Faculty

Institution

Unit

Venue

Roger R. Cooke

University of California, San Francisco

Affiliations

University of California San Francisco, Research

NoneRoger R. Cooke is currently serving as a University Of California San Francisco, Research faculty at University of California, San Francisco.

Honors

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Experiences

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Education

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Roger R. Cooke

University of California, San Francisco

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biophysics molecular biology biochemistry protein science physiology structural biology muscle function skeletal muscle protein structure membrane biology biophysical chemistry structural molecular biology biophysical modeling molecular biophysics mechanobiology biophysical review protein folding vascular biology biomechanics cellular physiology muscle injury cell motility molecular physiology single molecule biophysics nucleic acids applied physiology bone research biomolecular structure molecular cell biology experimental biophysics protein phosphorylation super-relaxed state biomolecules magnetic resonance musculoskeletal interaction mechanotransduction biomolecular interactions intracellular trafficking epr spectroscopy biological macromolecules protein nmr biophysical aspect nuclear magnetic resonance spectroscopy nucleotide pocket enzyme inhibition bioenergetics cell biomechanics single-molecule detection medical biophysics inhibitory activity ethanol-induced fluidization brain lipid bilayers skeletal muscle fibers protein chemistry human physiology cardiac muscle orthopedic biomechanics protein transport membrane transport lipid movement biochemical interaction excited state property protein assembly experimental biology cutaneous biology electron paramagnetic resonance myosin phosphorylation active site atpase activity cardiac myosin motor domain ramp stretches myosin inhibitor blebbistatin conformational change skeletal muscle myosin muscle cross-bridges

Notable Scholarly Works

Notable Federal Grants

Collaborators

Jak Inhibition With Tofacitinib Rapidly Increases Contractile Force in Human Skeletal Muscle. Life Science Alliance (2024)

Joseph B ShragerRyan RandleMyung LeeSyed Saadan AhmedWinston TropeNatalie LuiGeorge PoultsidesDoug LiouBrendan VisserJeffrey A NortonShannon M NesbitHao HeNtemena KapulaBailey WallenEmmanuel FatoduCheyenne A SadeghiHarrison B KonskerIrmina ElliottBrandon GuenthartLeah BackhusRoger CookeMark BerryHuibin Tang

inhibitory activitycontractile forcephysiologymuscle functionmuscle injuryjak inhibitionmechanobiologypharmacologyskeletal musclehuman skeletal muscle

Regulating Metabolic Rate via Skeletal Myosin Super Relaxed State. Biophysical Journal (2022)

Clyde F. WilsonNariman I. NaberRoger Cooke

biophysicsmetabolismenergy metabolismmetabolic statebiophysical reviewmetabolic regulationmetabolic controlmetabolic rateskeletal myosin superbiophysical modeling

Rationale and Design of a Mechanistic Clinical Trial of Jak Inhibition to Prevent Ventilator-Induced Diaphragm Dysfunction. Respiratory Medicine (2021)

Joseph B. ShragerYoyo WangMyung LeeShannon NesbitWinston TropeHarrison KonskerEmmanuel FatoduMark S. BerryGeorge PoulstidesJeffrey NortonThomas BurdonLeah BackhusRoger CookeHuibin Tang

cardiologypulmonary diseasestranslational medicinerespiratory neurobiologyrespiratory medicinemedicinal researchfunctional modificationventilationmechanistic clinical trialjak inhibitionventilator-induced diaphragm dysfunctionmechanobiologypharmacologymedicineapplied physiologyinhibitory processintensive carerehabilitation

Biophysics of Human Anatomy and Physiology—a Special Issue in Honor of Prof. Cristobal Dos Remedios on the Occasion of His 80Th Birthday. Biophysical Reviews (2020)

Damien HallAmy LiRoger Cooke

biophysicsanatomyhuman anatomyphysiology

Decision Letter: Full-Length Plasmodium Falciparum Myosin a and Essential Light Chain Pfelc Structures Provide New Anti-Malarial Targets. (2020)

James SpudichRoger Cooke

malariadecision letterinfectious diseases

Factors That Modulate the Stability of the Super Relaxed State of Myosin in Skeletal Muscle Fibers. Biophysical Journal (2020)

Nariman NaberClyde F. WilsonRoger Cooke

biophysicsbiophysical aspectmyositisphysiologymuscle functionmuscle injuryfiberscellular physiologymolecular physiologycytoskeletonmolecular motorsmechanobiologyskeletal muscle fibersskeletal muscleprotein foldingsystems biologybiophysical modelingbone research

Nanomolar Atp Binding to Single Myosin Cross-Bridges in Rigor: A Molecular Approach to Studying Myosin Atp Kinetics Using Single Human Cardiomyocytes. Biophysical Reviews (2020)

Elvis PandzicChristian A. MorkelAmy LiRoger CookeRenee M. WhanCristobal G. dos Remedios

molecular and cellular biologysingle-molecule detectionmyosin atp kineticsprotein transportbiophysical chemistrysingle human cardiomyocytesbiophysical reviewmolecular kineticscell biologymolecular sciencemolecular biophysicssingle myosin cross-bridgesmolecular biologycell biophysicsnanomolar atpsingle molecule biophysicsstructural biologybiophysicsprotein sciencemolecular physiologymembrane biologymolecular cell biology

