Faculty

Institution

Unit

Venue

William W Metcalf

Professor G William Arends Professor in Molecular & Cellular Biology Professor of Microbiology

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Microbiology

William W Metcalf is currently serving as a College Of Liberal Arts & Sciences Professor G William Arends Professor in Molecular & Cellular Biology Professor of Microbiology at University of Illinois Urbana-Champaign.

Honors

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Experiences

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Education

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William W Metcalf

University of Illinois Urbana-Champaign

Professor G William Arends Professor in Molecular & Cellular Biology Professor of Microbiology

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biochemistry microbiology molecular biology enzymes biosynthesis molecular metabolism biological chemistry bacteria applied microbiology natural product biosynthesis molecular microbiology microbial genetics biomolecules genetics biotechnology metabolism chemical biology biochemical sciences genome biology microbial cell factory metabolic pathways enzyme catalysis microbial physiology structural molecular biology biocatalysis bioenergetics biotransformation environmental microbiology mutagenesis (molecular biology technique) antimicrobial agents natural product research enzyme inhibition structure-function enzyme kinetics nucleic acids bacteriology biomolecular structure biochemical genetics protein biosynthesis molecular informatics natural product synthesis escherichia coli biological carbon fixation microbial proteomics metabolic models molecular biotechnology methanol carbonyl metabolism metabolic pathway analysis evolutionary microbiology secondary metabolites aldehyde dehydrogenase metabolic networks prokaryotic system microbial diversity active site genetic analysis cellular enzymology gene structure extremophiles proteomic technologies protein synthesis gene cluster methanosarcina acetivorans metabolomic profiling allele replacement h 2 phosphite dehydrogenase genetic methods genome mining computational framework carbon monoxide gene cluster families pepm gene new methods methyl-coenzyme m reductase hydrogenase function gene expression methanogenic archaea

Notable Scholarly Works

Notable Federal Grants

Collaborators

Expanding the Cultivable Human Archaeome: Methanobrevibacter Intestini Sp. Nov. and Strain Methanobrevibacter Smithii ‘Graz-2’ From Human Faeces. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2025)

Viktoria WeinbergerRokhsareh MohammadzadehMarcus BlohsKerstin KaltAlexander MahnertSarah MoserMarina CecoviniPolona MerteljTamara ZurabishviliBhawna AroraJacqueline WolfTejus ShindeTobias MadlHansjörg HabischDagmar KolbDominique PernitschKerstin HingerlWilliam MetcalfChristine Moissl-Eichinger

microbial systematicsapplied microbiologyfaecal sampleinfectious diseasesenvironmental microbiologyevolutionary microbiologymetagenomicshuman faecal samplesmicroorganismsmicrobial physiologymicrobiologybacteriagut microbesfood microbiologymicrobial diversityhuman faecesmicrobiomemicrobial ecology

Genetic and Biochemical Characterization of a Radical Sam Enzyme Required for Post-Translational Glutamine Methylation of Methyl-Coenzyme M Reductase. mBio (2025)

Roy J. Rodriguez CarreroCody T. LloydJanhavi BorkarShounak NathLiviu M. MiricaSatish NairSquire J. BookerWilliam Metcalf

metabolismradical sam enzymeenzymesenzyme catalysisactive sitebiocatalysismcra peptidebiochemistrybiochemical sciencesstructure-function enzyme kineticsbiological chemistrybiomolecular engineering

Phosphonate Products and Methods. U.S. Patent No. 12264172 (2025)

William W Metcalf

natural product researchpharmaceutical chemistrychemical synthesisphosphonate productsbiomolecular engineering

The Redox Landscape of Pyruvate: Ferredoxin Oxidoreductases Reveals Often Conserved Fe–S Cluster Potentials. Journal of Biological Chemistry (2025)

Sheila C BonitatibusRyan V PhamAndrew C WeitzMadeline M Lopéz-MuñozBin LiWilliam W MetcalfSatish K NairSean J Elliott

redox landscapemetabolismenzymesmolecular metabolismenzyme catalysismicrobial physiologybiochemistryma pforbioenergeticspfor enzymesmolecular biologystructure-function enzyme kineticsredox chemistryredox biology

Expanding the Cultivable Human Archaeome: Methanobrevibacter Intestini Sp. Nov. and Strain Methanobrevibacter Smithii “ Graz-2 ” From Human Feces. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Viktoria WeinbergerRokhsareh MohammadzadehMarcus BlohsKerstin KaltAlexander MahnertSarah MoserMarina CecoviniPolona MerteljTamara ZurabishviliJacqueline WolfTejus ShindeTobias MadlHansjörg HabischDagmar KolbDominique PernitschKerstin HingerlWilliam MetcalfChristine Moissl-Eichinger

mcra genemetagenomicsbacteriamicrobial cell factoryhuman fecesmicrobiomeinfectious diseasesevolutionary microbiologymicrobial physiologybiologymicrobial diversitymicrobial ecologymicroorganismsmicrobiologyfood microbiologyapplied microbiologyenvironmental microbiologymicrobial systematicsm. smithii graz-2

No Evidence for Methanotrophic Growth of Diverse Marine Methanogens. Proceedings of the National Academy of Sciences (2024)

Grayson L. ChadwickDipti D. NayakMichael RotherWilliam W. Metcalf

oceanographyocean sciencesbiogeochemistrymarine biotamethanotrophic growthbiologymarine systemsmarine biologyecologymarine chemistrybiological oceanographycold seeps

