Faculty

Institution

Unit

Venue

Paul Roepe

Georgetown University

Affiliations

School of Medicine

Biochemistry and Molecular & Cellular Biology

Georgetown University College of Arts & Sciences

Chemistry

NonePaul Roepe is currently serving as a Biochemistry And Molecular & Cellular Biology faculty at Georgetown University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Paul Roepe

Georgetown University

You can click a keyword to filter the displayed items

pharmacology biochemistry malaria infectious diseases drug resistance molecular biology parasitology medicinal chemistry tropical medicine gene expression membrane biology protein science plasmodium falciparum drug discovery molecular pharmacology clinical microbiology protein transport host-parasite relationships biological chemistry pharmaceutical chemistry membrane transport antiparasitic agent chloroquine resistance cellular physiology molecular physiology mammalian biology in vitro toxicology autophagy natural product research enzyme inhibition molecular regulation parasite genomics non-host resistance biomolecular analysis pharmaceutical sciences molecular microbiology emerging infectious diseases herb-drug interactions biological inorganic chemistry multidrug resistance toxoplasma gondii structural molecular biology biological invasions cell death plant physiology clinical chemistry functional modification cancer biology cell regulation heterocycle chemistry yeast phytochemistry natural product synthesis induced resistance experimental biophysics pathogen transmission drug targeting antimicrobial chemotherapy heme signaling mutagenesis pharmacokinetics protein overexpression digestive vacuolar ph bacteriorhodopsin photocycle antimalarial activity mdr protein quinine resistance intraerythrocytic malarial parasites pfcrt-mediated drug transport intracellular ph antimalarial drugs madagascar dry forest chloroquine transport molecular research cellular biology molecular evidence antimicrobial drug resistance pharmacological research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Additional Pfcrt Mutations Driven by Selective Pressure for Improved Fitness Can Result in the Loss of Piperaquine Resistance and Altered Plasmodium Falciparum Physiology. mBio (2023)

Laura M. HagenahSatish K. DhingraJennifer L. Small-SaundersTarrick QahashAndreas WillemsKyra A. SchindlerGabriel W. RangelEva Gil-IturbeJonathan KimEmiliya AkhundovaTomas YeoJohn OkomboFilippo ManciaMatthias QuickPaul D. RoepeManuel LlinásDavid A. Fidock

selective pressuregeneticsadditional pfcrt mutationspiperaquine resistancephysiologymolecular biologyfitness

Structures of Plasmodium Falciparum Chloroquine Resistance Transporter (Pfcrt) Isoforms and Their Interactions With Chloroquine. Biochemistry (2023)

Andreas WillemsAdrian KalawAyse EcerAmitesh KotwalLuke D. RoepePaul D. Roepe

anticoagulantsdrug metabolismvirus structurepharmaceutical chemistrypheromone biochemistrydrug resistanceprotein sciencemalariastructural molecular biologyprotein structurebiomolecular structurebiochemistrypharmacologyherb-drug interactionsmolecular biologyenzyme inhibitionthrombosisstructural biology

Evidence for the Early Emergence of Piperaquine-Resistant Plasmodium Falciparum Malaria and Modeling Strategies to Mitigate Resistance. PLoS Pathogens (2022)

Jennifer L. Small-SaundersLaura M. HagenahKathryn J. WichtSatish K. DhingraIoanna DeniJonathan KimJeremie VendomeEva Gil-IturbePaul D. RoepeMonica MehtaFilippo ManciaMatthias QuickMargaret J. EppsteinDavid A. Fidock

parasitologyglobal healthinduced resistanceearly emergenceinfection controlemerging infectious diseasesinfectious diseasesdrug resistancemicrobial pathogenesismalariaresistance managementclinical microbiologyinfectious disease modellingnon-host resistancetropical medicineantimicrobial resistanceepidemiology

Artemisinin-Based Drugs Target the Plasmodium Falciparum Heme Detoxification Pathway. Antimicrobial Agents and Chemotherapy (2021)

Kaleab A. RibbisoLaura E. HellerAbigail TayeErin JulianAndreas V. WillemsPaul D. Roepe

medicineinfectious diseasesantimicrobial chemotherapyclinical microbiologyartemisinin-based drugspharmacologydrug targetingantimicrobial resistance

