Faculty

Institution

Unit

Venue

Victor Hruby

Regents Professor Emeritus - Retired

University of Arizona

Affiliations

College of Science

Chemistry and Biochemistry

Victor Hruby is currently serving as a Chemistry And Biochemistry Regents Professor Emeritus - Retired at University of Arizona.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Victor Hruby

University of Arizona

Regents Professor Emeritus - Retired

You can click a keyword to filter the displayed items

pharmacology medicinal chemistry neuroscience drug discovery organic synthesis neuropharmacology receptors biochemistry physiology peptides endocrinology protein science peptide science organic chemistry structural biology peptide engineering peptide synthesis pharmaceutical chemistry medicinal research conformational studies mammalian biology pharmaceutical sciences pharmacokinetics pharmacotherapy biological chemistry receptor (biochemistry) asymmetric synthesis rational drug design pharmacological research melanoma protein chemistry neurochemistry drug targeting functional selectivity animal physiology clinical pharmacology molecular design clinical chemistry liver physiology stereoselective synthesis pain research experimental pharmacology biological evaluation enzyme inhibition melanocortin receptors functional modification mammalian physiology structure-activity relationships amino acids biochemical sciences cellular physiology enantioselective synthesis opioid receptors tumor targeting drug development biological activities structural chemistry inhibitory activity molecular docking endocrine research translational pharmacology pain therapy receptor tyrosine kinases derivative (chemistry) plasmonics comparative endocrinology rat brain plasmon-waveguide resonance spectroscopy human d-opioid receptor neuropathic pain biological activity structure-activity studies conformational analysis solid-phase synthesis opioid peptides michael addition reactions multimeric ligands non-peptide ligand addiction biology molecular pharmacology peptide hormones

Notable Scholarly Works

Notable Federal Grants

Collaborators

Design, Structure–Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-Like Peptide-1 Receptor Agonists. Molecules (2024)

Jonathon R. SawyerJoseph A. AudieJon SwansonDavid DillerSolimar SantiagoValentin K. GribkoffAllison AckermanVictor J. HrubyGianpaolo GobboMichael A. BellucciWilliam A. GlauserBrad L. PenteluteTomi K. Sawyer

peptide engineeringstructure-activity relationshipspharmacologyg protein-coupled receptorstructural molecular biologypeptide therapeuticspeptidesmolecular biologyreceptorscomputational modeling studiesbiomolecular structureprotein modelingbiochemistryprotein structurestructural biologymolecular modellingpeptide sciencereceptor (biochemistry)molecular pharmacologymolecular structure

Melanocortin Receptors in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

Vanni CarusoBiao-Xin ChaiAdrian J. L. ClarkRoger D. ConeAlex N. EberleSadaf FarooqiTung M. FongIra GantzCarrie Haskell-LuevanoVictor J. HrubyKathleen G. MountjoyColin PoutonHelgi SchiöthJeffrey B. TatroJarl E. S. Wikberg

psychiatrymelanocortin receptorspharmacologyneuropharmacology

Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His- D -Phe-Arg-Trp-Nh 2 Lead to Potent and Selective Agonists at Hmc1R and Hmc4r. Journal of Medicinal Chemistry (2023)

Yang ZhouSaghar Mowlazadeh HaghighiJonathon R. SawyerVictor J. HrubyMinying Cai

angle constrainssurface sciencelead identificationpeptide sciencepeptideschemistrypharmacologyc-terminus trp position

Clipsing Melanotan-II to Discover Multiple Functionally Selective Hmcr Agonists. Journal of Medicinal Chemistry (2022)

Stefano TomassiMarilisa Pia DimmitoMinying CaiAntonia D’AnielloAlessandra Del BeneAnna MessereZekun LiuTingyi ZhuVictor J. HrubyAzzurra StefanucciSandro CosconatiAdriano MollicaSalvatore Di Maro

functional selectivitymedicinal chemistrypharmacologydrug discoveryselective hmcr agonists

Contributors. Elsevier eBooks (2022)

