Faculty

Institution

Unit

Venue

Zhongsheng You

Professor of Cell Biology & Physiology

Washington University in St. Louis

Affiliations

School of Medicine

Cell Biology & Physiology

Zhongsheng You is currently serving as a Cell Biology & Physiology Professor of Cell Biology & Physiology at Washington University In St. Louis.

Honors

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Experiences

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Education

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Zhongsheng You

Washington University in St. Louis

Professor of Cell Biology & Physiology

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molecular biology genetics dna repair cell biology gene expression rna biology genome biology nucleic acids epigenetics molecular cell biology dna replication immunology replication cell regulation cancer biology genome instability cancer genetics cancer genomics nonsense-mediated rna decay structural biology transcription regulation cell cycle molecular genetics signal transduction mammalian biology protein science biological chemistry leukemia molecular cancer epigenetic changes gene function replication stress cancer cells molecular regulation dna analysis genomic mechanisms atm kinase activity dna damage response aberrant resection nonsense-mediated mrna decay cell death molecular physiology cell research cancer care medicinal research biochemical sciences cellular biochemistry cytogenetics gene regulation embryonic development cellular biology protein phosphorylation functional regulation tumor targeting radiation biology apoptosis breast oncology cancer treatment functional modification bioluminescence rna processing biochemical genetics blood cells non-coding rna renal function atm activation dna damage sites replication-dependent chromatin-binding protein xenopus atr dna replication checkpoint dna damage cell cycle checkpoints single-stranded dna embryonic lethality rapid activation replication stress response

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2844: A Cytosolic Dna/Ca2+-Dependent Signaling Pathway for Genome Protection During Replication Stress. Cancer Research (2025)

genome instabilityabstract 2844nucleic acidscell biologygenome biologygenomic mechanismsgenome protectionreplication stressdna replicationmolecular cell biologydna repaircellular biochemistrygenetics

Cytosolic Dna and Intracellular Ca2+: Maintaining Genome Stability During Replication Stress. DNA repair (2025)

molecular and cellular biologycell cyclegenome instabilitynucleic acidscell biologygenome biologygenomic mechanismsdna replicationmolecular cell biologycytosolic dnagenome stabilitymolecular biologyintracellular ca2+geneticscell and molecular biology

Distinct Regulation of Atm Signaling by Dna Single-Strand Breaks and Ape1. Nature Communications (2024)

Haichao ZhaoJia LiZhongsheng YouHoward D. LindsayShan Yan

atm signalingdistinct regulationcell signalingdna single-strand breakstranscription regulationmolecular biologydna repair

Tcaf1 Promotes Trpv2-Mediated Ca2+ Release in Response to Cytosolic Dna to Protect Stressed Replication Forks. Nature Communications (2024)

Lingzhen KongChen ChengAbigael CheruiyotJiayi YuanYichan YangSydney HwangDaniel FoustNing TsaoEmily WilkersonNima MosammaparastMichael B. MajorDavid W. PistonShan LiZhongsheng You

cell biologystressed replication forksmolecular biologyreplicationsignal transductiongene expressiongenetics

Author Response: The Atm-E6Ap-Mastl Axis Mediates Dna Damage Checkpoint Recovery. (2023)

Yanqiu LiFeifei WangXin LiLing WangZheng YangZhongsheng YouAimin Peng

author responsedna repaircell biologymolecular biology

Camkk2 and Chk1 Phosphorylate Human Stn1 in Response to Replication Stress to Protect Stalled Forks From Aberrant Resection. Nature Communications (2023)

Rishi Kumar JaiswalKai-Hang LeiMegan ChastainYuan WangOlga ShivaShan LiZhongsheng YouPeter ChiWeihang Chai

aberrant resectionreplication stresscell biologymolecular biologyreplicationdna repairgenetics

Clinical Evidence for a Role of E2F1-Induced Replication Stress in Modulating Tumor Mutational Burden and Immune Microenvironment. DNA repair (2023)

Ke TanYizhe SongMin XuZhongsheng You

cancer biologyimmunologycancer researchimmune microenvironmentmedicinetumor mutational burdendna repaironcologygenetics

Context-Dependent Pro- and Anti-Resection Roles of Zkscan3 in the Regulation of Fork Processing During Replication. Molecular Cell (2023)

oncogenescell cyclecell biologycell divisiondna replicationmolecular cell biologyfork processingsystems biologyanti-resection rolescell regulationdna repair

Cytosolic Dna Sensing by Cgas/Sting Promotes Trpv2-Mediated Ca2+ Release to Protect Stressed Replication Forks. Molecular Cell (2023)

Shan LiLingzhen KongYing MengChen ChengDelphine Sangotokun LemaconZheng YangKe TanAbigael CheruiyotZhimin LuZhongsheng You

cell signalingimmunologydna replicationmolecular cell biologymolecular biologycytosolic dna sensinggene expressiongenetics

Data From Nonsense-Mediated Rna Decay is a Unique Vulnerability of Cancer Cells Harboring I Sf3B1 /I or I U2Af1 /I Mutations. (2023)

