Faculty

Institution

Unit

Venue

John M Sedivy

Hermon C Bumpus Professor of Biology Associate Dean and Director Center for the Biology of Aging Associate Professor of Molecular Biology Cell Biology and Biochemistry

Brown University

Affiliations

Division of Biology and Medicine

Molecular Biology, Cell Biology, and Biochemistry

Warren Alpert Medical School

Molecular Biology, Cell Biology, & Biochemistry

John M Sedivy is currently serving as a Division Of Biology And Medicine Hermon C Bumpus Professor of Biology Associate Dean and Director Center for the Biology of Aging Associate Professor of Molecular Biology Cell Biology and Biochemistry at Brown University.

Honors

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Experiences

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Education

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John M Sedivy

Brown University

Hermon C Bumpus Professor of Biology Associate Dean and Director Center for the Biology of Aging Associate Professor of Molecular Biology Cell Biology and Biochemistry

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genetics molecular biology cell biology gene expression ageing tumor biology cellular senescence mammalian biology biogerontology pharmacology cell death cancer biology medicinal research cell signaling cell regulation molecular and cellular biology epigenetics membrane biology genome biology aging cell molecular regulation signal transduction protein science cancer genetics molecular cell biology apoptosis oncogenes gene regulation molecular cancer experimental gerontology cell cycle cancer genomics cellular physiology molecular physiology enzyme inhibition cancer cells cancer care cellular biology aging process cancer treatment biological chemistry transcription regulation epigenomics rna biology signaling pathways gene function senescent cells protein transport lifespan extension single-cell analysis genome instability mammalian cells gene transfer catalyst activation protein phosphorylation replicative senescence tumor suppression dna damage cytokines immune dysregulation autoinflammatory disease mammalian physiology protein expression biomolecular interactions experimental dermatology retrotransposable elements transposable elements organismal aging human fibroblasts normal human fibroblasts replicative cellular senescence c-myc expression dna damage-induced apoptosis glial cells path forward mitochondrial dna mutations chromatin remodeling cell cycle regulation systems biology chromatin

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2954: Androgen Deprivation Therapy (Adt) and Senescence-Associated Secretory Phenotype (Sasp) in Vitro: Correlation With Sasp in Tumor Specimens as Well as in the Serum of Patients After Adt. Cancer Research (2024)

Maximilian SchwermannMatthew HadfieldShaolei LuPraveen SrinivasanVida TajikniaWilliam MacDonaldAndrew GeorgeShengliang ZhangLeiqing ZhangKimberly MezaAndre De SouzaDragan GolijaninElias HyamsGalina LagosSheldon HolderAnthony MegaJohn SedivyHoward SafranWafik El-DeiryBenedito Carneiro

tumor targetingsenescence-associated secretory phenotypetumor specimensclinical researchcancer biologymolecular cancerandrogen deprivation therapycancer researchcancer genomicstumor biologypharmacologycancer treatmentoncologybrain tumor researchcancer carecancer managementcancer imagingbiomarkersradiation oncologymedicinal researchradiology

Abstract 5941: Small Molecule Nsc59984 Synergizes With Parp Inhibitors in Brca1 Wild Type Ovarian Cancer. Cancer Research (2024)

Shengliang ZhangLanlan ZhouLeiqing ZhangMaximilian Pinho-SchwermannBenedito CarneiroJohn SedivyWafik S. El-Deiry

ovarian canceranti-cancer agentsclinical researchparp inhibitorsgynecologic oncologycancer biologymolecular cancercancer researchcancer genomicspharmacologycancer treatmentoncologycancer careenzyme inhibitionradiation oncologymolecular biologytherapeutic efficacymedicinal researchtherapeutic targets

Age-Associated Clonal B Cells Drive B Cell Lymphoma in Mice. Nature Aging (2024)

José P. CastroAnastasia V. ShindyapinaAlessandro BarbieriKejun YingOlga S. StrelkovaJoão A. PauloAlexander TyshkovskiyRico MeinlCsaba KerepesiAnna P. PetrashenMarco MariottiMargarita V. MeerYan HuAlexander KaramyshevGrigoriy LosyevMafalda GalhardoElsa LogarinhoArtur A. IndzhykulianSteven P. GygiJohn M. SedivyJohn P. ManisVadim N. Gladyshev

lymphocyte developmentpathologyimmune responsescancer cellsageinglymphoid neoplasiaaging processaging-associated diseasestumor biologyimmunologyaging cellcell biologycellular senescence

Cgas Deficient Mice Display Premature Aging Associated With De-Repression of Line1 Elements and Inflammation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