Ron AltermanJeffrey E. ArleKerry BradleySergio CanaveroSteven M. FalowskiChad W. FarleyYakov GologorskyJianwen Wendy GuH. Louis JournéeJohn KastOlga KhazenJoachim K. KraussVignessh KumarMark LentRobert M. LevyAndres M. LozanoCharles MackelGeorge T. MandyburBryan L. McLaughlinDaniel R. MerrillAlon Y. MogilnerGabi MolnarGuillermo A. MonsalveRichard B. NorthYunseo Linda ParkJohn ParkerShrey PatelJulie G. PilitsisFrancisco A. PonceJason E. PopeAdolfo Ramirez-ZamoraLouis J. RasoJoshua M. RosenowJay L. ShilsPeter SingleKonstantin V. SlavinMichael D. StaudtMark M. SteckerHuy Q. Truong

Mc4R Biased Signalling and the Conformational Basis of Biological Function Selections. Journal of Cellular and Molecular Medicine (2022)

Zekun LiuVictor J. Hruby

conformational basisprotein sciencecell signalingcell biologysignaling pathwayspharmacologysignal transductiongene expressionbiological function selectionsgeneticscell and molecular biology

Aged Brains Express Less Melanocortin Receptors, Which Correlates With Age-Related Decline of Cognitive Functions. Molecules (2021)

Yang ZhouMonica K. ChawlaJose L. Rios-MonterrosaLingzhi WangMarc A. ZempareVictor J. HrubyCarol A. BarnesMinying Cai

neurologyneuroscience of agingcognitive functionsmelanocortin receptorscognitive neuroscienceneuroscienceage-related declinebrain science

Antagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Antinociception by Activating Src and Calcium/Calmodulin-Dependent Protein Kinase II Signaling. Pain (2021)

Attila KeresztesKeith OlsonPaul NguyenMarissa A. Lopez-PierRyan HeckselNatalie K. BarkerZekun LiuVictor HrubyJohn KonhilasPaul R. LanglaisJohn M. Streicher

pain researchneuropharmacologyneuroscienceaddictionmedicinepharmacologypain management

C-Terminal Modified Enkephalin-Like Tetrapeptides With Enhanced Affinities at the Kappa Opioid Receptor and Monoamine Transporters. Bioorganic & Medicinal Chemistry (2021)

None Mehr-un-NisaMunawar A. MunawarDavid RankinVictor J. HrubyFrank PorrecaYeon Sun Lee

enkephalin-like tetrapeptidesneuropharmacologyphysiologymedicinal chemistrykappa opioid receptorpharmacologyenhanced affinitiesdrug discoverymonoamine transportersreceptors

Multifunctional Enkephalin Analogs With a New Biological Profile: Mor/Dor Agonism and Kor Antagonism. Biomedicines (2021)

Yeon Sun LeeMichael RemesicCyf Ramos-ColonZhijun WuJustin LaVigneGabriella MolnarDagmara TymeckaAleksandra MisickaJohn M. StreicherVictor J. HrubyFrank Porreca

multifunctional enkephalin analogsphysiologytranslational medicinemedicinal chemistrymedicinepharmacologydrug discovery

1
2
3
4
5
121
10 / page

Victor Hruby

Regents Professor Emeritus - Retired

University of Arizona

Affiliations

College of Science

Chemistry and Biochemistry

Victor Hruby is currently serving as a Chemistry And Biochemistry Regents Professor Emeritus - Retired at University of Arizona.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Victor Hruby

University of Arizona

Regents Professor Emeritus - Retired

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Design, Structure–Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-Like Peptide-1 Receptor Agonists. Molecules (2024)

Melanocortin Receptors in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

psychiatrymelanocortin receptorspharmacologyneuropharmacology

Yang ZhouSaghar Mowlazadeh HaghighiJonathon R. SawyerVictor J. HrubyMinying Cai

angle constrainssurface sciencelead identificationpeptide sciencepeptideschemistrypharmacologyc-terminus trp position

Clipsing Melanotan-II to Discover Multiple Functionally Selective Hmcr Agonists. Journal of Medicinal Chemistry (2022)

Stefano TomassiMarilisa Pia DimmitoMinying CaiAntonia D’AnielloAlessandra Del BeneAnna MessereZekun LiuTingyi ZhuVictor J. HrubyAzzurra StefanucciSandro CosconatiAdriano MollicaSalvatore Di Maro

functional selectivitymedicinal chemistrypharmacologydrug discoveryselective hmcr agonists

