Faculty

Institution

Unit

Venue

Michael Botchan

Professor Emeritus of Molecular Therapeutics

University of California, Berkeley

Affiliations

College of Letters & Science

Biological Sciences

Molecular and Cell Biology

Michael Botchan is currently serving as a Biological Sciences Professor Emeritus of Molecular Therapeutics at University of California, Berkeley.

Honors

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Experiences

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Education

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Michael Botchan

University of California, Berkeley

Professor Emeritus of Molecular Therapeutics

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genetics molecular biology virology cell biology viral genetics gene expression dna replication virus research avian biology molecular virology developmental biology genome biology insect molecular biology general virology structural biology molecular genetics replication viral replication viral evolution genomics protein science animal virus molecular and cellular biology molecular cell biology mammalian biology structural molecular biology transcription regulation gene regulation molecular regulation cytogenetics developmental genetics virus-host interactions cancer genetics viral oncology biomolecular structure protein genetics chromosome biology gene function cellular biology animal biotechnology biological chemistry mutagenesis virus structure epigenomics gene recognition rna biology enzyme inhibition molecular structure molecular physiology molecular science genome sequencing cancer biology genome structure molecular research sequence assembly transformed cells viral dna protein function dna analysis gene characterization viral structural protein molecular biotechnology origin recognition complex cmg helicase eukaryotic replisome rat cells activation domain viral dna sequences viral excision viral dna replication eukaryotic chromosome genome sequence genomic engineering germline gene modification prudent path forward simian cells cell cycle genome editing plo biology genetic technologies crispr system

Notable Scholarly Works

Notable Federal Grants

Collaborators

Editor's Evaluation: Artificially Stimulating Retrotransposon Activity Increases Mortality and Accelerates a Subset of Aging Phenotypes in Drosophila. (2022)

Michael R Botchan

geneticsinhibitory activityretrotransposon activityevolutionary biologymortality

Editor's Evaluation: Mcmbp Promotes the Assembly of the Mcm2–7 Hetero-Hexamer to Ensure Robust Dna Replication in Human Cells. (2022)

Michael R Botchan

robust dna replicationgeneticsmarkov chain monte carlomolecular biologydna replicationbiochemistry

Decision Letter: Ddk Regulates Replication Initiation by Controlling the Multiplicity of Cdc45-Gins Binding to Mcm2-7. (2021)

Michael R BotchanDirk Remus

geneticsmolecular biologydna repairdecision letterreplication initiation

Editor's Evaluation: Cdc6 is Sequentially Regulated by Pp2A-Cdc55, Cdc14, and Sic1 for Origin Licensing in S. Cerevisiae. (2021)

Michael R Botchan

origin licensingmolecular biologycell biology

Molecular Determinants of Phase Separation for Drosophila Dna Replication Licensing Factors. eLife (2021)

Matthew W ParkerJonchee A KaoAlvin HuangJames M BergerMichael R Botchan

molecular researchavian biologygeneticsmolecular determinantsmolecular geneticsmolecular biologydevelopmental biologydna replicationphase separationinsect molecular biology

Structural Mechanisms for Replicating Dna in Eukaryotes. Annual Review of Biochemistry (2021)

Ilan AttaliMichael R. BotchanJames M. Berger

replicationstructural biologygeneticsmolecular biologystructural mechanismsdna replicationbiochemistry

A New Class of Disordered Elements Controls Dna Replication Through Initiator Self-Assembly. eLife (2019)

Matthew W ParkerMaren BellMustafa MirJonchee A KaoXavier DarzacqMichael R BotchanJames M Berger

dna replicationdisordered elementsmolecular biologygenetics

Decision Letter: A Conserved Mcm4 Motif is Required for Mcm2-7 Double-Hexamer Formation and Origin Dna Unwinding. (2019)

Michael R BotchanAlessandro Costa

genomicsgenome biologydevelopmental biologygeneticssequence motifmolecular geneticsmolecular biologyepigeneticsdecision letter

Molecular Basis for Atp-Hydrolysis-Driven Dna Translocation by the Cmg Helicase of the Eukaryotic Replisome. Cell Reports (2019)

Patrik EickhoffHazal B. KoseFabrizio MartinoTatjana PetojevicFerdos Abid AliJulia LockeNele TambergAndrea NansJames M. BergerMichael R. BotchanHasan YardimciAlessandro Costa

molecular researchmolecular biotechnologybiological chemistrydna repaircmg helicaseatp-hydrolysis-driven dna translocationcell biologygenome biologymolecular cell biologyenzymesgenetic engineeringcellular enzymologyprotein sciencecellular biologymembrane biologymolecular physiologyeukaryotic replisomegeneticsmolecular geneticsmolecular biologymolecular basis