In Vitro Growth Competition Experiments That Suggest Consequences of the Substandard Artemisinin Epidemic That May Be Accelerating Drug Resistance in P. Falciparum Malaria. PLoS ONE (2021)

Matthew R. HassettPaul D. Roepe

medicineinfectious diseasesdrug resistancemalariapharmacologytropical medicineexperimental medicine

Altered Drug Transport by Plasmodium Falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated With Piperaquine Resistance. Biochemistry (2020)

Bryce RiegelPaul D. Roepe

geneticsdrug resistancemalariapiperaquine resistancebiochemistrypharmacologymutagenesisdrug transportdrug delivery

Heterologous Expression, Purification, and Functional Analysis of the Plasmodium Falciparum Phosphatidylinositol 4-Kinase Iiiβ. Biochemistry (2020)

Anna R. SternbergPaul D. Roepe

microbiologyenzymesheterologous expressionmalariabiochemistrypharmacology

Structure and Drug Resistance of the Plasmodium Falciparum Transporter Pfcrt. Biophysical Journal (2020)

Jonathan KimYong Zi TanKathryn J. WichtSatchal K. ErramilliSatish K. DhingraJohn OkomboJeremie P. VendomeLaura M. HagenahSabrina I. GiacomettiClinton S. PotterBridget CarragherAnthony A. KossiakoffMatthias QuickDavid A. FidockFilippo Mancia

biophysicsdrug resistancemalariapharmacologymedical biophysicsexperimental biophysicsstructural biology

The Hydroxyl Functionality and a Rigid Proximal N Are Required for Forming a Novel Non-Covalent Quinine-Heme Complex. UNC Libraries (2020)

Alumasa, John N.Gorka, Alexander P.Casabianca, Leah B.Comstock, Ericade Dios, Angel C.Roepe, Paul D.

biophysicsinorganic compoundsinorganic chemistryinorganic synthesisbiological inorganic chemistrybiochemistrymaterials sciencecoordination chemistryhydroxyl functionality

Torin 2 Derivative, Ncats-Sm3710, Has Potent Multistage Antimalarial Activity Through Inhibition of P. Falciparum Phosphatidylinositol 4-Kinase ( Pf Pi4Kiiiβ). ACS Pharmacology & Translational Science (2020)

Karthik KrishnanPeter ZinielHao LiXiuli HuangDaniel HupaloNita GombakombaSandra Mendoza GuerreroThoai DotrangXiao LuDiana CaridhaAnna R. SternbergEmma HughesWei SunDaniel Y. BargieriPaul D. RoepeRichard J. SciottiMatthew D. WilkersonClifton L. DalgardGregory J. TawaAmy Q. WangXin XuWei ZhengPhilip E. SandersonWenwei HuangKim C. Williamson

tumor biologymedicineenzymesmedicinal chemistryantiparasitic agentmalariabiochemistrypharmacologydrug targetingenzyme inhibitiondrug discovery

1
2
3
4
5
16
10 / page

Paul Roepe

Georgetown University

Affiliations

School of Medicine

Biochemistry and Molecular & Cellular Biology

Georgetown University College of Arts & Sciences

Chemistry

NonePaul Roepe is currently serving as a Biochemistry And Molecular & Cellular Biology faculty at Georgetown University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Paul Roepe

Georgetown University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Additional Pfcrt Mutations Driven by Selective Pressure for Improved Fitness Can Result in the Loss of Piperaquine Resistance and Altered Plasmodium Falciparum Physiology. mBio (2023)

selective pressuregeneticsadditional pfcrt mutationspiperaquine resistancephysiologymolecular biologyfitness

Structures of Plasmodium Falciparum Chloroquine Resistance Transporter (Pfcrt) Isoforms and Their Interactions With Chloroquine. Biochemistry (2023)

Andreas WillemsAdrian KalawAyse EcerAmitesh KotwalLuke D. RoepePaul D. Roepe

Evidence for the Early Emergence of Piperaquine-Resistant Plasmodium Falciparum Malaria and Modeling Strategies to Mitigate Resistance. PLoS Pathogens (2022)

