Faculty

Institution

Unit

Venue

Timothy C. Chambers

University of Arkansas for Medical Sciences

Affiliations

University of Arkansas for Medical Sciences, Research

NoneTimothy C. Chambers is currently serving as a University Of Arkansas For Medical Sciences, Research faculty at University of Arkansas For Medical Sciences.

Honors

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Experiences

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Education

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Timothy C. Chambers

University of Arkansas for Medical Sciences

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molecular biology biochemistry cell biology tumor biology cell death medicinal research cell signaling biomolecular engineering enzyme inhibition protein phosphorylation oncogenes apoptosis cancer biology gene expression oncology molecular cell biology molecular and cellular biology signal transduction cancer research cancer cells therapeutic targets protein science anti-cancer agents biological chemistry cancer discovery cancer treatment leukemia vascular biology free radical biology signaling pathways pharmaceutical chemistry cell cycle biochemical sciences peptide science tumor targeting key site inhibitory activity hematological malignancies structural molecular biology peptides biomolecular interactions receptor tyrosine kinases mitophagy protein chemistry lymphoid neoplasia mitotic arrest microtubule inhibitors anticancer activity molecular pathways cell regulation tumor suppressors biochemical interaction molecular docking redox signaling phosphorylation sites cellular immune responses pharmacokinetics lipoprotein metabolism protein transport glycosylation g protein-coupled receptor molecular regulation cellular senescence malignant disease mitogen-activated protein kinases human p-glycoprotein phorbol ester p-glycoprotein phosphorylation linker region multidrug resistance key role molecular analysis apoptotic response vinblastine-induced apoptosis salinomycin analogs vinblastine-induced phosphorylation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anti-Glioblastoma Activity of Monensin and Its Analogs in an Organoid Model of Cancer. Biomedicine & Pharmacotherapy (2022)

Alicja UrbaniakMegan R. ReedBillie HeflinJohn GaydosSergio Piña-OviedoMarta JędrzejczykGreta KlejborowskaNatalia StępczyńskaTimothy C. ChambersAlan J. TackettAnaliz RodriguezAdam HuczyńskiRobert L. EoffAngus M. MacNicol

medicinecancer biologyclinical therapeuticspharmacologypharmaceuticsorganoid modeltumor biologycellular therapyoncologycancer treatmentanti-glioblastoma activitydrug discoveryimmunologymedicinal researchpharmacological researchdrug targetingclinical pharmacologyclinical researchpharmacotherapydrug delivery

Monensin and Its Analogues Show Anti‐Glioblastoma Activity in an Organoid Model of Cancer. The FASEB Journal (2022)

Alicja UrbaniakMegan R. ReedBillie HeflinJohn GaydosSergio Piña‐OviedoMarta JędrzejczykGreta KlejborowskaNatalia StępczyńskaTimothy C. ChambersAlan J. TackettAnaliz RodriguezAdam HuczyńskiRobert L. EoffAngus M. MacNicol

cancer immunotherapymedicinecancer biologypharmacologytumor biologycancer researchoncologycancer carecancer treatmentbrain tumor researchanti-glioblastoma activityanti-cancer agentsneuro-oncologyimmunologymedicinal researchcancer imaginghematological malignanciesdrug targetingorganoid modelenzyme inhibition

Primary Acute Lymphoblastic Leukemia Cells Are Susceptible to Microtubule Depolymerization in G1 and M Phases Through Distinct Cell Death Pathways. Journal of Biological Chemistry (2022)

Magdalena DelgadoRandall R. RainwaterBillie HeflinAlicja UrbaniakKaitlynn ButlerMari DavidsonReine M. ProtacioGiulia BaldiniAndrea EdwardsMegan R. ReedKevin D. RaneyTimothy C. Chambers

hematologytumor biologygeneticscancer biologycell biologycytogeneticsimmunologycell deathstructural biology

