Faculty

Institution

Unit

Venue

Wendel Nelson

Professor Emeritus

University of Washington

Affiliations

School of Pharmacy

Department of Medicinal Chemistry

Wendel Nelson is currently serving as a Medicinal Chemistry Professor Emeritus at University of Washington.

Honors

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Experiences

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Education

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Wendel Nelson

University of Washington

Professor Emeritus

You can click a keyword to filter the displayed items

pharmacology chemistry medicinal chemistry organic synthesis drug discovery medicine pharmaceutical chemistry biochemistry chemical synthesis pharmaceutical sciences drug metabolism metabolism medicinal research enzyme inhibition enzymes pharmacokinetics heterocyclic pharmaceutical research analytical chemistry pharmacotherapy protein science liver physiology pharmacological research mammalian biology transition metal chemistry pharmaceutical technology clinical pharmacology radiopharmaceutical therapy absolute configuration clinical chemistry redox biology enantioselective synthesis phytochemistry mutagenesis functional modification cardiovascular pharmacology stereospecific synthesis muscarinic receptors respiratory medicine molecular metabolism free radical biology biological chemistry avian biology vascular biology derivative (chemistry) hepatotoxicity residual stress secondary metabolites catalytic synthesis mammalian physiology mechanisms of action heterocycle chemistry radiation chemistry itraconazole metabolites distribution coefficient amine pka human liver microsomes opioid ligands gastrointestinal pharmacology clinical therapeutics pharmaceutical practice reference frame selective separation natural product biosynthesis biomedical research phytopharmacology clinical medicine separation science drug-induced osteomalacia other conditions ancient chinese herb tian ma retinoic acid hydroxylases functional characterization retinoic acid hydroxylase nmr methods chemical aspects natural product research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Differential Inactivation Mechanism and Covalent Adduct Formation of Aldh1A1 and Aldh1A2 by Win18,446. The FASEB Journal (2018)

Guo ZhongAlex ZelterTrisha N. DavisMichael R. HoopmannRobert L. MortizMichael MacCossWendel L. NelsonNina Isoherranen

biophysicsenzymesdifferential inactivation mechanismprotein sciencecovalent adduct formationbiochemistrytransition metal chemistrypharmacologyenzyme inhibitionfunctional modification

Validated Hplc-Ms/Ms Method to Quantify Low Levels of Domoic Acid in Plasma and Urine After Subacute Exposure. ACS Omega (2018)

Sara ShumJay S. KirkwoodJing JingRebekah PetroffBrenda CrouthamelKimberly S. GrantThomas M. BurbacherWendel L. NelsonNina Isoherranen

gas chromatographydomoic acidwater qualitychemical measurementlow levelsenvironmental sciencechromatographyanalytical chemistryliquid chromatographymass spectrometrypharmacologysubacute exposurewater pollutionexposure assessmenthealth sciencesaccelerator mass spectrometry

Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans. ACS Medicinal Chemistry Letters (2016)

Jennifer E. SagerJohn R. ChoiniereJustine ChangAlyssa Stephenson-FamyWendel L. NelsonNina Isoherranen

pharmaceutical chemistrystructural characterizationmedicinal chemistrymedicinepharmacologydrug metabolismdrug discovery

Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites. Synthesis (2015)

Aaron TeitelbaumMichele ScianWendel NelsonAllan Rettie

chain-shortened acid metabolitesefficient synthesespharmacologyorganic synthesis

Induction of Cyp26A1 by Metabolites of Retinoic Acid: Evidence That Cyp26A1 is an Important Enzyme in the Elimination of Active Retinoids. Molecular Pharmacology (2015)

Ariel R. TopletzSasmita TripathyRobert S. FotiJakob A. ShimshoniWendel L. NelsonNina Isoherranen

drug metabolismenzyme specificitymetabolismretinoic acidenzymesimportant enzymeactive retinoidsmetabolic regulationredox biologybiochemistrypharmacologymolecular pharmacologyophthalmologygene expressionenzyme inhibition

Special Section on Prediction of Human Pharmacokinetic Parameters From in Vitro Systems Stereoselective Inhibition of Cyp2C19 and Cyp3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time- Dependent Inhibitor Systems S. (2013)

Justin D. LutzBrooke M. VandenBrinkKatipudi N. BabuWendel L. NelsonKent L. KunzeNina Isoherranen

risk assessmentpharmacokineticshuman pharmacokinetic parameterspharmacologyimpact assessmentdrug discoverypharmacotherapyenzyme inhibitionclinical pharmacologystatistics

Stereoselective Inhibition of Cyp2C19 and Cyp3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems. Drug Metabolism and Disposition (2013)

Justin D. LutzBrooke M. VandenBrinkKatipudi N. BabuWendel L. NelsonKent L. KunzeNina Isoherranen

stereoselective inhibitionrisk assessmentpharmacokineticsmedicinepharmacologydrug metabolismclinical pharmacologypharmacotherapyenzyme inhibition

Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes. Journal of Biological Chemistry (2012)

