Faculty

Institution

Unit

Venue

Adrian Whitty

Associate Professor

Boston University

Affiliations

College of Arts & Sciences

Biochemistry & Molecular Biology

Chemistry

Molecular Biology, Cell Biology & Biochemistry

Adrian Whitty is currently serving as a Biochemistry & Molecular Biology Associate Professor at Boston University.

Honors

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Experiences

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Education

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Adrian Whitty

Boston University

Associate Professor

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pharmacology biochemistry immunology molecular biology drug discovery structural biology protein science medicinal chemistry cell signaling tumor biology receptors membrane biology biological chemistry enzyme inhibition medicinal research protein structure drug targeting biomolecular interactions catalyst activation pharmacotherapy cell adhesion cytokines quantitative analysis vascular biology biochemical sciences mammalian biology protein chemistry cell interactions drug development rational drug design cell regulation protein function nf-kb essential modulator future medicinal chemistry oncogenes molecular science molecular physiology chemical sciences protein transport drug targets pharmaceutical sciences biological inorganic chemistry transcription regulation receptor (biochemistry) protein-protein interfaces human sonic hedgehog receptor binding fragment-based drug discovery protein-protein interactions theoretical biology interface science animal science bioconjugation anti-cancer agents cancer treatment viral oncology organic material chemistry off-target effects molecular recognition gene function pathway analysis allelic variant endothelial dysfunction experimental analysis brain function neural science host factors covalent drugs small-molecule inhibition biological complexity druggable hot spots structural conservation chameleonic properties hydrophobic modification enhanced potency tnf family receptors mechanisms of action chemical biology biomolecular engineering non-peptide ligand small molecule library signal transduction

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Conserved Core Region of the Scaffold Nemo is Essential for Signal-Induced Conformational Change and Liquid-Liquid Phase Separation. Journal of Biological Chemistry (2023)

Christopher J. DiRussoAnthony M. DeMariaJudy WongWei WangJack J. JordanidesAdrian WhittyKaren N. AllenThomas D. Gilmore

liquid-liquid phase separationsignal-induced conformational changesystems biologymolecular and cellular biologymammalian biologyscaffold nemocore regioncell and molecular biologydevelopmental biologystructural biologyprotein scienceneuroscience

High Accuracy Prediction of Protac Complex Structures. Journal of the American Chemical Society (2023)

Mikhail IgnatovAkhil JindalSergei KotelnikovDmitri BeglovGanna PosternakXiaojing TangPierre MaisonneuveGennady PodaRobert A. BateyFrank SicheriAdrian WhittyPeter J. TongeSandor VajdaDima Kozakov

materials scienceprotac complex structurescomputational chemistrychemical engineeringchemistryhigh accuracy prediction

MENTAT: A Machine-Learning Approach for the Identification of Mutations to Increase Protein Stability. Proceedings of the National Academy of Sciences (2023)

Samantha N. MuellersKaren N. AllenAdrian Whitty

genomicssequence analysisprotein stabilitygeneticscomputational genomicsmolecular biologycomputational biologymachine learningbioinformatics

Conformational Effects on the Passive Membrane Permeability of Synthetic Macrocycles. Journal of Medicinal Chemistry (2022)

Anna A. RzepielaLauren A. Viarengo-BakerVictor TatarskiiRoman KombarovAdrian Whitty

medicinal chemistrydermatologymedicinepharmacologysynthetic macrocyclespassive membrane permeabilityconformational effects

Defining and Navigating Macrocycle Chemical Space. Chemical Science (2021)

Lauren A. Viarengo-BakerLauren E. BrownAnna A. RzepielaAdrian Whitty

macrocycle chemical spacechemical scienceschemistry

Recapitulating the Binding Affinity of Nrf2 for Keap1 in a Cyclic Heptapeptide, Guided by Nmr, X-Ray Crystallography, and Machine Learning. Journal of the American Chemical Society (2021)

Paula C. OrtetSamantha N. MuellersLauren A. Viarengo-BakerKristina StreuBlair R. SzymczynaAaron B. BeelerKaren N. AllenAdrian Whitty

biophysicspharmacologypeptidesprotein chemistrycyclic heptapeptidepeptide scienceenzymeschemistrystructural biologyprotein sciencex-ray crystallography

Structural Characterization of Keap1 R415K to Guide the Design of Keap1‐Nrf2 Peptide Inhibitors. The FASEB Journal (2021)

Gwendolyn PyeattSamantha MuellersAdrian WhittyKaren Allen

pharmacologydesignpeptidesrational drug designstructural characterizationstructural biologyprotein design

The Anti-MüLlerian Hormone Prodomain is Displaced From the Hormone/Prodomain Complex Upon Bivalent Binding to the Hormone Receptor. Journal of Biological Chemistry (2021)

Richard L. CateNathalie di ClementeChrystèle RacineNigel P. GroomeR. Blake PepinskyAdrian Whitty

endocrinologyhormonal receptorbiochemistryhormone receptorbivalent binding

Benchmark Sets for Binding Hot Spot Identification in Fragment-Based Ligand Discovery. Journal of Chemical Information and Modeling (2020)