Abstract Ps18-46: Inhibition of Breast Cancer Stem Cells in 2- and 3-Dimensional Culture by Novel Salinomycin Analogs. Cancer Research (2021)

Alicja Joanna UrbaniakMegan R. ReedMichał AntoszczakMichał SulikAdam HuczyńskiRobert L. EoffMelanie C. MacNicolTimothy C. ChambersAngus M. MacNicol

cancer researchcancer biologynovel salinomycin analogsmolecular biologybreast cancer

Phosphoproteomics Provides Novel Insights Into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS Omega (2021)

Magdalena DelgadoCharity L. WashamAlicja UrbaniakBillie HeflinAaron J. StoreyRenny S. LanSamuel G. MackintoshAlan J. TackettStephanie D. ByrumTimothy C. Chambers

tumor biologycancer biologycell biologycell cycleimmunologypharmacologyproteomicsbreast cancer

Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models. Biomedicine & Pharmacotherapy (2021)

Alicja UrbaniakMegan R ReedDaniel FilAnika MoorjaniSarah HeflinMichał AntoszczakMichał SulikAdam HuczyńskiMichalina KupsikRobert L EoffMelanie C MacNicolTimothy C ChambersAngus M MacNicol

tumor biologystem cell researchsalinomycin analogsbiomolecular engineeringstem-like cellsstem-cell therapystem cellsbreast cancer modelsbiomedical engineeringcancer treatmenttherapeutic targetssynthetic biologytumor targetingmolecular biologycancer discoverybreast cancermedicinal researchpharmacotherapy

Synthesis, Anticancer Activity and Molecular Docking Studies of N-Deacetylthiocolchicine and 4-Iodo-N-Deacetylthiocolchicine Derivatives. Bioorganic & Medicinal Chemistry (2021)

Greta KlejborowskaAlicja UrbaniakEwa MajJoanna WietrzykMahshad MoshariJordane PretoJack A. TuszynskiTimothy C. ChambersAdam Huczyński

anti-cancer agentspharmaceutical chemistryanticancer activitybiomolecular engineeringbioactive compoundsdrug developmentmedicinal chemistrymolecular dockingbioorganic chemistryrational drug designpeptide sciencebiochemistrytherapeutic targetsnatural product researchmolecular biologydrug discoverymedicinal research

Carbamate Derivatives of Colchicine Show Potent Activity Towards Primary Acute Lymphoblastic Leukemia and Primary Breast Cancer Cells—in Vitro and Ex Vivo Study. Journal of Biochemical and Molecular Toxicology (2020)

Alicja UrbaniakFariba JousheghanySergio Piña‐OviedoYouzhong YuanUrszula Majcher‐UchańskaGreta KlejborowskaAnika MoorjaniBehjatolah Monzavi‐KarbassiAdam HuczyńskiTimothy C. Chambers

in vitro toxicologyex vivo studybiochemistrycarbamate derivativesbreast cancer

Limitations of an Ex Vivo Breast Cancer Model for Studying the Mechanism of Action of the Anticancer Drug Paclitaxel. European Journal of Pharmacology (2020)

Alicja UrbaniakSergio Piña-OviedoYouzhong YuanAdam HuczyńskiTimothy C. Chambers

oncologyanticancer drug paclitaxelpharmacologycancer treatmentbreast cancer

Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells. The FASEB Journal (2020)

Alicja UrbaniakMegan R. ReedMichał AntoszczakMichał SulikAdam HuczyñskiRobert L. EoffMelanie C. MacNicolAngus M. MacNicolTimothy C. Chambers

stem cellscancer cellsnovel salinomycin analogscancer treatmenttherapeutic targetsmolecular biologycancer discoverybreast cancer

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Timothy C. Chambers

University of Arkansas for Medical Sciences

Affiliations

University of Arkansas for Medical Sciences, Research

NoneTimothy C. Chambers is currently serving as a University Of Arkansas For Medical Sciences, Research faculty at University of Arkansas For Medical Sciences.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Timothy C. Chambers

