Faculty

Institution

Unit

Venue

Shafi Kuchay

Associate Professor

University of Illinois Chicago

Affiliations

College of Medicine

Department of Biochemistry and Molecular Genetics

Shafi Kuchay is currently serving as a College Of Medicine Associate Professor at University of Illinois Chicago.

Honors

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Experiences

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Education

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Shafi Kuchay

University of Illinois Chicago

Associate Professor

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cell biology molecular biology pharmacology membrane biology cell death cell signaling protein science neuroscience structural biology tumor biology molecular and cellular biology medicinal research signal transduction gene expression molecular cell biology protein function cell regulation hepatology liver physiology hemostasis cellular biology apoptosis cellular physiology enzyme inhibition mitochondrial function molecular regulation vascular biology cancer cells gene function gene regulation cancer genomics cancer genetics signaling pathways protein biosynthesis gene inactivation ubiquitin ligase molecular cancer animal physiology avian biology livestock science animal science biomolecular structure structural chemistry redox signaling tumor targeting cancer prevention anti-cancer agents cancer treatment structural genomics protein expression enzyme specificity blood platelet biological targets molecular neurobiology neuroprotection brain function functional modification cell-matrix interactions knockout mice g protein-coupled receptor viral pathogenesis treatment and prevention cell transformation pten counteracts postmortem proteolysis auto-amplification loop warburg effect physiological target traumatic brain injury neuronal apoptosis calpain-mediated regulation platelet signaling pathways lipid homeostasis selective uptake matrix detachment monounsaturated fatty acids ubiquitin-proteasome system cellular biochemistry cell and molecular biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Geranylgeranylated Scffbxo10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function. Cell Reports (2024)

Sameer Ahmed BhatZahra VasiLiping JiangShruthi SelvarajRachel FergusonSanaz SalarvandAnish GudurRitika AdhikariVeronica CastilloHagar IsmailAvantika DhabariaBeatrix UeberheideShafi Kuchay

gene expressionmitochondrial dynamicssystems biologycell signalingmolecular and cellular biologymitochondrial functionmolecular cell biologymolecular biologymembrane proteinsmitophagymitochondrial biogenesiscellular biologymembrane biologycell biology

Geranylgeranylated-Scf Fbxo10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Sameer Ahmed BhatZahra VasiLiping JiangShruthi SelvarajRachel FergusonAnish GudurHagar IsmailRitika AdhikariAvantika DhabariaBeatrix UeberheideShafi Kuchay

mitochondrial functiongeneticsenzymesbiological functionmolecular biologygerm cell fateprotein sciencemembrane biologycell biology

Cd36 Maintains Lipid Homeostasis via Selective Uptake of Monounsaturated Fatty Acids During Matrix Detachment and Tumor Progression. Cell Metabolism (2023)

Alexander R. TerryVeronique NogueiraHyunsoo RhoGopalakrishnan RamakrishnanJing LiSoeun KangKoralege C. PathmasiriSameer Ahmed BhatLiping JiangShafi KuchayStephanie M. ColognaNissim Hay

selective uptakelipid homeostasisclinical lipidologylipidsvascular biologymatrix biologyprotein sciencetumor progressionmembrane biologycell metabolismdermatologymolecular and cellular biologycell-matrix interactionsmatrix detachmentfunctional modificationtumor biologygene expressiongeneticsmolecular biologymonounsaturated fatty acids

Detection of Membrane-Anchoring Lipid Modifications of Proteins in Cells by Radioactive Metabolic Labeling. STAR Protocols (2023)

Sameer Ahmed BhatRachel FergusonRitika AdhikariShafi Kuchay

lipid analysisbiophysicsproteomicsradioactive metabolic labelingredox biologymolecular biologymembrane-anchoring lipid modificationsstructural biologyprotein sciencemembrane biologycell biology

Editorial Overview: Immune Regulation and Cancers. Current Opinion in Pharmacology (2023)

Carlotta GiorgiShafi Kuchay

immunologymedicineeditorial overviewpharmacologyoncologyimmune regulationcancer biology

Palmitoylation and Pde6δ Regulate Membrane-Compartment-Specific Substrate Ubiquitylation and Degradation. Cell Reports (2023)

David LiangLiping JiangSameer Ahmed BhatSonia MissiroliMariasole PerroneAngela LauriolaRitika AdhikariAnish GudurZahra VasiIan AhearnDaniele GuardavaccaroCarlotta GiorgiMark PhilipsShafi Kuchay

biophysicsmolecular biologymembrane-compartment-specific substrate ubiquitylationstructural biologymembrane biologycell biology

Ubiquitin Proteasome System in Immune Regulation and Therapeutics. Current Opinion in Pharmacology (2022)

Sameer Ahmed BhatZahra VasiRitika AdhikariAnish GudurAsceal AliLiping JiangRachel FergusonDavid LiangShafi Kuchay

immunologymedicinepharmacologyproteomicsubiquitin proteasome systemimmune regulation

Ggtase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase. Nature Structural & Molecular Biology (2019)

Shafi KuchayHui WangAntonio MarzioKunj JainHarrison HomerNicole FehrenbacherMark R. PhilipsNing ZhengMichele Pagano

structural genomicsprotein structuregeneticsmolecular structurebiomolecular structureenzyme specificityenzymesmolecular biologystructural molecular biologystructural chemistryubiquitin ligaseprotein expressionstructural biologyprotein biosynthesisprotein scienceprotein engineeringmembrane biologybiochemistry

