Faculty

Institution

Unit

Venue

Marvin H. Caruthers

Distinguished Professor

University of Colorado Boulder

Affiliations

Natural Sciences

Biochemistry Department

College of Arts and Sciences

Natural Sciences

Marvin H. Caruthers is currently serving as a Biochemistry Distinguished Professor at University of Colorado Boulder.

Honors

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Experiences

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Education

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Marvin H. Caruthers

University of Colorado Boulder

Distinguished Professor

You can click a keyword to filter the displayed items

molecular biology biochemistry biomolecular engineering chemical synthesis oligonucleotides organic synthesis nucleic acids structural molecular biology nucleic acid chemistry synthetic biology biosynthesis peptide science transition metal chemistry gene expression chemical biology genetics protein science organic chemistry structural biology rna biology synthetic chemistry biological chemistry biomolecules coordination chemistry molecular science biomolecular structure nanoparticle research gene structure enzymatic modification gene control regions protein synthesis dna sequencing total synthesis structural gene molecular cell biology dna nanotechnology gene regulation peptide synthesis enantioselective synthesis virus research enzyme inhibition peptides gene function rna processing dna analysis protein phosphorylation key site escherichia coli phosphorodithioate dna solid-phase synthesis genome biology gene editing small rna biological inorganic chemistry nanostructure synthesis sequence assembly phosphoramidite method biological activity viral genetics gene transfer molecular regulation transcription regulation rna structure prediction synthesis methods lac repressor enzymic joining deoxypolynucleotide synthesis biological studies intron retention enzyme catalysis biocatalysis mutagenesis protein genetics key intermediates deoxynucleoside phosphoramidites lac operator

Notable Scholarly Works

Notable Federal Grants

Collaborators

Aso-Based Pkm Splice-Switching Therapy Increases Anti-Ctla-4 Antibody Efficacy in Pancreatic Ductal Adenocarcinoma. Cell Discovery (2026)

oncogenesanti-ctla-4 antibody efficacycancer immunotherapyimmunologycell biologynovel therapiesimmunotherapymolecular cancercellular therapypancreatic ductal adenocarcinomapancreatic cancertherapeutic targetscancer cellsimmune checkpoint inhibitorsoncology

Targeted Antisense Oligonucleotide Therapy Rescues Prpf31 Expression in Retinitis Pigmentosa Caused by a Splicing Mutation. Molecular Therapy (2026)

gene therapyantisense therapyretinitis pigmentosamutagenesis (molecular biology technique)molecular medicinecell biologynucleic acidssplicing variantsplicing mutationmolecular cell biologymolecular diagnosticsmolecular biologytherapeutic targetsophthalmology retinadna repair

Pkm Splice-Switching Asos Induce Upregulation of Dual-Specificity Phosphatases and Dephosphorylation of Erk1/2 in Hepatocellular Carcinoma. Journal of Biological Chemistry (2025)

oncogenespathologycancer cellstumor biologyprotein phosphorylationcell deathcell signalingcell biologymolecular cancersignaling pathwaysdual-specificity phosphatasescancer researchmolecular cell biologytumor suppressorsmolecular biologysignal transductionhepatocellular carcinomacancer biology

Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-In-Sarcoma Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences (2024)

Rita MejziniMarvin H. CaruthersBalazs SchaferOndrej KostovKavitha SudheendranMarija CibaMathias DanielsenSteve WiltonPatrick Anthony AkkariLoren L. Flynn

neurologyantisense therapysarcomamolecular medicineamyotrophic lateral sclerosisnovel therapiesmolecular scienceneurodegenerative diseasesallele-selective thiomorpholino antisenseoligonucleotidesmolecular biologytherapeutic targetstherapeutic efficacy

Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids. Nucleic Acid Therapeutics (2024)

Ledong WanAlexander J. KralDillon VossBalázs SchäferKavitha SudheendranMathias DanielsenMarvin H. CaruthersAdrian R. Krainer

dna sequencingsplice-switching antisense oligonucleotidesnucleic acidsgenomicsoligonucleotidespharmacologymolecular biologypancreas-cancer organoidsgene expressiononcologygenetics

Compromised Nonsense-Mediated Rna Decay Results in Truncated Rna-Binding Protein Production Upon Dux4 Expression. Cell Reports (2023)

Amy E. CampbellMichael C. DyleRoberto AlbaneseTyler MathenyKavitha SudheendranMichael A. CortázarThomas FormanRui FuAustin E. GillenMarvin H. CaruthersStephen N. FloorLorenzo CalvielloSujatha Jagannathan

gene expressionrna biologymolecular biology

Innovative Splice Switching Oligonucleotide Therapy for Niemann-Pick Type C1 Disease. IBRO Neuroscience Reports (2023)

Maria Martinez De LagranYu-Han HuangOndrej KostovHaiyan ZhouPaul GissenMarvin CaruthersTimothy YuDaniel GinbergMara Dierssen

oligonucleotidesoligonucleotide therapyinnovative spliceneuroscience

Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry. Molecules (2023)

