Faculty

Institution

Unit

Venue

Gabor Tigyi

University of Tennessee Health Science Center

Affiliations

Department of Physiology

NoneGabor Tigyi is currently serving as a Physiology faculty at University of Tennessee Health Science Center.

Honors

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Experiences

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Education

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Gabor Tigyi

University of Tennessee Health Science Center

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molecular biology biochemistry pharmacology cell biology receptors cell signaling medicinal research vascular biology receptor (biochemistry) signal transduction membrane biology lipids biological chemistry medicinal chemistry drug discovery enzyme inhibition cancer biology lysophosphatidic acid molecular and cellular biology molecular physiology protein science cellular physiology cancer cells signaling pathways receptor tyrosine kinases peptide science g protein-coupled receptor liver physiology molecular cell biology proteinlipid interaction protein phosphorylation cell regulation lysophosphatidic acid receptors clinical lipidology lipid science cardiovascular research pharmacological research vascular pharmacology inhibitory activity anti-cancer agents redox biology peptides lipid chemistry drug targeting pharmaceutical chemistry vascular disease cyclic phosphatidic acid blood platelet cancer growth radiation biology tumor suppressors lipoprotein metabolism lipid synthesis cancer treatment cell migration cell physiology lipid movement neurochemistry endothelial dysfunction platelet antagonist endothelial cells hemostasis experimental pharmacology cellular regulatory mechanism mammalian cells virtual screening mouse colon low density lipoprotein receptor interactions topical application fatty alcohol phosphates optical control multiple functions novel lipid mediator ovarian cancer cells pharmacological evaluation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Knockout or Inhibition of Dhps Suppresses Ovarian Tumor Growth and Metastasis by Attenuating the Tgfβ Pathway. Scientific Reports (2025)

Guannan ZhaoXinxin ZhaoZiping LiuBaojin WangPeixin DongHidemichi WatariLawrence M. PfefferGabor TigyiWenjing ZhangJunming Yue

metastasiscancer geneticsgynecologic oncologygynecologyovarian cancerreproductive immunologytgfb pathwaycancer biologyfibroblast growth factorscancer researchtumor suppressorscancer growthgynecologic cancerstumor biologysystems biologycancer discoverymolecular biologyoncogenescancer cells

Structure-Based Discovery of Molport-137: A Novel Autotaxin Inhibitor That Improves Paclitaxel Efficacy. International Journal of Molecular Sciences (2025)

Prateek RaiChristopher J. ClarkVandana KardamCarl B. WomackJoshua ThammathongDerek D. NormanGábor J. TigyiKevin BickerApril M. WeissmillerKshatresh Dutta DubeySouvik Banerjee

structure-based discoveryenzyme inhibitionpharmacologyrational drug designradiation oncologycancer discoverytherapeutic targetsanti-cancer agentsmolecular dockingdrug discoveryoncogenesmedicinal researchtumor microenvironmentdrug targetingcombination therapydrug targetspharmacological research

Deleting Autotaxin in Lysm+ Myeloid Cells Impairs Innate Tumor Immunity in Models of Metastatic Melanoma. iScience (2024)

Mélanie A DacheuxDerek D NormanYoojin ShinGábor J TigyiSue Chin Lee

immunologymelanomametastatic melanomainnate immune systemoncologyimmune responsestumor microenvironmentcancer biologytumor biology

Establishing Three-Dimensional Explant Culture of Human Dental Pulp Tissue. International Journal of Stem Cells (2024)

Eun Jin SeoSoyoung ParkEungyung LeeYang Hoon HuhYe Eun HaGabor J. TigyiTaesung JeongIl Ho JangJonghyun Shin

three-dimensional explant culturestem cellsstem cell researchtissue culture

Lpa Suppresses Hla-Dr Expression in Human Melanoma Cells: A Potential Immune Escape Mechanism Involving Lpar1 and Dr6-Mediated Release of Il-10. Acta Pharmacologica Sinica (2024)

Enikő MajorKuan-Hung LinSue Chin LeeKrisztina KáldiBalázs GyőrffyGábor J. TigyiZoltán Benyó

melanomaautoimmune diseasescellular immune responseshuman melanoma cellscell biologymolecular canceradaptive immune systemimmune responsesimmunosuppressionleukemiaimmune dysregulationcancer immunotherapyimmunity (medicine)tumor biologyimmunologypharmacologyhla-dr expressiononcogenescellular therapy

Novel Autotaxin Inhibitor Atx-1D Significantly Enhances Potency of Paclitaxel—an in Silico and in Vitro Study. Molecules (2024)

Prateek RaiChristopher J. ClarkCarl B. WomackCurtis DearingJoshua ThammathongDerek D. NormanGábor J. TigyiSubhabrata SenKevin BickerApril M. WeissmillerSouvik Banerjee

cancer resistancepharmacologycancer researchmolecular cancercancer discoverytherapeutic targetsdrug resistanceanti-cancer agentsdrug discoverycancer cellsmedicinal researchcancer biologytumor biologycell biology

Data From Lysophosphatidic Acid Inhibits Cd8 T-Cell Activation and Control of Tumor Progression. (2023)

Shannon K. OdaPamela StrauchYuko FujiwaraAmin Al-ShamiTamas OraveczGabor TigyiRoberta PelandaRaul M. Torres

immunologymedicinegene expressionpharmacologyenzyme inhibitioncellular immune responsescell signalingcancer immunotherapyanti-cancer agentstumor progressiononcologyimmune responsest-cell activationcell regulation

Emerging Roles of Lysophosphatidic Acid Receptor Subtype 5 (Lpar5) in Inflammatory Diseases and Cancer. Pharmacology & Therapeutics (2023)