Artemisinin-Based Drugs Target the Plasmodium Falciparum Heme Detoxification Pathway. Antimicrobial Agents and Chemotherapy (2021)

Kaleab A. RibbisoLaura E. HellerAbigail TayeErin JulianAndreas V. WillemsPaul D. Roepe

medicineinfectious diseasesantimicrobial chemotherapyclinical microbiologyartemisinin-based drugspharmacologydrug targetingantimicrobial resistance

In Vitro Growth Competition Experiments That Suggest Consequences of the Substandard Artemisinin Epidemic That May Be Accelerating Drug Resistance in P. Falciparum Malaria. PLoS ONE (2021)

Matthew R. HassettPaul D. Roepe

medicineinfectious diseasesdrug resistancemalariapharmacologytropical medicineexperimental medicine

Altered Drug Transport by Plasmodium Falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated With Piperaquine Resistance. Biochemistry (2020)

Bryce RiegelPaul D. Roepe

geneticsdrug resistancemalariapiperaquine resistancebiochemistrypharmacologymutagenesisdrug transportdrug delivery

Heterologous Expression, Purification, and Functional Analysis of the Plasmodium Falciparum Phosphatidylinositol 4-Kinase Iiiβ. Biochemistry (2020)

Anna R. SternbergPaul D. Roepe

microbiologyenzymesheterologous expressionmalariabiochemistrypharmacology

Structure and Drug Resistance of the Plasmodium Falciparum Transporter Pfcrt. Biophysical Journal (2020)

biophysicsdrug resistancemalariapharmacologymedical biophysicsexperimental biophysicsstructural biology

The Hydroxyl Functionality and a Rigid Proximal N Are Required for Forming a Novel Non-Covalent Quinine-Heme Complex. UNC Libraries (2020)

Alumasa, John N.Gorka, Alexander P.Casabianca, Leah B.Comstock, Ericade Dios, Angel C.Roepe, Paul D.

biophysicsinorganic compoundsinorganic chemistryinorganic synthesisbiological inorganic chemistrybiochemistrymaterials sciencecoordination chemistryhydroxyl functionality

tumor biologymedicineenzymesmedicinal chemistryantiparasitic agentmalariabiochemistrypharmacologydrug targetingenzyme inhibitiondrug discovery

1
2
3
4
5
16
10 / page

Similar Faculty Members

Suzanne Walker

Institution

Harvard University

molecular metabolism

drug resistance analysis

Jun Liu

Institution

Johns Hopkins University

pharmacology

medicine

Boris Striepen

Institution

University of Pennsylvania

neglected tropical disease

parasitology

Paul H. Schlesinger

Institution

Washington University in St. Louis

collagen mineralization

membrane protein

Choukri Mamoun

Institution

Yale University

neglected tropical disease

parasitology

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Shahriar Mobashery

Institution

University of Notre Dame

pharmacology

biochemistry

Elizabeth Winzeler

Institution

University of California, San Diego

neglected tropical disease

antiparasitic agent

Francis Castellino

Institution

University of Notre Dame

pharmacology

biochemistry

Roberto Docampo

Institution

University of Georgia

parasitology

molecular and cellular biology

Similar Faculty Members

Suzanne Walker

Institution

Harvard University

molecular metabolism

drug resistance analysis

Jun Liu

Institution

Johns Hopkins University

pharmacology

medicine

Boris Striepen

Institution

University of Pennsylvania

neglected tropical disease

parasitology

Paul H. Schlesinger

Institution

Washington University in St. Louis

collagen mineralization

membrane protein

Choukri Mamoun

Institution

Yale University

neglected tropical disease

parasitology

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Shahriar Mobashery

Institution

University of Notre Dame

pharmacology

biochemistry

Elizabeth Winzeler

Institution

University of California, San Diego

neglected tropical disease

antiparasitic agent

Francis Castellino

Institution

University of Notre Dame

pharmacology

biochemistry

Roberto Docampo

Institution

University of Georgia

parasitology

molecular and cellular biology