Faculty

Institution

Unit

Venue

Tad Koch

Professor Emeritus

University of Colorado Boulder

Affiliations

Natural Sciences

Chemistry Department

College of Arts and Sciences

Natural Sciences

Tad Koch is currently serving as a Chemistry Professor Emeritus at University of Colorado Boulder.

Honors

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Experiences

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Education

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Tad Koch

University of Colorado Boulder

Professor Emeritus

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biochemistry medicinal chemistry biomolecular engineering transition metal chemistry molecular biology organic chemistry medicinal research photochemistry pharmacology chemical biology pharmaceutical chemistry structural chemistry coordination chemistry chemical sciences drug discovery therapeutic targets protein science optical properties redox biology free radical biology quantum chemistry anti-cancer agents synthetic photochemistry enzyme inhibition redox chemistry tumor biology structural molecular biology nanoparticle research peptide science tumor targeting photobiology inorganic photochemistry radical (chemistry) reactive oxygen species cancer cells catalyst activation anthracycline antitumor drugs photochemical reactivity cross-link drug targeting protein chemistry cancer treatment mechanistic photochemistry inorganic synthesis surface reactivity nucleic acids biomolecules peptide synthesis organic charge-transfer compound photoelectrochemistry rna biology oncogenic agent supramolecular photochemistry selective separation inhibitory activity mechanistic studies keto imino ethers protein assembly protein biosynthesis laser photochemistry photochemical coupling carbon-nitrogen double bond di-tert-butyl nitroxide proteomic technologies nucleic acid chemistry early detection chemoprevention strategies antitumor drugs adriamycin anthracycline-formaldehyde conjugates tumor cells doxorubicin-formaldehyde conjugates breast cancer cells nuclear targeting doxorubicin-formaldehyde conjugate laboratory synthesis ribosomal proteins molecular diversity biotechnology advance bioorganic chemistry biotechnology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicsstructure elucidationcrystal researchcrystal diffraction studystructure determinationstructural chemistryccdc 2157502chemistrydeposited datasetcrystal engineeringchemical structurecrystal structurescrystallography

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence. ACS Chemical Biology (2019)

Ahil N. GaneshAhmed AmanJennifer LogieBen L. BarthelPeter CoganRima Al-awarTad H. KochBrian K. ShoichetMolly S. Shoichet

medicinal chemistrycolloidal systemspharmacokinetic consequencestabilitybiochemistrycolloid chemistrycolloidal propertychemical biologynano-drug deliverydispersion sciencedrug deliveryhigh serum conditionscontrolled releasecolloidal nanocrystalspharmacologynanoparticle researchbiomolecular engineeringdrug discoverymedicinal research

Photoactivatable Prodrug of Doxazolidine Targeting Exosomes. Journal of Medicinal Chemistry (2019)

Ryo TamuraAlla BalabanovaSamuel A. FrakesAustin BargmannJan GrimmTad H. KochHang Yin

medicinal chemistrypharmacologyphotomedicinedrug discoverydrug targetingphotoactivatable prodrug

Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations. Molecular Pharmaceutics (2017)

Ahil N. GaneshJennifer LogieChristopher K. McLaughlinBenjamin L. BarthelTad H. KochBrian K. ShoichetMolly S. Shoichet

colloidal systemsnanomedicinepharmacologypharmaceutical nanotechnologycolloidal nanocrystalsnanoparticle researchdrug deliverymolecular pharmacologypharmaceutical researchnanoparticlesnano-drug deliverymedicinal researchcolloidal aggregationdrug-rich nanoparticle formulationsnanotechnologypharmaceutics

Correlation of in Situ Oxazolidine Formation With Highly Synergistic Cytotoxicity and Dna Cross-Linking in Cancer Cells From Combinations of Doxorubicin and Formaldehyde. Journal of Medicinal Chemistry (2016)

Benjamin L. BarthelErin L. MoozLaura Elizabeth WienerGary G. KochTad H. Koch

medicinal chemistrymedicineenzyme inhibitionpharmacologycancer caresurface reactivitypharmaceutical chemistryin-situ conversiontumor biologydrug analysismolecular substratessitu oxazolidine formationdrug discoverymolecular biologyoncologydna cross-linkingcancer treatmentdrug delivery

Carboxylesterase-2 is a Highly Sensitive Target of the Antiobesity Agent Orlistat With Profound Implications in the Activation of Anticancer Prodrugs. Biochemical Pharmacology (2012)

Da XiaoDeshi ShiDongfang YangBenjamin BarthelTad H. KochBingfang Yan

antiobesity agentanticancer prodrugstherapeutic targetsbiochemistry

Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine. Journal of Medicinal Chemistry (2012)

Benjamin L. BarthelDaniel L. RudnickiThomas Price KirbySean M. ColvinDavid J. BurkhartTad H. Koch

medicinal chemistryenzyme inhibitionproteomicspharmaceutical chemistrytherapeutic targetschemical biologybiomolecular engineeringmolecular characterizationdrug discoverymolecular biologybiological characterizationmedicinal researchprotease-activated prodrugsprotein sciencebiochemistry