Abigael CheruiyotShan LiSridhar Nonavinkere SrivatsanTanzir AhmedYuhao ChenDelphine S. LemaconYing LiZheng YangBrian A. WaduguWayne A. WarnerShondra M. Pruett-MillerEsther A. ObengDaniel C. LinkDalin HeFei XiaoXiaowei WangJulie M. BailisMatthew J. WalterZhongsheng You

nonsense-mediated rna decaytumor biologycancer biologyrna biologycell biologymolecular cancercancer researchcancer geneticsgene functionmolecular biologygene expressionleukemiacancer genomicsgenetics

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Zhongsheng You

Professor of Cell Biology & Physiology

Washington University in St. Louis

Affiliations

School of Medicine

Cell Biology & Physiology

Zhongsheng You is currently serving as a Cell Biology & Physiology Professor of Cell Biology & Physiology at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Zhongsheng You

Washington University in St. Louis

Professor of Cell Biology & Physiology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2844: A Cytosolic Dna/Ca2+-Dependent Signaling Pathway for Genome Protection During Replication Stress. Cancer Research (2025)

genome instabilityabstract 2844nucleic acidscell biologygenome biologygenomic mechanismsgenome protectionreplication stressdna replicationmolecular cell biologydna repaircellular biochemistrygenetics

Cytosolic Dna and Intracellular Ca2+: Maintaining Genome Stability During Replication Stress. DNA repair (2025)

Distinct Regulation of Atm Signaling by Dna Single-Strand Breaks and Ape1. Nature Communications (2024)

Haichao ZhaoJia LiZhongsheng YouHoward D. LindsayShan Yan

atm signalingdistinct regulationcell signalingdna single-strand breakstranscription regulationmolecular biologydna repair

Tcaf1 Promotes Trpv2-Mediated Ca2+ Release in Response to Cytosolic Dna to Protect Stressed Replication Forks. Nature Communications (2024)

Lingzhen KongChen ChengAbigael CheruiyotJiayi YuanYichan YangSydney HwangDaniel FoustNing TsaoEmily WilkersonNima MosammaparastMichael B. MajorDavid W. PistonShan LiZhongsheng You

cell biologystressed replication forksmolecular biologyreplicationsignal transductiongene expressiongenetics

Author Response: The Atm-E6Ap-Mastl Axis Mediates Dna Damage Checkpoint Recovery. (2023)

Yanqiu LiFeifei WangXin LiLing WangZheng YangZhongsheng YouAimin Peng

author responsedna repaircell biologymolecular biology

Camkk2 and Chk1 Phosphorylate Human Stn1 in Response to Replication Stress to Protect Stalled Forks From Aberrant Resection. Nature Communications (2023)

Rishi Kumar JaiswalKai-Hang LeiMegan ChastainYuan WangOlga ShivaShan LiZhongsheng YouPeter ChiWeihang Chai

aberrant resectionreplication stresscell biologymolecular biologyreplicationdna repairgenetics

Clinical Evidence for a Role of E2F1-Induced Replication Stress in Modulating Tumor Mutational Burden and Immune Microenvironment. DNA repair (2023)

Ke TanYizhe SongMin XuZhongsheng You

cancer biologyimmunologycancer researchimmune microenvironmentmedicinetumor mutational burdendna repaironcologygenetics

Context-Dependent Pro- and Anti-Resection Roles of Zkscan3 in the Regulation of Fork Processing During Replication. Molecular Cell (2023)

oncogenescell cyclecell biologycell divisiondna replicationmolecular cell biologyfork processingsystems biologyanti-resection rolescell regulationdna repair

Cytosolic Dna Sensing by Cgas/Sting Promotes Trpv2-Mediated Ca2+ Release to Protect Stressed Replication Forks. Molecular Cell (2023)

Shan LiLingzhen KongYing MengChen ChengDelphine Sangotokun LemaconZheng YangKe TanAbigael CheruiyotZhimin LuZhongsheng You

cell signalingimmunologydna replicationmolecular cell biologymolecular biologycytosolic dna sensinggene expressiongenetics

Data From Nonsense-Mediated Rna Decay is a Unique Vulnerability of Cancer Cells Harboring I Sf3B1 /I or I U2Af1 /I Mutations. (2023)

nonsense-mediated rna decaytumor biologycancer biologyrna biologycell biologymolecular cancercancer researchcancer geneticsgene functionmolecular biologygene expressionleukemiacancer genomicsgenetics

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Similar Faculty Members

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Vanderbilt University

genome maintenance

molecular cancer

Cyrus Vaziri

Institution

University of North Carolina at Chapel Hill

genome instability

carcinogenesis

Tony T. Huang, PhD

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New York University

replication stress

molecular biology

Lucio Comai

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University of Southern California

cellular senescence

gene expression

Lee Zou

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Duke University

molecular biology

genetics

Jeffrey Parvin

Institution

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molecular informatics

dna replication

Robert Sobol

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oncology

cancer research

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molecular informatics

bioinformatics