Amanda E. WakefieldChristine YuehDmitri BeglovMarcelo S. CastilhoDima KozakovGyörgy M. KeserűAdrian WhittySandor Vajda

medicinal chemistrycomputational chemistryfragment-based ligand discoverydrug discoverybenchmark setschemistry

Structural Characterization of the Covalent Binding of Keap1 and Thiol‐Containing Small Molecules. The FASEB Journal (2020)

Gwendolyn PyeattSamantha MuellersAdrian WhittyKaren N. Allen

thiol-containing small moleculespharmacologyprotein structurestructural characterizationmolecular biologystructural biologycovalent bindingbiochemistry

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Adrian Whitty

Associate Professor

Boston University

Affiliations

College of Arts & Sciences

Biochemistry & Molecular Biology

Chemistry

Molecular Biology, Cell Biology & Biochemistry

Adrian Whitty is currently serving as a Biochemistry & Molecular Biology Associate Professor at Boston University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Adrian Whitty

Boston University

Associate Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Conserved Core Region of the Scaffold Nemo is Essential for Signal-Induced Conformational Change and Liquid-Liquid Phase Separation. Journal of Biological Chemistry (2023)

Christopher J. DiRussoAnthony M. DeMariaJudy WongWei WangJack J. JordanidesAdrian WhittyKaren N. AllenThomas D. Gilmore

High Accuracy Prediction of Protac Complex Structures. Journal of the American Chemical Society (2023)

Mikhail IgnatovAkhil JindalSergei KotelnikovDmitri BeglovGanna PosternakXiaojing TangPierre MaisonneuveGennady PodaRobert A. BateyFrank SicheriAdrian WhittyPeter J. TongeSandor VajdaDima Kozakov

materials scienceprotac complex structurescomputational chemistrychemical engineeringchemistryhigh accuracy prediction

MENTAT: A Machine-Learning Approach for the Identification of Mutations to Increase Protein Stability. Proceedings of the National Academy of Sciences (2023)

Samantha N. MuellersKaren N. AllenAdrian Whitty

genomicssequence analysisprotein stabilitygeneticscomputational genomicsmolecular biologycomputational biologymachine learningbioinformatics

Conformational Effects on the Passive Membrane Permeability of Synthetic Macrocycles. Journal of Medicinal Chemistry (2022)

Anna A. RzepielaLauren A. Viarengo-BakerVictor TatarskiiRoman KombarovAdrian Whitty

medicinal chemistrydermatologymedicinepharmacologysynthetic macrocyclespassive membrane permeabilityconformational effects

Defining and Navigating Macrocycle Chemical Space. Chemical Science (2021)

Lauren A. Viarengo-BakerLauren E. BrownAnna A. RzepielaAdrian Whitty

macrocycle chemical spacechemical scienceschemistry

Recapitulating the Binding Affinity of Nrf2 for Keap1 in a Cyclic Heptapeptide, Guided by Nmr, X-Ray Crystallography, and Machine Learning. Journal of the American Chemical Society (2021)

Paula C. OrtetSamantha N. MuellersLauren A. Viarengo-BakerKristina StreuBlair R. SzymczynaAaron B. BeelerKaren N. AllenAdrian Whitty

biophysicspharmacologypeptidesprotein chemistrycyclic heptapeptidepeptide scienceenzymeschemistrystructural biologyprotein sciencex-ray crystallography

Structural Characterization of Keap1 R415K to Guide the Design of Keap1‐Nrf2 Peptide Inhibitors. The FASEB Journal (2021)

Gwendolyn PyeattSamantha MuellersAdrian WhittyKaren Allen

pharmacologydesignpeptidesrational drug designstructural characterizationstructural biologyprotein design

The Anti-MüLlerian Hormone Prodomain is Displaced From the Hormone/Prodomain Complex Upon Bivalent Binding to the Hormone Receptor. Journal of Biological Chemistry (2021)

Richard L. CateNathalie di ClementeChrystèle RacineNigel P. GroomeR. Blake PepinskyAdrian Whitty

endocrinologyhormonal receptorbiochemistryhormone receptorbivalent binding

Benchmark Sets for Binding Hot Spot Identification in Fragment-Based Ligand Discovery. Journal of Chemical Information and Modeling (2020)

Amanda E. WakefieldChristine YuehDmitri BeglovMarcelo S. CastilhoDima KozakovGyörgy M. KeserűAdrian WhittySandor Vajda

medicinal chemistrycomputational chemistryfragment-based ligand discoverydrug discoverybenchmark setschemistry

Structural Characterization of the Covalent Binding of Keap1 and Thiol‐Containing Small Molecules. The FASEB Journal (2020)

Gwendolyn PyeattSamantha MuellersAdrian WhittyKaren N. Allen

thiol-containing small moleculespharmacologyprotein structurestructural characterizationmolecular biologystructural biologycovalent bindingbiochemistry

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5
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10 / page

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biomolecular engineering

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future medicinal chemistry

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Stephen W. Fesik

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drug discovery

biochemistry

Teruna Siahaan

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John Koomen

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