Faculty

Institution

Unit

Venue

Michael Weiss

Chair Distinguished Professor Robert A Harris Professor of Biochemistry & Molecular Biology Precision Health Initiative Professor

Indiana University Bloomington

Affiliations

School of Medicine

Biochemistry and Molecular Biology

College of Arts & Sciences

Molecular and Cellular Biochemistry, Department of

Michael Weiss is currently serving as a Biochemistry And Molecular Biology Chair Distinguished Professor Robert A Harris Professor of Biochemistry & Molecular Biology Precision Health Initiative Professor at Indiana University Bloomington.

Honors

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Experiences

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Education

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Michael Weiss

Indiana University Bloomington

Chair Distinguished Professor Robert A Harris Professor of Biochemistry & Molecular Biology Precision Health Initiative Professor

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molecular biology structural biology biochemistry genetics protein science pharmacology endocrinology protein structure biological chemistry protein folding insulin signaling membrane biology diabetes structural molecular biology medicinal chemistry biomolecular structure molecular physiology human genetics mammalian biology medicinal research receptor (biochemistry) endocrine research genome biology biomolecular interactions rna biology biochemical sciences human insulin protein chemistry diabetes mellitus insulin receptor cellular biochemistry molecular metabolism molecular science gene function phage biology insulin delivery human sex reversal diabetes-associated mutations solution structure raman spectroscopy liver physiology biochemical genetics integrative biology metabolic regulation medical genetics human proinsulin clinical biochemistry redox biology functional modification transcription regulation molecular regulation mutagenesis cytogenetics protein nmr protein evolution insulin fibrillation sexual dimorphism chiral mutagenesis hidden thermodynamics mutant proinsulin syndrome protein expression structural composition receptor tyrosine kinases protein misfolding pharmaceutical chemistry crystal structures molecular spectroscopy gene regulation cellular biology protein bioinformatics rational drug design structural switch receptor binding rna recognition insert domain ester insulin

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ultra-Stable Insulin-Glucagon Fusion Protein Exploits an Endogenous Hepatic Switch to Mitigate Hypoglycemic Risk. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Nicolas VarasRachel GrabowskiMark A. JarosinskiNingwen TaiRaimund I. HerzogFaramarz Ismail-BeigiYanwu YangAlan D. CherringtonMichael A. Weiss

liver physiologydiabetes managementpharmacologyendogenous hepatic switchnephrologyinsulin signalinghealth sciencesbiological engineeringdiabetic medicineendocrinologyallostatic loaddiabetesinsulin managementcardiovascular researchmetabolic regulationhepatologyhypoglycemic riskmolecular physiologymembrane biologydiabetes therapies

In Silico Investigation of the Clinical Translatability of Competitive Clearance Glucose-Responsive Insulins. ACS Pharmacology & Translational Science (2023)

Jing Fan YangSungyun YangXun GongNaveed A. BakhGe ZhangAllison B. WangAlan D. CherringtonMichael A. WeissMichael S. Strano

biochemistrymedicineclinical translatabilitypharmacologydrug discovery

Rational Design and Efficacy of Glucose‐Responsive Insulin Therapeutics and Insulin Delivery Systems by Computation Using Connected Human and Rodent Models. Advanced Healthcare Materials (2023)

Sungyun YangJing Fan YangXun GongMichael A. WeissMichael S. Strano

rational designcomputational biologydrug deliverymathematical biologycomputational medicinerodent modelsrational drug designhealth technologyglucose-responsive insulin therapeuticsmedicinepharmacologybiomedical modelinginsulin deliveryendocrinologyinsulin delivery systemshealth sciencestherapeutic efficacyformal methods

Se‐Glargine: Chemical Synthesis of a Basal Insulin Analogue Stabilized by an Internal Diselenide Bridge. ChemBioChem (2023)

Orit Weil‐KtorzaBalamurugan DhayalanYen‐Shan ChenMichael A. WeissNorman Metanis

basal insulin analoguechemical synthesischemistryinternal diselenide bridge

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Yen-Shan ChenBalamurugan DhayalanYanwu YangOrit Weil-KtorzaNorman MetanisMichael A. Weiss

biophysicsinternal diselenide bridgebasal insulin analogse-glargine iimolecular biologypharmacologynative functionendocrinology

Diabetes-Associated Mutations in Proinsulin Provide a “Molecular Rheostat” of Nascent Foldability. Current Diabetes Reports (2022)

Balamurugan DhayalanMichael A. Weiss

diabetes-associated mutationsprotein sciencenascent foldabilitydevelopmental biologymolecular rheostatmolecular biologydiabetesgenetics

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation. Frontiers in Endocrinology (2022)

Balamurugan DhayalanMichael D. GliddenAlexander N. ZaykovYen-Shan ChenYanwu YangNelson B. PhillipsFaramarz Ismail-BeigiMark A. JarosinskiRichard D. DiMarchiMichael A. Weiss

clinical correlationpeptide modelmutant proinsulin syndromepharmacologyendocrinology

Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications. Frontiers in Endocrinology (2022)