Conformational Control and Dna-Binding Mechanism of the Metazoan Origin Recognition Complex. Proceedings of the National Academy of Sciences (2018)

Franziska BleichertAlexander LeitnerRuedi AebersoldMichael R. BotchanJames M. Berger

molecular biophysicsbiophysicsconformational controlmolecular sciencegeneticsmolecular biologymolecular recognitionrna biologydna-binding mechanism

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Michael Botchan

Professor Emeritus of Molecular Therapeutics

University of California, Berkeley

Affiliations

College of Letters & Science

Biological Sciences

Molecular and Cell Biology

Michael Botchan is currently serving as a Biological Sciences Professor Emeritus of Molecular Therapeutics at University of California, Berkeley.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Botchan

University of California, Berkeley

Professor Emeritus of Molecular Therapeutics

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Editor's Evaluation: Artificially Stimulating Retrotransposon Activity Increases Mortality and Accelerates a Subset of Aging Phenotypes in Drosophila. (2022)

Michael R Botchan

geneticsinhibitory activityretrotransposon activityevolutionary biologymortality

Editor's Evaluation: Mcmbp Promotes the Assembly of the Mcm2–7 Hetero-Hexamer to Ensure Robust Dna Replication in Human Cells. (2022)

Michael R Botchan

robust dna replicationgeneticsmarkov chain monte carlomolecular biologydna replicationbiochemistry

Decision Letter: Ddk Regulates Replication Initiation by Controlling the Multiplicity of Cdc45-Gins Binding to Mcm2-7. (2021)

Michael R BotchanDirk Remus

geneticsmolecular biologydna repairdecision letterreplication initiation

Editor's Evaluation: Cdc6 is Sequentially Regulated by Pp2A-Cdc55, Cdc14, and Sic1 for Origin Licensing in S. Cerevisiae. (2021)

Michael R Botchan

origin licensingmolecular biologycell biology

Molecular Determinants of Phase Separation for Drosophila Dna Replication Licensing Factors. eLife (2021)

Matthew W ParkerJonchee A KaoAlvin HuangJames M BergerMichael R Botchan

molecular researchavian biologygeneticsmolecular determinantsmolecular geneticsmolecular biologydevelopmental biologydna replicationphase separationinsect molecular biology

Structural Mechanisms for Replicating Dna in Eukaryotes. Annual Review of Biochemistry (2021)

Ilan AttaliMichael R. BotchanJames M. Berger

replicationstructural biologygeneticsmolecular biologystructural mechanismsdna replicationbiochemistry

A New Class of Disordered Elements Controls Dna Replication Through Initiator Self-Assembly. eLife (2019)

Matthew W ParkerMaren BellMustafa MirJonchee A KaoXavier DarzacqMichael R BotchanJames M Berger

dna replicationdisordered elementsmolecular biologygenetics

Decision Letter: A Conserved Mcm4 Motif is Required for Mcm2-7 Double-Hexamer Formation and Origin Dna Unwinding. (2019)

Michael R BotchanAlessandro Costa

genomicsgenome biologydevelopmental biologygeneticssequence motifmolecular geneticsmolecular biologyepigeneticsdecision letter

Molecular Basis for Atp-Hydrolysis-Driven Dna Translocation by the Cmg Helicase of the Eukaryotic Replisome. Cell Reports (2019)

Patrik EickhoffHazal B. KoseFabrizio MartinoTatjana PetojevicFerdos Abid AliJulia LockeNele TambergAndrea NansJames M. BergerMichael R. BotchanHasan YardimciAlessandro Costa

Conformational Control and Dna-Binding Mechanism of the Metazoan Origin Recognition Complex. Proceedings of the National Academy of Sciences (2018)

Franziska BleichertAlexander LeitnerRuedi AebersoldMichael R. BotchanJames M. Berger

molecular biophysicsbiophysicsconformational controlmolecular sciencegeneticsmolecular biologymolecular recognitionrna biologydna-binding mechanism

1
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10 / page

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Similar Faculty Members

Jasper Rine

Institution

University of California, Berkeley

epigenetic mechanisms

chromatin remodeling

James T. Kadonaga

Institution

University of California, San Diego

chromatin remodeling

gene expression

James Wohlschlegel

Institution

University of California, Los Angeles

molecular informatics

bioinformatics

Robert Tjian

Institution

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molecular biology

genetics

Joan Steitz

Institution

Yale University

gene expression

splicing variant

Jennifer A. Doudna

Institution

University of California, Berkeley

molecular informatics

genetic engineering

Andrew Emili

Institution

Boston University

interactomics

biomedical informatics

Claudio Basilico

Institution

New York University

craniofacial research

cellular differentiation

Stanley N. Cohen

Institution

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molecular biology

mutagenesis (molecular biology technique)