Mélanie A. DacheuxDerek D. NormanGábor J. TigyiSue Chin Lee

pharmacologyinflammation

Functional Modulation of Lysophosphatidic Acid Type 2 G‐Protein Coupled Receptor Facilitates Alveolar Bone Formation. Journal of Cellular Physiology (2023)

Tae‐Young KimAnna KimYam Prasad AryalShijin SungElina PokharelSanjiv NeupaneSo‐Young ChoiJung‐Hong HaJae‐Kwang JungHitoshi YamamotoChang‐Hyeon AnJo‐Young SuhWern‐Joo SohnYoungkyun LeeIl‐Ho JangDerek D. NormanGabor J. TigyiSeo‐Young AnJae‐Young Kim

g protein-coupled receptorliver physiologycell biologyendocrinologyvascular biologycell physiologyalveolar bone formationbone researchcellular physiologyfunctional modulationregenerative medicinetissue physiologyremedial actionfunctional modificationtumor biologyphysiologyreceptorsgene expressionpharmacologyapplied physiology

Lysophosphatidic Acid Induces Proliferation and Osteogenic Differentiation of Human Dental Pulp Stem Cell Through Lysophosphatidic Acid Receptor 3/Extracellular Signal-Regulated Kinase Signaling Axis. Journal of Dental Sciences (2023)

Soon Chul HeoBo Ram KeumEun Jin SeoJinhwan YoonSanghwa JeongGabor J. TigyiDerek NormanIl Ho JangHyung Joon Kim

dentistryoral diseasesoral healthextracellular matrixlysophosphatidic acidstem cell researchoral biologystem cellsbone researchsignal-regulated kinaseregenerative medicinebiologyclinical dentistryoperative dentistrydevelopmental biologyosteogenic differentiationreceptorsmolecular biologydental disease

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Gabor Tigyi

University of Tennessee Health Science Center

Affiliations

Department of Physiology

NoneGabor Tigyi is currently serving as a Physiology faculty at University of Tennessee Health Science Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gabor Tigyi

University of Tennessee Health Science Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Knockout or Inhibition of Dhps Suppresses Ovarian Tumor Growth and Metastasis by Attenuating the Tgfβ Pathway. Scientific Reports (2025)

Guannan ZhaoXinxin ZhaoZiping LiuBaojin WangPeixin DongHidemichi WatariLawrence M. PfefferGabor TigyiWenjing ZhangJunming Yue

Structure-Based Discovery of Molport-137: A Novel Autotaxin Inhibitor That Improves Paclitaxel Efficacy. International Journal of Molecular Sciences (2025)

Prateek RaiChristopher J. ClarkVandana KardamCarl B. WomackJoshua ThammathongDerek D. NormanGábor J. TigyiKevin BickerApril M. WeissmillerKshatresh Dutta DubeySouvik Banerjee

Deleting Autotaxin in Lysm+ Myeloid Cells Impairs Innate Tumor Immunity in Models of Metastatic Melanoma. iScience (2024)

Mélanie A DacheuxDerek D NormanYoojin ShinGábor J TigyiSue Chin Lee

immunologymelanomametastatic melanomainnate immune systemoncologyimmune responsestumor microenvironmentcancer biologytumor biology

Establishing Three-Dimensional Explant Culture of Human Dental Pulp Tissue. International Journal of Stem Cells (2024)

Eun Jin SeoSoyoung ParkEungyung LeeYang Hoon HuhYe Eun HaGabor J. TigyiTaesung JeongIl Ho JangJonghyun Shin

three-dimensional explant culturestem cellsstem cell researchtissue culture

Lpa Suppresses Hla-Dr Expression in Human Melanoma Cells: A Potential Immune Escape Mechanism Involving Lpar1 and Dr6-Mediated Release of Il-10. Acta Pharmacologica Sinica (2024)

Enikő MajorKuan-Hung LinSue Chin LeeKrisztina KáldiBalázs GyőrffyGábor J. TigyiZoltán Benyó

Novel Autotaxin Inhibitor Atx-1D Significantly Enhances Potency of Paclitaxel—an in Silico and in Vitro Study. Molecules (2024)

Prateek RaiChristopher J. ClarkCarl B. WomackCurtis DearingJoshua ThammathongDerek D. NormanGábor J. TigyiSubhabrata SenKevin BickerApril M. WeissmillerSouvik Banerjee

Data From Lysophosphatidic Acid Inhibits Cd8 T-Cell Activation and Control of Tumor Progression. (2023)

Shannon K. OdaPamela StrauchYuko FujiwaraAmin Al-ShamiTamas OraveczGabor TigyiRoberta PelandaRaul M. Torres

Emerging Roles of Lysophosphatidic Acid Receptor Subtype 5 (Lpar5) in Inflammatory Diseases and Cancer. Pharmacology & Therapeutics (2023)

Mélanie A. DacheuxDerek D. NormanGábor J. TigyiSue Chin Lee

pharmacologyinflammation

Functional Modulation of Lysophosphatidic Acid Type 2 G‐Protein Coupled Receptor Facilitates Alveolar Bone Formation. Journal of Cellular Physiology (2023)

Soon Chul HeoBo Ram KeumEun Jin SeoJinhwan YoonSanghwa JeongGabor J. TigyiDerek NormanIl Ho JangHyung Joon Kim

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University of Illinois Chicago

endothelial dysfunction

endothelial cell biology

Clifford Steer

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gene editing

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cancer letter

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University of California, San Francisco

signaling pathway

cancer cell

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volatile organic compounds

free radical biology

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antibody engineering