The Role of the Super-Relaxed State of Myosin in Human Metabolism. Metabolism Open (2020)

Clyde WilsonNariman NaberRoger Cooke

metabolismenergy metabolismmetabolic statehuman metabolismsuper-relaxed statebiochemistry

Deciphering the Super Relaxed State of Human β-Cardiac Myosin and the Mode of Action of Mavacamten From Myosin Molecules to Muscle Fibers. Proceedings of the National Academy of Sciences (2018)

Robert L. AndersonDarshan V. TrivediSaswata S. SarkarMarcus HenzeWeikang MaHenry GongChristopher S. RogersJoshua M. GorhamFiona L. WongMakenna M. MorckJonathan G. SeidmanKathleen M. RuppelThomas C. IrvingRoger CookeEric M. GreenJames A. Spudich

liver physiologymuscle functionneurophysiologypharmacologyphysiologyprotein foldingapplied physiologyhuman physiologycardiovascular physiologycardiac musclecardiologycellular physiologymyosin moleculesskeletal muscleprotein structurebiophysicsmolecular physiologymembrane biologyhuman b-cardiac myosinmammalian biology

Mavacamten Stabilizes a Folded-Back Sequestered Super-Relaxed State of β-Cardiac Myosin. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Robert L. AndersonDarshan V. TrivediSaswata S. SarkarMarcus HenzeWeikang MaHenry GongChristopher S. RogersFiona L. WongMakenna M. MorckJonathan G. SeidmanKathleen M. RuppelThomas C. IrvingRoger CookeEric M. GreenJames A. Spudich

vascular biologycardiologyb-cardiac myosinstem cell researchprotein sciencecell biologymedicinal researchneurosciencein vivo systemsprotein foldinggene expressionreceptorshealth sciencescell and molecular biology

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Roger R. Cooke

University of California, San Francisco

Affiliations

University of California San Francisco, Research

NoneRoger R. Cooke is currently serving as a University Of California San Francisco, Research faculty at University of California, San Francisco.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Roger R. Cooke

University of California, San Francisco

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Jak Inhibition With Tofacitinib Rapidly Increases Contractile Force in Human Skeletal Muscle. Life Science Alliance (2024)

inhibitory activitycontractile forcephysiologymuscle functionmuscle injuryjak inhibitionmechanobiologypharmacologyskeletal musclehuman skeletal muscle

Regulating Metabolic Rate via Skeletal Myosin Super Relaxed State. Biophysical Journal (2022)

Clyde F. WilsonNariman I. NaberRoger Cooke

biophysicsmetabolismenergy metabolismmetabolic statebiophysical reviewmetabolic regulationmetabolic controlmetabolic rateskeletal myosin superbiophysical modeling

Rationale and Design of a Mechanistic Clinical Trial of Jak Inhibition to Prevent Ventilator-Induced Diaphragm Dysfunction. Respiratory Medicine (2021)

Joseph B. ShragerYoyo WangMyung LeeShannon NesbitWinston TropeHarrison KonskerEmmanuel FatoduMark S. BerryGeorge PoulstidesJeffrey NortonThomas BurdonLeah BackhusRoger CookeHuibin Tang

Biophysics of Human Anatomy and Physiology—a Special Issue in Honor of Prof. Cristobal Dos Remedios on the Occasion of His 80Th Birthday. Biophysical Reviews (2020)

Damien HallAmy LiRoger Cooke

biophysicsanatomyhuman anatomyphysiology

Decision Letter: Full-Length Plasmodium Falciparum Myosin a and Essential Light Chain Pfelc Structures Provide New Anti-Malarial Targets. (2020)

James SpudichRoger Cooke

malariadecision letterinfectious diseases

Factors That Modulate the Stability of the Super Relaxed State of Myosin in Skeletal Muscle Fibers. Biophysical Journal (2020)

Nariman NaberClyde F. WilsonRoger Cooke

Nanomolar Atp Binding to Single Myosin Cross-Bridges in Rigor: A Molecular Approach to Studying Myosin Atp Kinetics Using Single Human Cardiomyocytes. Biophysical Reviews (2020)

Elvis PandzicChristian A. MorkelAmy LiRoger CookeRenee M. WhanCristobal G. dos Remedios

The Role of the Super-Relaxed State of Myosin in Human Metabolism. Metabolism Open (2020)

Clyde WilsonNariman NaberRoger Cooke

metabolismenergy metabolismmetabolic statehuman metabolismsuper-relaxed statebiochemistry

Deciphering the Super Relaxed State of Human β-Cardiac Myosin and the Mode of Action of Mavacamten From Myosin Molecules to Muscle Fibers. Proceedings of the National Academy of Sciences (2018)

Mavacamten Stabilizes a Folded-Back Sequestered Super-Relaxed State of β-Cardiac Myosin. bioRxiv (Cold Spring Harbor Laboratory) (2018)

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