Faculty

Institution

Unit

Venue

Michael Leffak

Professor Biochemistry & Molecular Biology Vice Chair of Research Biochemistry & Molecular Biology

Wright State University

Affiliations

Boonshoft School of Medicine

Biochemistry and Molecular Biology

College of Science and Mathematics

Biochemistry and Molecular Biology

Michael Leffak is currently serving as a Biochemistry And Molecular Biology Professor Biochemistry & Molecular Biology Vice Chair of Research Biochemistry & Molecular Biology at Wright State University.

Honors

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Experiences

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Education

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Michael Leffak

Wright State University

Professor Biochemistry & Molecular Biology Vice Chair of Research Biochemistry & Molecular Biology

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molecular biology genetics cell biology structural biology replication molecular and cellular biology biochemistry dna replication gene expression dna repair molecular genetics genome biology nucleic acids protein science chromosome biology chromatin molecular cell biology biological chemistry avian biology mammalian biology cytogenetics cellular biology cancer genetics rna biology structural molecular biology genome instability protein assembly gene regulation transcription regulation gene transfer sequence assembly cancer biology microbial genetics mutagenesis retina photobiology dna synthesis replication stress break-induced replication cellular biochemistry cellular physiology cell research cell death biomolecular structure free radical biology animal biotechnology general virology viral replication molecular research molecular basis cell proliferation cell autophagy cell regulation chromatin remodeling epigenetic changes chromosomal rearrangements avian evolution vision research in vivo systems crystal structures metalloproteins protein x-ray crystallography nucleic acid chemistry epstein-barr virus human orc conservative assembly replication-dependent instability repeat hairpins human c-myc gene chromosomal replication origin autonomous replication dna fragment mammalian chromosomal replicator multiple functional elements unpaired structures ectopic chromosomal location dna sequencing dna sequences forensic genetics chromosome instability

Notable Scholarly Works

Notable Federal Grants

Collaborators

Microsatellite Break-Induced Replication Generates Highly Mutagenized Extrachromosomal Circular Dnas. NAR Cancer (2024)

Rujuta Yashodhan GadgilS Dean RiderResha ShresthaVenicia AlhawachDavid C HitchMichael Leffak

microsatellite break-induced replicationcancer biologymutagenesisrna biologycancer researchgeneticsreplicationcancer geneticscancer genomicsoncologybreast cancer

Suppressors of Break-Induced Replication in Human Cells. Genes (2023)

Stanley Dean RiderFrench J. DamewoodRujuta Yashodhan GadgilDavid C. HitchVenicia AlhawachResha ShresthaMatilyn ShanahanNathen ZavadaMichael Leffak

physiologycell biologybreak-induced replicationreplicationdna repairgenetics

Contributors. Elsevier eBooks (2022)

Ron AltermanJeffrey E. ArleKerry BradleySergio CanaveroSteven M. FalowskiChad W. FarleyYakov GologorskyJianwen Wendy GuH. Louis JournéeJohn KastOlga KhazenJoachim K. KraussVignessh KumarMark LentRobert M. LevyAndres M. LozanoCharles MackelGeorge T. MandyburBryan L. McLaughlinDaniel R. MerrillAlon Y. MogilnerGabi MolnarGuillermo A. MonsalveRichard B. NorthYunseo Linda ParkJohn ParkerShrey PatelJulie G. PilitsisFrancisco A. PonceJason E. PopeAdolfo Ramirez-ZamoraLouis J. RasoJoshua M. RosenowJay L. ShilsPeter SingleKonstantin V. SlavinMichael D. StaudtMark M. SteckerHuy Q. Truong

Stable G-Quadruplex Dna Structures Promote Replication-Dependent Genome Instability. Journal of Biological Chemistry (2022)

S. Dean RiderRujuta Yashodhan GadgilDavid C. HitchFrench J. DamewoodNathen ZavadaMatilyn ShanahanVenicia AlhawachResha ShresthaKazuo Shin-yaMichael Leffak

genome instabilityreplication-dependent genome instabilitybiochemistrybiologymolecular biologystructural biologygenome biology

Replication Stress at Microsatellites Causes Dna Double-Strand Breaks and Break-Induced Replication. Journal of Biological Chemistry (2020)

Rujuta Yashodhan GadgilEric J. RomerCaitlin C. GoodmanS.Dean RiderFrench J. DamewoodJoanna R. BarthelemyKazuo Shin-yaHelmut HanenbergMichael Leffak

biophysicsreplication stressbiochemistrymolecular biologyreplicationstructural biologybreak-induced replication

Analysis of Trinucleotide Repeat Stability by Integration at a Chromosomal Ectopic Site. Methods in molecular biology (2019)

Rujuta Yashodhan GadgilS. Dean RiderTodd LewisJoanna BarthelemyMichael Leffak

trinucleotide repeat stabilitymolecular biologychromosomal ectopic sitestructural biologygenetics

Deficiency of the Fanconi Anemia E2 Ubiqitin Conjugase Ube2T Only Partially Abrogates Alu-Mediated Recombination in a New Model of Homology Dependent Recombination. (2019)

Todd W. LewisJoanna R. BarthelemyElizabeth L. VirtsFelicia M. KennedyRujuta Y. GadgilConstanze WiekRene M. LinkaFeng ZhangPaul R. AndreassenHelmut HanenbergMichael Leffak

alu-mediated recombinationprotein sciencehomology dependent recombinationepigeneticsbiochemistrymolecular biologydna repairgenetics