Jakob A. ShimshoniArthur G. RobertsMichele ScianAriel R. TopletzSean A. BlankertJames R. HalpertWendel L. NelsonNina Isoherranen

metabolismenzymesmolecular metabolismprotein sciencebiochemistrypharmacologymolecular biologybiological chemistrystereoselective formation

Comparison of the Function and Expression of Cyp26A1 and Cyp26B1, the Two Retinoic Acid Hydroxylases. Biochemical Pharmacology (2011)

Ariel R. TopletzJayne E. ThatcherAlex ZelterJustin D. LutzSuzanne TayWendel L. NelsonNina Isoherranen

enzymesbiochemistrymolecular biologypharmacologygene expressionretinoic acid hydroxylases

Metabolism of Diltiazem: A Short Efficient Synthesis of N,N-Didesmethyldiltiazem - an Important Product of N-Demethylation. Synthesis (2011)

Wendel NelsonKantipudi BabuKent Kunze

short efficient synthesismetabolismpharmacologyorganic synthesis

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Wendel Nelson

Professor Emeritus

University of Washington

Affiliations

School of Pharmacy

Department of Medicinal Chemistry

Wendel Nelson is currently serving as a Medicinal Chemistry Professor Emeritus at University of Washington.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Wendel Nelson

University of Washington

Professor Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Differential Inactivation Mechanism and Covalent Adduct Formation of Aldh1A1 and Aldh1A2 by Win18,446. The FASEB Journal (2018)

Guo ZhongAlex ZelterTrisha N. DavisMichael R. HoopmannRobert L. MortizMichael MacCossWendel L. NelsonNina Isoherranen

biophysicsenzymesdifferential inactivation mechanismprotein sciencecovalent adduct formationbiochemistrytransition metal chemistrypharmacologyenzyme inhibitionfunctional modification

Validated Hplc-Ms/Ms Method to Quantify Low Levels of Domoic Acid in Plasma and Urine After Subacute Exposure. ACS Omega (2018)

Sara ShumJay S. KirkwoodJing JingRebekah PetroffBrenda CrouthamelKimberly S. GrantThomas M. BurbacherWendel L. NelsonNina Isoherranen

Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans. ACS Medicinal Chemistry Letters (2016)

Jennifer E. SagerJohn R. ChoiniereJustine ChangAlyssa Stephenson-FamyWendel L. NelsonNina Isoherranen

pharmaceutical chemistrystructural characterizationmedicinal chemistrymedicinepharmacologydrug metabolismdrug discovery

Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites. Synthesis (2015)

Aaron TeitelbaumMichele ScianWendel NelsonAllan Rettie

chain-shortened acid metabolitesefficient synthesespharmacologyorganic synthesis

Induction of Cyp26A1 by Metabolites of Retinoic Acid: Evidence That Cyp26A1 is an Important Enzyme in the Elimination of Active Retinoids. Molecular Pharmacology (2015)

Ariel R. TopletzSasmita TripathyRobert S. FotiJakob A. ShimshoniWendel L. NelsonNina Isoherranen

Justin D. LutzBrooke M. VandenBrinkKatipudi N. BabuWendel L. NelsonKent L. KunzeNina Isoherranen

risk assessmentpharmacokineticshuman pharmacokinetic parameterspharmacologyimpact assessmentdrug discoverypharmacotherapyenzyme inhibitionclinical pharmacologystatistics

Justin D. LutzBrooke M. VandenBrinkKatipudi N. BabuWendel L. NelsonKent L. KunzeNina Isoherranen

stereoselective inhibitionrisk assessmentpharmacokineticsmedicinepharmacologydrug metabolismclinical pharmacologypharmacotherapyenzyme inhibition

Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes. Journal of Biological Chemistry (2012)

Jakob A. ShimshoniArthur G. RobertsMichele ScianAriel R. TopletzSean A. BlankertJames R. HalpertWendel L. NelsonNina Isoherranen

metabolismenzymesmolecular metabolismprotein sciencebiochemistrypharmacologymolecular biologybiological chemistrystereoselective formation

Comparison of the Function and Expression of Cyp26A1 and Cyp26B1, the Two Retinoic Acid Hydroxylases. Biochemical Pharmacology (2011)

Ariel R. TopletzJayne E. ThatcherAlex ZelterJustin D. LutzSuzanne TayWendel L. NelsonNina Isoherranen

enzymesbiochemistrymolecular biologypharmacologygene expressionretinoic acid hydroxylases

Metabolism of Diltiazem: A Short Efficient Synthesis of N,N-Didesmethyldiltiazem - an Important Product of N-Demethylation. Synthesis (2011)

Wendel NelsonKantipudi BabuKent Kunze

short efficient synthesismetabolismpharmacologyorganic synthesis

1
2
3
4
5
12
10 / page

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future medicinal chemistry

medicinal chemistry

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Christopher R McCurdy

Institution

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pharmacological research

pharmacotherapy

Aleem Gangjee

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receptor tyrosine kinase inhibitors

synthetic medicinal chemistry

Werner Geldenhuys

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neurochemical biomarkers

Arun Ghosh

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