Sibasish PaulMarvin H. Caruthers

enzymatic modificationphosphoramidite chemistrybiological macromoleculesbiochemical engineeringbiomoleculessynthetic biologyfunctional modificationmolecular sciencebiochemistryorganic synthesischemical synthesisbiopolymersoligonucleotidesmolecular biologybackbone-modified morpholino oligonucleotidesstructural molecular biologybiomolecular engineeringbiosynthesis

Thiomorpholino Oligonucleotides as a Robust Class of Next Generation Platforms for Alternate Mrna Splicing. Proceedings of the National Academy of Sciences (2022)

Bao T. LeSibasish PaulKatarzyna JastrzebskaHeera LangerMarvin H. CaruthersRakesh N. Veedu

thiomorpholino oligonucleotidesalternate mrnaoligonucleotidestranscription (biology)molecular biologynext generation platforms

Nuclear Compartmentalization of Tert Mrna and Tug1 Lncrna is Driven by Intron Retention. Nature Communications (2021)

Gabrijela DumbovićUlrich BraunschweigHeera K. LangnerMichael SmalleganJosep BiaynaEvan P. HassKatarzyna JastrzebskaBenjamin BlencoweThomas R. CechMarvin H. CaruthersJohn L. Rinn

intron retentiontert mrnanuclear organizationmolecular biologynuclear compartmentalization

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Marvin H. Caruthers

Distinguished Professor

University of Colorado Boulder

Affiliations

Natural Sciences

Biochemistry Department

College of Arts and Sciences

Natural Sciences

Marvin H. Caruthers is currently serving as a Biochemistry Distinguished Professor at University of Colorado Boulder.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Marvin H. Caruthers

University of Colorado Boulder

Distinguished Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Aso-Based Pkm Splice-Switching Therapy Increases Anti-Ctla-4 Antibody Efficacy in Pancreatic Ductal Adenocarcinoma. Cell Discovery (2026)

Targeted Antisense Oligonucleotide Therapy Rescues Prpf31 Expression in Retinitis Pigmentosa Caused by a Splicing Mutation. Molecular Therapy (2026)

Pkm Splice-Switching Asos Induce Upregulation of Dual-Specificity Phosphatases and Dephosphorylation of Erk1/2 in Hepatocellular Carcinoma. Journal of Biological Chemistry (2025)

Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-In-Sarcoma Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences (2024)

Rita MejziniMarvin H. CaruthersBalazs SchaferOndrej KostovKavitha SudheendranMarija CibaMathias DanielsenSteve WiltonPatrick Anthony AkkariLoren L. Flynn

Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids. Nucleic Acid Therapeutics (2024)

Ledong WanAlexander J. KralDillon VossBalázs SchäferKavitha SudheendranMathias DanielsenMarvin H. CaruthersAdrian R. Krainer

dna sequencingsplice-switching antisense oligonucleotidesnucleic acidsgenomicsoligonucleotidespharmacologymolecular biologypancreas-cancer organoidsgene expressiononcologygenetics

Compromised Nonsense-Mediated Rna Decay Results in Truncated Rna-Binding Protein Production Upon Dux4 Expression. Cell Reports (2023)

gene expressionrna biologymolecular biology

Innovative Splice Switching Oligonucleotide Therapy for Niemann-Pick Type C1 Disease. IBRO Neuroscience Reports (2023)

Maria Martinez De LagranYu-Han HuangOndrej KostovHaiyan ZhouPaul GissenMarvin CaruthersTimothy YuDaniel GinbergMara Dierssen

oligonucleotidesoligonucleotide therapyinnovative spliceneuroscience

Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry. Molecules (2023)

Sibasish PaulMarvin H. Caruthers

Thiomorpholino Oligonucleotides as a Robust Class of Next Generation Platforms for Alternate Mrna Splicing. Proceedings of the National Academy of Sciences (2022)

Bao T. LeSibasish PaulKatarzyna JastrzebskaHeera LangerMarvin H. CaruthersRakesh N. Veedu

thiomorpholino oligonucleotidesalternate mrnaoligonucleotidestranscription (biology)molecular biologynext generation platforms

Nuclear Compartmentalization of Tert Mrna and Tug1 Lncrna is Driven by Intron Retention. Nature Communications (2021)

Gabrijela DumbovićUlrich BraunschweigHeera K. LangnerMichael SmalleganJosep BiaynaEvan P. HassKatarzyna JastrzebskaBenjamin BlencoweThomas R. CechMarvin H. CaruthersJohn L. Rinn

intron retentiontert mrnanuclear organizationmolecular biologynuclear compartmentalization

1
2
3
4
5
21
10 / page

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Scott K Silverman

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nucleic acid

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Carol A. Fierke

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biochemistry

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Paul Hergenrother

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antibacterial compounds

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synthetic biology

biomimetic chemistry

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Dean J Tantillo

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organic chemistry

polycyclization reactions

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