Faculty

Institution

Unit

Venue

Philip Portoghese

Distinguished Professor Emeritus Department of Medicinal Chemistry Distinguished Professor

University of Minnesota

Affiliations

College of Pharmacy

Medical Laboratory Sciences

Philip Portoghese is currently serving as a College Of Pharmacy Distinguished Professor Emeritus Department of Medicinal Chemistry Distinguished Professor at University of Minnesota.

Honors

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Experiences

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Education

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Philip Portoghese

University of Minnesota

Distinguished Professor Emeritus Department of Medicinal Chemistry Distinguished Professor

You can click a keyword to filter the displayed items

pharmacology medicinal chemistry neuropharmacology neuroscience receptors drug discovery neurology medicine medicinal research pharmaceutical chemistry addiction molecular pharmacology pharmacotherapy pharmacological research experimental pharmacology therapeutic targets stereochemical studies pharmaceutical sciences clinical pharmacology medicinal agents protein science pharmacokinetics opioid receptors mammalian biology addiction biology receptor (biochemistry) opioid use disorder peptide science enzyme inhibition food toxicology neurochemistry opioid overdose toxicology functional selectivity food science peptides drug targets pain research drug targeting fema gras assessment applied pharmacology food chemistry substance use inhibitory activity psychopharmacology experimental medicine spinal cord molecular docking heterocyclic rational drug design stereoselective synthesis absolute configuration opioid epidemic mechanisms of action opioid receptor antagonists flavor ingredients experimental biology heterocycle chemistry bivalent ligand antagonist activities biological evaluation dopamine in vivo systems rhesus monkeys bicyclic bases analgetic potency neuropeptide receptors neuropathic pain key site substance addiction morphine tolerance differential antagonism bivalent ligands behavioural pharmacology brain science mammalian physiology addiction medicine pain medicine pain management

Notable Scholarly Works

Notable Federal Grants

Collaborators

Peripherally Mediated Opioid Combination Therapy in Mouse and Pig. Journal of Pain (2024)

C D PetersonC M LarsonD J BruceB M ClementsK R PflepsenE AkgünK F KittoM M LunzerC A FairbanksP S PortogheseG L Wilcox

opioid use disordermedicinepain managementpharmacologydrug treatmentchronic painpain therapypain medicinepain researchpharmacotherapyanesthesiologyopioid combination therapypain mechanismtherapeutic approachesopioid overdose

Linh T. TranKatie T. FreemanMary M. LunzerPhilip S. PortogheseCarrie Haskell-Luevano

receptor selectivity profilespharmacologytranslational researchtranslational pharmacologypharmacological antinociceptive profilespharmacological studiesexperimental pharmacologypharmacological research

In Memory of Professor Hualiang Jiang. Journal of Medicinal Chemistry (2023)

Craig W. Lindsley, Ph.D

medicinal chemistrymedicinepharmacologychemistryprofessor hualiang jiangmemory

Mmg22 Potently Blocks Hyperalgesia in Cisplatin-Treated Mice. Neuroscience (2023)

Giuseppe CataldoMary M. LunzerEyup AkgünHenry L. WongPhilip S. PortogheseDonald A. Simone

neurologycisplatin-treated miceneurophysiologyneuroscienceneuroanatomy

Opioid Receptors in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

Anna BorsodiMichael BruchasGirolamo CalóCharles ChavkinMacDonald J. ChristieOlivier CivelliMark ConnorBrian M. CoxLakshmi A. DeviChristopher EvansVolker HölltGraeme HendersonStephen HusbandsEamonn KellyBrigitte KiefferIan KitchenMary-Jeanne KreekLee-Yuan Liu-ChenDavide MalfaciniDominique MassotJean-Claude MeunierPhilip S. PortogheseStefan SchulzToni S. ShippenbergEric J. SimonLawrence TollJohn R. TraynorHiroshi UedaYung H. WongNurulain ZaveriAndreas Zimmer

physiologyopioid receptorspharmacologyneuropharmacology

Fbnti, a Dor-Selective Antagonist That Allosterically Activates Mor Within a Mor–Dor Heteromer. Biochemistry (2020)

Eyup AkgünMary M. LunzerDefeng TianMichael AnsonoffJohn PintarDaniel BruceJon E. HawkinsonGeorge L. WilcoxPhilip S. Portoghese

neurologydor-selective antagonistgene expressionsignal transductionneurosciencemor-dor heteromerbiochemistry

The Bivalent Ligand, Mmg22, Reduces Neuropathic Pain After Nerve Injury Without the Side Effects of Traditional Opioids. Pain (2020)

Rebecca SpeltzMary M. LunzerSarah S. ShuebEyup AkgünRachelle ReedAlex KalyuzhnyPhilip S. PortogheseDonald A. Simone

neurologypain managementpharmacologyneuropathic paintraditional opioidsbivalent ligandnerve injuryneuroscience

Opioid Receptors (Version 2019.4) in the Iuphar/Bps Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE (2019)