Structural Organization of Pyruvate: Ferredoxin Oxidoreductase From the Methanogenic Archaeon Methanosarcina Acetivorans. Structure (2024)

Matteo CossuDaniel CatlinSean J ElliottWilliam W MetcalfSatish K Nair

enzymesmolecular metabolismenzyme catalysisbiocatalysisbiochemistrystructural organizationchemical biologymolecular biologybiological chemistrystructure-function enzyme kineticsferredoxin oxidoreductaseredox biology

The Redox Landscape of the 2-Oxoacid: Ferredoxin Oxidoreductase Superfamily Reveals Universally Conserved Fe–S Cluster Potentials. SSRN Electronic Journal (2024)

Sheila BonitatibusAndrew WeitzMadeline M. Lopez-MuñozBin LiMatteo CossuWilliam MetcalfSatish K. NairSean Elliott

redox landscapestructural molecular biologyenzymesredox biologyredox signalingbiochemistrychemical biologytransition metal chemistrymolecular biologyoxidative stressfree radical biologybiological chemistryredox chemistrybiophysical chemistry

Transcriptional Response of Methanosarcina Acetivorans to Repression of the Energy-Conserving Methanophenazine: Com-Cob Heterodisulfide Reductase Enzyme Hdred. Microbiology Spectrum (2024)

Nicole R. BuanWilliam W. Metcalf

metabolismenzymesmolecular metabolismmicrobial physiologymetabolic pathwaysexponential growthbiochemistrycell metabolismbioenergeticschemical biologymolecular biologycarbonyl metabolismatp availabilitybiosynthesismethanosarcina acetivorans

A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin is Widespread in Actinobacteria. Journal of Bacteriology (2023)

Luke BownRyuichi HirotaMichelle N. GoettgeJerry CuiDavid T. KristLingyang ZhuConstantin GiurgiuWilfred A. van der DonkKou-San JuWilliam W. Metcalf

natural product researchnatural product biosynthesisnatural productsbiomoleculesbranched carbon skeletonbioinformatic analysesbiochemistrymicrobiologybiotechnologybiochemical taxonomynovel pathwaynatural product synthesisbiotransformationbiosynthesis

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William W Metcalf

Professor G William Arends Professor in Molecular & Cellular Biology Professor of Microbiology

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Microbiology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

William W Metcalf

University of Illinois Urbana-Champaign

Professor G William Arends Professor in Molecular & Cellular Biology Professor of Microbiology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Genetic and Biochemical Characterization of a Radical Sam Enzyme Required for Post-Translational Glutamine Methylation of Methyl-Coenzyme M Reductase. mBio (2025)

Roy J. Rodriguez CarreroCody T. LloydJanhavi BorkarShounak NathLiviu M. MiricaSatish NairSquire J. BookerWilliam Metcalf

metabolismradical sam enzymeenzymesenzyme catalysisactive sitebiocatalysismcra peptidebiochemistrybiochemical sciencesstructure-function enzyme kineticsbiological chemistrybiomolecular engineering

Phosphonate Products and Methods. U.S. Patent No. 12264172 (2025)

William W Metcalf

natural product researchpharmaceutical chemistrychemical synthesisphosphonate productsbiomolecular engineering

The Redox Landscape of Pyruvate: Ferredoxin Oxidoreductases Reveals Often Conserved Fe–S Cluster Potentials. Journal of Biological Chemistry (2025)

Sheila C BonitatibusRyan V PhamAndrew C WeitzMadeline M Lopéz-MuñozBin LiWilliam W MetcalfSatish K NairSean J Elliott

Expanding the Cultivable Human Archaeome: Methanobrevibacter Intestini Sp. Nov. and Strain Methanobrevibacter Smithii “ Graz-2 ” From Human Feces. bioRxiv (Cold Spring Harbor Laboratory) (2024)

No Evidence for Methanotrophic Growth of Diverse Marine Methanogens. Proceedings of the National Academy of Sciences (2024)

Grayson L. ChadwickDipti D. NayakMichael RotherWilliam W. Metcalf

oceanographyocean sciencesbiogeochemistrymarine biotamethanotrophic growthbiologymarine systemsmarine biologyecologymarine chemistrybiological oceanographycold seeps

Structural Organization of Pyruvate: Ferredoxin Oxidoreductase From the Methanogenic Archaeon Methanosarcina Acetivorans. Structure (2024)

Matteo CossuDaniel CatlinSean J ElliottWilliam W MetcalfSatish K Nair

The Redox Landscape of the 2-Oxoacid: Ferredoxin Oxidoreductase Superfamily Reveals Universally Conserved Fe–S Cluster Potentials. SSRN Electronic Journal (2024)

Sheila BonitatibusAndrew WeitzMadeline M. Lopez-MuñozBin LiMatteo CossuWilliam MetcalfSatish K. NairSean Elliott

Transcriptional Response of Methanosarcina Acetivorans to Repression of the Energy-Conserving Methanophenazine: Com-Cob Heterodisulfide Reductase Enzyme Hdred. Microbiology Spectrum (2024)

Nicole R. BuanWilliam W. Metcalf

A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin is Widespread in Actinobacteria. Journal of Bacteriology (2023)

Luke BownRyuichi HirotaMichelle N. GoettgeJerry CuiDavid T. KristLingyang ZhuConstantin GiurgiuWilfred A. van der DonkKou-San JuWilliam W. Metcalf

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