Faculty

Institution

Unit

Venue

Stephen L Helfand

George D Eggleston Professor of Biochemistry Vice Chair of Neurology

Brown University

Affiliations

Division of Biology and Medicine

Molecular Biology, Cell Biology, and Biochemistry

Warren Alpert Medical School

Molecular Biology, Cell Biology, & Biochemistry

Stephen L Helfand is currently serving as a Division Of Biology And Medicine George D Eggleston Professor of Biochemistry Vice Chair of Neurology at Brown University.

Honors

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Experiences

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Education

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Stephen L Helfand

Brown University

George D Eggleston Professor of Biochemistry Vice Chair of Neurology

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genetics longevity biogerontology insect molecular biology biology physiology gene expression ageing mammalian biology geriatrics genome biology avian biology aging cell gene regulation health sciences endocrinology metabolism lifespan extension drosophila melanogaster genomics cell metabolism lifespan development dietary restriction cell signaling molecular cell biology experimental gerontology cellular senescence animal physiology metabolic regulation molecular regulation cell death oncogenes animal science animal nutrition cytokines chromosome biology chromatin remodeling cancer genomics aging process transcription regulation life span autophagy liver physiology molecular metabolism immune dysregulation autoinflammatory disease later adulthood cytogenetics energy metabolism insulin signaling mitochondrial function renal function mammalian physiology gene function senescent cells retrotransposable elements life span extension insulin resistance epigenomics rna biology energy homeostasis human nutrition dietary health protein function epigenetic changes gene editing biomineralization age-associated diseases gene expression change histone 3 gene expression stability metabolic homeostasis somatic pirna pathway drosophila fat body normal lifespan conditioned medium developmental biology molecular genetics developmental genetics

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Specialized Metabolic Pathway Partitions Citrate in Hydroxyapatite to Impact Mineralization of Bones and Teeth. Proceedings of the National Academy of Sciences (2022)

Naomi DirckxQian ZhangEmily Y. ChuRobert J. TowerZhu LiShenghao GuoShichen YuanPratik A. KhareCissy ZhangAngela VerardoLucy O. AlejandroAngelina ParkMarie-Claude FaugereStephen L. HelfandMartha J. SomermanRyan C. RiddleRafael de CaboAnne LeKlaus Schmidt-RohrThomas L. Clemens

biophysicsmetabolic engineeringchemical sciencesregenerative medicinegeochemistrymetabolismtissue engineeringbiomineralizationphysiologymolecular sciencecell metabolismbone metabolismbioenergeticsmineral metabolismbiotransformationmineralized systemmaterials sciencebone research

Sirt6 Regulates Lifespan in Drosophila Melanogaster. Proceedings of the National Academy of Sciences (2022)

Jackson R. TaylorJason G. WoodEvan MizerakSamuel HinthornJulianna LiuMatthew FinnSarah GordonLouis ZingasChengyi ChangMark A. KleinJohn M. DenuVera GorbunovaAndrei SeluanovJef D. BoekeJohn M. SedivyStephen L. Helfand

lifespan developmentinsect molecular biologybiogerontologytranscription factorsageingdevelopmental biologybiologyavian biologymammalian biologygene regulationgeriatricslifespan extensiongene expressionlongevitymolecular regulationgenetics

Evidence That Overnight Fasting Could Extend Healthy Lifespan. Nature (2021)

Stephen L. HelfandRafael de Cabo

healthy agingnaturebiogerontologylifespan extensionlongevityhealthy lifespanbehavioral sciences

The Longevity Gene Mindy (I’M Not Dead, yet) Affects Blood Pressure Through Sympathoadrenal Mechanisms. JCI Insight (2021)

Diana M. WillmesMartin DanielsAnica KurzbachStefanie LieskeNicole BechmannTina SchumannChristine HenkeNermeen N. El-AgroudyAndrey C. Da Costa GoncalvesMirko PeitzschAnja HofmannWaldemar KanczkowskiKristin KräkerDominik N. MüllerHenning MorawietzAndreas DeussenMichael WagnerAli El-ArmoucheStephen L. HelfandStephan R. BornsteinRafael de CaboMichel BernierGraeme EisenhoferJens TankJens JordanAndreas L. Birkenfeld

cardiovascular diseasecardiovascular researchsympathoadrenal mechanismsphysiologyrespiratory medicineblood pressurerenal pathophysiologyhuman geneticsendocrinologylongevityhealth scienceshypertensiongenetics

The Role of Retrotransposable Elements in Ageing and Age-Associated Diseases. Nature (2021)

Vera GorbunovaAndrei SeluanovPaolo MitaWilson McKerrowDavid FenyöJef D. BoekeSara B. LinkerFred H. GageJill A. KreilingAnna P. PetrashenTrenton A. WoodhamJackson R. TaylorStephen L. HelfandJohn M. Sedivy

age-associated diseaseshealth sciencesretrotransposable elementsgeriatrics

Mechanisms of Lifespan Extension by Sirt6 in Drosophila Melanogaster. Innovation in Aging (2020)

Jackson TaylorJason WoodMatthew FinnJulianna LiuEvan MizerakSarah GordonCorinne HutfilzStephen Helfand

animal sciencedrosophila melanogasterbiogerontologymechanism (biology)developmental biologybiologymammalian biologyavian biologygeriatricslifespan extensionpopulation geneticslongevitygenetics

Author Correction: L1 Drives Ifn in Senescent Cells and Promotes Age-Associated Inflammation. Nature (2019)