Contributors. Elsevier eBooks (2022)

Mc4R Biased Signalling and the Conformational Basis of Biological Function Selections. Journal of Cellular and Molecular Medicine (2022)

Zekun LiuVictor J. Hruby

conformational basisprotein sciencecell signalingcell biologysignaling pathwayspharmacologysignal transductiongene expressionbiological function selectionsgeneticscell and molecular biology

Aged Brains Express Less Melanocortin Receptors, Which Correlates With Age-Related Decline of Cognitive Functions. Molecules (2021)

Yang ZhouMonica K. ChawlaJose L. Rios-MonterrosaLingzhi WangMarc A. ZempareVictor J. HrubyCarol A. BarnesMinying Cai

neurologyneuroscience of agingcognitive functionsmelanocortin receptorscognitive neuroscienceneuroscienceage-related declinebrain science

Antagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Antinociception by Activating Src and Calcium/Calmodulin-Dependent Protein Kinase II Signaling. Pain (2021)

Attila KeresztesKeith OlsonPaul NguyenMarissa A. Lopez-PierRyan HeckselNatalie K. BarkerZekun LiuVictor HrubyJohn KonhilasPaul R. LanglaisJohn M. Streicher

pain researchneuropharmacologyneuroscienceaddictionmedicinepharmacologypain management

C-Terminal Modified Enkephalin-Like Tetrapeptides With Enhanced Affinities at the Kappa Opioid Receptor and Monoamine Transporters. Bioorganic & Medicinal Chemistry (2021)

None Mehr-un-NisaMunawar A. MunawarDavid RankinVictor J. HrubyFrank PorrecaYeon Sun Lee

enkephalin-like tetrapeptidesneuropharmacologyphysiologymedicinal chemistrykappa opioid receptorpharmacologyenhanced affinitiesdrug discoverymonoamine transportersreceptors

Multifunctional Enkephalin Analogs With a New Biological Profile: Mor/Dor Agonism and Kor Antagonism. Biomedicines (2021)

Yeon Sun LeeMichael RemesicCyf Ramos-ColonZhijun WuJustin LaVigneGabriella MolnarDagmara TymeckaAleksandra MisickaJohn M. StreicherVictor J. HrubyFrank Porreca

multifunctional enkephalin analogsphysiologytranslational medicinemedicinal chemistrymedicinepharmacologydrug discovery

1
2
3
4
5
121
10 / page

Similar Faculty Members

Craig W. Lindsley, Ph.D

Institution

Vanderbilt University

neuroscience

medicine

Amos Smith

Institution

University of Pennsylvania

protein folding

bioorganic chemistry

Alexandros Makriyannis

Institution

Northeastern University

biological chemistry

receptor

Lawrence J. Marnett

Institution

Vanderbilt University

anti-inflammatory agent

biochemistry

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Francis Castellino

Institution

University of Notre Dame

pharmacology

biochemistry

Allan Sherry

Institution

University of Texas at Dallas

radiology

magnetic resonance spectroscopy

Baldomero Olivera

Institution

University of Utah

evolutionary biology

chemical ecology

Jonathan V Sweedler

Institution

University of Illinois Urbana-Champaign

applied microbiology

systems biology

Vsevolod Gurevich

Institution

Vanderbilt University

molecular biology

arrestin proteins

Similar Faculty Members

Craig W. Lindsley, Ph.D

Institution

Vanderbilt University

neuroscience

medicine

Amos Smith

Institution

University of Pennsylvania

protein folding

bioorganic chemistry

Alexandros Makriyannis

Institution

Northeastern University

biological chemistry

receptor

Lawrence J. Marnett

Institution

Vanderbilt University

anti-inflammatory agent

biochemistry

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Francis Castellino

Institution

University of Notre Dame

pharmacology

biochemistry

Allan Sherry

Institution

University of Texas at Dallas

radiology

magnetic resonance spectroscopy

Baldomero Olivera

Institution

University of Utah

evolutionary biology

chemical ecology

Jonathan V Sweedler

Institution

University of Illinois Urbana-Champaign

applied microbiology

systems biology

Vsevolod Gurevich

Institution

Vanderbilt University

molecular biology

arrestin proteins