Interaction Between Due-B and Treslin is Required to Load Cdc45 on Chromatin in Human Cells. Journal of Biological Chemistry (2018)

Sumeet PoudelJianhong YaoMichael G. KempMichael Leffak

protein sciencecell biologychromosome biologyhuman biologybiologymolecular biologychromatinbiological chemistrybiomolecular interactionsgene expression

Break‐Induced Replication Links Microsatellite Expansion to Complex Genome Rearrangements. BioEssays (2017)

Michael Leffak

replicationcomplex genome rearrangementsmolecular biology

Replication Stalling and Dna Microsatellite Instability. Biophysical Chemistry (2017)

R. GadgilJ. BarthelemyT. LewisM. Leffak

biophysicsdna microsatellite instabilitymolecular biologyreplication stallingbiophysical chemistry

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Michael Leffak

Professor Biochemistry & Molecular Biology Vice Chair of Research Biochemistry & Molecular Biology

Wright State University

Affiliations

Boonshoft School of Medicine

Biochemistry and Molecular Biology

College of Science and Mathematics

Biochemistry and Molecular Biology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Leffak

Wright State University

Professor Biochemistry & Molecular Biology Vice Chair of Research Biochemistry & Molecular Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Microsatellite Break-Induced Replication Generates Highly Mutagenized Extrachromosomal Circular Dnas. NAR Cancer (2024)

Rujuta Yashodhan GadgilS Dean RiderResha ShresthaVenicia AlhawachDavid C HitchMichael Leffak

microsatellite break-induced replicationcancer biologymutagenesisrna biologycancer researchgeneticsreplicationcancer geneticscancer genomicsoncologybreast cancer

Suppressors of Break-Induced Replication in Human Cells. Genes (2023)

Stanley Dean RiderFrench J. DamewoodRujuta Yashodhan GadgilDavid C. HitchVenicia AlhawachResha ShresthaMatilyn ShanahanNathen ZavadaMichael Leffak

physiologycell biologybreak-induced replicationreplicationdna repairgenetics

Contributors. Elsevier eBooks (2022)

Stable G-Quadruplex Dna Structures Promote Replication-Dependent Genome Instability. Journal of Biological Chemistry (2022)

S. Dean RiderRujuta Yashodhan GadgilDavid C. HitchFrench J. DamewoodNathen ZavadaMatilyn ShanahanVenicia AlhawachResha ShresthaKazuo Shin-yaMichael Leffak

genome instabilityreplication-dependent genome instabilitybiochemistrybiologymolecular biologystructural biologygenome biology

Replication Stress at Microsatellites Causes Dna Double-Strand Breaks and Break-Induced Replication. Journal of Biological Chemistry (2020)

Rujuta Yashodhan GadgilEric J. RomerCaitlin C. GoodmanS.Dean RiderFrench J. DamewoodJoanna R. BarthelemyKazuo Shin-yaHelmut HanenbergMichael Leffak

biophysicsreplication stressbiochemistrymolecular biologyreplicationstructural biologybreak-induced replication

Analysis of Trinucleotide Repeat Stability by Integration at a Chromosomal Ectopic Site. Methods in molecular biology (2019)

Rujuta Yashodhan GadgilS. Dean RiderTodd LewisJoanna BarthelemyMichael Leffak

trinucleotide repeat stabilitymolecular biologychromosomal ectopic sitestructural biologygenetics

Deficiency of the Fanconi Anemia E2 Ubiqitin Conjugase Ube2T Only Partially Abrogates Alu-Mediated Recombination in a New Model of Homology Dependent Recombination. (2019)

Todd W. LewisJoanna R. BarthelemyElizabeth L. VirtsFelicia M. KennedyRujuta Y. GadgilConstanze WiekRene M. LinkaFeng ZhangPaul R. AndreassenHelmut HanenbergMichael Leffak

alu-mediated recombinationprotein sciencehomology dependent recombinationepigeneticsbiochemistrymolecular biologydna repairgenetics

Interaction Between Due-B and Treslin is Required to Load Cdc45 on Chromatin in Human Cells. Journal of Biological Chemistry (2018)

Sumeet PoudelJianhong YaoMichael G. KempMichael Leffak

protein sciencecell biologychromosome biologyhuman biologybiologymolecular biologychromatinbiological chemistrybiomolecular interactionsgene expression

Break‐Induced Replication Links Microsatellite Expansion to Complex Genome Rearrangements. BioEssays (2017)

Michael Leffak

replicationcomplex genome rearrangementsmolecular biology

Replication Stalling and Dna Microsatellite Instability. Biophysical Chemistry (2017)

R. GadgilJ. BarthelemyT. LewisM. Leffak

biophysicsdna microsatellite instabilitymolecular biologyreplication stallingbiophysical chemistry

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Colorado State University

genome instability

dna repair pathways

Karolin Luger

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Colorado State University

molecular biology

structural biology

Carl W. Schmid

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University of California, Davis

gene expression

genetics

Prescott Deininger

Institution

Tulane University

cancer letter

human genetics

Wolf-Dietrich Heyer

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University of California, Davis

homologous recombination

genome instability

Michael Botchan

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University of California, Berkeley

genetic technologies

dna replication

Brian D. Strahl

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chromatin remodeling

yeast

Carol Greider

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University of California, Santa Cruz

dna replication

genetics

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epigenetic mechanisms

chromatin remodeling

Bruce Alberts

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carcinogenesis

cancer cell