Marco De CeccoTakahiro ItoAnna P. PetrashenAmy E. EliasNicholas J. SkvirSteven W. CriscioneAlberto CaligianaGreta BrocculiEmily M. AdneyJef D. BoekeOanh LeChristian BeauséjourJayakrishna AmbatiKameshwari AmbatiMatthew SimonAndrei SeluanovVera GorbunovaP. Eline SlagboomStephen L. HelfandNicola NerettiJohn M. Sedivy

inflammationaging cellage-associated inflammationcell deathcell signalingimmunologycell biologychronic inflammationcellular senescenceimmune dysregulationsenescent cellsimmune responsesautophagyauthor correctionautoinflammatory diseasecytokines

L1 Drives Ifn in Senescent Cells and Promotes Age-Associated Inflammation. Nature (2019)

inflammationaging cellcell deathcell signalingimmunologycell biologycellular physiologycellular senescenceimmune dysregulationsenescent cellsimmune responsesautophagyautoinflammatory diseasecytokines

Line1 Derepression in Aged Wild-Type and Sirt6-Deficient Mice Drives Inflammation. Cell Metabolism (2019)

Matthew SimonMichael Van MeterJulia AblaevaZhonghe KeRaul S. GonzalezTaketo TaguchiMarco De CeccoKaterina I. LeonovaValeria KoganStephen L. HelfandNicola NerettiAsael RoichmanHaim Y. CohenMargarita V. MeerVadim N. GladyshevMarina P. AntochAndrei V. GudkovJohn M. SedivyAndrei SeluanovVera Gorbunova

animal scienceinflammationphysiologybiogerontologydermatologycell metabolismmembrane biologylater adulthoodmammalian biologygenetics

Inhibition of Retrotransposition Improves Health and Extends Lifespan of Sirt6 Knockout Mice. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Matthew SimonMichael Van MeterJulia AblaevaZhonghe KeRaul S. GonzalezTaketo TaguchiMarco De CeccoKaterina I. LeonovaValeria KoganStephen L. HelfandNicola NerettiAsael RoichmanHaim Y. CohenMarina AntochAndrei GudkovJohn M. SedivyAndrei SeluanovVera Gorbunova

lifespan developmentregenerative medicineknockout micelifespan extensionimmunologybiogerontologyageingphage biologyexperimental gerontologygeneticsveterinary medicinemammalian biologylongevityhealth sciencesmortality

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Stephen L Helfand

George D Eggleston Professor of Biochemistry Vice Chair of Neurology

Brown University

Affiliations

Division of Biology and Medicine

Molecular Biology, Cell Biology, and Biochemistry

Warren Alpert Medical School

Molecular Biology, Cell Biology, & Biochemistry

Stephen L Helfand is currently serving as a Division Of Biology And Medicine George D Eggleston Professor of Biochemistry Vice Chair of Neurology at Brown University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Stephen L Helfand

Brown University

George D Eggleston Professor of Biochemistry Vice Chair of Neurology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Specialized Metabolic Pathway Partitions Citrate in Hydroxyapatite to Impact Mineralization of Bones and Teeth. Proceedings of the National Academy of Sciences (2022)

Sirt6 Regulates Lifespan in Drosophila Melanogaster. Proceedings of the National Academy of Sciences (2022)

Evidence That Overnight Fasting Could Extend Healthy Lifespan. Nature (2021)

Stephen L. HelfandRafael de Cabo

healthy agingnaturebiogerontologylifespan extensionlongevityhealthy lifespanbehavioral sciences

The Longevity Gene Mindy (I’M Not Dead, yet) Affects Blood Pressure Through Sympathoadrenal Mechanisms. JCI Insight (2021)

The Role of Retrotransposable Elements in Ageing and Age-Associated Diseases. Nature (2021)

age-associated diseaseshealth sciencesretrotransposable elementsgeriatrics

Mechanisms of Lifespan Extension by Sirt6 in Drosophila Melanogaster. Innovation in Aging (2020)

Jackson TaylorJason WoodMatthew FinnJulianna LiuEvan MizerakSarah GordonCorinne HutfilzStephen Helfand

animal sciencedrosophila melanogasterbiogerontologymechanism (biology)developmental biologybiologymammalian biologyavian biologygeriatricslifespan extensionpopulation geneticslongevitygenetics

Author Correction: L1 Drives Ifn in Senescent Cells and Promotes Age-Associated Inflammation. Nature (2019)

L1 Drives Ifn in Senescent Cells and Promotes Age-Associated Inflammation. Nature (2019)

inflammationaging cellcell deathcell signalingimmunologycell biologycellular physiologycellular senescenceimmune dysregulationsenescent cellsimmune responsesautophagyautoinflammatory diseasecytokines

Line1 Derepression in Aged Wild-Type and Sirt6-Deficient Mice Drives Inflammation. Cell Metabolism (2019)

animal scienceinflammationphysiologybiogerontologydermatologycell metabolismmembrane biologylater adulthoodmammalian biologygenetics

Inhibition of Retrotransposition Improves Health and Extends Lifespan of Sirt6 Knockout Mice. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Matthew SimonMichael Van MeterJulia AblaevaZhonghe KeRaul S. GonzalezTaketo TaguchiMarco De CeccoKaterina I. LeonovaValeria KoganStephen L. HelfandNicola NerettiAsael RoichmanHaim Y. CohenMarina AntochAndrei GudkovJohn M. SedivyAndrei SeluanovVera Gorbunova

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cellular senescence

chromatin remodeling

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evolutionary biology

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