Faculty

Institution

Unit

Venue

Lou Romano

Distinguished Professor Emeritus

Wayne State University

Affiliations

College of Liberal Arts and Sciences

Chemistry

Lou Romano is currently serving as a Chemistry Distinguished Professor Emeritus at Wayne State University.

Honors

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Experiences

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Education

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Lou Romano

Wayne State University

Distinguished Professor Emeritus

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molecular biology biochemistry genetics enzymes protein science biological chemistry structural biology gene expression molecular genetics klenow fragment dna replication nucleic acids biological inorganic chemistry chemical biology mutagenesis (molecular biology technique) replication biochemical sciences enzyme inhibition mutagenesis biochemical genetics oligonucleotides active site structural molecular biology molecular cancer cancer biology cancer growth conformational change pharmacology redox biology bacteriophages molecular biotechnology gene editing rna biology cancer genetics protein chemistry cancer risk dna sequencing sequence context free radical biology cellular biochemistry molecular science biomolecular structure molecular structure in vitro toxicology cancer cells oncogenes microbial genetics bacteriology phage biology gene transfer epigenetic changes sequence assembly nucleic acid amplification epigenomics biocatalysis catalytic process enzyme catalysis molecular catalysis yeast genomic mechanisms dna analysis enzymatic modification functional modification structure-function enzyme kinetics cytosine methylation cpg sequence interstrand dna cross-links malondialdehyde mutagenicity salmonella typhimurium nucleobase shape complementarity closed polymerase-dna complex hydrogen bonding uvrabc nuclease uvrabc nuclease incision primer-template interactions dna helicase activity molecular technology dna synthesis pharmaceutical biotechnology cancer letter biotechnology advance chemical carcinogenesis laboratory investigation

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations. Scientific Reports (2017)

Pramodha S. LiyanageAlice R. WalkerAlfonso BrenllaG. Andrés CisnerosLouis J. RomanoDavid Rueda

bulky lesion bypassgeneticsmolecular biologystructural biologyprotein sciencedistinct conformations

Effect of N -2-Acetylaminofluorene and 2-Aminofluorene Adducts on Dna Binding and Synthesis by Yeast Dna Polymerase Η. Biochemistry (2009)

Venkataramana VooradiLouis J. Romano

dna bindingyeastgeneticsenzymesmolecular biologydna repairrna biologybiochemistry

Monitoring the Conformation of Benzo[ a ]Pyrene Adducts in the Polymerase Active Site Using Fluorescence Resonance Energy Transfer. Biochemistry (2009)

Thomas D. ChristianLouis J. Romano

biophysicsenzymespolymerase active sitemolecular biologydna repairstructural biologyprotein sciencebiochemistry

The Role of Specific Amino Acid Residues in the Active Site of Escherichia Coli Dna Polymerase I on Translesion Dna Synthesis Across From and Past an N -2-Aminofluorene Adduct. Biochemistry (2007)

Samer LoneLouis J. Romano

gene editingbiological chemistrytranslesion dna synthesisbiochemistryenzymesgenetic engineeringprotein sciencenucleic acidsprotein chemistryprotein synthesisgene expressionenzyme inhibitiongenome editingredox biologygeneticsbiological inorganic chemistrymolecular biologymolecular geneticsactive siteprotein expression

Mechanism for N -Acetyl-2-Aminofluorene-Induced Frameshift Mutagenesis by Escherichia Coli Dna Polymerase I (Klenow Fragment). Biochemistry (2005)

Joshua P. GillLouis J. Romano

molecular biophysicsgenomic mechanismsklenow fragmentbiochemical geneticsmutagenesisgeneticsenzymesbiological inorganic chemistryframeshift mutagenesismolecular biologymolecular geneticsprotein sciencemutagenesis (molecular biology technique)biochemistry

Crystal Structures of 2-Acetylaminofluorene and 2-Aminofluorene in Complex With T7 Dna Polymerase Reveal Mechanisms of Mutagenesis. Proceedings of the National Academy of Sciences (2004)

Shuchismita DuttaYing LiDonald JohnsonLeonid DzantievCharles C. RichardsonLouis J. RomanoTom Ellenberger

biophysicsmutagenesisgeneticsmolecular biologystructural biologyprotein sciencemutagenesis (molecular biology technique)

Mechanistic Insights Into Replication Across From Bulky Dna Adducts: A Mutant Polymerase I Allows an N -Acetyl-2-Aminofluorene Adduct to Be Accommodated During Dna Synthesis. Biochemistry (2003)

Samer LoneLouis J. Romano

bulky dna adductsreplicationgeneticsmolecular biologydna synthesisbiochemistry

Effects of Benzo[ a ]Pyrene Adduct Stereochemistry on Downstream Dna Replication in Vitro: Evidence for Different Adduct Conformations Within the Active Site of Dna Polymerase I (Klenow Fragment). Biochemistry (2002)

Yuriy O. AlekseyevLouis J. Romano

structure-function enzyme kineticsbiological chemistrydna replicationsurface reactivitybiochemistrydownstream dna replicationreplicationklenow fragmentdifferent adduct conformationsenzymesstructural biologyprotein sciencebiochemical sciencesmolecular substratesfunctional modificationmutagenesis (molecular biology technique)redox biologygeneticsmolecular biologystructural molecular biologyenzymatic modificationactive site