Abstract A29: Bcl-2 Overexpression Provides Short-Term Resistance to Doxorubicin-Dna Adducts but Does Not Protect Against Longer-Term Treatments in Hl-60 Cells.. Molecular Cancer Therapeutics (2011)

Michal UgarenkoAda RephaeliAbraham NudelmanTad H. KochDon R. PhillipsSuzanne M. Cutts

cancer researchmolecular cancerlonger-term treatmentsdoxorubicin-dna adductstherapeutic targetsdrug resistanceoncologymolecular biologymedicinal researchcancer treatmentbiochemistry

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. PLoS ONE (2010)

Larry GoldDeborah AyersJennifer BertinoChristopher BockAshley BockEdward N. BrodyJeff CarterAndrew B. DalbyBruce E. EatonTim FitzwaterDylan FlatherAshley ForbesTrudi ForemanCate FowlerBharat GawandeMeredith GossMagda GunnShashi GuptaDennis HalladayJim HeilJoe HeiligBrian HickeGregory HusarNebojsa JanjicThale JarvisSusan JenningsEvaldas KatiliusTracy R. KeeneyNancy KimTad H. KochStephan KraemerLuke KroissNgan LeDaniel LevineWes LindseyBridget LolloWes MayfieldMike MehanRobert MehlerSally K. NelsonMichele NelsonDan NieuwlandtMalti NikradUrs OchsnerRachel M. OstroffMatt OtisThomas ParkerSteve PietrasiewiczDaniel I. ResnicowJohn RohloffGlenn SandersSarah SattinDaniel SchneiderBritta SingerMartin StantonAlana SterkelAlex StewartSuzanne StratfordJonathan D. VaughtMike VrkljanJeffrey J. WalkerMike WatrobkaSheela WaughAllison WeissSheri K. WilcoxAlexey WolfsonSteven K. WolkChi ZhangDom Zichi

biomarker discoveryproteomicsbiological engineeringproteomic technologies

Abstract #677: Design, Synthesis and Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine: Pentyl Pabc-Doxaz. Cancer Research (2009)

Daniel ChanBenjamin BarthelZhiyong ZhangChristopher ColdrenTad Koch

preclinical efficacycancer researchpentyl pabc-doxaztherapeutic efficacysynthetic biologybiochemistry

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Tad Koch

Professor Emeritus

University of Colorado Boulder

Affiliations

Natural Sciences

Chemistry Department

College of Arts and Sciences

Natural Sciences

Tad Koch is currently serving as a Chemistry Professor Emeritus at University of Colorado Boulder.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Tad Koch

University of Colorado Boulder

Professor Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence. ACS Chemical Biology (2019)

Ahil N. GaneshAhmed AmanJennifer LogieBen L. BarthelPeter CoganRima Al-awarTad H. KochBrian K. ShoichetMolly S. Shoichet

Photoactivatable Prodrug of Doxazolidine Targeting Exosomes. Journal of Medicinal Chemistry (2019)

Ryo TamuraAlla BalabanovaSamuel A. FrakesAustin BargmannJan GrimmTad H. KochHang Yin

medicinal chemistrypharmacologyphotomedicinedrug discoverydrug targetingphotoactivatable prodrug

Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations. Molecular Pharmaceutics (2017)

Ahil N. GaneshJennifer LogieChristopher K. McLaughlinBenjamin L. BarthelTad H. KochBrian K. ShoichetMolly S. Shoichet

Benjamin L. BarthelErin L. MoozLaura Elizabeth WienerGary G. KochTad H. Koch

Carboxylesterase-2 is a Highly Sensitive Target of the Antiobesity Agent Orlistat With Profound Implications in the Activation of Anticancer Prodrugs. Biochemical Pharmacology (2012)

Da XiaoDeshi ShiDongfang YangBenjamin BarthelTad H. KochBingfang Yan

antiobesity agentanticancer prodrugstherapeutic targetsbiochemistry

Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine. Journal of Medicinal Chemistry (2012)

Benjamin L. BarthelDaniel L. RudnickiThomas Price KirbySean M. ColvinDavid J. BurkhartTad H. Koch

Michal UgarenkoAda RephaeliAbraham NudelmanTad H. KochDon R. PhillipsSuzanne M. Cutts

cancer researchmolecular cancerlonger-term treatmentsdoxorubicin-dna adductstherapeutic targetsdrug resistanceoncologymolecular biologymedicinal researchcancer treatmentbiochemistry

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. PLoS ONE (2010)

biomarker discoveryproteomicsbiological engineeringproteomic technologies

Abstract #677: Design, Synthesis and Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine: Pentyl Pabc-Doxaz. Cancer Research (2009)

Daniel ChanBenjamin BarthelZhiyong ZhangChristopher ColdrenTad Koch

preclinical efficacycancer researchpentyl pabc-doxaztherapeutic efficacysynthetic biologybiochemistry

1
2
3
4
5
15
10 / page

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