Murkin

University at Buffalo

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Demystifying Functional Parameters for Irreversible Enzyme Inhibitors. Journal of Medicinal Chemistry (2024)

David E. HeppnerBlessing C. OgbooDaniel A. UrulEarl W. MayErik M. SchaeferAndrew S. MurkinMatthias Gehringer

Methylthio-D-Ribose-1-Phosphate Isomerase Uses a Novel Mechanism for Aldose–Ketose Isomerization. (2024)

Andrew MurkinSubashi Ubayawardhana

Kinetic Characterization of Methylthio-D-Ribose-1-Phosphate Isomerase. Methods in enzymology on CD-ROM/Methods in enzymology (2023)

Vamsee M VeeramachineniSubashi T UbayawardhanaAndrew S Murkin

kinetic characterizationenzymesbiological engineeringbiochemistry

Covalent Adduct Formation in Methylthio- D -Ribose-1-Phosphate Isomerase: Reaction Intermediate or Artifact?. Biochemistry (2022)

Vamsee M. VeeramachineniSubashi T. UbayawardhanaAndrew S. Murkin

covalent adduct formationenzymescrystallographybiochemistry

Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions. Molecules (2020)

Patrick L. FernandezAndrew S. Murkin

enzyme catalysisbiocatalysisbiochemistrycatalysisenzyme-catalyzed reactions

New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design. Biochemistry (2019)

Sneha RayAndrew S. Murkin

medicinal chemistrypharmacologydrug discoveryenzyme inhibitionbiochemistry

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition. ACS Chemical Biology (2018)

Sneha RayDale F. KreitlerAndrew M. GulickAndrew S. Murkin

medicinal chemistrypharmacologydrug discoverybiological chemistrybiochemistrycovalent enzyme inhibitionnitro groupchemical biology

Mechanism-Based Inactivator of Isocitrate Lyases 1 and 2 From Mycobacterium Tuberculosis. Proceedings of the National Academy of Sciences (2017)

Truc V. PhamAndrew S. MurkinMargaret M. MoynihanLawrence HarrisPeter C. TylerNishant ShettyJames C. SacchettiniHsiao-ling HuangThomas D. Meek

tuberculosismicrobiologyinfectious diseasesbiochemistrymechanism-based inactivator

COMMENTARY: Ohm's Law as an Analogy for Enzyme Kinetics. Biochemistry and Molecular Biology Education (2015)

Andrew S. Murkin

biophysicsenzyme catalysisenzyme kineticsbiochemistrymolecular biologyenzymes

The Role of Phosphate in a Multistep Enzymatic Reaction: Reactions of the Substrate and Intermediate in Pieces. Journal of the American Chemical Society (2015)

Svetlana A. KholodarC. Leigh AllenAndrew M. GulickAndrew S. Murkin

chemical kineticsmolecular substratesstructural biologybiological chemistrymultistep enzymatic reactionbiochemistrymolecular biologychemical sciencesenzymeschemical biologychemistry

1
2
3
4
10 / page

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Dr. David Merkler

Institution

University of South Florida

molecular metabolism

biochemistry

Evan R. Kantrowitz

Institution

Boston College

enzymes

biochemistry

Richard C. Holz

Institution

Colorado School of Mines

mechanistic enzymology

process biochemistry

Hung-wen Liu

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Amy Rosenzweig

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biochemistry

molecular biology

Dehua Pei

Institution

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intracellular biologics

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James Cowan

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biomedical informatics

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future medicinal chemistry

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