Effects of Benzo[ a ]Pyrene Dna Adducts on Escherichia Coli Dna Polymerase I (Klenow Fragment) Primer−Template Interactions: Evidence for Inhibition of the Catalytically Active Ternary Complex Formation. Biochemistry (2001)

Yuriy O. AlekseyevLeonid DzantievLouis J. Romano

molecular catalysisbiological chemistryenzyme catalysisdna replicationbiochemistrycell biologyklenow fragmentchemical biologyenzymesprotein sciencenucleic acidscatalysisbiocatalysiscatalytic processgene expressionenzyme inhibitionprimer-template interactionsbiological inorganic chemistrymolecular biology

Significance of Nucleobase Shape Complementarity and Hydrogen Bonding in the Formation and Stability of the Closed Polymerase−Dna Complex. Biochemistry (2001)

Leonid DzantievYuriy O. AlekseyevJuan C. MoralesEric T. KoolLouis J. Romano

hydrogen bondingclosed polymerase-dna complexmolecular biologystructural biologybiochemistrynucleobase shape complementarity

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Lou Romano

Distinguished Professor Emeritus

Wayne State University

Affiliations

College of Liberal Arts and Sciences

Chemistry

Lou Romano is currently serving as a Chemistry Distinguished Professor Emeritus at Wayne State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Lou Romano

Wayne State University

Distinguished Professor Emeritus

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations. Scientific Reports (2017)

Pramodha S. LiyanageAlice R. WalkerAlfonso BrenllaG. Andrés CisnerosLouis J. RomanoDavid Rueda

bulky lesion bypassgeneticsmolecular biologystructural biologyprotein sciencedistinct conformations

Effect of N -2-Acetylaminofluorene and 2-Aminofluorene Adducts on Dna Binding and Synthesis by Yeast Dna Polymerase Η. Biochemistry (2009)

Venkataramana VooradiLouis J. Romano

dna bindingyeastgeneticsenzymesmolecular biologydna repairrna biologybiochemistry

Monitoring the Conformation of Benzo[ a ]Pyrene Adducts in the Polymerase Active Site Using Fluorescence Resonance Energy Transfer. Biochemistry (2009)

Thomas D. ChristianLouis J. Romano

biophysicsenzymespolymerase active sitemolecular biologydna repairstructural biologyprotein sciencebiochemistry

The Role of Specific Amino Acid Residues in the Active Site of Escherichia Coli Dna Polymerase I on Translesion Dna Synthesis Across From and Past an N -2-Aminofluorene Adduct. Biochemistry (2007)

Samer LoneLouis J. Romano

Mechanism for N -Acetyl-2-Aminofluorene-Induced Frameshift Mutagenesis by Escherichia Coli Dna Polymerase I (Klenow Fragment). Biochemistry (2005)

Joshua P. GillLouis J. Romano

Crystal Structures of 2-Acetylaminofluorene and 2-Aminofluorene in Complex With T7 Dna Polymerase Reveal Mechanisms of Mutagenesis. Proceedings of the National Academy of Sciences (2004)

Shuchismita DuttaYing LiDonald JohnsonLeonid DzantievCharles C. RichardsonLouis J. RomanoTom Ellenberger

biophysicsmutagenesisgeneticsmolecular biologystructural biologyprotein sciencemutagenesis (molecular biology technique)

Mechanistic Insights Into Replication Across From Bulky Dna Adducts: A Mutant Polymerase I Allows an N -Acetyl-2-Aminofluorene Adduct to Be Accommodated During Dna Synthesis. Biochemistry (2003)

Samer LoneLouis J. Romano

bulky dna adductsreplicationgeneticsmolecular biologydna synthesisbiochemistry

Yuriy O. AlekseyevLouis J. Romano

Yuriy O. AlekseyevLeonid DzantievLouis J. Romano

Significance of Nucleobase Shape Complementarity and Hydrogen Bonding in the Formation and Stability of the Closed Polymerase−Dna Complex. Biochemistry (2001)

Leonid DzantievYuriy O. AlekseyevJuan C. MoralesEric T. KoolLouis J. Romano

hydrogen bondingclosed polymerase-dna complexmolecular biologystructural biologybiochemistrynucleobase shape complementarity

1
2
3
10 / page

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Ashis Basu

Institution

University of Connecticut

genome instability

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Carmelo Rizzo

Institution

Vanderbilt University

molecular biology

mutagenesis

Michael P. Stone

Institution

Vanderbilt University

molecular biology

biochemistry

John-Stephen Taylor

Institution

Washington University in St. Louis

breast cancer imaging

heat shock proteins

Thomas Spratt

Institution

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dna sequencing

mutagenesis (molecular biology technique)

Francis Johnson

Institution

Stony Brook University

natural product communication

medicinal chemistry

Danith Ly

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general chemistry

molecular and cellular biology

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California Institute of Technology

genome instability

genomic stability

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cancer letter

endocrinology

Ferreira, Gloria

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University of South Florida

heme degradation

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