John C. MartinezFrancesco MorandiniLucinda FitzgibbonsNatasha SieczkiewiczSung Jae BaeMichael E. MeadowEric HillpotJoseph CuttingVictoria PaigeSeyed Ali BiashadMatthew SimonJohn SedivyAndrei SeluanovVera Gorbunova

biologyvascular aginginflammationageingchronic inflammationoxidative stressmolecular biologyaging-associated diseasessystems biologyaging cellvascular biologyimmune responsescell deathcellular senescence

Guidelines for Minimal Information on Cellular Senescence Experimentation in Vivo. Cell (2024)

Mikolaj OgrodnikJuan Carlos AcostaPeter D. AdamsFabrizio d’Adda di FagagnaDarren J. BakerCleo L. BishopTamir ChandraManuel ColladoJesus GilVassilis GorgoulisFlorian GruberEiji HaraPidder Jansen-DürrDiana JurkSundeep KhoslaJames L. KirklandValery KrizhanovskyTohru MinaminoLaura J. NiedernhoferJoão F. PassosNadja A.R. RingHeinz RedlPaul D. RobbinsFrancis RodierKarin Scharffetter-KochanekJohn M. SedivyEwa SikoraKenneth WitwerThomas von ZglinickiMaximina H. YunJohannes GrillariMarco Demaria

cell specializationcellular physiologyexperimental dermatologycell detectionstem cellsgeneticsneurosciencetumor biologyvascular biologyneurologygene expressioncell manipulationstem cell researchminimal informationmammalian biologylower boundscellular senescence experimentationcellular differentiationbone researchextracellular matrix

Identification and Characterization of Small Molecule Inhibitors of the Line-1 Retrotransposon Endonuclease. Nature Communications (2024)

Alexandra M. D’OrdineGerwald JoglJohn M. Sedivy

medicinal chemistrypharmacologydrug discoverymolecular biologysmall molecule inhibitorsmolecular pharmacologylead identification

Longevity Biotechnology: Bridging AI, Biomarkers, Geroscience and Clinical Applications for Healthy Longevity. Aging (2024)

Yu-Xuan LyuQiang FuDominika WilczokKejun YingAaron KingAdam AntebiAleksandar VojtaAlexandra StolzingAlexey MoskalevAnastasia GeorgievskayaAndrea B. MaierAndrea OlsenAnja GrothAnna Katharina SimonAnne BrunetAisyah JamilAnton KulagaAsif BhattiBenjamin YadenBente Klarlund PedersenBjörn SchumacherBoris DjordjevicBrian KennedyChieh ChenChristine Yuan HuangChristoph U. CorrellColeen T. MurphyCollin Y. EwaldDanica ChenDario Riccardo ValenzanoDariusz SołdackiDavid ErritzoeDavid MeyerDavid A. SinclairEduardo Nunes ChiniEmma C. TeelingEric MorgenEric VerdinErik VernetEstefano PinillaEvandro F. FangEvelyne BischofEvi M. MerckenFabian FingerFolkert KuipersFrank W. PunGabor GyülvesziGabriele CivilettoGarri ZmudzeGil BlanderHarold A. PincusJoshua McClureJames L. KirklandJames PeyerJamie N. JusticeJan VijgJennifer R. GruhnJerry McLaughlinJoan MannickJoão PassosJoseph A. BaurJoe Betts-LaCroixJohn M. SedivyJohn R. SpeakmanJordan ShlainJulia von MaltzahnKatrin I. AndreassonKelsey MoodyKonstantinos PalikarasKristen FortneyLaura J. NiedernhoferLene Juel RasmussenLiesbeth M. VeenhoffLisa MeltonLuigi FerrucciMarco QuartaMaria KovalMaria MarinovaMark HamalainenMaximilian UnfriedMichael S. RingelMilos FilipovicMourad ToporsNatalia MitinNawal RoyNika PintarNir BarzilaiPaolo BinettiParminder SinghPaul KohlhaasPaul D. RobbinsPaul RubinPeter O. FedichevPetrina KamyaPura Muñoz-CanovesRafael de CaboRichard G. A. FaragherRob KonradRoberto RipaRobin Mansukhani

health sciencesbiomarkersclinical applicationsbridging aibiotechnologylongevitylongevity biotechnologyhealthy longevity

Loss of Epigenetic Information as a Cause of Mammalian Aging. Cell (2024)