Yanwu YangMichael D. GliddenBalamurugan DhayalanAlexander N. ZaykovYen-Shan ChenNalinda P. WickramasingheRichard D. DiMarchiMichael A. Weiss

biological implicationspeptide modelnascent structuremutant proinsulin syndromepharmacologyendocrinology

Rf04 | Psun233 Design of an Ultra-Stable Insulin/Glucagon Fusion Protein. Journal of the Endocrine Society (2022)

Rachel GrabowskiFaramarz Ismail-BeigiMark JarosinskiNelson PhillipsShayan PoordianNicolas VarasMichael Weiss

fusionprotein designprotein engineeringendocrine researchendocrinologybiomolecular engineering

Single-Chain Insulin Analogs Threaded by the Insulin Receptor αCt Domain. Biophysical journal (2022)

Nicholas A. SmithJohn G. MentingMichael A. WeissMichael C. LawrenceBrian J. Smith

biophysicssingle-chain insulin analogsphysiologyprotein sciencemolecular biophysicspharmacologyendocrinologybiophysical chemistrystructural biology

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Michael Weiss

Chair Distinguished Professor Robert A Harris Professor of Biochemistry & Molecular Biology Precision Health Initiative Professor

Indiana University Bloomington

Affiliations

School of Medicine

Biochemistry and Molecular Biology

College of Arts & Sciences

Molecular and Cellular Biochemistry, Department of

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Weiss

Indiana University Bloomington

Chair Distinguished Professor Robert A Harris Professor of Biochemistry & Molecular Biology Precision Health Initiative Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ultra-Stable Insulin-Glucagon Fusion Protein Exploits an Endogenous Hepatic Switch to Mitigate Hypoglycemic Risk. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Nicolas VarasRachel GrabowskiMark A. JarosinskiNingwen TaiRaimund I. HerzogFaramarz Ismail-BeigiYanwu YangAlan D. CherringtonMichael A. Weiss

In Silico Investigation of the Clinical Translatability of Competitive Clearance Glucose-Responsive Insulins. ACS Pharmacology & Translational Science (2023)

Jing Fan YangSungyun YangXun GongNaveed A. BakhGe ZhangAllison B. WangAlan D. CherringtonMichael A. WeissMichael S. Strano

biochemistrymedicineclinical translatabilitypharmacologydrug discovery

Rational Design and Efficacy of Glucose‐Responsive Insulin Therapeutics and Insulin Delivery Systems by Computation Using Connected Human and Rodent Models. Advanced Healthcare Materials (2023)

Sungyun YangJing Fan YangXun GongMichael A. WeissMichael S. Strano

Se‐Glargine: Chemical Synthesis of a Basal Insulin Analogue Stabilized by an Internal Diselenide Bridge. ChemBioChem (2023)

Orit Weil‐KtorzaBalamurugan DhayalanYen‐Shan ChenMichael A. WeissNorman Metanis

basal insulin analoguechemical synthesischemistryinternal diselenide bridge

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Yen-Shan ChenBalamurugan DhayalanYanwu YangOrit Weil-KtorzaNorman MetanisMichael A. Weiss

biophysicsinternal diselenide bridgebasal insulin analogse-glargine iimolecular biologypharmacologynative functionendocrinology

Diabetes-Associated Mutations in Proinsulin Provide a “Molecular Rheostat” of Nascent Foldability. Current Diabetes Reports (2022)

Balamurugan DhayalanMichael A. Weiss

diabetes-associated mutationsprotein sciencenascent foldabilitydevelopmental biologymolecular rheostatmolecular biologydiabetesgenetics

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation. Frontiers in Endocrinology (2022)

Balamurugan DhayalanMichael D. GliddenAlexander N. ZaykovYen-Shan ChenYanwu YangNelson B. PhillipsFaramarz Ismail-BeigiMark A. JarosinskiRichard D. DiMarchiMichael A. Weiss

clinical correlationpeptide modelmutant proinsulin syndromepharmacologyendocrinology

Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications. Frontiers in Endocrinology (2022)

Yanwu YangMichael D. GliddenBalamurugan DhayalanAlexander N. ZaykovYen-Shan ChenNalinda P. WickramasingheRichard D. DiMarchiMichael A. Weiss

biological implicationspeptide modelnascent structuremutant proinsulin syndromepharmacologyendocrinology

Rf04 | Psun233 Design of an Ultra-Stable Insulin/Glucagon Fusion Protein. Journal of the Endocrine Society (2022)

Rachel GrabowskiFaramarz Ismail-BeigiMark JarosinskiNelson PhillipsShayan PoordianNicolas VarasMichael Weiss

fusionprotein designprotein engineeringendocrine researchendocrinologybiomolecular engineering

Single-Chain Insulin Analogs Threaded by the Insulin Receptor αCt Domain. Biophysical journal (2022)

Nicholas A. SmithJohn G. MentingMichael A. WeissMichael C. LawrenceBrian J. Smith

biophysicssingle-chain insulin analogsphysiologyprotein sciencemolecular biophysicspharmacologyendocrinologybiophysical chemistrystructural biology

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2
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4
5
19
10 / page

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