University of Arkansas for Medical Sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anti-Glioblastoma Activity of Monensin and Its Analogs in an Organoid Model of Cancer. Biomedicine & Pharmacotherapy (2022)

Monensin and Its Analogues Show Anti‐Glioblastoma Activity in an Organoid Model of Cancer. The FASEB Journal (2022)

Primary Acute Lymphoblastic Leukemia Cells Are Susceptible to Microtubule Depolymerization in G1 and M Phases Through Distinct Cell Death Pathways. Journal of Biological Chemistry (2022)

Magdalena DelgadoRandall R. RainwaterBillie HeflinAlicja UrbaniakKaitlynn ButlerMari DavidsonReine M. ProtacioGiulia BaldiniAndrea EdwardsMegan R. ReedKevin D. RaneyTimothy C. Chambers

hematologytumor biologygeneticscancer biologycell biologycytogeneticsimmunologycell deathstructural biology

Abstract Ps18-46: Inhibition of Breast Cancer Stem Cells in 2- and 3-Dimensional Culture by Novel Salinomycin Analogs. Cancer Research (2021)

Alicja Joanna UrbaniakMegan R. ReedMichał AntoszczakMichał SulikAdam HuczyńskiRobert L. EoffMelanie C. MacNicolTimothy C. ChambersAngus M. MacNicol

cancer researchcancer biologynovel salinomycin analogsmolecular biologybreast cancer

Phosphoproteomics Provides Novel Insights Into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS Omega (2021)

Magdalena DelgadoCharity L. WashamAlicja UrbaniakBillie HeflinAaron J. StoreyRenny S. LanSamuel G. MackintoshAlan J. TackettStephanie D. ByrumTimothy C. Chambers

tumor biologycancer biologycell biologycell cycleimmunologypharmacologyproteomicsbreast cancer

Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models. Biomedicine & Pharmacotherapy (2021)

Alicja UrbaniakMegan R ReedDaniel FilAnika MoorjaniSarah HeflinMichał AntoszczakMichał SulikAdam HuczyńskiMichalina KupsikRobert L EoffMelanie C MacNicolTimothy C ChambersAngus M MacNicol

Synthesis, Anticancer Activity and Molecular Docking Studies of N-Deacetylthiocolchicine and 4-Iodo-N-Deacetylthiocolchicine Derivatives. Bioorganic & Medicinal Chemistry (2021)

Greta KlejborowskaAlicja UrbaniakEwa MajJoanna WietrzykMahshad MoshariJordane PretoJack A. TuszynskiTimothy C. ChambersAdam Huczyński

Alicja UrbaniakFariba JousheghanySergio Piña‐OviedoYouzhong YuanUrszula Majcher‐UchańskaGreta KlejborowskaAnika MoorjaniBehjatolah Monzavi‐KarbassiAdam HuczyńskiTimothy C. Chambers

in vitro toxicologyex vivo studybiochemistrycarbamate derivativesbreast cancer

Limitations of an Ex Vivo Breast Cancer Model for Studying the Mechanism of Action of the Anticancer Drug Paclitaxel. European Journal of Pharmacology (2020)

Alicja UrbaniakSergio Piña-OviedoYouzhong YuanAdam HuczyńskiTimothy C. Chambers

oncologyanticancer drug paclitaxelpharmacologycancer treatmentbreast cancer

Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells. The FASEB Journal (2020)

Alicja UrbaniakMegan R. ReedMichał AntoszczakMichał SulikAdam HuczyñskiRobert L. EoffMelanie C. MacNicolAngus M. MacNicolTimothy C. Chambers

stem cellscancer cellsnovel salinomycin analogscancer treatmenttherapeutic targetsmolecular biologycancer discoverybreast cancer

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proteomics

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Institution

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protein modeling

protein bioinformatics

Raul A. Urrutia, MD

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Frank Mccormick

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cancer biology

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