Jae-Hyun YangMotoshi HayanoPatrick T. GriffinJoão A. AmorimMichael S. BonkowskiJohn K. ApostolidesElias L. SalfatiMarco BlanchetteElizabeth M. MundingMital BhaktaYap Ching ChewWei GuoXiaojing YangSun Maybury-LewisXiao TianJaime M. RossGiuseppe CoppotelliMargarita V. MeerRyan Rogers-HammondDaniel L. VeraYuancheng Ryan LuJeffrey W. PippinMichael L. CreswellZhixun DouCaiyue XuSarah J. MitchellAbhirup DasBrendan L. O’ConnellSachin ThakurAlice E. KaneQiao SuYasuaki MohriEmi K. NishimuraLaura SchaevitzNeha GargAna-Maria BaltaMeghan A. RegoMeredith Gregory-KsanderTatjana C. JakobsLei ZhongHiroko WakimotoJihad El AndariDirk GrimmRaul MostoslavskyAmy J. WagersKazuo TsubotaStephen J. BonaseraCarlos M. PalmeiraJonathan G. SeidmanChristine E. SeidmanNorman S. WolfJill A. KreilingJohn M. SedivyGeorge F. MurphyRichard E. GreenBenjamin A. GarciaShelley L. BergerPhilipp OberdoerfferStuart J. ShanklandVadim N. GladyshevBruce R. KsanderAndreas R. PfenningLuis A. RajmanDavid A. Sinclair

biologybiogerontologyepigeneticsmammalian biologyepigenetic information

Te-Seq: A Transposable Element Annotation and Rna-Seq Pipeline. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Maxfield M.G. KelseyRadha A. KalekarJohn M. Sedivy

bioinformaticsgene sequence annotationmolecular biologytransposable element annotationrna-seq pipelinebiomedical informatics

Analysis of Somatic Mutations in Senescent Cells Using Single-Cell Whole-Genome Sequencing. (2023)

Xiao DongJohn M. SedivyJan VijgLei ZhangMarco De CeccoMoonsook LeeXiaoxiao HaoAlexander Y. MaslovCristina MontagnaJudith Campisi

geneticshuman geneticssomatic mutationssingle-cell analysisbioinformaticsgenome sequencinggenomicssingle-cell whole-genome sequencingsenescent cellsmolecular biologygenome biologyepigenomicscell biologycellular senescencegenome analysis

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John M Sedivy

Hermon C Bumpus Professor of Biology Associate Dean and Director Center for the Biology of Aging Associate Professor of Molecular Biology Cell Biology and Biochemistry

Brown University

Affiliations

Division of Biology and Medicine

Molecular Biology, Cell Biology, and Biochemistry

Warren Alpert Medical School

Molecular Biology, Cell Biology, & Biochemistry

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John M Sedivy

Brown University

Hermon C Bumpus Professor of Biology Associate Dean and Director Center for the Biology of Aging Associate Professor of Molecular Biology Cell Biology and Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5941: Small Molecule Nsc59984 Synergizes With Parp Inhibitors in Brca1 Wild Type Ovarian Cancer. Cancer Research (2024)

Shengliang ZhangLanlan ZhouLeiqing ZhangMaximilian Pinho-SchwermannBenedito CarneiroJohn SedivyWafik S. El-Deiry

Age-Associated Clonal B Cells Drive B Cell Lymphoma in Mice. Nature Aging (2024)

lymphocyte developmentpathologyimmune responsescancer cellsageinglymphoid neoplasiaaging processaging-associated diseasestumor biologyimmunologyaging cellcell biologycellular senescence

Cgas Deficient Mice Display Premature Aging Associated With De-Repression of Line1 Elements and Inflammation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Guidelines for Minimal Information on Cellular Senescence Experimentation in Vivo. Cell (2024)

Identification and Characterization of Small Molecule Inhibitors of the Line-1 Retrotransposon Endonuclease. Nature Communications (2024)

Alexandra M. D’OrdineGerwald JoglJohn M. Sedivy

medicinal chemistrypharmacologydrug discoverymolecular biologysmall molecule inhibitorsmolecular pharmacologylead identification

Longevity Biotechnology: Bridging AI, Biomarkers, Geroscience and Clinical Applications for Healthy Longevity. Aging (2024)

health sciencesbiomarkersclinical applicationsbridging aibiotechnologylongevitylongevity biotechnologyhealthy longevity

Loss of Epigenetic Information as a Cause of Mammalian Aging. Cell (2024)

biologybiogerontologyepigeneticsmammalian biologyepigenetic information

Te-Seq: A Transposable Element Annotation and Rna-Seq Pipeline. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Maxfield M.G. KelseyRadha A. KalekarJohn M. Sedivy

bioinformaticsgene sequence annotationmolecular biologytransposable element annotationrna-seq pipelinebiomedical informatics

Analysis of Somatic Mutations in Senescent Cells Using Single-Cell Whole-Genome Sequencing. (2023)

Xiao DongJohn M. SedivyJan VijgLei ZhangMarco De CeccoMoonsook LeeXiaoxiao HaoAlexander Y. MaslovCristina MontagnaJudith Campisi

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University of Pennsylvania

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