Faculty

Institution

Unit

Venue

Leslie V. Parise

Dean of the College of Agriculture and Life Sciences

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Biochemistry and Biophysics

Leslie V. Parise is currently serving as a Biochemistry And Biophysics Dean of the College of Agriculture and Life Sciences at University of North Carolina At Chapel Hill.

Honors

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Experiences

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Education

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Leslie V. Parise

University of North Carolina at Chapel Hill

Dean of the College of Agriculture and Life Sciences

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hematology pharmacology cell biology physiology immunology vascular biology cell signaling thrombosis structural biology hemostasis membrane biology blood platelet tumor biology inflammation biological chemistry protein science medicinal research liver physiology signal transduction cellular physiology gene expression sickle cell disease cardiovascular research cancer biology biochemical sciences cell adhesion angiogenesis molecular physiology mammalian biology angiology structural molecular biology integrative biology receptor (biochemistry) cellular biology cell migration biomolecular interactions cell regulation molecular cell biology oncogenes protein function tumor targeting blood cells cancer risk platelet antagonist carbohydrate-protein interactions biological invasions cellular therapy cell motility catalyst activation protein phosphorylation cell-matrix interactions cell physiology clinical physiology cardiovascular physiology biological inorganic chemistry signaling pathways acute pain vascular disease molecular regulation sickle cell adhesion cib binding phospholipid vesicles acute pain episodes potential compensation tmj disorder remedial action integrin-mediated cell motility actin cytoskeleton affinity modulation rbc adhesion cyclic amp-mediated activation novel epinephrine platelet integrins necessary co-receptor collagen-induced activation cytoplasmic domains cardiovascular toxicity cardiovascular disease cardiology circulatory physiology cardiac pathologies cardiovascular translational research medicine

Notable Scholarly Works

Notable Federal Grants

Collaborators

Susan S. Smyth (1965–2022). Arteriosclerosis Thrombosis and Vascular Biology (2023)

Leslie V. PariseBarry S. CollerSidney W. WhiteheartCam Patterson

immunologycardiologyphysiologyhematologythrombosisatherosclerosisvascular biologyangiology

Discovery and Development of Cyclic Peptide Inhibitors of Cib1. ACS Medicinal Chemistry Letters (2021)

Victoria A. HabermanSteven R. FlemingTina M. LeisnerAna C. PuhlEmerald FengLing XieXian ChenYuki GotoHiroaki SugaLeslie V. PariseDmitri KireevKenneth H. PearceAlbert A. Bowers

medicinal chemistrydrug discoverypharmacologycyclic peptide inhibitors

Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1. ACS Chemical Biology (2020)

Ana C. PuhlJonathan W. BogartVictoria A. HabermanJacob E. LarsonAndre S. GodoyJacqueline L. Norris-DrouinStephanie H. CholenskyTina M. LeisnerStephen V. FryeLeslie V. PariseAlbert A. BowersKenneth H. Pearce

medicinal chemistryreceptorspeptide inhibitorspharmacologydrug discoverychemistry

Identification of Novel Integrin Binding Partners for Cib1: Structural and Thermodynamic Basis of Cib1 Promiscuity. UNC Libraries (2020)

Freeman, Thomas C.Black, Justin L.Bray, Holly G.Dagliyan, OnurWu, Yi I.Tripathy, AshutoshDokholyan, Nikolay V.Leisner, Tina M.Parise, Leslie V.

medicinal chemistrymaterials sciencebiomolecular interactionsmolecular biophysicspharmacologylead identificationprotein structurebiomolecular structurebiomolecular engineeringstructural molecular biologymolecular recognitionstructural biologyprotein designstructural genomicsthermodynamic basis

Cib1 Depletion With Docetaxel or Trail Enhances Triple-Negative Breast Cancer Cell Death. Cancer Cell International (2019)

Alexander H. ChungTina M. LeisnerGabrielle J. DardisMarissa M. BivinsAlana L. KellerLeslie V. Parise

tumor targetingdermatologycell deathpharmacologycancer carecancer researchcancer immunotherapycellular therapyapoptosisoncologybreast canceroncogenic agentcancer cellsmedicinal researchcancer riskcancer biologytumor biologycell biology

Ether Lipid Metabolism by Aadacl1 Regulates Platelet Function and Thrombosis. Blood Advances (2019)

Stephen P. HollyNidhi GeraPutianqi WangAlexander WilsonZiqiang GuanLing LinBrian CooleyHammodah R. AlfarRuchi G. PatilRaymond PiattTina M. LeisnerWolfgang BergmeierRinku MajumderLeslie V. Parise

physiologyliver physiologylipid metabolismpharmacologyhematologythrombosisnephrologyhealth scienceshemostasis

Machine Learning to Quantitate Neutrophil Netosis. Scientific Reports (2019)

Laila ElsherifNoah SciakyCarrington A. MettsMd. ModasshirIoannis RekleitisChristine A. BurrisJoshua A. WalkerNadeem RamadanTina M. LeisnerStephen P. HollyMartis W. CowlesKenneth I. AtagaJoshua N. CooperLeslie V. Parise

immunologyquantitative biologyscientific datacomputational biologymachine learninghealth sciencesneutrophil netosis