Ggtase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase. Nat Struct Mol Biol (2019)

molecular researchgene expressionbiochemical geneticssystems biologymolecular and cellular biologymolecular cell biologymolecular biologybiological chemistryubiquitin ligaseprotein biosynthesismutagenesis (molecular biology technique)

Ns5A Promotes Constitutive Degradation of Ip3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. Cell Reports (2018)

immunologycell deathmedical virologyconstitutive degradationcell signalinghepatitisapoptosisviral hepatitisliver physiologyhepatitis c viruscell biology

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Shafi Kuchay

Associate Professor

University of Illinois Chicago

Affiliations

College of Medicine

Department of Biochemistry and Molecular Genetics

Shafi Kuchay is currently serving as a College Of Medicine Associate Professor at University of Illinois Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Shafi Kuchay

University of Illinois Chicago

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Geranylgeranylated Scffbxo10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function. Cell Reports (2024)

Sameer Ahmed BhatZahra VasiLiping JiangShruthi SelvarajRachel FergusonSanaz SalarvandAnish GudurRitika AdhikariVeronica CastilloHagar IsmailAvantika DhabariaBeatrix UeberheideShafi Kuchay

Geranylgeranylated-Scf Fbxo10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Sameer Ahmed BhatZahra VasiLiping JiangShruthi SelvarajRachel FergusonAnish GudurHagar IsmailRitika AdhikariAvantika DhabariaBeatrix UeberheideShafi Kuchay

mitochondrial functiongeneticsenzymesbiological functionmolecular biologygerm cell fateprotein sciencemembrane biologycell biology

Cd36 Maintains Lipid Homeostasis via Selective Uptake of Monounsaturated Fatty Acids During Matrix Detachment and Tumor Progression. Cell Metabolism (2023)

Alexander R. TerryVeronique NogueiraHyunsoo RhoGopalakrishnan RamakrishnanJing LiSoeun KangKoralege C. PathmasiriSameer Ahmed BhatLiping JiangShafi KuchayStephanie M. ColognaNissim Hay

Detection of Membrane-Anchoring Lipid Modifications of Proteins in Cells by Radioactive Metabolic Labeling. STAR Protocols (2023)

Sameer Ahmed BhatRachel FergusonRitika AdhikariShafi Kuchay

lipid analysisbiophysicsproteomicsradioactive metabolic labelingredox biologymolecular biologymembrane-anchoring lipid modificationsstructural biologyprotein sciencemembrane biologycell biology

Editorial Overview: Immune Regulation and Cancers. Current Opinion in Pharmacology (2023)

Carlotta GiorgiShafi Kuchay

immunologymedicineeditorial overviewpharmacologyoncologyimmune regulationcancer biology

Palmitoylation and Pde6δ Regulate Membrane-Compartment-Specific Substrate Ubiquitylation and Degradation. Cell Reports (2023)

David LiangLiping JiangSameer Ahmed BhatSonia MissiroliMariasole PerroneAngela LauriolaRitika AdhikariAnish GudurZahra VasiIan AhearnDaniele GuardavaccaroCarlotta GiorgiMark PhilipsShafi Kuchay

biophysicsmolecular biologymembrane-compartment-specific substrate ubiquitylationstructural biologymembrane biologycell biology

Ubiquitin Proteasome System in Immune Regulation and Therapeutics. Current Opinion in Pharmacology (2022)

Sameer Ahmed BhatZahra VasiRitika AdhikariAnish GudurAsceal AliLiping JiangRachel FergusonDavid LiangShafi Kuchay

immunologymedicinepharmacologyproteomicsubiquitin proteasome systemimmune regulation

Ggtase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase. Nature Structural & Molecular Biology (2019)

Shafi KuchayHui WangAntonio MarzioKunj JainHarrison HomerNicole FehrenbacherMark R. PhilipsNing ZhengMichele Pagano

Ggtase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase. Nat Struct Mol Biol (2019)

Ns5A Promotes Constitutive Degradation of Ip3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. Cell Reports (2018)

immunologycell deathmedical virologyconstitutive degradationcell signalinghepatitisapoptosisviral hepatitisliver physiologyhepatitis c viruscell biology

1
2
3
4
10 / page

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Nissim Hay

Institution

University of Illinois Chicago

cancer biology

cancer research

Andrius Kazlauskas

Institution

University of Illinois Chicago

endothelial dysfunction

endothelial cell biology

Ganes C. Sen

Institution

Case Western Reserve University

viral oncology

viral pathogenesis

Dafna Bar-Sagi

Institution

New York University

oncogene

oncogene function

Kermit Carraway

Institution

University of California, Davis

pharmacological research

toxicological mechanism

Charles Lang

Institution

Pennsylvania State University

physiology

endocrinology

Pradeep K. Dudeja

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gastroenterology

cell biology

Jacob I Sznajder

Institution

Northwestern University

respiratory medicine

physiology

Thomas M. McIntyre

Institution

Case Western Reserve University

free radical biology

apoptosis

Rafael Fridman

Institution

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proteases

cancer biology