Anna BorsodiMichael BruchasGirolamo CalóCharles ChavkinMacDonald J. ChristieOlivier CivelliMark ConnorBrian M. CoxLakshmi A. DeviChristopher EvansVolker HölltGraeme HendersonStephen HusbandsEamonn KellyBrigitte KiefferIan KitchenMary-Jeanne KreekLee-Yuan Liu-ChenDominique MassotJean-Claude MeunierPhilip S. PortogheseStefan SchulzToni S. ShippenbergEric J. SimonLawrence TollJohn R. TraynorHiroshi UedaYung H. WongNurulain ZaveriAndreas Zimmer

physiologyopioid receptorspharmacologyneuropharmacology

Stereochemistry and Innate Immune Recognition: (+)‐Norbinaltorphimine Targets Myeloid Differentiation Protein 2 and Inhibits Toll‐Like Receptor 4 Signaling. The FASEB Journal (2019)

Xiaozheng ZhangYinghua PengPeter M. GraceMatthew D. MetcalfAndrew J. KwilaszYibo WangTianshu ZhangSiru WuBrandon R. SelfridgePhilip S. PortogheseKenner C. RiceLinda R. WatkinsMark R. HutchinsonXiaohui Wang

immunologyreceptorsinnate immune systeminnate immune recognition

Targeting Mor-Mglur5 Heteromers Reduces Bone Cancer Pain by Activating Mor and Inhibiting Mglur5. Neuropharmacology (2019)

Sarah S. ShuebSamuel J. ErbMary M. LunzerRebecca SpeltzCatherine Harding-RoseEyup AkgünDonald A. SimonePhilip S. Portoghese

tumor targetingmedicinebone cancer painneuropharmacologyanti-cancer agentsbone researchinflammationcancer paintherapeutic targetscancer immunotherapydrug targetingcancer treatmentenzyme inhibitionpharmacologypain researchpharmacotherapyoncologymedicinal researchneuroscience

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Philip Portoghese

Distinguished Professor Emeritus Department of Medicinal Chemistry Distinguished Professor

University of Minnesota

Affiliations

College of Pharmacy

Medical Laboratory Sciences

Philip Portoghese is currently serving as a College Of Pharmacy Distinguished Professor Emeritus Department of Medicinal Chemistry Distinguished Professor at University of Minnesota.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Philip Portoghese

University of Minnesota

Distinguished Professor Emeritus Department of Medicinal Chemistry Distinguished Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Peripherally Mediated Opioid Combination Therapy in Mouse and Pig. Journal of Pain (2024)

C D PetersonC M LarsonD J BruceB M ClementsK R PflepsenE AkgünK F KittoM M LunzerC A FairbanksP S PortogheseG L Wilcox

Linh T. TranKatie T. FreemanMary M. LunzerPhilip S. PortogheseCarrie Haskell-Luevano

In Memory of Professor Hualiang Jiang. Journal of Medicinal Chemistry (2023)

Craig W. Lindsley, Ph.D

medicinal chemistrymedicinepharmacologychemistryprofessor hualiang jiangmemory

Mmg22 Potently Blocks Hyperalgesia in Cisplatin-Treated Mice. Neuroscience (2023)

Giuseppe CataldoMary M. LunzerEyup AkgünHenry L. WongPhilip S. PortogheseDonald A. Simone

neurologycisplatin-treated miceneurophysiologyneuroscienceneuroanatomy

Opioid Receptors in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

physiologyopioid receptorspharmacologyneuropharmacology

Fbnti, a Dor-Selective Antagonist That Allosterically Activates Mor Within a Mor–Dor Heteromer. Biochemistry (2020)

Eyup AkgünMary M. LunzerDefeng TianMichael AnsonoffJohn PintarDaniel BruceJon E. HawkinsonGeorge L. WilcoxPhilip S. Portoghese

neurologydor-selective antagonistgene expressionsignal transductionneurosciencemor-dor heteromerbiochemistry

The Bivalent Ligand, Mmg22, Reduces Neuropathic Pain After Nerve Injury Without the Side Effects of Traditional Opioids. Pain (2020)

Rebecca SpeltzMary M. LunzerSarah S. ShuebEyup AkgünRachelle ReedAlex KalyuzhnyPhilip S. PortogheseDonald A. Simone

neurologypain managementpharmacologyneuropathic paintraditional opioidsbivalent ligandnerve injuryneuroscience

Opioid Receptors (Version 2019.4) in the Iuphar/Bps Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE (2019)

Anna BorsodiMichael BruchasGirolamo CalóCharles ChavkinMacDonald J. ChristieOlivier CivelliMark ConnorBrian M. CoxLakshmi A. DeviChristopher EvansVolker HölltGraeme HendersonStephen HusbandsEamonn KellyBrigitte KiefferIan KitchenMary-Jeanne KreekLee-Yuan Liu-ChenDominique MassotJean-Claude MeunierPhilip S. PortogheseStefan SchulzToni S. ShippenbergEric J. SimonLawrence TollJohn R. TraynorHiroshi UedaYung H. WongNurulain ZaveriAndreas Zimmer

physiologyopioid receptorspharmacologyneuropharmacology

Stereochemistry and Innate Immune Recognition: (+)‐Norbinaltorphimine Targets Myeloid Differentiation Protein 2 and Inhibits Toll‐Like Receptor 4 Signaling. The FASEB Journal (2019)

immunologyreceptorsinnate immune systeminnate immune recognition

Targeting Mor-Mglur5 Heteromers Reduces Bone Cancer Pain by Activating Mor and Inhibiting Mglur5. Neuropharmacology (2019)

Sarah S. ShuebSamuel J. ErbMary M. LunzerRebecca SpeltzCatherine Harding-RoseEyup AkgünDonald A. SimonePhilip S. Portoghese

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