Targeted Delivery of Sirna Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer. Advanced Science (2019)

Elizabeth C. WayneChristian LongMatthew J. HaneyElena V. BatrakovaTina M. LeisnerLeslie V. PariseAlexander V. Kabanov

immunologygene therapydermatologytumor targetingnanomedicinebiomedical engineeringgene transfergene deliverytissue engineeringdrug targetingsirna lipoplexestargeted deliverydrug deliverydelivery systems

Abstract 3967: Potent Treatment Combinations With Cib1 Depletion in Triple-Negative Breast Cancer. Cancer Research (2018)

Alexander H. ChungTina M. LeisnerGabrielle DardisMarissa BivinsLeslie V. Parise

triple-negative breast cancerpharmacologynanomedicinecancer carecancer managementradiation oncologycancer researchcancer immunotherapyanti-cancer agentsbreast canceroncologypotent treatment combinationsmedicinal researchcancer treatmentcancer biologybreast oncology

Effect of Eptifibatide on Inflammation During Acute Pain Episodes in Sickle Cell Disease. American Journal of Hematology (2018)

Julia E. BrittainCiprian AneaPayal DesaiJack DelaneyAdam McDonaldStephen W. LooneyNigel S. KeyLeslie V. PariseKenneth I. Ataga

dermatologypharmacologyhematologygeneticsacute painacute pain episodessickle cell diseaseinflammation

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Leslie V. Parise

Dean of the College of Agriculture and Life Sciences

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Biochemistry and Biophysics

Leslie V. Parise is currently serving as a Biochemistry And Biophysics Dean of the College of Agriculture and Life Sciences at University of North Carolina At Chapel Hill.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Leslie V. Parise

University of North Carolina at Chapel Hill

Dean of the College of Agriculture and Life Sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Susan S. Smyth (1965–2022). Arteriosclerosis Thrombosis and Vascular Biology (2023)

Leslie V. PariseBarry S. CollerSidney W. WhiteheartCam Patterson

immunologycardiologyphysiologyhematologythrombosisatherosclerosisvascular biologyangiology

Discovery and Development of Cyclic Peptide Inhibitors of Cib1. ACS Medicinal Chemistry Letters (2021)

Victoria A. HabermanSteven R. FlemingTina M. LeisnerAna C. PuhlEmerald FengLing XieXian ChenYuki GotoHiroaki SugaLeslie V. PariseDmitri KireevKenneth H. PearceAlbert A. Bowers

medicinal chemistrydrug discoverypharmacologycyclic peptide inhibitors

Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1. ACS Chemical Biology (2020)

medicinal chemistryreceptorspeptide inhibitorspharmacologydrug discoverychemistry

Identification of Novel Integrin Binding Partners for Cib1: Structural and Thermodynamic Basis of Cib1 Promiscuity. UNC Libraries (2020)

Freeman, Thomas C.Black, Justin L.Bray, Holly G.Dagliyan, OnurWu, Yi I.Tripathy, AshutoshDokholyan, Nikolay V.Leisner, Tina M.Parise, Leslie V.

Cib1 Depletion With Docetaxel or Trail Enhances Triple-Negative Breast Cancer Cell Death. Cancer Cell International (2019)

Alexander H. ChungTina M. LeisnerGabrielle J. DardisMarissa M. BivinsAlana L. KellerLeslie V. Parise

Ether Lipid Metabolism by Aadacl1 Regulates Platelet Function and Thrombosis. Blood Advances (2019)

Stephen P. HollyNidhi GeraPutianqi WangAlexander WilsonZiqiang GuanLing LinBrian CooleyHammodah R. AlfarRuchi G. PatilRaymond PiattTina M. LeisnerWolfgang BergmeierRinku MajumderLeslie V. Parise

physiologyliver physiologylipid metabolismpharmacologyhematologythrombosisnephrologyhealth scienceshemostasis

Machine Learning to Quantitate Neutrophil Netosis. Scientific Reports (2019)

immunologyquantitative biologyscientific datacomputational biologymachine learninghealth sciencesneutrophil netosis

Targeted Delivery of Sirna Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer. Advanced Science (2019)

Elizabeth C. WayneChristian LongMatthew J. HaneyElena V. BatrakovaTina M. LeisnerLeslie V. PariseAlexander V. Kabanov

Abstract 3967: Potent Treatment Combinations With Cib1 Depletion in Triple-Negative Breast Cancer. Cancer Research (2018)

Alexander H. ChungTina M. LeisnerGabrielle DardisMarissa BivinsLeslie V. Parise

Effect of Eptifibatide on Inflammation During Acute Pain Episodes in Sickle Cell Disease. American Journal of Hematology (2018)

Julia E. BrittainCiprian AneaPayal DesaiJack DelaneyAdam McDonaldStephen W. LooneyNigel S. KeyLeslie V. PariseKenneth I. Ataga

dermatologypharmacologyhematologygeneticsacute painacute pain episodessickle cell diseaseinflammation

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